{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:15:39Z","timestamp":1790381739120,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vitamin D deficiency is a well-described preventable cause of many cancers; the association of vitamin D use with the development of head and neck cancer (HNC) is not clear. We aim to conduct a systematic review of the studies assessing the relation between vitamin D exposure and the prevention and prognosis of the HNC using meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, EMBASE, Cochrane Library, Web of Science up to 1 January 2021, and reference lists of related studies were searched. We extracted observational studies reporting the association between vitamin D (vitamin D receptor gene polymorphisms, 25-hydroxyvitamin D concentrations, and vitamin D intake) and the outcomes of interest (HNC incidence and HNC mortality) in HNC patients aged 18 or older. Fixed effects models were used to calculate pooled effect sizes and 95% confidence intervals (CIs) by RevMan (version 5.3).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen studies with a total of 81,908 participants were enrolled in our meta-analysis. Based on the pooled genomic analysis, comparing with participants with the genotypes of\n                      <jats:italic>Ff<\/jats:italic>\n                      +\n                      <jats:italic>FF<\/jats:italic>\n                      or\n                      <jats:italic>FF<\/jats:italic>\n                      , the pooled odds ratio (OR) of participants with the genotype of\n                      <jats:italic>ff<\/jats:italic>\n                      was 0.77 (95% CI: 0.61 to 0.97) and 0.75 (0.58 to 0.97), respectively. A similar trend was noted when comparing\n                      <jats:italic>tt<\/jats:italic>\n                      with\n                      <jats:italic>Tt<\/jats:italic>\n                      +\n                      <jats:italic>TT<\/jats:italic>\n                      or\n                      <jats:italic>TT<\/jats:italic>\n                      , in which OR (95% CI) was 0.70 (0.55 to 0.90) and 0.72 (0.55 to 0.95). No significant association was identified between\n                      <jats:italic>BsmI<\/jats:italic>\n                      polymorphism and HNC. Furthermore, the OR of HNC incidence was 0.77 (0.65 to 0.92) for participants with vitamin D intake over the ones with a regular diet. High concentrations of circulated 25-hydroxyvitamin D (25-OHD) significantly decreased by 32% of HNC incidence (OR (95% CI): 0.68 (0.59 to 0.78)) and increased HNC survival (pooled hazard ratio 1.13, 1.05 to 1.22) during a 4\u20135 years follow-up. High concentrations of circulating 25-OHD in patients with HNC led to a decreased risk of mortality to 0.75 (0.60 to 0.94) as the follow-up extends to 8\u201312 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated activities of vitamin D by diet intake, genomic polymorphisms, or circulated 25-OHD may protect people from HNC and improve the prognosis of patients with HNC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      PROSPERO, identifier CRD42020176002 (\n                      <jats:uri>https:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?RecordID=176002<\/jats:uri>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2021.627226","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T23:34:24Z","timestamp":1614036864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Association Between Vitamin D Exposure and Head and Neck Cancer: A Systematic Review With Meta-Analysis"],"prefix":"10.3389","volume":"12","author":[{"given":"Yuting","family":"Pu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangcai","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene X. Y.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"899","DOI":"10.6004\/jnccn.2020.7590","article-title":"Evolving Role of Immunotherapy in Recurrent Metastatic Head and Neck Cancer","volume":"18","author":"Le","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000446117","article-title":"Global Epidemiology of Head and Neck Cancers: A Continuing Challenge","volume":"91","author":"Gupta","year":"2016","journal-title":"Oncology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1056\/NEJMra1715715","article-title":"Head and Neck Cancer","volume":"382","author":"Chow","year":"2020","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/coa.13144","article-title":"The changing aetiology of head and neck squamous cell cancer: A tale of three cancers","volume":"43","author":"Thomas","year":"2018","journal-title":"Clin Otolaryngol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3390\/jcm7090241","article-title":"A Review of HPV-Related Head and Neck Cancer","volume":"7","author":"Kobayashi","year":"2018","journal-title":"J Clin Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200823","article-title":"Early metabolic 18F-FDG PET\/CT response of locally advanced squamous-cell carcinoma of