{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:20:24Z","timestamp":1793038824233,"version":"4.5.0"},"reference-count":158,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["AAAA-A15-115123110026-3"],"award-info":[{"award-number":["AAAA-A15-115123110026-3"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The burden of heart failure (HF), developing after myocardial infarction MI, still represents a major issue in clinical practice. Failure of appropriate resolution of inflammation during post-myocardial injury is associated with unsuccessful left ventricular remodeling and underlies HF pathogenesis. Cells of the immune system have been shown to mediate both protective and damaging effects in heart remodeling. This ambiguity of the role of the immune system and inconsistent results of the recent clinical trials question the benefits of anti-inflammatory therapies during acute MI. The present review will summarize knowledge of the roles that different cells of the immune system play in the process of post-infarct cardiac healing. Data on the phenotype, active molecules and functions of the immune cells, based on the results of both experimental and clinical studies, will be provided. For some cellular subsets, such as macrophages, neutrophils, dendritic cells and lymphocytes, an anti-inflammatory activity has been attributed to the specific subpopulations. Activity of other cells, such as eosinophils, mast cells, natural killer (NK) cells and NKT cells has been shown to be highly dependent of the signals created by micro-environment. Also, new approaches for classification of cellular phenotypes based on the single-cell RNA sequencing allow better understanding of the phenotype of the cells involved in resolution of inflammation. Possible perspectives of immune-mediated therapy for AMI patients are discussed in the conclusion. We also outline unresolved questions that need to be solved in order to implement the current knowledge on the role of the immune cells in post-MI tissue repair into practice.<\/jats:p>","DOI":"10.3389\/fimmu.2021.664457","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:13:51Z","timestamp":1617322431000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":308,"title":["Cells of the Immune System in Cardiac Remodeling: Main Players in Resolution of Inflammation and Repair After Myocardial Infarction"],"prefix":"10.3389","volume":"12","author":[{"given":"Irina","family":"Kologrivova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Shtatolkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Suslova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyacheslav","family":"Ryabov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12872-017-0482-9","article-title":"Mortality and morbidity trends after the first year in survivors of acute myocardial infarction: a systematic review","volume":"17","author":"Johansson","year":"2017","journal-title":"BMC Cardiovasc Disord"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.09.015","article-title":"Post-Myocardial Infarction Heart Failure","volume":"6","author":"Bahit","year":"2018","journal-title":"J Am Coll Cardiol HF"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt109","article-title":"Contemporary trends in heart failure with reduced and preserved ejection fraction after myocardial infarction: a community study","volume":"178","author":"Gerber","year":"2013","journal-title":"Am J Epidemiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.08.014","article-title":"Left ventricular post-infarct remodeling","volume":"8","author":"van der Bijl","year":"2020","journal-title":"J Am Coll Cardiol HF"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7018393","article-title":"Ischemia\/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists","volume":"2017","author":"Neri","year":"2017","journal-title":"Mediators Inflamm"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-006-0043-1","article-title":"Autologous mononuclear cells in restorative regeneration during acute myocardial infarction","volume":"4","author":"Karpov","year":"2005","journal-title":"Bull Exp Biol Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.04.001","article-title":"The balance between pro- and anti-inflammatory cytokines is associated with platelet aggregability in acute coronary syndrome patients","volume":"202","author":"Gori","year":"2009","journal-title":"Atherosclerosis"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodeling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.25.2981","article-title":"Left ventricular remodeling after myocardial infarction: pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"B10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jb\/mvaa051","article-title":"Efferocytosis during myocardial infarction","volume":"168","author":"Yoshimura","year":"2020","journal-title":"J Biochem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz336","article-title":"Cardiac monocytes and macrophages after myocardial infarction","volume":"116","author":"Peet","year":"2020","journal-title":"Cardiovasc Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00270","article-title":"Emerging roles of eosinophils and eosinophil-derived lipid mediators in the resolution of inflammation","volume":"3","author":"Isobe","year":"2012","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-3-030-21735-8_6","article-title":"Specialized