{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:58:55Z","timestamp":1793383135194,"version":"4.5.0"},"reference-count":356,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AI153612"],"award-info":[{"award-number":["RO1 AI153612"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The recent dramatic advances in preventing \u201cinitial xenograft dysfunction\u201d in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. Here we review the molecular, cellular, and immune mechanisms that characterize IRI and associated \u201cprimary graft dysfunction\u201d in allotransplantation and consider how they correspond with \u201cxeno-associated\u201d injury mechanisms. Based on this analysis, we describe potential genetic modifications as well as novel technical strategies that may minimize IRI for heart and other organ xenografts and which could facilitate safe and effective clinical xenotransplantation.<\/jats:p>","DOI":"10.3389\/fimmu.2021.681504","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T09:18:12Z","timestamp":1631179092000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Minimizing Ischemia Reperfusion Injury in Xenotransplantation"],"prefix":"10.3389","volume":"12","author":[{"given":"Parth M.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor M.","family":"Coe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Calhoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Pollok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Markmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Burdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Azimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joren C.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Richard N.","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ciresp.2016.12.008","article-title":"Clinical Xenotransplantation, a Closer Reality: Literature Review","volume":"95","author":"Aristizabal","year":"2017","journal-title":"Cir Esp. Feb"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2007.00404.x","article-title":"Xenotransfusions, Past and Present","volume":"14","author":"Roux","year":"2007","journal-title":"Xenotransplantation"},{"key":"B3","first-page":"256","volume-title":"\u00dcber Den Einfluss Der Temperatur\u00e4nderungen Auf Zahl, Dauer Und St\u00e4rke Der Herzschl\u00e4ge. Berichte \u00dcber Die Verhandlungen Der K\u00f6niglich S\u00e4chsischen Gesellschaft Der Wissenschaften Zu Leipzig, Mathematisch-Physische Classe1866","author":"Cyon","year":"1866"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03060","article-title":"Xenotransplantation: Current Status in Preclinical Research","volume":"10","author":"Lu","year":"2019","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2015.06.060","article-title":"A Brief History of Clinical Xenotransplantation","volume":"23","author":"Cooper","year":"2015","journal-title":"Int J Surg"},{"key":"B6","article-title":"The Transplantation of Organs: A Preliminary Communication. 1905 [Classical Article]","volume":"74","author":"Carrel","year":"2001","journal-title":"Yale J Biol Med"},{"key":"B7","article-title":"Xenografts: Clinical Trials and Perspectives","volume":"27","author":"Camsonne","year":"1998","journal-title":"Presse Med May"},{"key":"B8","article-title":"La Technique Operatoire Des Anastomosis Vasculaires Et La Transplnatation Des Visceres","volume":"1","author":"Carrel","year":"1902","journal-title":"Lyon Med"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1084\/jem.15.5.516","article-title":"On The Permanent Life Of Tissues Outside Of The Organism","volume":"15","author":"Carrel","year":"1912","journal-title":"J Exp Med May"},{"key":"B10","article-title":"Technique and Remote Results of Vacular Anastomosis","volume":"11","author":"Carrel","year":"1912","journal-title":"Surg Gynecol Obstret"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.81.2112.621","article-title":"The Culture Of Whole Organs","volume":"81","author":"Carrel","year":"1935","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108178","article-title":"Regional Myocardial Functional and Electrophysiological Alterations After Brief Coronary Artery Occlusion in Conscious Dogs","volume":"56","author":"Heyndrickx","year":"1975","journal-title":"J Clin Invest Oct"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1124","article-title":"Reperfusion Damage- A Story of Success, Failure, and Hope","volume":"81","author":"Ferrari","year":"2017","journal-title":"Circ J Jan"},{"key":"B14","first-page":"68","article-title":"Myocardial Necrosis Induced by Temporary Occlusion of a Coronary Artery in the Dog","volume":"70","author":"Jennings","year":"1960","journal-title":"Arch Pathol"},{"key":"B15","article-title":"The No Reflow Phenomenon in Renal Ischemia","volume":"25","author":"Summers","year":"1971","journal-title":"Lab Invest"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197803000-00017","article-title":"The Effects of the Perfusion of Various Solutions on the No-Reflow Phenomenon in Experimental Free Flaps","volume":"61","author":"Chait","year":"1978","journal-title":"Plast Reconstr Surg"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-Derived Free Radicals in Postischemic Tissue Injury","volume":"312","author":"McCord","year":"1985","journal-title":"N Engl J Med"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960x(90)90001-9","article-title":"Leucocyte Cellular Adhesion Molecules","volume":"4","author":"Yong","year":"1990","journal-title":"Blood Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1042\/bst0181143","article-title":"Biological Functions of the Complement System","volume":"18","author":"Lachmann","year":"1990","journal-title":"Biochem Soc Trans"},{"key":"B20","article-title":"Necrosis and Apoptosis: Distinct Modes of Cell Death With Fundamentally Different Significance","author":"Searle","year":"1982","journal-title":"Pathol Annu"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061420","article-title":"Regenerative Cardiovascular Therapies: Stem Cells and Beyond","volume":"20","author":"Wernly","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0047-9","article-title":"A Randomized Trial of Normothermic Preservation in Liver Transplantation","volume":"557","author":"Nasralla","year":"2018","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000304","article-title":"Mechanisms of Lung Ischemia-Reperfusion Injury","volume":"21","author":"Laubach","year":"2016","journal-title":"Curr Opin Organ Transplant"},{"key":"B24","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5500\/wjt.v5.i2.52","article-title":"Update on Ischemia-Reperfusion Injury in Kidney Transplantation: Pathogenesis and Treatment","volume":"5","author":"Salvadori","year":"2015","journal-title":"World J Transplant"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0765-z","article-title":"Consistent Success in Life-Supporting Porcine Cardiac Xenotransplantation","volume":"564","author":"L\u00e4ngin","year":"2018","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.01.064","article-title":"Predictive Risk Factors for Primary Graft Failure Requiring Temporary Extra-Corporeal Membrane Oxygenation Support After Cardiac Transplantation in Adults","volume":"40","author":"D\u2019Alessandro","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-019-0213-3","article-title":"Evidence for the Important Role of Inflammation in Xenotransplantation","volume":"16","author":"Li","year":"2019","journal-title":"J Inflammation (Lond)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00553.2011","article-title":"Pathophysiology of Myocardial Reperfusion Injury: Preconditioning, Postconditioning, and Translational Aspects of Protective Measures","volume":"301","author":"Sanada","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-009-0004-8","article-title":"The Mitochondrial Permeability Transition Pore and Ischemia-Reperfusion