{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:04:33Z","timestamp":1788984273718,"version":"build-2803163510"},"reference-count":111,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Renal ischemia is the most common cause of acute kidney injury (AKI) that might be exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here, the renal ischemia reperfusion injury (I\/R) was performed in Fc gamma receptor 2b deficient (Fcgr2b-\/-) lupus mice and the <jats:italic>in vitro<\/jats:italic> experiments. At 24\u00a0h post-renal I\/R injury, NETs in peripheral blood neutrophils and in kidneys were detected using myeloperoxidase (MPO), neutrophil elastase (NE) and citrullinated histone H3 (CitH3), as well as kidney apoptosis (activating caspase-3), which were prominent in Fcgr2b-\/- mice more compared to wild-type (WT). After 120\u00a0h renal-I\/R injury, renal NETs (using MPO and NE) were non-detectable, whereas glomerular immunoglobulin (Ig) deposition and serum anti-dsDNA were increased in Fcgr2b-\/- mice. These results imply that renal NETs at 24\u00a0h post-renal I\/R exacerbated the lupus nephritis at 120\u00a0h post-renal I\/R injury in Fcgr2b-\/- lupus mice. Furthermore, a Syk inhibitor attenuated NETs, that activated by phorbol myristate acetate (PMA; a NETs activator) or lipopolysaccharide (LPS; a potent inflammatory stimulator), more prominently in Fcgr2b-\/- neutrophils than the WT cells as determined by dsDNA, <jats:italic>PAD4<\/jats:italic> and MPO. In addition, the inhibitors against Syk and PAD4 attenuated lupus characteristics (serum creatinine, proteinuria, and anti-dsDNA) in Fcgr2b-\/- mice at 120\u00a0h post-renal I\/R injury. In conclusion, renal I\/R in Fcgr2b-\/- mice induced lupus exacerbation at 120\u00a0h post-I\/R injury partly because Syk-enhanced renal NETs led to apoptosis-induced anti-dsDNA, which was attenuated by a Syk inhibitor.<\/jats:p>","DOI":"10.3389\/fimmu.2021.669162","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T08:43:16Z","timestamp":1624524196000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":55,"title":["Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury"],"prefix":"10.3389","volume":"12","author":[{"given":"Wilasinee","family":"Saisorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supichcha","family":"Saithong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornpimol","family":"Phuengmaung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanyarat","family":"Udompornpitak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thansita","family":"Bhunyakarnjanarat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peerapat","family":"Visitchanakun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awirut","family":"Chareonsappakit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapaporn","family":"Pisitkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Direkrit","family":"Chiewchengchol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asada","family":"Leelahavanichkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(00)00027-3","article-title":"Spontaneous Autoimmune Disease in Fc\u03b3riib-Deficient Mice Results From Strain-Specific Epistasis","volume":"13","author":"Bolland","year":"2000","journal-title":"Immunity"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608889104","article-title":"Systemic Lupus Erythematosus-Associated Defects in the Inhibitory Receptor Fc\u03b3riib Reduce Susceptibility to Malaria","volume":"104","author":"Clatworthy","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.78","article-title":"Gene-Function Studies in Systemic Lupus Erythematosus","volume":"9","author":"Crisp\u00edn","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2004.00142.x","article-title":"Association of Fc\u03b3 Receptor IIb Polymorphism With Susceptibility to Systemic Lupus Erythematosus in Chinese: A Common Susceptibility Gene in the Asian Populations","volume":"63","author":"Chu","year":"2004","journal-title":"Tissue Antigens"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0915133107","article-title":"A Defunctioning Polymorphism in FCGR2B Is Associated With Protection Against Malaria But Susceptibility to Systemic Lupus Erythematosus","volume":"107","author":"Willcocks","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nri2762","article-title":"FcgammaRIIB in Autoimmunity and Infection: Evolutionary and Therapeutic Implications","volume":"10","author":"Smith","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000796","article-title":"Fc Gamma Receptor IIB Deficient Mice: A Lupus Model With Increased Endotoxin Tolerance-Related Sepsis Susceptibility","volume":"47","author":"Ondee","year":"2017","journal-title":"Shock"},{"key":"B8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000486321","article-title":"The Synergy of Endotoxin and (1\u2192 3)-\u03b2-D-glucan, From Gut Translocation, Worsens Sepsis Severity in a Lupus Model of Fc Gamma Receptor IIb-Deficient