pro-resolving mediators directs cardiac healing and repair with activation of inflammation and resolution program in heart failure","volume":"1161","author":"Halade","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J Clin Invest"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.07.024","article-title":"Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction","volume":"46","author":"Fosshaug","year":"2019","journal-title":"EBioMedicine"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800254R","article-title":"Unified nexus of macrophages and maresins in cardiac reparative mechanisms","volume":"32","author":"Jadapalli","year":"2018","journal-title":"FASEB J"},{"key":"B18","article-title":"Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury","volume":"22","author":"Markworth","year":"2016","journal-title":"Exerc Immunol Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009","article-title":"Proresolving lipid mediators and mechanisms in the resolution of acute inflammation","volume":"40","author":"Buckley","year":"2014","journal-title":"Immunity"},{"key":"B20","doi-asserted-by":"publisher","first-page":"353ra111","DOI":"10.1126\/scitranslmed.aaf7483","article-title":"Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses","volume":"8","author":"Chiurchi\u00f9","year":"2016","journal-title":"Sci Transl Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"eaao1818","DOI":"10.1126\/scisignal.aao1818","article-title":"Splenic leukocytes define the resolution of inflammation in heart failure","volume":"11","author":"Halade","year":"2018","journal-title":"Sci Signal"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12730","article-title":"Race-based and sex-based differences in bioactive lipid mediators after myocardial infarction","volume":"7","author":"Halade","year":"2020","journal-title":"ESC Heart Fail"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01057.2009","article-title":"Resolvin E1 protects the rat heart against reperfusion injury","volume":"299","author":"Keyes","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2015.04.003","article-title":"Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function","volume":"84","author":"Kain","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14041","article-title":"Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice","volume":"175","author":"Liu","year":"2018","journal-title":"Br J Pharmacol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.10.008","article-title":"Lack of resolution sensor drives age-related cardiometabolic and cardiorenal defects and impedes inflammation-resolution in heart failure","volume":"31","author":"Tourki","year":"2020","journal-title":"Mol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"6753","DOI":"10.1038\/s41598-018-25143-y","article-title":"Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response","volume":"8","author":"de Jong","year":"2018","journal-title":"Sci Rep"},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.yjmcc.2019.12.011","article-title":"Cathelicidin aggravates myocardial ischemia\/reperfusion injury via activating TLR4 signaling and P2X7R\/NLRP3 inflammasome","volume":"139","author":"Wu","year":"2020","journal-title":"J Mol Cell Cardiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw002","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur Heart J"},{"key":"B30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12265-020-10006-7","article-title":"Chemokines in myocardial infarction","volume":"14","author":"Chen","year":"2021","journal-title":"J Cardiovasc Transl Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/cvr\/cvw024","article-title":"Neutrophil roles in left ventricular remodeling following myocardial infarction","volume":"6","author":"Ma","year":"2013","journal-title":"Fibrogen Tissue Repair"},{"key":"B32","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s00395-018-0712-z","article-title":"Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction","volume":"114","author":"Jung","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00395-019-0746-x","article-title":"Neutrophil proteome shifts over the myocardial infarction time continuum","volume":"114","author":"Daseke","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx017","article-title":"Neutrophil contributions to ischaemic heart disease","volume":"38","author":"Hoyer","year":"2017","journal-title":"Eur Heart J"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700109R","article-title":"Leukocyte diversity in resolving and nonresolving mechanisms of cardiac remodeling","volume":"31","author":"Tourki","year":"2017","journal-title":"FASEB J"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/b978-0-12-800096-0.00001-9","article-title":"Myeloperoxidase in cardiovascular disease","volume":"62","author":"Koeth","year":"2013","journal-title":"Adv Clin Chem"},{"key":"B37","doi-asserted-by":"publisher","first-page":"16304","DOI":"10.1038\/s41598-019-52671-y","article-title":"Neutrophil extracellular traps and monocyte subsets at the culprit lesion site of myocardial infarction patients","volume":"9","author":"Mangold","year":"2019","journal-title":"Sci Rep"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00381.2014","article-title":"Neutrophil