Injury","volume":"104","author":"Baines","year":"2009","journal-title":"Basic Res Cardiol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.007","article-title":"The Molecular Composition of the Mitochondrial Permeability Transition Pore","volume":"46","author":"Baines","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell Biology of Ischemia\/Reperfusion Injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00044.2007","article-title":"Ion Transport and Energetics During Cell Death and Protection","volume":"23","author":"Murphy","year":"2008","journal-title":"Physiol (Bethesda)"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp264","article-title":"Targeting Calcium Transport in Ischaemic Heart Disease","volume":"84","author":"Talukder","year":"2009","journal-title":"Cardiovasc Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/211646a0","article-title":"Paradoxical Influence of Calcium Ions on the Permeability of the Cell Membranes of the Isolated Rat Heart","volume":"211","author":"Zimmerman","year":"1966","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2010.05.005","article-title":"Mitochondria: The Calcium Connection","volume":"1797","author":"Contreras","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-6-218","article-title":"The Calpains: Modular Designs and Functional Diversity","volume":"8","author":"Croall","year":"2007","journal-title":"Genome Biol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010253","article-title":"Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair","volume":"9","author":"Nieuwenhuijs-Moeke","year":"2020","journal-title":"J Clin Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.5.H2145","article-title":"Attenuation of Postischemic Reperfusion Injury Is Related to Prevention of [Ca2+]m Overload in Rat Hearts","volume":"271","author":"Miyamae","year":"1996","journal-title":"Am J Physiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-3-0348-8988-9_7","article-title":"The pH Paradox in Ischemia-Reperfusion Injury to Cardiac Myocytes","volume":"76","author":"Lemasters","year":"1996","journal-title":"EXS"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00008","article-title":"Transplantation of Hearts Donated After Circulatory Death","volume":"5","author":"White","year":"2018","journal-title":"Front Cardiovasc Med"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1042\/cs20150223","article-title":"Molecular Pathways in Protecting the Liver From Ischaemia\/Reperfusion Injury: A 2015 Update","volume":"129","author":"Gracia-Sancho","year":"2015","journal-title":"Int J Mol Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.207381","article-title":"S-Nitrosylation in Cardiovascular Signaling","volume":"106","author":"Lima","year":"2010","journal-title":"Circ Res Mar"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.10.050","article-title":"A Key Role for Mitochondria in Endothelial Signaling by Plasma Cysteine\/Cystine Redox Potential","volume":"48","author":"Go","year":"2010","journal-title":"Free Radic Biol Med Jan"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00731.2011","article-title":"Biphasic Modulation of the Mitochondrial Electron Transport Chain in Myocardial Ischemia and Reperfusion","volume":"302","author":"Lee","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4330\/wjc.v3.i6.186","article-title":"Ischemia\/reperfusion Injury and Cardioprotective Mechanisms: Role of Mitochondria and Reactive Oxygen Species","volume":"3","author":"Perrelli","year":"2011","journal-title":"World J Cardiol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.10.056","article-title":"JNK Signaling Pathway Is a Key Modulator in Cell Death Mediated by Reactive Oxygen and Nitrogen Species","volume":"40","author":"Shen","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.07.005","article-title":"Primary Graft Dysfunction After Lung Transplantation","volume":"38","author":"Porteous","year":"2017","journal-title":"Clin Chest Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.5.1404","article-title":"Direct Measurement of Free Radical Generation Following Reperfusion of Ischemic Myocardium","volume":"84","author":"Zweier","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"B49","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.jtcvs.2008.10.044","article-title":"CD4+ T Lymphocytes Mediate Acute Pulmonary Ischemia-Reperfusion Injury","volume":"137","author":"Yang","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.08.033","article-title":"Adenosine A2A Receptor Activation on CD4+ T Lymphocytes and Neutrophils Attenuates Lung Ischemia-Reperfusion Injury","volume":"139","author":"Sharma","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00205.2013","article-title":"NADPH Oxidase Mediates Synergistic Effects of IL-17 and TNF-\u03b1 on CXCL1 Expression by Epithelial Cells After Lung Ischemia-Reperfusion","volume":"306","author":"Sharma","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201506-1253OC","article-title":"NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury","volume":"193","author":"Sharma","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/590987","article-title":"Oxidative Stress and Lung Ischemia-Reperfusion Injury","volume":"2015","author":"Ferrari","year":"2015","journal-title":"Oxid Med Cell Longev"},{"key":"B54","volume-title":"StatPearls","year":"2020"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-2828(03)00043-9","article-title":"The Mitochondrial Permeability Transition Pore: Its Fundamental Role in Mediating Cell Death During Ischaemia and Reperfusion","volume":"35","author":"Hausenloy","year":"2003","journal-title":"J Mol Cell Cardiol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12035","article-title":"Hyperacute Rejection in the Xenogenic Transplanted Rat Liver Is Triggered by the Complement System Only in the Presence of Leukocytes and Free Radical Species","volume":"20","author":"Ngo","year":"2013","journal-title":"Xenotransplantation"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318188ab04","article-title":"Hydrogen Peroxide-Induced VCAM-1 Expression in Pancreatic Islets and Beta-Cells Through Extracellular Ca2+ Influx","volume":"86","author":"Lee","year":"2008","journal-title":"Transplantation"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.0229","article-title":"Real-Time Quantitation of Renal Ischemia Using Targeted Microbubbles: In-Vivo Measurement of P-Selectin Expression","volume":"23","author":"Andonian","year":"2009","journal-title":"J Endourol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1865","article-title":"Coronary Endothelial P-Selectin in Pathogenesis of Myocardial Ischemia-Reperfusion Injury","volume":"275","author":"Palazzo","year":"1998","journal-title":"Am J Physiol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0209117","article-title":"PSGL-1-Dependent Myeloid Leukocyte Activation","volume":"86","author":"Zarbock","year":"2009","journal-title":"J Leukoc Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050326","article-title":"Cytokine and Adhesion Molecule Requirements for Neutrophil Recruitment During Glycogen-Induced Peritonitis","volume":"47","author":"Mulligan","year":"1998","journal-title":"Inflammation Res"},{"key":"B62","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/s1072-7515(00)00360-4","article-title":"P-Selectin and Chemokine Response After Liver Ischemia and Reperfusion","volume":"191","author":"Martinez-Mier","year":"2000","journal-title":"J Am Coll Surg"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00058","article-title":"Human Myocardium Releases Heat Shock Protein 27 (HSP27) After Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 Through Toll-Like Receptor (TLR)-2 and TLR4","volume":"20","author":"Jin","year":"2014","journal-title":"Mol Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6678457","article-title":"Heat Shock