{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:26:52Z","timestamp":1788326812892,"version":"build-2803163510"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disorder disproportionally affecting women. A similar sex difference exists in the murine New Zealand Black\/White hybrid model (NZBWF1) of SLE with all females, but only 30-40% of males, developing disease within the first year of life. Myeloid-derived suppressor cells (MDSCs) are prominent in NZBWF1 males and while depletion of these cells in males, but not females, promotes disease development, the mechanism of suppression remains unknown. S100a9, expressed by neutrophils and MDSCs, has previously been shown to exert immunosuppressive functions in cancer and inflammation. Here we investigated if S100a9 exerts immunosuppressive functions in NZBWF1 male and female mice.<jats:italic>S100a9<\/jats:italic><jats:sup>+\/+<\/jats:sup>,<jats:italic>S100a9<\/jats:italic><jats:sup>+\/-<\/jats:sup>and<jats:italic>S100a9<\/jats:italic><jats:sup>-\/-<\/jats:sup>NZBWF1 mice were followed for disease development for up to 8 months of age. Serum autoantibody levels, splenomegaly, lymphocyte activation, glomerulonephritis and proteinuria were measured longitudinally or at the time of harvest. In accordance with an immunosuppressive function of MDSCs in male mice,<jats:italic>S100a9-<\/jats:italic>deficient male NZBWF1 mice developed accelerated autoimmunity as indicated by increased numbers of differentiated effector B and T cells, elevated serum autoantibody levels, increased immune-complex deposition and renal inflammation, and accelerated development of proteinuria. In contrast, female mice showed either no response to S100a9-deficiency or even a slight reduction in disease symptoms. Furthermore, male, but not female,<jats:italic>S100a9<jats:sup>-\/-<\/jats:sup><\/jats:italic>NZBWF1 mice displayed an elevated type I interferon-induced gene signature, suggesting that S100a9 may dampen a pathogenic type I interferon signal in male mice. Taken together, S100a9 exerts an immunosuppressive function in male NZBWF1 mice effectively moderating lupus-like disease development<jats:italic>via<\/jats:italic>inhibition of type I interferon production, lymphocyte activation, autoantibody production and the development of renal disease.<\/jats:p>","DOI":"10.3389\/fimmu.2021.681503","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:55:05Z","timestamp":1623927305000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["S100a9 Protects Male Lupus-Prone NZBWF1 Mice From Disease Development"],"prefix":"10.3389","volume":"12","author":[{"given":"Laura M.","family":"Davison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres A.","family":"Alberto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardik A.","family":"Dand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma J.","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Patt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Dvorina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nodoka","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren N.","family":"Liegl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine N.","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"B1","article-title":"Systemic Lupus Erythrematosus","volume-title":"Clinical Immunology. Principles and Practice","author":"Kotzin","year":"2001"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00794","article-title":"Androgen-Induced Immunosuppression","volume":"9","author":"Gubbels Bupp","year":"2018","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem342","article-title":"Testosterone Patches in the Management of Patients with Mild\/Moderate Systemic Lupus Erythematosus","volume":"47","author":"Gordon","year":"2008","journal-title":"Rheumatol (Oxford)"},{"key":"B4","article-title":"Experience With 19-Nortestosterone in the Therapy of Systemic Lupus Erythematosus: Worsened Disease After Treatment With 19-Nortestosterone in Men and Lack of Improvement in Women","volume":"19","author":"Lahita","year":"1992","journal-title":"J Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1517\/14656566.3.1.23","article-title":"Dehydroepiandrosterone for the Treatment of Systemic Lupus Erythematosus","volume":"3","author":"van Vollenhoven","year":"2002","journal-title":"Expert Opin Pharmacother"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108729","article-title":"Androgenic Hormones Modulate Autoantibody Responses and Improve Survival in Murine Lupus","volume":"59","author":"Roubinian","year":"1977","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.147.6.1568","article-title":"Effect of Castration and Sex Hormone Treatment on Survival, Anti- Nucleic Acid Antibodies, and Glomerulonephritis in NZB\/NZW F1 Mice","volume":"147","author":"Roubinian","year":"1978","journal-title":"J Exp Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109390","article-title":"Delayed Androgen Treatment Prolongs Survival in Murine Lupus","volume":"63","author":"Roubinian","year":"1979","journal-title":"J Clin Invest"},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/sj.gene.6364447","article-title":"Identification of Candidate Genes That Influence Sex Hormone-Dependent Disease Phenotypes in Mouse Lupus","volume":"9","author":"Gubbels