extracellular traps in ischemia-reperfusion injury-induced myocardial no-reflow: therapeutic potential of DNase-based reperfusion strategy","volume":"308","author":"Ge","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)02136-8","article-title":"The effect of blockade of the CD11\/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study","volume":"40","author":"Faxon","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243162","article-title":"Regulation of the inflammatory response in cardiac repair","volume":"110","author":"Frangogiannis","year":"2012","journal-title":"Circ Res"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz143","article-title":"Interferon-c regulates cardiacmyeloid cells in myocardial infarction","volume":"115","author":"Hoyer","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-087833","article-title":"The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1","volume":"111","author":"Cross","year":"2018","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.10.026","article-title":"Matrix metalloproteinase-12 as an endogenous resolution promoting factor following myocardial infarction","volume":"137","author":"Mouton","year":"2018","journal-title":"Pharmacol Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-013-0367-8","article-title":"5-Lipoxygenase facilitates healing after myocardial infarction","volume":"108","author":"Bl\u00f6mer","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00395-019-0746-x","article-title":"Neutrophil proteome shifts over the myocardial infarction time continuum","volume":"114","author":"Daseke","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.012","article-title":"Neutrophil diversity in health and disease","volume":"40","author":"Silvestre-Roig","year":"2019","journal-title":"Trends Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9095275","article-title":"Eosinophils from physiology to disease: a comprehensive review","volume":"2018","author":"Ramirez","year":"2018","journal-title":"BioMed Res Int"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85664","article-title":"Lung-resident eosinophils represent a distinct regulatory eosinophil subset","volume":"126","author":"Mesnil","year":"2016","journal-title":"J Clin Invest"},{"key":"B49","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1038\/s41467-020-19297-5","article-title":"Eosinophils improve cardiac function after myocardial infarction","volume":"11","author":"Liu","year":"2020","journal-title":"Nat Commun"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e0206344","DOI":"10.1371\/journal.pone.0206344","article-title":"Characterization and implications of the dynamics of eosinophils in blood and in the infarcted myocardium after coronary reperfusion","volume":"13","author":"Rios-Navarro","year":"2018","journal-title":"PLoS One"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD-0020-2015","article-title":"The regulatory function of eosinophils","volume":"4","author":"Wen","year":"2016","journal-title":"Microbiol Spectr"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2008.72","article-title":"IL-5-overexpressing mice exhibit eosinophilia and altered wound healing through mechanisms involving prolonged inflammation","volume":"87","author":"Leitch","year":"2009","journal-title":"Immunol Cell Biol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00062","article-title":"Regulation of Type 2 Immunity in Myocardial Infarction","volume":"10","author":"Xu","year":"2019","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.05.005","article-title":"Eosinophil deficiency promotes aberrant repair and adverse remodeling following acute myocardial infarction","volume":"5","author":"Toor","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6877","DOI":"10.1038\/s41598-017-07328-z","article-title":"IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice","volume":"7","author":"Shintani","year":"2017","journal-title":"Sci Rep"},{"key":"B56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ijcard.2016.12.182","article-title":"Monocyte subsets in myocardial infarction: A review","volume":"231","author":"Arfvidsson","year":"2017","journal-title":"Int J Cardiol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304652","article-title":"Monocytes in myocardial infarction","volume":"35","author":"Dutta","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e87315","DOI":"10.1172\/jci.insight.87315","article-title":"Heart-resident CCR2+ macrophages promote neutrophil extravasation through TLR9\/MyD88\/CXCL5 signaling","volume":"1","author":"Li","year":"2016","journal-title":"JCI Insight"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000116","article-title":"Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice","volume":"127","author":"Majmudar","year":"2013","journal-title":"Circulation"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.021","article-title":"Impact of heterogeneity of human peripheral blood monocyte subsets on myocardial salvage in patients with primary acute myocardial infarction","volume":"54","author":"Tsujioka","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060547","article-title":"Macrophage depletion impairs wound healing and increases left ventricular remodeling after myocardial injury in mice","volume":"170","author":"van