head and neck to induction chemotherapy: A prospective pilot study","volume":"13","author":"Nicolau","year":"2018","journal-title":"PloS One"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1626","article-title":"Induction chemotherapy in the treatment of nasopharyngeal carcinoma: Clinical outcomes and patterns of care","volume":"7","author":"Gabani","year":"2018","journal-title":"Cancer Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3725837","article-title":"Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer","volume":"2018","author":"Bhattacharyya","year":"2018","journal-title":"J Oncol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.910224","article-title":"The Role of Immunotherapy and Radiation Therapy in Tumor Chemosensitivity in Advanced Head and Neck Cancer","volume":"19","author":"Atiq","year":"2018","journal-title":"Am J Case Rep"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.oraloncology.2018.05.018","article-title":"Metabolic signature of squamous cell carcinoma of the head and neck: Consequences of TP53 mutation and therapeutic perspectives","volume":"83","author":"Wilkie","year":"2018","journal-title":"Oral Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa306","article-title":"Is there a survival advantage of oral immunonutrition in head and neck cancer","volume":"112","author":"Adiamah","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/jcsm.12127","article-title":"A systematic review on the role of vitamins, minerals, proteins, and other supplements for the treatment of cachexia in cancer: a European Palliative Care Research Centre cachexia project","volume":"8","author":"Mochamat","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B14","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3390\/nu8030163","article-title":"Micronutrients in Oncological Intervention","volume":"8","author":"Grober","year":"2016","journal-title":"Nutrients"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1195","article-title":"Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine","volume":"98","author":"Bouillon","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.014","article-title":"Genetics and biology of vitamin D receptor polymorphisms","volume":"338","author":"Uitterlinden","year":"2004","journal-title":"Gene"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1371\/journal.pmed.0040103","article-title":"A prospective study of plasma vitamin D metabolites, vitamin D receptor polymorphisms, and prostate cancer","volume":"4","author":"Li","year":"2007","journal-title":"PloS Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/s0303-7207(01)00406-3","article-title":"Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene","volume":"177","author":"Whitfield","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010062929140","article-title":"Molecular nature of the vitamin D receptor and its role in regulation of gene expression","volume":"2","author":"Jurutka","year":"2001","journal-title":"Rev Endocr Metab Disord"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/9.3.227","article-title":"Do sunlight and vitamin D reduce the likelihood of colon cancer","volume":"9","author":"Garland","year":"1980","journal-title":"Int J Epidemiol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-1141","article-title":"Meta-analyses of vitamin D intake, 25-hydroxyvitamin D status, vitamin D receptor polymorphisms, and colorectal cancer risk","volume":"20","author":"Touvier","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B22","doi-asserted-by":"publisher","first-page":"R74","DOI":"10.1186\/bcr2920","article-title":"Serum 25-hydroxyvitamin D and postmenopausal breast cancer survival: a prospective patient cohort study","volume":"13","author":"Vrieling","year":"2011","journal-title":"Breast Cancer Res"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.10.036","article-title":"Suppression of prostate cancer cell rolling and adhesion to endothelium by 1alpha,25-dihydroxyvitamin D3","volume":"178","author":"Hsu","year":"2011","journal-title":"Am J Pathol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.201939","article-title":"Low plasma 25-hydroxyvitamin D and risk of tobacco-related cancer","volume":"59","author":"Afzal","year":"2013","journal-title":"Clin Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep36017","article-title":"Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort","volume":"6","author":"Fanidi","year":"2016","journal-title":"Sci Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj101","article-title":"Prospective study of predictors of vitamin D status and cancer incidence and mortality in men","volume":"98","author":"Giovannucci","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp036","article-title":"and cancers of the oral cavity and esophagus","volume":"20","author":"Lipworth","year":"2009","journal-title":"Ann Oncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1481-y","article-title":"Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract","volume":"268","author":"Gugatschka","year":"2011","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0153","article-title":"Serum 25-hydroxyvitamin D and risk of oropharynx and larynx cancers in finnish men","volume":"20","author":"Arem","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0007","article-title":"Prospective population-based study of the association between serum 25-hydroxyvitamin-D levels and the incidence of specific types of cancer","volume":"23","author":"Skaaby","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000401)86:1<122::AID-IJC19>3.0.CO;2-2","article-title":"Selected micronutrients and oral and pharyngeal cancer","volume":"86","author":"Negri","year":"2000","journal-title":"Int J Cancer"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20846","article-title":"Dairy products, leanness, and head and neck squamous cell carcinoma","volume":"30","author":"Peters","year":"2008","journal-title":"Head Neck"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0428-2","article-title":"Circulating 25-hydroxyvitamin D up to 3\u00a0decades prior to diagnosis in relation to overall and organ-specific cancer survival","volume":"33","author":"Weinstein","year":"2018","journal-title":"Eur J Epidemiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1476817","article-title":"Vitamin D deficiency in head and neck cancer patients\u2013prevalence, prognostic value and impact on immune function","volume":"7","author":"Bochen","year":"2018","journal-title":"OncoImmunology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25496","article-title":"Dietary vitamin D intake and serum 25-hydroxyvitamin D level in relation to disease outcomes in head and neck cancer patients","volume":"128","author":"Meyer","year":"2011","journal-title":"Int J Cancer"},{"key":"B36","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11912-020-00996-7","article-title":"Vitamin D in Head and Neck Cancer: a Systematic Review","volume":"23","author":"Makitie","year":"2020","journal-title":"Curr Oncol Rep"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"B41","article-title":"Association of Vitamin D Receptor Taq I Polymorphism and Susceptibility to Oral Squamous Cell Carcinoma","volume":"24","author":"Bektas-Kayhan","year":"2010","journal-title":"In Vivo"},{"key":"B42","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5582\/bst.2011.v5.3.99","article-title":"No association between Vitamin D receptor gene polymorphisms and nasopharyngeal carcinoma in a Chinese Han population","volume":"5","author":"Huang","year":"2011","journal-title":"Biosci Trends"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1097\/01213011-200503000-00004","article-title":"Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer","volume":"15","author":"Liu","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01164.x","article-title":"Vitamin D receptor, CYP27B1 and CYP24A1 genes polymorphisms association with oral cancer risk and survival","volume":"41","author":"Zeljic","year":"2012","journal-title":"J Oral Pathol Med"},{"key":"B45","first-page":"24","article-title":"Hypovitaminosis D: a widespread epidemic","volume":"63","author":"Cherniack","year":"2008","journal-title":"Geriatrics"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00692-0","article-title":"Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III","volume":"30","author":"Looker","year":"2002","journal-title":"Bone"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.10.2350","article-title":"Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb\/c mice","volume":"135","author":"Tangpricha","year":"2005","journal-title":"J Nutr"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1721S","article-title":"Vitamin D and breast cancer: insights from animal models","volume":"80","author":"Welsh","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.6.1586","article-title":"Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial","volume":"85","author":"Lappe","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0611","article-title":"Dairy, calcium, and vitamin D intake and postmenopausal breast cancer risk in the Cancer Prevention Study II Nutrition Cohort","volume":"14","author":"McCullough","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2008.06.002","article-title":"Intake of vitamin D and risk of breast cancer\u2013a meta-analysis","volume":"111","author":"Gissel","year":"2008","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.002","article-title":"Vitamin D and cancer incidence in the Harvard cohorts","volume":"19","author":"Giovannucci","year":"2009","journal-title":"Ann Epidemiol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"Holick","year":"2006","journal-title":"Mayo Clin Proc"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21954","article-title":"High prevalence of vitamin D insufficiency in patients with head and neck cancer at diagnosis","volume":"34","author":"Orell-Kotikangas","year":"2012","journal-title":"Head