Bupp","year":"2008","journal-title":"Genes Immun"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364458","article-title":"Estrogen Receptor-Alpha Deficiency Attenuates Autoimmune Disease in (NZB x NZW)F1 Mice","volume":"9","author":"Bynote","year":"2008","journal-title":"Genes Immun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-4-19","article-title":"Sex Differences in the Expression of Lupus-Associated miRNAs in Splenocytes From Lupus-Prone NZB\/WF1 Mice","volume":"4","author":"Dai","year":"2013","journal-title":"Biol Sex Differ"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod44.4.707","article-title":"Hormonal Manipulation of the Prenatal Environment Alters Reproductive Morphology and Increases Longevity in Autoimmune NZB\/W Mice","volume":"44","author":"Keisler","year":"1991","journal-title":"Biol Reprod"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01271","article-title":"Androgen-Mediated Anti-inflammatory Cellular Processes as Therapeutic Targets in Lupus","volume":"11","author":"Jones","year":"2020","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/art.38048","article-title":"Gr1(high)CD11b(+) Cells Suppress B Cell Differentiation and Lupus-Like Disease in Lupus-Prone Male Mice","volume":"65","author":"Trigunaite","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700354","article-title":"Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers","volume":"199","author":"Bird","year":"2017","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-08-1323","article-title":"Androgen Receptor Modulates Foxp3 Expression in CD4+CD25+Foxp3+ Regulatory T-Cells","volume":"26","author":"Walecki","year":"2015","journal-title":"Mol Biol Cell"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2008.12.002","article-title":"Gonadectomy of Male BALB\/c Mice Increases Tim-3(+) Alternatively Activated M2 Macrophages, Tim-3(+) T cells, Th2 Cells and Treg in the Heart During Acute Coxsackievirus-Induced Myocarditis","volume":"23","author":"Frisancho-Kiss","year":"2009","journal-title":"Brain Behav Immun"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23536","article-title":"Forkhead Box p3+ Regulatory T Cell Underlies Male Resistance to Experimental Type 2 Autoimmune Hepatitis","volume":"51","author":"Lapierre","year":"2010","journal-title":"Hepatology"},{"key":"B19","article-title":"Suppressed Androgen Receptor Expression Promotes M2 Macrophage Reprogramming Through the STAT3\/SOCS3 pathway","volume":"18","author":"Ma","year":"2019","journal-title":"Excli J"},{"key":"B20","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/s41419-019-1358-y","article-title":"Loss of the androgen Receptor Suppresses Intrarenal Calcium Oxalate Crystals Deposition via Altering Macrophage Recruitment\/M2 Polarization with Change of the miR-185-5p\/CSF-1 Signals","volume":"10","author":"Zhu","year":"2019","journal-title":"Cell Death Dis"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506","article-title":"Myeloid-Derived Suppressor Cells as Regulators of the Immune System","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.049","article-title":"Markedly Elevated Serum Levels of Calcium-Binding S100A8\/A9 Proteins in Psoriatic Arthritis are Due to Activated Monocytes\/Macrophages","volume":"64","author":"Aochi","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.08.092","article-title":"Alterations of Circulating Endogenous Secretory RAGE and S100A9 Levels Indicating Dysfunction of the AGE-RAGE Axis in Autism","volume":"410","author":"Boso","year":"2006","journal-title":"Neurosci Lett"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e45478","DOI":"10.1371\/journal.pone.0045478","article-title":"An inflammation Loop Orchestrated by S100A9 and Calprotectin is Critical for Development of Arthritis","volume":"7","author":"Cesaro","year":"2012","journal-title":"PLoS. One"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080132","article-title":"Inhibition of Dendritic Cell Differentiation and Accumulation of Myeloid-Derived Suppressor Cells in Cancer is Regulated by S100A9 Protein","volume":"205","author":"Cheng","year":"2008","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-546416","article-title":"CLL-Cells Induce IDOhi CD14+HLA-DRlo Myeloid-Derived Suppressor Cells That Inhibit T-Cell Responses and Promote TRegs","volume":"124","author":"Jitschin","year":"2014","journal-title":"Blood"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2011.00495.x","article-title":"& de, C.F. Myeloid-Derived Suppressor Cells Limit the Inflammation by Promoting T Lymphocyte Apoptosis in the Spinal Cord of a Murine Model of Multiple Sclerosis","volume":"21","author":"Moline-Velazquez","year":"2011","journal-title":"Brain Pathol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2197","article-title":"Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma","volume":"13","author":"Ochoa","year":"2007","journal-title":"Clin Cancer Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24700","article-title":"Myeloid Suppressor Cells Induced by Hepatitis C Virus Suppress T-Cell Responses Through the Production of Reactive Oxygen Species","volume":"55","author":"Tacke","year":"2012","journal-title":"Hepatology"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-3-36","article-title":"The Subcellular