Mice","volume":"10","author":"Issara-Amphorn","year":"2018","journal-title":"J Innate Immun"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: A Cell With Many Roles in Inflammation or Several Cell Types","volume":"9","author":"Rosales","year":"2018","journal-title":"Front Physiol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/ar4325","article-title":"Role of Neutrophils in Systemic Autoimmune Diseases","volume":"15","author":"Kaplan","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B11","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.clim.2016.08.010","article-title":"Cell Death in the Pathogenesis of Systemic Lupus Erythematosus and Lupus Nephritis","volume":"185","author":"Mistry","year":"2017","journal-title":"Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00035","article-title":"Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE","volume":"7","author":"Mahajan","year":"2016","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s41598-019-57275-0","article-title":"Leaky-Gut Enhanced Lupus Progression in the Fc Gamma Receptor-IIb Deficient and Pristane-Induced Mouse Models of Lupus","volume":"10","author":"Thim-Uam","year":"2020","journal-title":"Sci Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4294","article-title":"An Emerging Role for Neutrophil Extracellular Traps in Noninfectious Disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET Formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/s41419-018-0846-9","article-title":"ApoNETosis: Discovery of a Novel Form of Neutrophil Death With Concomitant Apoptosis and Netosis","volume":"9","author":"Azzouz","year":"2018","journal-title":"Cell Death Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cei.13041","article-title":"Self-dsDNA in the Pathogenesis of Systemic Lupus Erythematosus","volume":"191","author":"Bai","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/690438","article-title":"Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant","volume":"2010","author":"Jin","year":"2010","journal-title":"J BioMed Biotechnol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines1030278","article-title":"Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination","volume":"1","author":"Kobiyama","year":"2013","journal-title":"Vaccines (Basel)"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000509111","article-title":"Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis","volume":"12","author":"Issara-Amphorn","year":"2020","journal-title":"J Innate Immun"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/0961203320941106","article-title":"Syk Inhibitor Attenuates Inflammation in Lupus Mice From FcgRIIb Deficiency But Not in Pristane Induction: The Influence of Lupus Pathogenesis on the Therapeutic Effect","volume":"29","author":"Issara-Amphorn","year":"2020","journal-title":"Lupus"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000139","article-title":"Neutrophil Extracellular Traps and Systemic Lupus Erythematosus","volume":"4","author":"Yu","year":"2013","journal-title":"J Clin Cell Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/ar2100","article-title":"Shining Light on Lupus and UV","volume":"9","author":"Kuechle","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4049\/jimminol.171.11.5778","article-title":"Ultraviolet B Radiation-Induced Cell Death: Critical Role of Ultraviolet Dose in Inflammation and Lupus Autoantigen Redistribution","volume":"171","author":"Caricchio","year":"2003","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00164","article-title":"Breaking Immunological Tolerance in Systemic Lupus Erythematosus","volume":"5","author":"Pieterse","year":"2014","journal-title":"Front Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfz087","article-title":"The Epidemiology and Characteristics of Acute Kidney Injury in the Southeast Asia Intensive Care Unit: A Prospective Multicentre Study","volume":"35","author":"Srisawat","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2019.1602054","article-title":"The Prominent Impairment of Liver\/Intestinal Cytochrome P450 and Intestinal Drug Transporters in Sepsis-Induced Acute Kidney Injury Over Acute and Chronic Renal Ischemia, a Mouse Model Comparison","volume":"41","author":"Sukkummee","year":"2019","journal-title":"Ren Fail"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12501","article-title":"Serum miRNA-122 in Acute Liver Injury Induced by Kidney Injury and Sepsis in CD-1 Mouse Models","volume":"45","author":"Leelahavanichkul","year":"2015","journal-title":"Hepatol Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.689","article-title":"Neutrophils in Acute Kidney Injury: Not Neutral Any More","volume":"75","author":"Bolisetty","year":"2009","journal-title":"Kidney Int"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45161","article-title":"Cellular Pathophysiology of Ischemic Acute Kidney Injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.10.1616","article-title":"Fate of Neutrophils During the Recovery Phase of Ischemia\/Reperfusion