{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:22:34Z","timestamp":1785288154122,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Psoriasis is a recurrent autoimmune skin disease with aberrant regulation of keratinocytes and immunocytes. There is no universally accepted single treatment available for psoriasis, and the establishment of a common treatment option to control its signs and symptoms is urgently needed. Here, we found Ebosin, a novel exopolysaccharide isolated from <jats:italic>Streptomyces<\/jats:italic> sp. 139 by our lab, not only could ameliorate inflammation in LPS-induced keratinocytes through IKK\/NF-kapaB pathway, but also attenuate psoriatic skin lesions and reduce inflammatory factors expression in imiquimod (IMQ)-mediated psoriatic mice. Except for inhibiting the expression of epidermal differentiation related proteins, Ebosin significantly increased the percentage of CD4<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> Tregs and decreased CD4<jats:sup>+<\/jats:sup>IL17A<jats:sup>+<\/jats:sup> Th17 cells in psoriatic mice. Furthermore, we demonstrate that Ebosin significantly suppressed the IL-17 signaling pathway <jats:italic>via<\/jats:italic> A20 (encoded by <jats:italic>tnfaip3<\/jats:italic>) <jats:italic>in vivo<\/jats:italic>. As the direct binding of <jats:italic>tnfaip3<\/jats:italic> to miR-155 has been demonstrated by luciferase reporter assay, and Ebosin has been demonstrated to inhibit miR-155 level <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, our study first indicates that Ebosin reduces inflammation through the miR-155-<jats:italic>tnfaip3<\/jats:italic>-IL-17 axis and T cell differentiation in a psoriasis-like model. Thus, we conclude that Ebosin can act as a promising therapeutic candidate for the treatment of psoriasis.<\/jats:p>","DOI":"10.3389\/fimmu.2021.662362","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T05:29:21Z","timestamp":1619414961000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Ebosin Ameliorates Psoriasis-Like Inflammation of Mice via miR-155 Targeting tnfaip3 on IL-17 Pathway"],"prefix":"10.3389","volume":"12","author":[{"given":"Weiwei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuochen","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and Clinical Features of Psoriasis","volume":"370","author":"Cem","year":"2007","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and Therapy of Psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.det.2014.09.004","article-title":"Psoriasis Is a Systemic Disease With Multiple Cardiovascular and Metabolic Comorbidities","volume":"33","author":"Ryan","year":"2015","journal-title":"Dermatol Clin"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.12865\/CHSJ.40.01.12","article-title":"Bullous Pemphigoid Associated With Psoriasis, Breast Cancer and Parkinson\u2019s Disease","volume":"40","author":"Stoica","year":"2014","journal-title":"Curr Health Sci J"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140878","article-title":"Systematic Review of Treatment Effectiveness and Outcome Measures for Enthesitis in Psoriatic Arthritis","volume":"41","author":"Orbai","year":"2014","journal-title":"J Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.12.006","article-title":"Obesity and the Metabolic Syndrome in Pediatric Psoriasis","volume":"33","author":"Gutmark-Little","year":"2015","journal-title":"Clin Dermatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300418","article-title":"Psoriasis Relapse Evaluation With Week-End Cyclosporine A Treatment: Results of a Randomized, Double-Blind, Multicenter Study","volume":"23","author":"Colombo","year":"2010","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1660","article-title":"Biologic Therapies for Chronic Plaque Psoriasis and Cardiovascular Events","volume":"306","author":"Tzellos","year":"2011","journal-title":"JAMA"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1195812","article-title":"Tofacitinib for the Treatment of Psoriasis","volume":"17","author":"Galluzzo","year":"2016","journal-title":"Expert Opin Pharmacother"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1013534","article-title":"Tofacitinib for the Treatment of Moderate-to-Severe Psoriasis","volume":"11","author":"Chiricozzi","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.1023295","article-title":"Ixekizumab for Treatment of Psoriasis","volume":"11","author":"Dyring-Andersen","year":"2015","journal-title":"Expert Rev Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(15)60125-8","article-title":"Comparison of Ixekizumab With Etanercept or Placebo in Moderate-to-Severe Psoriasis (UNCOVER-2 and UNCOVER-3): Results From Two Phase 3 Randomised Trials","volume":"386","author":"Griffiths","year":"2015","journal-title":"Lancet"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2012.06670.x","article-title":"Development of the IL-12\/23 Antagonist Ustekinumab in Psoriasis: Past, Present, and Future Perspectives - 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