Distribution of Myeloid-Related Protein 8 (MRP8) and MRP14 in Human Neutrophils","volume":"3","author":"Stroncek","year":"2005","journal-title":"J Transl Med"},{"key":"B31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/jlb.53.2.197","article-title":"MRP-8 and MRP-14, Two Abundant Ca(2+)-Binding Proteins of Neutrophils and Monocytes","volume":"53","author":"Hessian","year":"1993","journal-title":"J Leukoc Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.23.7.2564-2576.2003","article-title":"Myeloid Cell Function in MRP-14 (S100A9) Null Mice","volume":"23","author":"Hobbs","year":"2003","journal-title":"Mol Cell Biol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-247460","article-title":"A New Protective Role for S100A9 in Regulation of Neutrophil Recruitment During Invasive Pneumococcal Pneumonia","volume":"28","author":"De","year":"2014","journal-title":"FASEB J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/ki.2014.216","article-title":"The Calcium-Binding Protein Complex S100A8\/A9 Has a Crucial Role in Controlling Macrophage-Mediated Renal Repair Following Ischemia\/Reperfusion","volume":"87","author":"Dessing","year":"2015","journal-title":"Kidney Int"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1507","article-title":"Tumour-Mediated Upregulation of Chemoattractants and Recruitment of Myeloid Cells Predetermines Lung Metastasis","volume":"8","author":"Hiratsuka","year":"2006","journal-title":"Nat Cell Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e88924","DOI":"10.1371\/journal.pone.0088924","article-title":"S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS. One"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01774","article-title":"Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice","volume":"8","author":"Zhang","year":"2017","journal-title":"Front Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01565","article-title":"Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells During Late Sepsis","volume":"8","author":"Dai","year":"2017","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.2","article-title":"S100A8\/A9 and S100A9 Reduce Acute Lung Injury","volume":"95","author":"Hiroshima","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081302","article-title":"Phagocyte-specific S100A8\/A9 Protein Levels During Disease Exacerbations and Infections in Systemic Lupus Erythematosus","volume":"36","author":"Soyfoo","year":"2009","journal-title":"J Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/207368a0","article-title":"Genetic Investigations of Autoimmune Disease in Mice","volume":"207","author":"Burnet","year":"1965","journal-title":"Nature"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302479","article-title":"Gr1+ Cells Suppress T-Dependent Antibody Responses in (NZB x NZW)F1 Male Mice Through Inhibition of T Follicular Helper Cells and Germinal Center Formation","volume":"192","author":"Der","year":"2014","journal-title":"J Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364430","article-title":"Type I interferon Signaling is Involved in the Spontaneous Development of Lupus-Like Disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) Mice","volume":"8","author":"Jorgensen","year":"2007","journal-title":"Genes Immun"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1966.03100040091025","article-title":"NZB\/NZW Mice as a Model of Systemic Lupus Erythematosus","volume":"195","author":"Dubois","year":"1966","journal-title":"JAMA"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.119.4.1534","article-title":"Abnormal Polyclonal B Cell Activation in NZB\/NZW F1 Mice","volume":"119","author":"Cohen","year":"1977","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.7.4159","article-title":"Separation of the New Zealand Black Genetic Contribution to Lupus from New Zealand Black Determined Expansions of Marginal Zone B and B1a Cells","volume":"172","author":"Atencio","year":"2004","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.04.005","article-title":"Anti-CD3 Antibody Therapy Attenuates the Progression of Hypertension in Female Mice with Systemic Lupus Erythematosus","volume":"120","author":"Mathis","year":"2017","journal-title":"Pharmacol Res"},{"key":"B48","article-title":"Autoimmune and Immunoproliferative Diseases of NZB\/Bl mice and hybrids","volume":"5","author":"Mellors","year":"1966","journal-title":"Int Rev Exp Pathol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2194","article-title":"B Cell-Helper Neutrophils Stimulate the Diversification and Production of Immunoglobulin in the Marginal Zone of the Spleen","volume":"13","author":"Puga","year":"2011","journal-title":"Nat Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.448","article-title":"IRF7 Regulates the Development of Granulocytic Myeloid-Derived Suppressor Cells Through S100A9 Transrepression in Cancer","volume":"36","author":"Yang","year":"2017","journal-title":"Oncogene"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/art.30087","article-title":"Interferon-Alpha Accelerates Murine Systemic Lupus Erythematosus in a T Cell-Dependent Manner","volume":"63","author":"Liu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2499","article-title":"IFN-Alpha Induces Early Lethal Lupus in Preautoimmune (New Zealand Black x New Zealand White) F1 