Amerongen","year":"2007","journal-title":"Am J Pathol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"36","DOI":"10.37796\/2211-8039.1015","article-title":"Frequency of monocyte subsets is linked to the severity of atherosclerosis in patients with ischemic heart disease: A case-control study","volume":"10","author":"Kologrivova","year":"2020","journal-title":"BioMedicine"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1989-P","article-title":"Loss of Fractalkine-CX3CR1 Signaling Exacerbates Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance through M1 Dominant Shift in Macrophages","volume":"67","author":"Nagashimada","year":"2018","journal-title":"Diabetes"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303204","article-title":"Ly-6C high monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium","volume":"114","author":"Hilgendorf","year":"2014","journal-title":"Circ Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00107","article-title":"Myocardial infarction: a critical role of macrophages in cardiac remodeling","volume":"16","author":"Weinberger","year":"2015","journal-title":"Front Physiol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.089","article-title":"Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis","volume":"55","author":"Panizzi","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04603.x","article-title":"The CD14++CD16+ monocytes subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction","volume":"10","author":"Tapp","year":"2012","journal-title":"J Thromb Haemost"},{"key":"B70","doi-asserted-by":"publisher","first-page":"e45466","DOI":"10.1371\/journal.pone.0045466","article-title":"High-Resolution Transcriptome of Human Macrophages","volume":"7","author":"Beyer","year":"2012","journal-title":"PLoS One"},{"key":"B71","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12929-017-0322-3","article-title":"Macrophage activation and polarization in post-infarction cardiac remodeling","volume":"24","author":"Gombozhapova","year":"2017","journal-title":"J BioMed Sci"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00057","article-title":"Modulation of macrophage efferocytosis in inflammation","volume":"2","author":"Korns","year":"2011","journal-title":"Front Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.172","article-title":"The clearance of dying cells: table for two","volume":"23","author":"Green","year":"2016","journal-title":"Cell Death Differ"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01428","article-title":"Efferocytosis and outside-in signaling by cardiac phagocytes. Links to repair, cellular programming, and intercellular crosstalk in heart","volume":"8","author":"DeBerge","year":"2017","journal-title":"Front Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301198","article-title":"Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction","volume":"113","author":"Wan","year":"2013","journal-title":"Circ Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700450R","article-title":"Thorp EB Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1-dependent mechanisms of cardiac repair","volume":"32","author":"Dehn","year":"2018","journal-title":"FASEB J"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.11.006","article-title":"Cardiac CD68+ and stabilin-1+ macrophages in wound healing following myocardial infarction: From experiment to clinic","volume":"223","author":"Ryabov","year":"2018","journal-title":"Immunobiology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85782","article-title":"Alternatively activated macrophages determine repair of the infarcted adult murine heart","volume":"126","author":"Shiraishi","year":"2016","journal-title":"J Clin Invest"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.11.023","article-title":"In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing","volume":"40","author":"Courties","year":"2014","journal-title":"J Am Cardiol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.jacc.2018.05.061","article-title":"Deficiency of GATA3-positive macrophages improves cardiac function following myocardial infarction or pressure overload hypertrophy","volume":"72","author":"Yang","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5MA1116-457R","article-title":"Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow","volume":"102","author":"Roussel","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.029","article-title":"Deciphering the dynamic transcriptional and post-transcriptional networks of macrophages in the healthy heart and after myocardial injury","volume":"23","author":"Walter","year":"2018","journal-title":"Cell Rep"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00580","article-title":"Mast cells in cardiac fibrosis: new insights suggest opportunities for intervention","volume":"10","author":"Legere","year":"2019","journal-title":"Front Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143395","article-title":"Mast cells in cardiovascular disease: from bench to bedside","volume":"20","author":"Hermans","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.04.018","article-title":"Mast cells are increased in the media of coronary lesions in patients with myocardial infarction and may favor atherosclerotic plaque instability","volume":"69","author":"Kupreishvili","year":"2017","journal-title":"J