Proteins in Oxidative Stress and Ischemia\/Reperfusion Injury and Benefits From Physical Exercises: A Review to the Current Knowledge","volume":"2021","author":"Szyller","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B65","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"Myocardial Ischemia-Reperfusion Injury: A Neglected Therapeutic Target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J Clin Invest"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060958","article-title":"Targeting the Innate Immune Response to Improve Cardiac Graft Recovery After Heart Transplantation: Implications for the Donation After Cardiac Death","volume":"17","author":"Toldo","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195491","article-title":"Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071059","article-title":"The Danger Model: A Renewed Sense of Self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1422-4","article-title":"Toll-Like Receptors 2 and 4 in Renal Ischemia\/Reperfusion Injury","volume":"25","author":"Rusai","year":"2010","journal-title":"Pediatr Nephrol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nrcardio.2011.38","article-title":"Innate Immune Signaling in Cardiac Ischemia","volume":"8","author":"Arslan","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 Inflammasome in Acute Myocardial Infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042501","article-title":"Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production","volume":"141","author":"Liu","year":"2020","journal-title":"Circulation"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26322","article-title":"IKK\/NF-kappaB Signaling: Balancing Life and Death\u2013a New Approach to Cancer Therapy","volume":"115","author":"Luo","year":"2005","journal-title":"J Clin Invest"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.068338","article-title":"The Nlrp3 Inflammasome Promotes Myocardial Dysfunction in Structural Cardiomyopathy Through Interleukin-1\u03b2","volume":"98","author":"Bracey","year":"2013","journal-title":"Exp Physiol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt091","article-title":"The NLRP3 Inflammasome Is Up-Regulated in Cardiac Fibroblasts and Mediates Myocardial Ischaemia-Reperfusion Injury","volume":"99","author":"Sandanger","year":"2013","journal-title":"Cardiovasc Res"},{"key":"B76","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1161\/CIRCULATIONAHA.110.982777","article-title":"Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia\/Reperfusion Injury","volume":"123","author":"Kawaguchi","year":"2011","journal-title":"Circulation"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12283","article-title":"Gene Set Enrichment Analysis Identifies Key Innate Immune Pathways in Primary Graft Dysfunction After Lung Transplantation","volume":"13","author":"Cantu","year":"2013","journal-title":"Am J Transplant"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.5.2343","article-title":"Reperfusion Injury of Ischemic Skeletal Muscle Is Mediated by Natural Antibody and Complement","volume":"183","author":"Weiser","year":"1996","journal-title":"J Exp Med May"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12988","article-title":"Bortezomib, C1-Inhibitor and Plasma Exchange do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons","volume":"15","author":"Le Bas-Bernardet","year":"2015","journal-title":"Am J Transplant"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2574-z","article-title":"Complement Component C3 Promotes Cerebral Ischemia\/Reperfusion Injury Mediated by TLR2\/Nf\u03bab Activation in Diabetic Mice","volume":"43","author":"Lin","year":"2018","journal-title":"Neurochem Res"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12556","article-title":"Complementing the Inflammasome","volume":"147","author":"Triantafilou","year":"2016","journal-title":"Immunology"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03475.x","article-title":"Crosstalk Between Complement and Toll-Like Receptor Activation in Relation to Donor Brain Death and Renal Ischemia-Reperfusion Injury","volume":"11","author":"Damman","year":"2011","journal-title":"Am J Transplant"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061750","article-title":"Complement Activation in Liver Transplantation: Role of Donor Macrosteatosis and Implications in Delayed Graft Function","volume":"19","author":"N\u00fa\u00f1ez","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-7-16","article-title":"The Role of Complement in the Pathogenesis of Renal Ischemia-Reperfusion Injury and Fibrosis","volume":"7","author":"Danobeitia","year":"2014","journal-title":"Fibrogenesis Tissue Repair"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01151","article-title":"The Lectin Pathway of Complement in Myocardial Ischemia\/Reperfusion Injury-Review of Its Significance and the Potential Impact of Therapeutic Interference by C1 Esterase Inhibitor","volume":"9","author":"Panagiotou","year":"2018","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.01.002","article-title":"Plasma-Derived and Recombinant C1 Esterase Inhibitor: Binding Profiles and Neuroprotective Properties in Brain Ischemia\/Reperfusion Injury","author":"Mercurio","year":"2021","journal-title":"Brain Behav Immun"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16404","article-title":"A Novel Injury Site-Natural Antibody Targeted Complement Inhibitor Protects Against Lung Transplant Injury","author":"Li","year":"2020","journal-title":"Am J Transplant"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003302","article-title":"Complement 5 Inhibition Ameliorates Hepatic Ischemia\/reperfusion Injury in Mice, Dominantly via the C5a-Mediated Cascade","volume":"104","author":"Kusakabe","year":"2020","journal-title":"Transplantation"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90487-3","article-title":"Reduction of Myocardial Reperfusion Injury With Human Soluble Complement Receptor Type 1 (BRL 55730)","volume":"236","author":"Smith","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000034","article-title":"C1-Esterase-Inhibitor for Primary Graft Dysfunction in Lung Transplantation","volume":"97","author":"Sommer","year":"2014","journal-title":"Transplantation"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04840419","article-title":"Three-Year Outcomes of a Randomized, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients","volume":"15","author":"Huang","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199108000-00006","article-title":"Immunopathology of Hyperacute Xenograft Rejection in a Swine-to-Primate Model","volume":"52","author":"Platt","year":"1991","journal-title":"Transplantation"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61091-X","article-title":"Clinical Xenotransplantation: The Next Medical Revolution","volume":"379","author":"Ekser","year":"2012","journal-title":"Lancet"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900325","article-title":"Complement Activation, Its Consequences, and Blockade by Gene Transfer","volume":"21","author":"Carrington","year":"1997","journal-title":"World J Surg"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070672","article-title":"Thrombotic Microangiopathy Associated With Humoral Rejection of Cardiac Xenografts From Alpha1,3-Galactosyltransferase Gene-Knockout Pigs in Baboons","volume":"172","author":"Shimizu","year":"2008","journal-title":"Am J Pathol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12673","article-title":"Expression of Human CD46 Modulates Inflammation Associated With GalTKO Lung Xenograft Injury","volume":"14","author":"Burdorf","year":"2014","journal-title":"Am J Transplant"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.09.186","article-title":"Prevention of Hyperacute Rejection in a Model of Orthotopic Liver Xenotransplantation From Pig to Baboon