but Not in BALB\/c mice","volume":"174","author":"Mathian","year":"2005","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902199","article-title":"A Distinct Subset of Proinflammatory Neutrophils Isolated From Patients With Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs","volume":"184","author":"Denny","year":"2010","journal-title":"J Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3108","article-title":"A Cell-Surface Molecule Selectively Expressed on Murine Natural Interferon-Producing Cells That Blocks Secretion of Interferon-Alpha","volume":"103","author":"Blasius","year":"2004","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cellimm.2015.02.004","article-title":"Suppressive Effects of Androgens on the Immune System","volume":"294","author":"Trigunaite","year":"2015","journal-title":"Cell Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201238.29","article-title":"Defects Within the Myeloid Derived Supressor Cells (MDSCx) Compartment May Facilitate Aberrant Immune Responses in Systemic Lupus Erythematosus (SLE)","volume":"71","author":"Vlachou","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.021","article-title":"Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-\u03b3 Production via the Generation of Reactive Oxygen Species","volume":"12","author":"Huang","year":"2015","journal-title":"Cell Rep"},{"key":"B58","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.160.8.3713","article-title":"IFN-Gamma Receptor Deletion Prevents Autoantibody Production and Glomerulonephritis in Lupus-Prone (NZB x NZW)F1 Mice","volume":"160","author":"Haas","year":"1998","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021996","article-title":"Type-I Interferon Receptor Deficiency Reduces Lupus-like Disease in NZB Mice","volume":"197","author":"Santiago-Raber","year":"2003","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are Endogenous Activators of Toll-Like Receptor 4, Promoting Lethal, Endotoxin-Induced Shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv028","article-title":"Myeloid-Related Protein 14 Promotes Inflammation and Injury in Meningitis","volume":"212","author":"Wache","year":"2015","journal-title":"J Infect Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02243","article-title":"S100A9 Regulates MDSCs-Mediated Immune Suppression via the RAGE and TLR4 Signaling Pathways in Colorectal Carcinoma","volume":"10","author":"Huang","year":"2019","journal-title":"Front Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89867","article-title":"Autoinhibitory Regulation of S100A8\/S100A9 Alarmin Activity Locally Restricts Sterile Inflammation","volume":"128","author":"Vogl","year":"2018","journal-title":"J Clin Invest"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00447","article-title":"Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8\/A9","volume":"9","author":"Schenten","year":"2018","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.075242","article-title":"S-Glutathionylation Regulates Inflammatory Activities of S100A9","volume":"285","author":"Lim","year":"2010","journal-title":"J Biol Chem"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5627","article-title":"S-Nitrosylated S100A8: Novel Anti-Inflammatory Properties","volume":"181","author":"Lim","year":"2008","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225699","article-title":"miRNAs Regulate Cytokine Secretion Induced by Phosphorylated S100A8\/A9 in Neutrophils","volume":"20","author":"Jung","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e0174585","DOI":"10.1371\/journal.pone.0174585","article-title":"MicroRNA Expression profiles Identify Disease-Specific Alterations in Systemic Lupus Erythematosus and Primary Sj\u00f6gren\u2019s Syndrome","volume":"12","author":"Chen","year":"2017","journal-title":"PloS One"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25575","article-title":"Next Generation Sequencing Identifies miRNA-Based Biomarker Panel for Lupus Nephritis","volume":"9","author":"Su","year":"2018","journal-title":"Oncotarget"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2011.12.020","article-title":"Increased Expression and Phosphorylation of the Two S100A9 Isoforms in Mononuclear Cells From Patients With Systemic Lupus Erythematosus: A Proteomic Signature for Circulating Low-Density Granulocytes","volume":"75","author":"Pavon","year":"2012","journal-title":"J Proteomics"},{"key":"B71","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1093\/cvr\/cvp368","article-title":"17beta-Estradiol Induces Protein S-Nitrosylation in the Endothelium","volume":"85","author":"Chakrabarti","year":"2010","journal-title":"Cardiovasc Res"},{"key":"B72","first-page":"600","article-title":"Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis","volume":"11","author":"Alkhateeb","year":"2020","journal-title":"J Clin Cell Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.681503\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:42:57Z","timestamp":1699144977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.681503\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":72,"alternative-id":["10.3389\/fimmu.2021.681503"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.681503","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]},"article-number":"681503"}}