Cardiol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1568-2_8","article-title":"The emerging prominence of the cardiac mast cell as a potent mediator of adverse myocardial remodeling","volume":"1220","author":"Janicki","year":"2015","journal-title":"Methods Mol Biol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1358\/mf.2007.29.9.1161005","article-title":"Cardioprotective effects of mast cell modulators in ischemia-reperfusion- induced injury in rats","volume":"29","author":"Jaggi","year":"2007","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.069","article-title":"Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies","volume":"48","author":"Kim","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12079-011-0146-y","article-title":"Tryptase activates isolated adult cardiac fibroblasts via protease activated receptor-2 (PAR-2)","volume":"6","author":"Murray","year":"2012","journal-title":"J Cell Commun Signal"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00160","article-title":"Resolution of Inflammation: What Controls Its Onset","volume":"7","author":"Sugimoto","year":"2016","journal-title":"Front Immunol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03176","article-title":"Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy","volume":"9","author":"Patente","year":"2019","journal-title":"Front Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01222","article-title":"What makes a pDC: recent advances in understanding plasmacytoid DC development and heterogeneity","volume":"10","author":"Musumeci","year":"2019","journal-title":"Front Immunol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800322","article-title":"Conventional dendritic cells impair recovery after myocardial infarction","volume":"201","author":"Lee","year":"2018","journal-title":"J Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.079","article-title":"Myocardial infarction primes autoreactive T cells through activation of dendritic cells","volume":"18","author":"Van der Borght","year":"2017","journal-title":"Cell Rep"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.12.028","article-title":"Exosomes derived from dendritic cells improve cardiac function via activation of CD4(+) T lymphocytes after myocardial infarction","volume":"91","author":"Liu","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1038\/srep42996","article-title":"Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7","volume":"7","author":"Wei","year":"2017","journal-title":"Sci Rep"},{"key":"B98","doi-asserted-by":"publisher","first-page":"e004406","DOI":"10.1161\/JAHA.116.004406","article-title":"Interleukin-37 and dendritic cells treated with interleukin-37 plus troponin I ameliorate cardiac remodeling after myocardial infarction","volume":"5","author":"Zhu","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023106","article-title":"Infarcted myocardium-primed dendritic cells improve remodeling and cardiac function after myocardial infarction by modulating the regulatory T cell and macrophage polarization","volume":"135","author":"Choo","year":"2017","journal-title":"Circulation"},{"key":"B100","doi-asserted-by":"publisher","first-page":"e53030","DOI":"10.1371\/journal.pone.0053030","article-title":"Influence of pentraxin 3 (PTX3) genetic variants on myocardial infarction risk and PTX3 plasma levels","volume":"7","author":"Barbati","year":"2012","journal-title":"PLoS One"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701172","article-title":"Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation","volume":"199","author":"Sundblad","year":"2017","journal-title":"J Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv639","article-title":"Role of T-cells in myocardial infarction","volume":"37","author":"Hofmann","year":"2016","journal-title":"Eur Heart J"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2995-5","article-title":"Immune responses in cardiac repair and regeneration: a comparative point of view","volume":"76","author":"Lai","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649244","article-title":"Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes","volume":"114","author":"Yang","year":"2006","journal-title":"Circulation"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e004408","DOI":"10.1161\/JAHA.112.004408","article-title":"Deleterious effect of the IL-23\/IL-17A axis and \u03b3\u03b4T cells on left ventricular remodeling after myocardial infarction","volume":"1","author":"Yan","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.913891","article-title":"Increased Ratio of Circulating T-Helper 1 to T-Helper 2 Cells and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction: A Prospective Observational Study","volume":"25","author":"Li","year":"2019","journal-title":"Med Sci Monit"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.06.003","article-title":"Toll-like receptor regulation of effector T lymphocyte function","volume":"34","author":"Reynolds","year":"2013","journal-title":"Trends Immunol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx684","article-title":"Matrix metalloproteinase-9 might affect adaptive immunity in non-ST segment elevation acute coronary syndromes by increasing CD31 cleavage on CD4+ T-cells","volume":"39","author":"Angelini","year":"2018","journal-title":"Eur Heart