{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:44:42Z","timestamp":1786797882833,"version":"build-2736575974"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["AI122369"],"award-info":[{"award-number":["AI122369"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["AI51588"],"award-info":[{"award-number":["AI51588"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["GM140359"],"award-info":[{"award-number":["GM140359"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008455","name":"Medical School, University of Michigan","doi-asserted-by":"publisher","award":["CASE-283529 UM-MTRAC"],"award-info":[{"award-number":["CASE-283529 UM-MTRAC"]}],"id":[{"id":"10.13039\/100008455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008455","name":"Medical School, University of Michigan","doi-asserted-by":"publisher","award":["MICHR Accelerating Synergy Award"],"award-info":[{"award-number":["MICHR Accelerating Synergy Award"]}],"id":[{"id":"10.13039\/100008455","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    B cell differentiation and memory are controlled by the transmembrane activator and CAML interactor (TACI), a receptor encoded by\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    .\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    mutations are frequently found in common variable immunodeficiency (CVID) and in IgA -deficiency; yet, ~98% of those with mutant\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    are healthy. Indeed,\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    is among the 5% most polymorphic genes in man. Other mammals evidence polymorphism at comparable loci. We hypothesize that\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    diversity might promote rather than detract from well-being by controlling key elements of innate immunity. We shall discuss how extraordinary diversity of\n                    <jats:italic>TNFRSF13B<\/jats:italic>\n                    could have evolved and persisted across diverse species of mammals by controlling innate and adaptive B cell responses in apparently paradoxical ways.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2021.634544","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T16:43:19Z","timestamp":1613752999000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["TNFRSF13B Diversification Fueled by B Cell Responses to Environmental Challenges\u2014A Hypothesis"],"prefix":"10.3389","volume":"12","author":[{"given":"Marilia","family":"Cascalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.cell.2019.03.016","article-title":"B cell responses: cell interaction dynamics and decisions","volume":"177","author":"Cyster","year":"2019","journal-title":"Cell."},{"key":"B2","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1600-065X.2010.00924.x","article-title":"The immortality of humoral immunity","volume":"236","author":"Elgueta","year":"2010","journal-title":"Immunol Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1182\/blood-2005-01-0256","article-title":"Selective activation of TACI by syndecan-2","volume":"107","author":"Bischof","year":"2006","journal-title":"Blood."},{"key":"B4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1084\/jem.192.1.137","article-title":"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation","volume":"192","author":"Xia","year":"2000","journal-title":"J Exp Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"13R","DOI":"10.1203\/PDR.0b013e31819dbf88","article-title":"Common variable immunodeficiency","volume":"65","author":"Bonilla","year":"2009","journal-title":"Pediatr Res."},{"key":"B6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1126\/science.278.5335.138","article-title":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily","volume":"278","author":"von Bulow","year":"1997","journal-title":"Science."},{"key":"B7","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.jaci.2011.04.052","article-title":"Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation","volume":"128","author":"Ozcan","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"E4094","DOI":"10.1073\/pnas.1421580112","article-title":"TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection","volume":"112","author":"Allman","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1038\/ni.1914","article-title":"The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88","volume":"11","author":"He","year":"2010","journal-title":"Nat Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.3389\/fimmu.2018.02125","article-title":"TACI isoforms regulate ligand binding and receptor function","volume":"9","author":"Garcia-Carmona","year":"2018","journal-title":"Front Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/s41467-017-01602-4","article-title":"mTOR intersects antibody-inducing signals from TACI in marginal zone B cells","volume":"8","author":"Sintes","year":"2017","journal-title":"Nat Commun."},{"key":"B12","doi-asserted-by":"publisher","first-page":"5832","DOI":"10.1182\/blood-2011-05-353961","article-title":"TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow","volume":"118","author":"Tsuji","year":"2011","journal-title":"Blood."},{"key":"B13","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"3135","DOI":"10.3389\/fimmu.2018.03135","article-title":"CVID-associated tumors: czech nationwide study focused on epidemiology, immunology, and genetic background in a cohort of patients with CVID","volume":"9","author":"Kralickova","year":"2018","journal-title":"Front Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1172\/JCI69854","article-title":"CVID-associated TACI mutations affect autoreactive B cell selection and activation","volume":"123","author":"Romberg","year":"2013","journal-title":"J Clin Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"4857","DOI":"10.1172\/JCI74428","article-title":"TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen","volume":"124","author":"Tsuji","year":"2014","journal-title":"J Clin Invest."