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Immunol."],"abstract":"<jats:p>\u03b3\u03b4T cells are an unconventional population of T lymphocytes that play an indispensable role in host defense, immune surveillance, and homeostasis of the immune system. They display unique developmental, distributional, and functional patterns and rapidly respond to various insults and contribute to diverse diseases. Although \u03b3\u03b4T cells make up only a small portion of the total T cell pool, emerging evidence suggest that aberrantly activated \u03b3\u03b4T cells may play a role in the pathogenesis of psoriasis. Dermal \u03b3\u03b4T cells are the major IL-17-producing cells in the skin that respond to IL-23 stimulation. Furthermore, \u03b3\u03b4T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. This review discusses the differentiation, development, distribution, and biological function of \u03b3\u03b4T cells and the mechanisms by which they contribute to psoriasis. 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