{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:14:44Z","timestamp":1787026484203,"version":"build-2736575974"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012483","name":"University of Georgia Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Tuberculosis can occur during any stage of Human Immunodeficiency virus 1 (HIV) -infection including times when CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell numbers have reconstituted and viral replication suppressed. We have previously shown that CD11b\n                    <jats:sup>+<\/jats:sup>\n                    CD33\n                    <jats:sup>+<\/jats:sup>\n                    CD14\n                    <jats:sup>+<\/jats:sup>\n                    HLA-DR\n                    <jats:sup>-\/lo<\/jats:sup>\n                    monocytic myeloid-derived suppressor cells (MDSC) persist in HIV-infected individuals on combined anti-retroviral therapy (cART) and with virologic suppression. The response of MDSC to\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb) is not known. In this study, we compared the anti-mycobacterial activity of MDSC isolated from HIV \u2013infected individuals on cART with virologic suppression (HIV MDSC) and HIV-uninfected healthy controls (HIV (-) MDSC). Compared to HIV (-) MDSC, HIV MDSC produced significantly less quantities of anti-mycobacterial cytokines IL-12p70 and TNF\u03b1, and reactive oxygen species when cultured with infectious Mtb or Mtb antigens. Furthermore, HIV MDSC showed changes in the Toll-like receptor and IL-27 signaling, including reduced expression of MyD88 and higher levels of IL-27. Neutralizing IL-27 and overexpression of MyD88 synergistically controlled intracellular replication of Mtb in HIV MDSC. These results demonstrate that MDSC in fully suppressed HIV-infected individuals are permissive to Mtb and exhibit downregulated anti-mycobacterial innate immune activity through mechanisms involving IL-27 and TLR signaling. Our findings suggest MDSC as novel mediators of tuberculosis in HIV-Mtb co-infected individuals with virologic suppression.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2021.647019","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:29:59Z","timestamp":1619580599000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Monocytic-Myeloid Derived Suppressor Cells of HIV-Infected Individuals With Viral Suppression Exhibit Suppressed Innate Immunity to Mycobacterium tuberculosis"],"prefix":"10.3389","volume":"12","author":[{"given":"Priyanka","family":"Namdev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi","family":"Sparling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankita","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"B1","volume-title":"Global Tuberculosis Report","year":"2015"},{"key":"B2","unstructured":"Unaids Report on Global Aids Epidemic 20102010"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e1002464","DOI":"10.1371\/journal.ppat.1002464","article-title":"Tuberculosis and HIV 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