Using Polytransgenic Pig Livers (CD55, CD59, and H-Transferase)","volume":"37","author":"Ram\u00edrez","year":"2005","journal-title":"Transplant Proc"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4823","article-title":"Mitochondria as a Therapeutic Target for Cardiac Ischemia\u2212Reperfusion Injury (Review)","volume":"47","author":"Marin","year":"2021","journal-title":"Int J Mol Med"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103335","article-title":"Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies","volume":"57","author":"Lesnefsky","year":"2017","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(09)70014-3","article-title":"Mitochondria and Vascular Pathology","volume":"61","author":"Di Lisa","year":"2009","journal-title":"Pharmacol Rep"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr312","article-title":"New Roles for Mitochondria in Cell Death in the Reperfused Myocardium","volume":"94","author":"Ong","year":"2012","journal-title":"Cardiovasc Res"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.6.C1783","article-title":"Mitochondrial Permeability Transition in pH-Dependent Reperfusion Injury to Rat Hepatocytes","volume":"273","author":"Qian","year":"1997","journal-title":"Am J Physiol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0014-5793(01)03314-2","article-title":"Regulated and Unregulated Mitochondrial Permeability Transition Pores: A New Paradigm of Pore Structure and Function","volume":"512","author":"He","year":"2002","journal-title":"FEBS Lett"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1042\/bj3070093","article-title":"Mitochondrial non-Specific Pores Remain Closed During Cardiac Ischaemia, But Open Upon Reperfusion","volume":"307","author":"Griffiths","year":"1995","journal-title":"Biochem J"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.021","article-title":"What Is the Mitochondrial Permeability Transition Pore","volume":"46","author":"Halestrap","year":"2009","journal-title":"J Mol Cell Cardiol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1146\/annurev-physiol-021909-135929","article-title":"The Cardiac Mitochondrion: Nexus of Stress","volume":"72","author":"Baines","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"B107","article-title":"Mitochondria and Heart Failure: New Insights Into an Energetic Problem","volume":"58","author":"Chen","year":"2010","journal-title":"Minerva Cardioangiol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.491","article-title":"Mitochondrial Fission in Endothelial Cells After Simulated Ischemia\/Reperfusion: Role of Nitric Oxide and Reactive Oxygen Species","volume":"52","author":"Giedt","year":"2012","journal-title":"Free Radic Biol Med"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00057.x","article-title":"Extracellular Matrix, Junctional Integrity and Matrix Metalloproteinase Interactions in Endothelial Permeability Regulation","volume":"200","author":"Alexander","year":"2002","journal-title":"J Anat"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1017\/S1462399409001112","article-title":"Molecular Mechanisms of Endothelial Hyperpermeability: Implications in Inflammation","volume":"11","author":"Kumar","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"B111","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1152\/physrev.00012.2005","article-title":"Signaling Mechanisms Regulating Endothelial Permeability","volume":"86","author":"Mehta","year":"2006","journal-title":"Physiol Rev"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq090","article-title":"Role of Blood Cells in Ischaemia-Reperfusion Induced Endothelial Barrier Failure","volume":"87","author":"Rodrigues","year":"2010","journal-title":"Cardiovasc Res"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513150","article-title":"Blood Cell-Derived RANTES Mediates Cerebral Microvascular Dysfunction, Inflammation, and Tissue Injury After Focal Ischemia-Reperfusion","volume":"39","author":"Terao","year":"2008","journal-title":"Stroke"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01710.x","article-title":"Sphingosine 1-Phosphate Inhibits Ischemia Reperfusion Injury Following Experimental Lung Transplantation","volume":"7","author":"Okazaki","year":"2007","journal-title":"Am J Transplant"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01000.2003","article-title":"Leukocyte Dependence of Platelet Adhesion in Postcapillary Venules","volume":"286","author":"Cooper","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000132690.96836.7F","article-title":"Platelet-Leukocyte-Endothelial Cell Interactions After Middle Cerebral Artery Occlusion and Reperfusion","volume":"24","author":"Ishikawa","year":"2004","journal-title":"J Cereb Blood Flow Metab"},{"key":"B117","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.cardiores.2003.11.036","article-title":"Role of Platelets in Coronary Thrombosis and Reperfusion of Ischemic Myocardium","volume":"61","author":"Gawaz","year":"2004","journal-title":"Cardiovasc Res"},{"key":"B118","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1549-8719.2000.tb00739.x","article-title":"Endothelial Cells Exposed to Anoxia\/Reoxygenation Are Hyperadhesive to T-Lymphocytes: Kinetics and Molecular Mechanisms","volume":"7","author":"Kokura","year":"2000","journal-title":"Microcirculation"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1105645","article-title":"The Role of JAM-A and PECAM-1 in Modulating Leukocyte Infiltration in Inflamed and Ischemic Tissues","volume":"80","author":"Nourshargh","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2062","article-title":"The Junctional Adhesion Molecule JAM-C Regulates Polarized Transendothelial Migration of Neutrophils In Vivo","volume":"12","author":"Woodfin","year":"2011","journal-title":"Nat Immunol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111622","article-title":"Pericytes Support Neutrophil Subendothelial Cell Crawling and Breaching of Venular Walls In Vivo","volume":"209","author":"Proebstl","year":"2012","journal-title":"J Exp Med"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.022","article-title":"MMP-9 Deficiency Shelters Endothelial PECAM-1 Expression and Enhances Regeneration of Steatotic Livers After Ischemia and Reperfusion Injury","volume":"60","author":"Kato","year":"2014","journal-title":"J Hepatol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24755","article-title":"Addition of Simvastatin to Cold Storage Solution Prevents Endothelial Dysfunction in Explanted Rat Livers","volume":"55","author":"Russo","year":"2012","journal-title":"Hepatology"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e228db","article-title":"Flow Cessation Triggers Endothelial Dysfunction During Organ Cold Storage Conditions: Strategies for Pharmacologic Intervention","volume":"90","author":"Gracia-Sancho","year":"2010","journal-title":"Transplantation"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200206150-00003","article-title":"VEGF-A and -C But Not -B Mediate Increased Vascular Permeability in Preserved Lung Grafts","volume":"73","author":"Abraham","year":"2002","journal-title":"Transplantation"},{"key":"B126","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/s1053-2498(01)00346-1","article-title":"Co-Expression of Endothelin-1 and Vascular Endothelial Growth Factor Mediates Increased Vascular Permeability in Lung Grafts Before Reperfusion","volume":"21","author":"Taghavi","year":"2002","journal-title":"J Heart Lung Transplant"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01673.x","article-title":"Recipient Vascular Endothelial Growth Factor Serum Levels Predict Primary Lung Graft Dysfunction","volume":"7","author":"Krenn","year":"2007","journal-title":"Am J Transplant"},{"key":"B128","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ejcts.2007.04.006","article-title":"Vascular Endothelial Growth Factor Increases