Induced Acute Kidney Injury","volume":"32","author":"Cho","year":"2017","journal-title":"J Korean Med Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200205000-00006","article-title":"Role of Apoptosis in the Pathogenesis of Acute Renal Failure","volume":"11","author":"Bonegio","year":"2002","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.495","article-title":"A Possible Mechanism of Renal Cell Death After Ischemia\/Reperfusion","volume":"81","author":"Price","year":"2012","journal-title":"Kidney Int"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016080925","article-title":"Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI","volume":"28","author":"Nakazawa","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3638562","article-title":"Programmed Cell Death Pathways in the Pathogenesis of Systemic Lupus Erythematosus","volume":"2019","author":"Yang","year":"2019","journal-title":"J Immunol Res"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-0964-9","article-title":"TLR4 Regulates ROS and Autophagy to Control Neutrophil Extracellular Traps Formation Against Streptococcus Pneumoniae in Acute Otitis Media","volume":"89","author":"Dong","year":"2020","journal-title":"Pediatr Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK Tyrosine Kinase: A Crucial Player in Diverse Biological Functions","volume":"10","author":"M\u00f3csai","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"ra71","DOI":"10.1126\/scisignal.2003973","article-title":"The Tyrosine Kinase Syk Differentially Regulates Toll-Like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3","volume":"6","author":"Lin","year":"2013","journal-title":"Sci Signal"},{"key":"B39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1159\/000365249","article-title":"Src Family Kinases and Syk Are Required for Neutrophil Extracellular Trap Formation in Response to \u03b2-Glucan Particles","volume":"7","author":"Nan\u00ec","year":"2015","journal-title":"J Innate Immun"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s40267-018-0551-x","article-title":"Fostamatinib in Chronic Immune Thrombocytopenia: A Profile of Its Use in the USA","volume":"34","author":"McKeage","year":"2018","journal-title":"Drugs Ther Perspect"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009030263","article-title":"A Spleen Tyrosine Kinase Inhibitor Reduces the Severity of Established Glomerulonephritis","volume":"21","author":"Smith","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jphs.2017.02.015","article-title":"Effects of a Spleen Tyrosine Kinase Inhibitor on Progression of the Lupus Nephritis in Mice","volume":"134","author":"Kitai","year":"2017","journal-title":"J Pharmacol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013090978","article-title":"Spleen Tyrosine Kinase Inhibition Attenuates Autoantibody Production and Reverses Experimental Autoimmune GN","volume":"25","author":"McAdoo","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/srep40006","article-title":"The Role of Macrophages in the Susceptibility of Fc Gamma Receptor IIb Deficient Mice to Cryptococcus neoformans","volume":"7","author":"Surawut","year":"2017","journal-title":"Sci Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s12275-019-8311-8","article-title":"Increased Susceptibility Against Cryptococcus Neoformans of Lupus Mouse Models (Pristane-Induction and FcGRIIb Deficiency) Is Associated With Activated Macrophage, Regardless of Genetic Background","volume":"57","author":"Surawut","year":"2019","journal-title":"J Microbiol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.18.7.4209","article-title":"The Syk Protein Tyrosine Kinase Is Essential for Fcgamma Receptor Signaling in Macrophages and Neutrophils","volume":"18","author":"Kiefer","year":"1998","journal-title":"Mol Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1038\/s41467-020-16191-y","article-title":"Neutrophil Extracellular Traps Released by Neutrophils Impair Revascularization and Vascular Remodeling After Stroke","volume":"11","author":"Kang","year":"2020","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1172\/JCI9244","article-title":"CTLA4Ig Inhibits T Cell-Dependent B-Cell Maturation in Murine Systemic Lupus Erythematosus","volume":"106","author":"Mihara","year":"2000","journal-title":"J Clin Invest"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/1.2.257","article-title":"Thermal Denaturation of Calf Thymus DNA: Existence of a GC-Richer Fraction","volume":"1","author":"Li","year":"1974","journal-title":"Nucleic Acids Res"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309897","article-title":"Novel Role of IL (Interleukin)-1\u03b2 in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms","volume":"38","author":"Meher","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10067-014-2800-2","article-title":"The Protective Effect of GM-CSF on Serum-Induced Neutrophil Apoptosis in Juvenile Systemic Lupus Erythematosus Patients","volume":"34","author":"Chiewchengchol","year":"2015","journal-title":"Clin