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Immune and inflammatory responses contribute to both the clearance of<jats:italic>Chlamydia<\/jats:italic>infection and pathology in host tissues.<jats:italic>Chlamydia<\/jats:italic>infection stimulates host cells to produce a large number of cytokines that trigger and regulate host immune responses against<jats:italic>Chlamydia<\/jats:italic>. However, inappropriate responses can occur with excessive production of cytokines, resulting in overreactive inflammatory responses and alterations in host or<jats:italic>Chlamydia<\/jats:italic>metabolism. As a result,<jats:italic>Chlamydia<\/jats:italic>persists and causes wound healing delays, leading to more severe tissue damage and triggering long-lasting fibrotic sequelae. Here, we summarize the roles of cytokines in<jats:italic>Chlamydia<\/jats:italic>infection and pathogenesis, thus advancing our understanding chlamydial infection biology and the pathogenic mechanisms involved.<\/jats:p>","DOI":"10.3389\/fimmu.2021.639834","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T07:46:23Z","timestamp":1621583183000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Insights Into Host Cell Cytokines in Chlamydia 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