J"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.05.009","article-title":"Autoimmunity in myocardial infarction","volume":"112","author":"Liao","year":"2006","journal-title":"Int J Cardiol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1172\/JCI123859","article-title":"Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses","volume":"129","author":"Rieckmann","year":"2019","journal-title":"J Clin Invest"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80055","article-title":"T lymphocytes and fractalkine contribute to myocardial ischemia\/reperfusion injury in patients","volume":"125","author":"Boag","year":"2015","journal-title":"J Clin Invest"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12059","article-title":"Cytomegalovirus infection is associated with increased mortality in the older population","volume":"12","author":"Savva","year":"2013","journal-title":"Aging Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00112.2019","article-title":"CD8+ T-cells negatively regulate inflammation post-myocardial infarction","volume":"317","author":"Ilatovskaya","year":"2019","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903681","article-title":"Identification of noncytotoxic and IL-10-producing CD8+AT2R+ T cell population in response to ischemic heart injury","volume":"185","author":"Curato","year":"2010","journal-title":"J Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12574","article-title":"The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function","volume":"19","author":"Skorska","year":"2015","journal-title":"J Cell Mol Med"},{"key":"B116","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1038\/s41467-018-04908-z","article-title":"Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction","volume":"9","author":"Zacchigna","year":"2018","journal-title":"Nat Commun"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090759","article-title":"CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells","volume":"176","author":"Dobaczewski","year":"2010","journal-title":"Am J Pathol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140672","article-title":"Activated regulatory T-cells attenuate myocardial ischaemia\/reperfusion injury through a CD39-dependent mechanism","volume":"128","author":"Xia","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"B119","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","article-title":"Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte\/macrophage differentiation","volume":"115","author":"Weirather","year":"2014","journal-title":"Circ Res"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00328.2014","article-title":"Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function","volume":"307","author":"Saxena","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/167086","article-title":"Statins as modulators of regulatory T-cell biology","volume":"2013","author":"Forero-Pe\u00f1a","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0232-6","article-title":"Regulatory T cells ameliorate cardiac remodeling after myocardial infarction","volume":"107","author":"Tang","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150","article-title":"Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards","volume":"7","author":"Bronte","year":"2016","journal-title":"Nat Commun"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e60","DOI":"10.1016\/j.atherosclerosis.2017.06.201","article-title":"Mesenchymal stem cells promote the infiltration of myeloid derived suppressor cells in a mouse myocardial infarction model","volume":"263","author":"Kim","year":"2017","journal-title":"Atherosclerosis"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e2695","DOI":"10.1038\/cddis.2017.86","article-title":"The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis"},{"key":"B128","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/15384047.2018.1450116","article-title":"Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer","volume":"19","author":"Li","year":"2018","journal-title":"Cancer Biol Ther"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030811","article-title":"Cardioprotective role of myeloid-derived suppressor cells in heart failure","volume":"138","author":"Zhou","year":"2018","journal-title":"Circulation"},{"key":"B130","first-page":"77","article-title":"Introduction to T and B lymphocytes","volume-title":"Autoimmunity: From Bench to Bedside","author":"Cano","year":"2013"},{"key":"B131","doi-asserted-by":"publisher","first-page":"e0150606","DOI":"10.1371\/journal.pone.0150606","article-title":"A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues","volume":"11","author":"Yu","year":"2016","journal-title":"PloS One"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304072","article-title":"Role of lymphocytes in myocardial injury, healing, and remodeling after myocardial infarction","volume":"116","author":"Hofmann","year":"2015","journal-title":"Circ Res"},{"key":"B133","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","article-title":"Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction","volume":"62","author":"Yan","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq141","article-title":"Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction","volume":"87","author":"Haas","year":"2010","journal-title":"Cardiovasc