},{"key":"B18","doi-asserted-by":"publisher","first-page":"eaat7117","DOI":"10.1126\/sciimmunol.aat7117","article-title":"Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells","volume":"5","author":"Grasset","year":"2020","journal-title":"Sci Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"976","DOI":"10.4049\/jimmunol.181.2.976","article-title":"Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL","volume":"181","author":"Kanswal","year":"2008","journal-title":"J Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.jaci.2016.07.028","article-title":"Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice","volume":"139","author":"Jabara","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/08923970600623541","article-title":"Influenza virus host response of C57Bl\/6 mice treated with TACI-Ig","volume":"28","author":"Roque","year":"2006","journal-title":"Immunopharmacol Immunotoxicol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3954","DOI":"10.1172\/JCI57362DS1","article-title":"Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI","volume":"121","author":"Wolf","year":"2011","journal-title":"J Clin Invest."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1182\/blood-2008-02-141937","article-title":"Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes","volume":"113","author":"Salzer","year":"2009","journal-title":"Blood."},{"key":"B24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S1074-7613(01)00130-3","article-title":"Regulation of the T-independent humoral response by TACI","volume":"14","author":"von Bulow","year":"2001","journal-title":"Immunity."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2282","DOI":"10.4049\/jimmunol.179.4.2282","article-title":"TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens","volume":"179","author":"Mantchev","year":"2007","journal-title":"J Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.4049\/jimmunol.1201678","article-title":"IL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells","volume":"190","author":"Ding","year":"2013","journal-title":"J Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/eji.200636623","article-title":"TACI attenuates antibody production costimulated by BAFF-R and CD40","volume":"37","author":"Sakurai","year":"2007","journal-title":"Eur J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1016\/j.jaci.2015.05.012","article-title":"TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development","volume":"136","author":"Romberg","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.tig.2020.01.008","article-title":"Advances in the evolutionary understanding of MHC polymorphism","volume":"36","author":"Radwan","year":"2020","journal-title":"Trends Genet."},{"key":"B30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1084\/jem.20032000","article-title":"TACI and BAFF-R mediate isotype switching in B cells","volume":"201","author":"Castigli","year":"2005","journal-title":"J Exp Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1172\/JCI31023","article-title":"Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)","volume":"117","author":"Garibyan","year":"2007","journal-title":"J Clin Invest."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.jaci.2010.08.017","article-title":"The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency","volume":"126","author":"Lee","year":"2010","journal-title":"J Allergy Clin Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1182\/blood-2008-11-189720","article-title":"The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function","volume":"114","author":"Lee","year":"2009","journal-title":"Blood."},{"key":"B35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cell.2019.02.033","article-title":"Human immunology through the lens of evolutionary genetics","volume":"177","author":"Quintana-Murci","year":"2019","journal-title":"Cell."},{"key":"B36","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/gene.2009.43","article-title":"An evolutionary approach to the medical implications of the tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) gene","volume":"10","author":"Sazzini","year":"2009","journal-title":"Genes Immunity."},{"key":"B37","doi-asserted-by":"publisher","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl (2018)","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1182\/blood-2014-05-575845","article-title":"Differential induction of plasma cells by isoforms of human TACI","volume":"125","author":"Garcia-Carmona","year":"2015","journal-title":"Blood."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2996","DOI":"10.1093\/molbev\/msx209","article-title":"Detecting long-term balancing selection using allele frequency correlation","volume":"34","author":"Siewert","year":"2017","journal-title":"Mol Biol Evol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/molbev\/msx314","article-title":"Disentangling Immediate adaptive introgression from selection on standing introgressed variation in humans","volume":"35","author":"Jagoda","year":"2018","journal-title":"Mol Biol Evol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1080\/1744666X.2017.1248410","article-title":"The long and winding road to IgA deficiency: causes and consequences","volume":"13","author":"Vo Ngoc","year":"2017","journal-title":"Expert Rev Clin Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1023\/A:1012241117984","article-title":"Physiology of IgA and IgA deficiency","volume":"21","author":"Cunningham-Rundles","year":"2001","journal-title":"J Clin Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0006-3002(53)90233-9","article-title":"[Method permitting the combined study of the electrophoretic and the immunochemical properties of protein mixtures; application to blood serum]","volume":"10","author":"Grabar","year":"1953","journal-title":"Biochim Biophys Acta."},{"key":"B44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/antib8040057","article-title":"IgA: structure, function, and developability","volume":"8","author":"de","year":"2019","journal-title":"Antibodies."},{"key":"B45","doi-asserted-by":"publisher","first-page":"12643","DOI":"10.1021\/bi00165a014","article-title":"Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M","volume":"31","author":"Frutiger","year":"1992","journal-title":"Biochemistry."