Pulmonary Vascular Permeability in Cystic Fibrosis Patients Undergoing Lung Transplantation","volume":"32","author":"Krenn","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"key":"B129","doi-asserted-by":"publisher","first-page":"e51932","DOI":"10.1371\/journal.pone.0051932","article-title":"Elevated Plasma Angiopoietin-2 Levels and Primary Graft Dysfunction After Lung Transplantation","volume":"7","author":"Diamond","year":"2012","journal-title":"PloS One"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2007.087387","article-title":"Angiopoietin-2, Permeability Oedema, Occurrence and Severity of ALI\/ARDS in Septic and Non-Septic Critically Ill Patients","volume":"63","author":"van der Heijden","year":"2008","journal-title":"Thorax"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02957.x","article-title":"Concomitant Endothelin-1 Overexpression in Lung Transplant Donors and Recipients Predicts Primary Graft Dysfunction","volume":"10","author":"Salama","year":"2010","journal-title":"Am J Transplant"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000161627.84481.5e","article-title":"Dual Role of Vascular Endothelial Growth Factor in Hepatic Ischemia-Reperfusion Injury","volume":"79","author":"Tsurui","year":"2005","journal-title":"Transplantation"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv186","article-title":"Rip2 Modifies VEGF-Induced Signalling and Vascular Permeability in Myocardial Ischaemia","volume":"107","author":"Andersson","year":"2015","journal-title":"Cardiovasc Res"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00329.x","article-title":"Renal Ischemia-Reperfusion Increases Endothelial VEGFR-2 Without Increasing VEGF or VEGFR-1 Expression","volume":"61","author":"Kanellis","year":"2002","journal-title":"Kidney Int"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-010-0083-6","article-title":"Direct Relationship Between Levels of TNF-Alpha Expression and Endothelial Dysfunction in Reperfusion Injury","volume":"105","author":"Zhang","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328324b7c2","article-title":"The Impact of Ischaemia-Reperfusion on the Blood Vessel","volume":"26","author":"Gourdin","year":"2009","journal-title":"Eur J Anaesthesiol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-3848(98)00155-8","article-title":"Increased Platelet Sensitivity Toward Platelet Inhibitors During Physical Exercise in Patients With Coronary Artery Disease","volume":"93","author":"Lindemann","year":"1999","journal-title":"Thromb Res"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.20.14368","article-title":"Nitric Oxide Inhibits Thrombin Receptor-Activating Peptide-Induced Phosphoinositide 3-Kinase Activity in Human Platelets","volume":"274","author":"Pigazzi","year":"1999","journal-title":"J Biol Chem"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200209150-00016","article-title":"Platelet Adhesion Mediated by Fibrinogen-Intercelllular Adhesion Molecule-1 Binding Induces Tissue Injury in the Postischemic Liver In Vivo","volume":"74","author":"Khandoga","year":"2002","journal-title":"Transplantation"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051283","article-title":"The Costimulatory Pathways and T Regulatory Cells in Ischemia-Reperfusion Injury: A Strong Arm in the Inflammatory Response","volume":"19","author":"de Ramon","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B141","article-title":"Hypoxia-Inducible Factor 1 Alpha Contributes to Pulmonary Vascular Dysfunction in Lung Ischemia-Reperfusion Injury","volume":"7","author":"Zhao","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.06.025","article-title":"Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1\u03b1\/Mir-26a\/TRPC6\/PARP1 Signaling","volume":"17","author":"Shen","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201007-1173OC","article-title":"Natural Killer T Cell-Derived IL-17 Mediates Lung Ischemia-Reperfusion Injury","volume":"183","author":"Sharma","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"252ra124","DOI":"10.1126\/scitranslmed.3009443","article-title":"The HMGB1-RAGE Axis Mediates Traumatic Brain Injury-Induced Pulmonary Dysfunction in Lung Transplantation","volume":"6","author":"Weber","year":"2014","journal-title":"Sci Transl Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a Therapeutic Target in Inflammatory Diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert Opin Ther Targets"},{"key":"B146","doi-asserted-by":"publisher","first-page":"e12381","DOI":"10.1111\/xen.12381","article-title":"P- and E-Selectin Receptor Antagonism Prevents Human Leukocyte Adhesion to Activated Porcine Endothelial Monolayers and Attenuates Porcine Endothelial Damage","volume":"25","author":"Laird","year":"2018","journal-title":"Xenotransplantation"},{"key":"B147","doi-asserted-by":"publisher","first-page":"e12385","DOI":"10.1111\/xen.12385","article-title":"Interleukin-8 Mediates Neutrophil-Endothelial Interactions in Pig-to-Human Xenogeneic Models","volume":"25","author":"French","year":"2018","journal-title":"Xenotransplantation"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199600001-00007","article-title":"The Microvascular Cell and Ischemia-Reperfusion Injury","volume":"27","author":"Verrier","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"B149","article-title":"Prolonged Discordant Xenograft Survival by Inhibition of the Intrinsic Coagulation Pathway in Complement C6-Deficient Recipients","volume":"17","author":"Jakobs","year":"1998","journal-title":"J Heart Lung Transplant"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401762","article-title":"Decreased Fibrinolytic Activity in Porcine-to-Primate Cardiac Xenotransplantation","volume":"4","author":"Kalady","year":"1998","journal-title":"Mol Med Sep"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12301","article-title":"The Potentiating Effect of hTFPI in the Presence of Hcd47 Reduces the Cytotoxicity of Human Macrophages","volume":"24","author":"Jung","year":"2017","journal-title":"Xenotransplantation"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12176","article-title":"Early Graft Failure of GalTKO Pig Organs in Baboons Is Reduced by Expression of a Human Complement Pathway-Regulatory Protein","volume":"22","author":"Azimzadeh","year":"2015","journal-title":"Xenotransplantation"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15329","article-title":"Long-Term Survival of Pig-to-Rhesus Macaque Renal Xenografts Is Dependent on CD4 T Cell Depletion","volume":"19","author":"Kim","year":"2019","journal-title":"Am J Transplant"},{"key":"B154","doi-asserted-by":"publisher","first-page":"e12465","DOI":"10.1111\/xen.12465","article-title":"Cardiac Xenografts Show Reduced Survival in the Absence of Transgenic Human Thrombomodulin Expression in Donor Pigs","volume":"26","author":"Singh","year":"2019","journal-title":"Xenotransplantation"},{"key":"B155","doi-asserted-by":"publisher","first-page":"e12458","DOI":"10.1111\/xen.12458","article-title":"Thromboxane and Histamine Mediate PVR Elevation During Xenogeneic Pig Lung Perfusion With Human Blood","volume":"26","author":"Burdorf","year":"2019","journal-title":"Xenotransplantation"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.jtcvs.2014.06.002","article-title":"Genetically Engineered Pigs and Target-Specific Immunomodulation Provide Significant Graft Survival and Hope for Clinical Cardiac Xenotransplantation","volume":"148","author":"Mohiuddin","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B157","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/xen.12073","article-title":"Regulation of Human Platelet Aggregation by Genetically Modified Pig Endothelial Cells and Thrombin Inhibition","volume":"21","author":"Iwase","year":"2014","journal-title":"Xenotransplantation"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B159","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: Cellular and Molecular Mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J Pathol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.05.010","article-title":"The Role of the Autophagy in Myocardial Ischemia\/Reperfusion Injury","volume":"1852","author":"Ma","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N Engl J Med"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1305538110","article-title":"Two Independent Pathways of Regulated Necrosis Mediate Ischemia-Reperfusion Injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000046236.20251.fa","article-title":"Apoptosis and Cellular Activation in the Pathogenesis of Acute Vascular Rejection","volume":"91","author":"Holzknecht","year":"2002","journal-title":"Circ Res"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780086","article-title":"Acute Humoral Xenograft Rejection: Destruction of the Microvascular Capillary Endothelium in Pig-to-Nonhuman Primate Renal Grafts","volume":"80","author":"Shimizu","year":"2000","journal-title":"Lab Invest"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.01228.x","article-title":"New Cellular and Molecular Immune Pathways in Ischemia\/Reperfusion Injury","volume":"6","author":"Boros","year":"2006","journal-title":"Am J Transplant"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12291","article-title":"Human IL-6, IL-17, IL-1\u03b2, and TNF-\u03b1 Differently Regulate the Expression of Pro-Inflammatory Related Genes, Tissue Factor, and Swine Leukocyte Antigen Class I in Porcine Aortic Endothelial Cells","volume":"24","author":"Gao","year":"2017","journal-title":"Xenotransplantation"},{"key":"B167","doi-asserted-by":"publisher","first-page":"e12408","DOI":"10.1111\/xen.12408","article-title":"Porcine IL-6, IL-1\u03b2, and TNF-\u03b1 Regulate the Expression of Pro-Inflammatory-Related Genes and Tissue Factor in Human Umbilical Vein Endothelial Cells","volume":"25","author":"Gao","year":"2018","journal-title":"Xenotransplantation"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12296","article-title":"Therapeutic Regulation of Systemic Inflammation in Xenograft Recipients","volume":"24","author":"Iwase","year":"2017","journal-title":"Xenotransplantation"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6935147","article-title":"Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection","volume":"2019","author":"Liu","year":"2019","journal-title":"Cardiol Res Pract"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial Reperfusion Injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N Engl J Med Sep"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00381.2014","article-title":"Neutrophil Extracellular Traps in Ischemia-Reperfusion Injury-Induced Myocardial No-Reflow: Therapeutic Potential of DNase-Based Reperfusion Strategy","volume":"308","author":"Ge","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109558","article-title":"Reperfusion Injury as a Target for Diminishing Infarct Size","volume":"137","author":"Barzyc","year":"2020","journal-title":"Med Hypotheses"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.11.021","article-title":"Statins Inhibit Neutrophil Infiltration in Skeletal Muscle Reperfusion Injury","volume":"141","author":"Cowled","year":"2007","journal-title":"J Surg Res Aug"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001504","article-title":"Targeted Complement Inhibitors Protect Against Posttransplant Cardiac Ischemia and Reperfusion Injury and Reveal an Important Role for the Alternative Pathway of Complement Activation","volume":"185","author":"Atkinson","year":"2010","journal-title":"J Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000174337.53658.b0","article-title":"Disruption of P-Selectin Signaling Modulates Cell Trafficking and Results in Improved Outcomes After Mouse Warm Intestinal Ischemia and Reperfusion Injury","volume":"80","author":"Farmer","year":"2005","journal-title":"Transplantation"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.2741\/chamoun","article-title":"Pathophysiologic Role of Selectins and Their Ligands in Ischemia Reperfusion Injury","volume":"5","author":"Chamoun","year":"2000","journal-title":"Front Biosci"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.271.2.F408","article-title":"Renal Ischemic-Reperfusion Injury in L-Selectin-Deficient Mice","volume":"271","author":"Rabb","year":"1996","journal-title":"Am J Physiol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.81.3.304","article-title":"Exacerbation of Cerebral Injury in Mice That Express the P-Selectin Gene: Identification of P-Selectin Blockade as a New Target for the Treatment of Stroke","volume":"81","author":"Connolly","year":"1997","journal-title":"Circ Res"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448","article-title":"Exploring the Full Spectrum of Macrophage Activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.3.R577","article-title":"Tumor Necrosis Factor in the Heart","volume":"274","author":"Meldrum","year":"1998","journal-title":"Am J Physiol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.022","article-title":"Pre-Conditioning With Tanshinone IIA Attenuates the Ischemia\/Reperfusion Injury Caused by Liver Grafts via Regulation of HMGB1 in Rat Kupffer Cells","volume":"89","author":"Li","year":"2017","journal-title":"BioMed Pharmacother"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding Cell Death Signals in Liver Inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J Hepatol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI22675","article-title":"Selective Depletion of Macrophages Reveals Distinct, Opposing Roles During Liver Injury and Repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.11.7661","article-title":"Hepatic Ischemia\/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells","volume":"175","author":"Tsung","year":"2005","journal-title":"J Immunol"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042614","article-title":"The Nuclear Factor HMGB1 Mediates Hepatic Injury After Murine Liver Ischemia-Reperfusion","volume":"201","author":"Tsung","year":"2005","journal-title":"J Exp Med"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.113603","article-title":"Lung Transplant Reperfusion Injury Involves Pulmonary Macrophages and Circulating Leukocytes in a Biphasic Response","volume":"121","author":"Fiser","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B187","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1164\/rccm.200207-670SO","article-title":"Ischemia-Reperfusion-Induced Lung Injury","volume":"167","author":"de Perrot","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0090OC","article-title":"Pulmonary Macrophage Subpopulations in the Induction and Resolution of Acute Lung Injury","volume":"47","author":"Johnston","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5223(03)00390-8","article-title":"Early Activation of the Alveolar Macrophage Is Critical to the Development of Lung Ischemia-Reperfusion Injury","volume":"126","author":"Naidu","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000783","article-title":"Early Growth Response-1 Plays an Important Role in Ischemia-Reperfusion Injury in Lung Transplants by Regulating Polymorphonuclear Neutrophil Infiltration","volume":"99","author":"Yamamoto","year":"2015","journal-title":"Transplantation"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00086.2006","article-title":"Alveolar Macrophage Activation Is a Key Initiation Signal for Acute Lung Ischemia-Reperfusion Injury","volume":"291","author":"Zhao","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2015.03.009","article-title":"Interleukin-17 Receptor Polymorphism Predisposes to Primary Graft Dysfunction After Lung Transplantation","volume":"34","author":"Somers","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.01.022","article-title":"Activation