Res"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103483","article-title":"Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells","volume":"189","author":"Ramon","year":"2012","journal-title":"J Immunol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat Med"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.08.010","article-title":"Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction","volume":"2","author":"Goodchild","year":"2009","journal-title":"JACC Cardiovasc Interv"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911464116","article-title":"IL-10\u2013producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction","volume":"116","author":"Wu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B139","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clim.2016.11.010","article-title":"Natural killer cells in inflammatory heart disease","volume":"175","author":"Ong","year":"2017","journal-title":"Clin Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301437","article-title":"Angiotensin II-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and NK-cells","volume":"33","author":"Kossmann","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00295","article-title":"Interplay of NK cells and monocytes in vascular inflammation and myocardial infarction","volume":"5","author":"Knorr","year":"2014","journal-title":"Front Physiol"},{"key":"B142","doi-asserted-by":"publisher","first-page":"e32691","DOI":"10.1371\/journal.pone.0032691","article-title":"Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome","volume":"7","author":"Backteman","year":"2012","journal-title":"PLoS One"},{"key":"B143","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.atherosclerosis.2007.10.031","article-title":"NK cell apoptosis in coronary artery disease: relation to oxidative stress","volume":"19","author":"Li","year":"2008","journal-title":"Atherosclerosis"},{"key":"B144","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/cvr\/cvu208","article-title":"Natural killer cell crosstalk with allogeneic human cardiac-derived stem\/progenitor cells controls persistence","volume":"104","author":"Boukouaci","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.270132","article-title":"Activation of natural killer T cells ameliorates postinfarct cardiac remodeling and failure in mice","volume":"111","author":"Sobirin","year":"2012","journal-title":"Circ Res"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.12.019","article-title":"Lower prevalence of circulating invariant natural killer T (iNKT) cells in patients with acute myocardial infarction undergoing primary coronary stenting","volume":"11","author":"Liu","year":"2011","journal-title":"Int Immunopharmacol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.016","article-title":"iNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury","volume":"47","author":"Liew","year":"2017","journal-title":"Immunity"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.06.004","article-title":"Activation of invariant natural killer T cells by alpha-galactosylceramide ameliorates myocardial ischemia\/reperfusion injury in mice","author":"Homma","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02799","article-title":"Extracellular vesicle-mediated immune regulation of tissue remodeling and angiogenesis after myocardial infarction","volume":"9","author":"S\u00e1nchez-Alonso","year":"2018","journal-title":"Front Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N Engl J Med"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914","article-title":"CANTOS Trial Group. Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0291-z","article-title":"Targeting immunometabolism as an anti-inflammatory strategy","volume":"30","author":"Palsson-McDermott","year":"2020","journal-title":"Cell Res"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00042","article-title":"Immunometabolism of phagocytes and relationships to cardiac repair","volume":"6","author":"Zhang","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2576-2","article-title":"Dichotomous engagement of HDAC3 activity governs inflammatory responses","volume":"584","author":"Nguyen","year":"2020","journal-title":"Nature"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01342","article-title":"(Re) Solving Repair After Myocardial Infarction","volume":"9","author":"Leoni","year":"2018","journal-title":"Front Pharmacol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.trac.2017.02.009","article-title":"Single-cell analysis by ambient mass spectrometry","volume":"90","author":"Yang","year":"2017","journal-title":"TrAC Trends Anal Chem"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00173","article-title":"Single-cell RNA sequencing of the cardiovascular system: new looks for old diseases","volume":"6","author":"Chaudhry","year":"2019","journal-title":"Front Cardiovasc Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.664457\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:13:56Z","timestamp":1617322436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.664457\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,2]]},"references-count":158,"alternative-id":["10.3389\/fimmu.2021.664457"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.664457","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,2]]},"article-number":"664457"}}