{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:45:53Z","timestamp":1790552753347,"version":"4.1.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Humoral immune components have been individually studied in the context of interaction of host with <jats:italic>Aspergillus fumigatus<\/jats:italic>, a major airborne fungal pathogen. However, a global view of the multitude and complex nature of humoral immune components is needed to bring new insight into host-<jats:italic>Aspergillus<\/jats:italic> interaction. Therefore, we undertook comparative proteomic analysis of the bronchoalveolar lavage fluid collected from individuals infected or colonized with <jats:italic>A. fumigatus<\/jats:italic> versus controls, to identify those alveolar humoral components affected upon <jats:italic>A. fumigatus<\/jats:italic> infection. Complement proteins C1q, C8 beta-chain, factor-H, ficolin-1, ficolin-2, mannan binding lectin serine peptidase 2, pentraxin-3 and the surfactant protein-D were identified as the major humoral immune components affected by <jats:italic>A. fumigatus<\/jats:italic> infection and colonization. Based on this observation, we hypothesize that crosstalk between these humoral components is essential during host-<jats:italic>Aspergillus<\/jats:italic> interaction giving new specific leads to study for better understanding the pathogenesis. Furthermore, the affected humoral components could be potential diagnostic markers of <jats:italic>A. fumigatus<\/jats:italic> infection or colonization.<\/jats:p>","DOI":"10.3389\/fimmu.2021.677798","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T05:20:51Z","timestamp":1622006451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus"],"prefix":"10.3389","volume":"12","author":[{"given":"Sarah","family":"Delli\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Duchateau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Sze 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