Mechanisms and Multifaceted Effects of Mast Cells in Ischemia Reperfusion Injury","volume":"376","author":"He","year":"2019","journal-title":"Exp Cell Res"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01260","article-title":"Platelet Contributions to Myocardial Ischemia\/Reperfusion Injury","volume":"10","author":"Schanze","year":"2019","journal-title":"Front Immunol"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2003.01692.x","article-title":"The Membrane Attack Complex of Complement Contributes to Plasmin-Induced Synthesis of Platelet-Activating Factor by Endothelial Cells and Neutrophils","volume":"109","author":"Lupia","year":"2003","journal-title":"Immunology"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3400304","article-title":"Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces Ischaemia\/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and Pyroptosis","volume":"120","author":"Chueh","year":"2020","journal-title":"Thromb Haemost"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.2174\/187152506777698317","article-title":"Antiplatelet and Antileukocyte Effects of Cardiovascular, Immunomodulatory and Chemotherapeutic Drugs","volume":"4","author":"Nosal","year":"2006","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"B198","doi-asserted-by":"publisher","first-page":"e12517","DOI":"10.1111\/xen.12517","article-title":"The Complex Functioning of the Complement System in Xenotransplantation","volume":"26","author":"Zhou","year":"2019","journal-title":"Xenotransplantation"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.09.188","article-title":"Cd3","author":"Hsu","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.761_4.x","article-title":"T Cells as Mediators in Renal Ischemia\/Reperfusion Injury","volume":"66","author":"Ysebaert","year":"2004","journal-title":"Kidney Int"},{"key":"B201","doi-asserted-by":"publisher","first-page":"4995","DOI":"10.4049\/jimmunol.171.10.4995","article-title":"Recipient T Cells Mediate Reperfusion Injury After Lung Transplantation in the Rat","volume":"171","author":"de Perrot","year":"2003","journal-title":"J Immunol"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005090954","article-title":"Role of CXC Chemokine Receptor 3 Pathway in Renal Ischemic Injury","volume":"17","author":"Fiorina","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00378.x","article-title":"The T Cell as a Bridge Between Innate and Adaptive Immune Systems: Implications for the Kidney","volume":"61","author":"Rabb","year":"2002","journal-title":"Kidney Int"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.3.F525","article-title":"Pathophysiological Role of T Lymphocytes in Renal Ischemia-Reperfusion Injury in Mice","volume":"279","author":"Rabb","year":"2000","journal-title":"Am J Physiol Renal Physiol"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.12.007","article-title":"Regulatory T Cells and Organ Transplantation","volume":"16","author":"Waldmann","year":"2004","journal-title":"Semin Immunol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12158","article-title":"Induction of Transplantation Tolerance Through Regulatory Cells: From Mice to Men","volume":"258","author":"Ferrer","year":"2014","journal-title":"Immunol Rev"},{"key":"B207","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.149.4.1416","article-title":"Early Recognition of a Discordant Xenogeneic Organ by Human Circulating Lymphocytes","volume":"149","author":"Inverardi","year":"1992","journal-title":"J Immunol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.007415","article-title":"Trends in Brain-Dead Organ Donor Characteristics: A 13-Year Analysis","volume":"59","author":"Hassanain","year":"2016","journal-title":"Can J Surg"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01879.x","article-title":"Systemic Inflammation in the Brain-Dead Organ Donor","volume":"53","author":"Barklin","year":"2009","journal-title":"Acta Anaesthesiol Scand"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/78.5.520","article-title":"Transcranial Cytokine Gradients in Patients Requiring Intensive Care After Acute Brain Injury","volume":"78","author":"McKeating","year":"1997","journal-title":"Br J Anaesth"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649","article-title":"The NF-Kappa B and I Kappa B Proteins: New Discoveries and Insights","volume":"14","author":"Baldwin","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2006.11.005","article-title":"Endothelial Injury in the Initiation and Progression of Vascular Disorders","volume":"46","author":"Tesfamariam","year":"2007","journal-title":"Vascul Pharmacol"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199408270-00004","article-title":"Changes in Hemodynamic and Metabolic Parameters Following Induced Brain Death in the Pig","volume":"58","author":"Mertes","year":"1994","journal-title":"Transplantation"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.04.008","article-title":"Alteration of Neuropeptides in the Lung Tissue Correlates Brain Death-Induced Neurogenic Edema","volume":"28","author":"Barklin","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"B215","article-title":"The Pathophysiological Effects of Brain Death on Potential Donor Organs, With Particular Reference to the Heart","volume":"71","author":"Cooper","year":"1989","journal-title":"Ann R Coll Surg Engl"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1065","article-title":"Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach","volume":"36","author":"Tanriverdi","year":"2015","journal-title":"Endocr Rev"},{"key":"B217","first-page":"77","article-title":"Pseudo- and Central Precocious Puberty Due to Adrenogenital Syndrome","volume":"54","author":"Pouw","year":"1986","journal-title":"Tijdschr Kindergeneeskd"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14674","article-title":"The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific","volume":"18","author":"Michel","year":"2018","journal-title":"Am J Transplant"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508103330601","article-title":"High Survival Rates of Kidney Transplants From Spousal and Living Unrelated Donors","volume":"333","author":"Terasaki","year":"1995","journal-title":"N Engl J Med"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420901","article-title":"Improved Graft Survival After Renal Transplantation in the United States, 1988 to 1996","volume":"342","author":"Hariharan","year":"2000","journal-title":"N Engl J Med"},{"key":"B221","doi-asserted-by":"publisher","first-page":"e0148815","DOI":"10.1371\/journal.pone.0148815","article-title":"The Impact of Ischemia\/Reperfusion Injury on Liver Allografts From Deceased After Cardiac Death Versus Deceased After Brain Death Donors","volume":"11","author":"Xu","year":"2016","journal-title":"PloS One"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01799.x","article-title":"Brain Death Activates Donor Organs and Is Associated With a Worse I\/R Injury After Liver Transplantation","volume":"7","author":"Weiss","year":"2007","journal-title":"Am J Transplant"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182104784","article-title":"Biliary Complications After Liver Transplantation From Donation After Cardiac Death Donors: An Analysis of Risk Factors and Long-Term Outcomes From a Single Center","volume":"253","author":"Foley","year":"2011","journal-title":"Ann Surg"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01243.x","article-title":"Risk Factors for Graft Survival After Liver Transplantation From Donation After Cardiac Death Donors: An Analysis of OPTN\/UNOS Data","volume":"6","author":"Mateo","year":"2006","journal-title":"Am J Transplant"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.07.82","article-title":"Donors After Cardiocirculatory Death and Lung Transplantation","volume":"9","author":"Inci","year":"2017","journal-title":"J