Neck"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.7566","article-title":"Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies","volume":"29","author":"Ma","year":"2011","journal-title":"J Clin Oncol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0593-9","article-title":"Meta-analysis of vitamin D, calcium and the prevention of breast cancer","volume":"121","author":"Chen","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"B58","doi-asserted-by":"publisher","first-page":"k671","DOI":"10.1136\/bmj.k671","article-title":"Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort","volume":"360","author":"Budhathoki","year":"2018","journal-title":"BMJ"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-010-9706-3","article-title":"Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose-response meta-analysis","volume":"22","author":"Gilbert","year":"2011","journal-title":"Cancer Causes Control"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.7301","article-title":"Population-based study of competing mortality in head and neck cancer","volume":"29","author":"Rose","year":"2011","journal-title":"J Clin Oncol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1903","article-title":"Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies","volume":"348","author":"Chowdhury","year":"2014","journal-title":"BMJ"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.175","article-title":"Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: a meta-analysis","volume":"110","author":"Kim","year":"2014","journal-title":"Br J Cancer"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.3390\/nu11102295","article-title":"25-Hydroxyvitamin D and Total Cancer Incidence and Mortality: A Meta-Analysis of Prospective Cohort Studies","volume":"11","author":"Han","year":"2019","journal-title":"Nutrients"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp103","article-title":"Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk","volume":"30","author":"Raimondi","year":"2009","journal-title":"Carcinogenesis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s13277-013-1011-9","article-title":"TaqI polymorphism of VDR gene contributes to breast cancer risk","volume":"35","author":"Wang","year":"2014","journal-title":"Tumour Biol"},{"key":"B66","article-title":"Vitamin D receptor gene polymorphisms and risk of prostate cancer: a meta-analysis","volume":"12","author":"Ntais","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1544-y","article-title":"Systematic review and meta-analysis on vitamin D receptor polymorphisms and cancer risk","volume":"35","author":"Xu","year":"2014","journal-title":"Tumor Biol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.3.325","article-title":"The nuclear vitamin D receptor: biological and molecular regulatory properties revealed","volume":"13","author":"Haussler","year":"1998","journal-title":"J Bone Miner Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0459-7","article-title":"Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamm D3","volume":"53","author":"Lathers","year":"2004","journal-title":"Cancer Immunol Immunother"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1886","article-title":"Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers","volume":"12","author":"Badoual","year":"2006","journal-title":"Clin Cancer Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00148","article-title":"The vitamin d receptor and T cell function","volume":"4","author":"Kongsbak","year":"2013","journal-title":"Front Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2015.1094443","article-title":"Role of vitamin D in cytotoxic T lymphocyte immunity to pathogens and cancer","volume":"53","author":"Sarkar","year":"2016","journal-title":"Crit Rev Clin Lab Sci"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1851","article-title":"Vitamin D controls T cell antigen receptor signaling and activation of human T cells","volume":"11","author":"von Essen","year":"2010","journal-title":"Nat Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/s0385-8146(03)00091-9","article-title":"Anti-tumor effect of vitamin A and D on head and neck squamous cell carcinoma","volume":"30","author":"Satake","year":"2003","journal-title":"Auris Nasus Larynx"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.11.1149","article-title":"Treatment with 1-alpha,25-dihydroxyvitamin D3 (vitamin D 3) to inhibit carcinogenesis in the hamster buccal pouch model","volume":"133","author":"Meier","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.627226\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T23:34:34Z","timestamp":1614036874000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.627226\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"references-count":75,"alternative-id":["10.3389\/fimmu.2021.627226"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.627226","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,23]]},"article-number":"627226"}}