},{"key":"B46","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/3-540-30657-9_8","article-title":"Structural insights into antibody-mediated mucosal immunity","volume":"308","author":"Hamburger","year":"2006","journal-title":"Curr Top Microbiol Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.0105-2896.2005.00278.x","article-title":"The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces","volume":"206","author":"Kaetzel","year":"2005","journal-title":"Immunol Rev."},{"key":"B48","doi-asserted-by":"publisher","first-page":"20140","DOI":"10.1074\/jbc.M301436200","article-title":"Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems","volume":"278","author":"Royle","year":"2003","journal-title":"J Biol Chem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1084\/jem.20180427","article-title":"IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria","volume":"215","author":"Nakajima","year":"2018","journal-title":"J Exp Med."},{"key":"B50","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.4049\/jimmunol.161.10.5445","article-title":"Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: a possible implication for mucosal defense","volume":"161","author":"Crottet","year":"1998","journal-title":"J Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1074-7613(02)00341-2","article-title":"Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo","volume":"17","author":"Phalipon","year":"2002","journal-title":"Immunity"},{"key":"B52","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1126\/science.272.5258.104","article-title":"Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity","volume":"272","author":"Burns","year":"1996","journal-title":"Science."},{"key":"B53","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S1471-4906(01)01873-7","article-title":"IgA and the IgA Fc receptor","volume":"22","author":"van Egmond","year":"2001","journal-title":"Trends Immunol."},{"key":"B54","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4049\/jimmunol.159.1.244","article-title":"Structural requirements for assembly of dimeric IgA probed by site-directed mutagenesis of J chain and a cysteine residue of the alpha-chain CH2 domain","volume":"159","author":"Krugmann","year":"1997","journal-title":"J Immunol."},{"key":"B55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2567.1998.00560.x","article-title":"Lack of SC\/pIgR-mediated epithelial transport of a human polymeric IgA devoid of J chain: in vitro and in vivo studies","volume":"95","author":"Vaerman","year":"1998","journal-title":"Immunology."},{"key":"B56","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<171::AID-IMMU171>3.0.CO;2-#","article-title":"Antibody against the human J chain inhibits polymeric Ig receptor-mediated biliary and epithelial transport of human polymeric IgA","volume":"28","author":"Vaerman","year":"1998","journal-title":"Eur J Immunol."},{"key":"B57","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1128\/MCB.8.10.4197","article-title":"Selective removal of alpha heavy-chain glycosylation sites causes immunoglobulin A degradation and reduced secretion","volume":"8","author":"Taylor","year":"1988","journal-title":"Mol Cell Biol."},{"key":"B58","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4049\/jimmunol.157.1.156","article-title":"Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly","volume":"157","author":"Atkin","year":"1996","journal-title":"J Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4049\/jimmunol.168.1.102","article-title":"Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation","volume":"168","author":"Heystek","year":"2002","journal-title":"J Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1128\/IAI.64.2.616-623.1996","article-title":"Monoclonal immunoglobulin A derived from peritoneal B cells is encoded by both germ line and somatically mutated VH genes and is reactive with commensal bacteria","volume":"64","author":"Bos","year":"1996","journal-title":"Infect Immun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"13574","DOI":"10.1038\/s41598-019-49923-2","article-title":"IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM","volume":"9","author":"Catanzaro","year":"2019","journal-title":"Sci Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1126\/science.aaq0926","article-title":"Gut microbiota utilize immunoglobulin A for mucosal colonization","volume":"360","author":"Donaldson","year":"2018","journal-title":"Science."},{"key":"B63","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev-immunol-042617-053238","article-title":"IgA function in relation to the intestinal microbiota","volume":"36","author":"Macpherson","year":"2018","journal-title":"Annu Rev Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"17239","DOI":"10.1074\/jbc.M110.209015","article-title":"Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates","volume":"286","author":"Mathias","year":"2011","journal-title":"J Biol Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.chom.2008.09.007","article-title":"Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont","volume":"4","author":"Martens","year":"2008","journal-title":"Cell Host Microbe."},{"key":"B66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s10875-009-9357-x","article-title":"Selective IgA deficiency","volume":"30","author":"Yel","year":"2010","journal-title":"J Clin Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1097\/ACI.0b013e3283594219","article-title":"IgA deficiency: what is new?","volume":"12","author":"Wang","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clim.2003.12.005","article-title":"IgA deficiency: clinical correlates and responses to pneumococcal vaccine","volume":"111","author":"Edwards","year":"2004","journal-title":"Clin Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.634544\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T10:40:15Z","timestamp":1697884815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.634544\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2021.634544"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.634544","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739703328.793584195","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"article-number":"634544"}}