Rheumatol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/iid3.90","article-title":"Differential Changes in Gene Expression in Human Neutrophils Following TNF-\u03b1 Stimulation: Up-Regulation of Anti-Apoptotic Proteins and Down-Regulation of Proteins Involved in Death Receptor Signaling","volume":"4","author":"Chiewchengchol","year":"2015","journal-title":"Immun Inflammation Dis"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.287","article-title":"Angiotensin II Overcomes Strain-Dependent Resistance of Rapid CKD Progression in a New Remnant Kidney Mouse Model","volume":"78","author":"Leelahavanichkul","year":"2010","journal-title":"Kidney Int"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.261","article-title":"Chronic Kidney Disease Worsens Sepsis and Sepsis-Induced Acute Kidney Injury by Releasing High Mobility Group Box Protein-1","volume":"80","author":"Leelahavanichkul","year":"2011","journal-title":"Kidney Int"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e0236038","DOI":"10.1371\/journal.pone.0236038","article-title":"Over-Expression of miR-223 Induces M2 Macrophage Through Glycolysis Alteration and Attenuates LPS-Induced Sepsis Mouse Model, the Cell-Based Therapy in Sepsis","volume":"15","author":"Dang","year":"2020","journal-title":"PloS One"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00337.2019","article-title":"Gut Leakage Enhances Sepsis Susceptibility in Iron-Overloaded \u03b2-Thalassemia Mice Through Macrophage Hyperinflammatory Responses","volume":"318","author":"Visitchanakun","year":"2020","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(82)90130-2","article-title":"Elicitation of Peritoneal Polymorphonuclear Neutrophils From Mice","volume":"49","author":"Baron","year":"1982","journal-title":"J Immunol Methods"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S252433","article-title":"Defective Neutrophil Function in Patients With Sepsis Is Mostly Restored by Ex Vivo Ascorbate Incubation","volume":"13","author":"Sae-Khow","year":"2020","journal-title":"J Inflammation Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061354","article-title":"Decreased Protein Kinase C-\u03b2 Type II Associated With the Prominent Endotoxin Exhaustion in the Macrophage of FcGRIIb-\/- Lupus Prone Mice Is Revealed by Phosphoproteomic Analysis","volume":"20","author":"Ondee","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805507200","article-title":"Ischemic Injury to Kidney Induces Glomerular Podocyte Effacement and Dissociation of Slit Diaphragm Proteins Neph1 and ZO-1","volume":"283","author":"Wagner","year":"2008","journal-title":"J Biol Chem"},{"key":"B61","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12882-019-1298-x","article-title":"The Role of Podocyte Damage in the Etiology of Ischemia-Reperfusion Acute Kidney Injury and Post-Injury Fibrosis","volume":"20","author":"Chen","year":"2019","journal-title":"BMC Nephrol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78084","article-title":"Autoantibodies in Systemic Autoimmune Diseases: Specificity and Pathogenicity","volume":"125","author":"Suurmond","year":"2015","journal-title":"J Clin Invest"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03119.x","article-title":"Antibodies to Wounded Tissue Enhance Cutaneous Wound Healing","volume":"128","author":"Nishio","year":"2009","journal-title":"Immunology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.clim.2006.09.008","article-title":"Triggers of Inflammation After Renal Ischemia\/Reperfusion","volume":"123","author":"Thurman","year":"2007","journal-title":"Clin Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00660","article-title":"Caspase Activation During Phorbol Ester-Induced Apoptosis Requires ROCK-Dependent Myosin-Mediated Contraction","volume":"116","author":"Lai","year":"2003","journal-title":"J Cell Sci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.vetimm.2017.10.002","article-title":"Lipopolysaccharide-Induced Neutrophil Extracellular Trap Formation in Canine Neutrophils Is Dependent on Histone H3 Citrullination by Peptidylarginine Deiminase","author":"Li","year":"2017","journal-title":"Vet Immunol Immunopathol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e0218946","DOI":"10.1371\/journal.pone.0218946","article-title":"Neutrophil Extracellular Traps (NET) Induced by Different Stimuli: A Comparative Proteomic Analysis","volume":"14","author":"Petretto","year":"2019","journal-title":"PloS One"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-Like Receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol Med"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e40999","DOI":"10.1371\/journal.pone.0040999","article-title":"PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation","volume":"7","author":"Chang","year":"2012","journal-title":"PloS One"},{"key":"B70","doi-asserted-by":"publisher","first-page":"16247","DOI":"10.1038\/s41598-018-34548-8","article-title":"PMA Inhibits Endothelial Cell Migration Through Activating the PKC-\u03b4\/Syk\/Nf\u03bab-Mediated Up-Regulation of Thy-1","volume":"8","author":"Wen","year":"2018","journal-title":"Sci Rep"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa789","article-title":"Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic","volume":"223","author":"Strich","year":"2021","journal-title":"J Infect Dis"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1720902","article-title":"Performance Characteristics of Different Anti-Double-Stranded DNA Antibody Assays in the Monitoring of Systemic Lupus Erythematosus","volume":"2017","author":"Mahler","year":"2017","journal-title":"J Immunol Res"},{"key":"B73","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ki.2011.120","article-title":"Apoptosis and Acute Kidney Injury","volume":"80","author":"Havasi","year":"2011","journal-title":"Kidney Int"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1159\/000476077","article-title":"A Role of Remote Organs Effect in Acute Kidney Injury Outcome","volume":"137","author":"D\u00e9pret","year":"2017","journal-title":"Nephron"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.031","article-title":"Neutrophil Extracellular Traps in Ischemic AKI: New Way to Kill","volume":"93","author":"Liu","year":"2018","journal-title":"Kidney Int"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nri3684","article-title":"The Mycobiota: Interactions Between Commensal Fungi and the Host Immune System","volume":"14","author":"Underhill","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031377","article-title":"Prominent Indomethacin-Induced Enteropathy in Fcgriib Deficient Lupus Mice: An Impact of Macrophage Responses and Immune Deposition in Gut","volume":"22","author":"Bhunyakarnjanarat","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.smim.2003.10.001","article-title":"Toll Receptor Families: Structure and Function","volume":"16","author":"Akira","year":"2004","journal-title":"Semin Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/672395","article-title":"Dampening Inflammation by Modulating TLR Signalling","volume":"2010","author":"Piccinini","year":"2010","journal-title":"Mediators Inflammation"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 Activates Neutrophil Extracellular Traps to Ensnare Bacteria in Septic Blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.10.5268","article-title":"Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span","volume":"170","author":"Sabroe","year":"2003","journal-title":"J Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00469.2013","article-title":"Role of Toll-Like Receptor-4 in Renal Graft Ischemia-Reperfusion Injury","volume":"306","author":"Zhao","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e3596","DOI":"10.1371\/journal.pone.0003596","article-title":"Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia\/Reperfusion Injury","volume":"3","author":"Pulskens","year":"2008","journal-title":"PloS One"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2020.12.4.560","article-title":"Is TLR4 Critical for Neutrophil Apoptosis in Occupational Asthma","volume":"12","author":"Choi","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.8.4294","article-title":"A Dominant Role of Toll-Like Receptor 4 in the Signaling of Apoptosis in Bacteria-Faced Macrophages","volume":"171","author":"Haase","year":"2003","journal-title":"J Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/j.cell.2017.07.026","article-title":"Clonal Evolution of Autoreactive Germinal Centers","volume":"170","author":"Degn","year":"2017","journal-title":"Cell"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.6390","article-title":"Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study","volume":"180","author":"Hsu","year":"2020","journal-title":"JAMA Intern Med"},{"key":"B88","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3109\/08916934.2012.719953","article-title":"Apoptosis and NET Formation in the Pathogenesis of SLE","volume":"45","author":"Bouts","year":"2012","journal-title":"Autoimmunity"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.06.009","article-title":"Lupus Nephritis: Role of Antinucleosome Autoantibodies","volume":"31","author":"van der Vlag","year":"2011","journal-title":"Semin Nephrol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.46","article-title":"The Role of Defective Clearance of Apoptotic Cells in Systemic Autoimmunity","volume":"6","author":"Mu\u00f1oz","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00550","article-title":"Pathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus Erythematosus","volume":"6","author":"Gottschalk","year":"2015","journal-title":"Front Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.immuni.2019.12.006","article-title":"Signaling Through the Inhibitory Fc Receptor Fc\u03b3riib Induces CD8(+)\u00a0T Cell Apoptosis to Limit T Cell Immunity","volume":"52","author":"Morris","year":"2020","journal-title":"Immunity"},{"key":"B93","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2005.11.010","article-title":"Fcgamma Receptors: Old Friends and New Family Members","volume":"24","author":"Nimmerjahn","year":"2006","journal-title":"Immunity"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297920100065","article-title":"Netosis: Molecular Mechanisms, Role in Physiology and Pathology","volume":"85","author":"Vorobjeva","year":"2020","journal-title":"Biochem (Mosc)"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/srep37252","article-title":"Neutrophil Extracellular Traps Are Indirectly Triggered by Lipopolysaccharide and Contribute to Acute Lung Injury","volume":"6","author":"Liu","year":"2016","journal-title":"Sci Rep"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201167","article-title":"A serpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation","volume":"189","author":"Farley","year":"2012","journal-title":"J Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1023\/B:APPT.0000031453.90821.6a","article-title":"LPS-Induced Apoptosis Is Dependent Upon Mitochondrial Dysfunction","volume":"9","author":"Kuwabara","year":"2004","journal-title":"Apoptosis"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/270302","article-title":"Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses","volume":"2014","author":"Yi","year":"2014","journal-title":"Mediators Inflammation"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400478","article-title":"Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes Via Fc\u03b3riiib and Mac-1","volume":"193","author":"Behnen","year":"2014","journal-title":"J Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107602","article-title":"Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4","volume":"31","author":"Tsourouktsoglou","year":"2020","journal-title":"Cell Rep"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.12.014","article-title":"Amelioration of Sepsis-Induced Acute Kidney Injury Through Inhibition of Inflammatory Cytokines and Oxidative Stress in Dendritic Cells and Neutrophils Respectively in Mice: Role of Spleen Tyrosine Kinase Signaling","volume":"158","author":"Al-Harbi","year":"2019","journal-title":"Biochimie"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4236\/jct.2014.51015","article-title":"SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia","volume":"5","author":"Uckun","year":"2014","journal-title":"J Cancer Ther"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010032","article-title":"Histone Acetylation Promotes Neutrophil Extracellular Trap Formation","volume":"9","author":"Hamam","year":"2019","journal-title":"Biomolecules"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance","volume":"7","author":"Nguyen","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1189\/jib.0610376","article-title":"Protein Kinase C\u03b4 Is a Critical Component of Dectin-1 Signaling in Primary Human Monocytes","volume":"90","author":"Elsori","year":"2011","journal-title":"J Leukoc Biol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e1000464","DOI":"10.1371\/journal.ppat.1000464","article-title":"Cross-Talk Between TLR4 and FcgammaReceptorIII (CD16) Pathways","volume":"5","author":"Rittirsch","year":"2009","journal-title":"PloS Pathog"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1002\/art.23428","article-title":"An Orally Bioavailable Spleen Tyrosine Kinase Inhibitor Delays Disease Progression and Prolongs Survival in Murine Lupus","volume":"58","author":"Bahjat","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/art.23992","article-title":"Treatment of Rheumatoid Arthritis With a Syk Kinase Inhibitor: A Twelve-Week, Randomized, Placebo-Controlled Trial","volume":"58","author":"Weinblatt","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1002\/art.27452","article-title":"Suppression of Skin and Kidney Disease by Inhibition of Spleen Tyrosine Kinase in Lupus-Prone Mice","volume":"62","author":"Deng","year":"2010","journal-title":"Arthritis Rheum"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxs078","article-title":"Syk-Dependent Signaling Pathways in Neutrophils and Macrophages Are Indispensable in the Pathogenesis of Anti-Collagen Antibody-Induced Arthritis","volume":"24","author":"Ozaki","year":"2012","journal-title":"Int Immunol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041252","article-title":"The Role of Syk\/CARD9 Coupled C-Type Lectins in Antifungal Immunity","volume":"41","author":"Drummond","year":"2011","journal-title":"Eur J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.669162\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T13:23:43Z","timestamp":1624627423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.669162\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,24]]},"references-count":111,"alternative-id":["10.3389\/fimmu.2021.669162"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.669162","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,24]]},"article-number":"669162"}}