Thorac Dis"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.02.004","article-title":"Lung Transplantation With Donation After Cardiac Death Donors: Long-Term Follow-Up in a Single Center","volume":"139","author":"De Oliveira","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B227","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1186\/s12931-017-0704-9","article-title":"Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Lung Ischemia-Reperfusion Injury and Enhance Reconditioning of Donor Lungs After Circulatory Death","volume":"18","author":"Stone","year":"2017","journal-title":"Respir Res"},{"key":"B228","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.athoracsur.2007.03.082","article-title":"N-Acetylcysteine Attenuates Lung Ischemia-Reperfusion Injury After Lung Transplantation","volume":"84","author":"Inci","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.2011151","article-title":"Interleukin-8 Release During Early Reperfusion Predicts Graft Function in Human Lung Transplantation","volume":"165","author":"De Perrot","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1086OC","article-title":"Neutrophil Extracellular Traps Are Pathogenic in Primary Graft Dysfunction After Lung Transplantation","volume":"191","author":"Sayah","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12368","article-title":"Receptor for Advanced Glycation End Products (RAGE) on iNKT Cells Mediates Lung Ischemia-Reperfusion Injury","volume":"13","author":"Sharma","year":"2013","journal-title":"Am J Transplant"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.032","article-title":"Blockade of Receptor for Advanced Glycation End Product Attenuates Pulmonary Reperfusion Injury in Mice","volume":"136","author":"Sternberg","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B233","doi-asserted-by":"publisher","first-page":"e0142115","DOI":"10.1371\/journal.pone.0142115","article-title":"A Peptide to Reduce Pulmonary Edema in a Rat Model of Lung Transplantation","volume":"10","author":"Schossleitner","year":"2015","journal-title":"PloS One"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13605","article-title":"Inhibiting Integrin \u03b1v\u03b25 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice","volume":"16","author":"Mallavia","year":"2016","journal-title":"Am J Transplant"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00302.2014","article-title":"Sphingosine-1-Phosphate Receptor 1 Agonism Attenuates Lung Ischemia-Reperfusion Injury","volume":"308","author":"Stone","year":"2015","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.09.034","article-title":"Human Recombinant Apyrase Therapy Protects Against Canine Pulmonary Ischemia-Reperfusion Injury","volume":"34","author":"Ibrahim","year":"2015","journal-title":"J Heart Lung Transplant"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.04.049","article-title":"Apyrase Treatment Prevents Ischemia-Reperfusion Injury in Rat Lung Isografts","volume":"138","author":"Sugimoto","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.10.031","article-title":"\u03b11-Antitrypsin Inhibits Ischemia Reperfusion-Induced Lung Injury by Reducing Inflammatory Response and Cell Death","volume":"33","author":"Gao","year":"2014","journal-title":"J Heart Lung Transplant"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2806","article-title":"Mesenchymal Stem Cells Attenuate Acute Ischemia-Reperfusion Injury in a Rat Model","volume":"10","author":"Lu","year":"2015","journal-title":"Exp Ther Med"},{"key":"B240","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s00408-014-9654-x","article-title":"Infusion of Mesenchymal Stem Cells Protects Lung Transplants From Cold Ischemia-Reperfusion Injury in Mice","volume":"193","author":"Tian","year":"2015","journal-title":"Lung"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1186\/2047-1440-3-19","article-title":"Multipotent Adult Progenitor Cells Decrease Cold Ischemic Injury in Ex Vivo Perfused Human Lungs: An Initial Pilot and Feasibility Study","volume":"3","author":"La Francesca","year":"2014","journal-title":"Transplant Res"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2015.10.112","article-title":"Annexin V Homodimer Protects Against Ischemia Reperfusion-Induced Acute Lung Injury in Lung Transplantation","volume":"151","author":"Hashimoto","year":"2016","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B243","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/ajt.13445","article-title":"\u03b4v1-1 Reduces Pulmonary Ischemia Reperfusion-Induced Lung Injury by Inhibiting Necrosis and Mitochondrial Localization of Pkc\u03b4 and P53","volume":"16","author":"Kim","year":"2016","journal-title":"Am J Transplant"},{"key":"B244","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13287-017-0603-5","article-title":"Immunoregulatory Effects of Multipotent Adult Progenitor Cells in a Porcine Ex Vivo Lung Perfusion Model","volume":"8","author":"Martens","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.09.019","article-title":"\u03b11-Anti-Trypsin Improves Function of Porcine Donor Lungs during Ex-Vivo Lung Perfusion","volume":"37","author":"Lin","year":"2018","journal-title":"J Heart Lung Transplant"},{"key":"B246","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1136\/thoraxjnl-2018-211576","article-title":"Therapeutic Effects of Human Mesenchymal Stem Cell Microvesicles in an Ex Vivo Perfused Human Lung Injured With Severe","volume":"74","author":"Park","year":"2019","journal-title":"Thorax"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25779","article-title":"The Role of Ischemia-Reperfusion Injury in Early Hepatic Allograft Dysfunction","volume":"26","author":"Zhou","year":"2020","journal-title":"Liver Transplantation"},{"key":"B248","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1111\/liv.14091","article-title":"Ischaemia Reperfusion Injury in Liver Transplantation: Cellular and Molecular Mechanisms","volume":"39","author":"Dar","year":"2019","journal-title":"Liver Int"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030846","article-title":"Ischemia-Reperfusion Injury in Marginal Liver Grafts and the Role of Hypothermic Machine Perfusion: Molecular Mechanisms and Clinical Implications","volume":"9","author":"Czigany","year":"2020","journal-title":"J Clin Med"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101421","article-title":"Potential Therapeutic Roles of Stem Cells in Ischemia-Reperfusion Injury","volume":"37","author":"Barzegar","year":"2019","journal-title":"Stem Cell Res"},{"key":"B251","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1056\/NEJMoa0802289","article-title":"Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation","volume":"360","author":"Moers","year":"2009","journal-title":"N Engl J Med"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1111038","article-title":"Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation","volume":"366","author":"Moers","year":"2012","journal-title":"N Engl J Med"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438637.29214.10","article-title":"Pulsatile Perfusion Reduces the Risk of Delayed Graft Function in Deceased Donor Kidney Transplants, Irrespective of Donor Type and Cold Ischemic Time","volume":"97","author":"Gill","year":"2014","journal-title":"Transplantation"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.116","article-title":"Sodium Nitrite Protects Against Kidney Injury Induced by Brain Death and Improves Post-Transplant Function","volume":"82","author":"Kelpke","year":"2012","journal-title":"Kidney Int"},{"key":"B255","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1681\/ASN.2006090998","article-title":"Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury","volume":"19","author":"Hill","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000264200.38926.70","article-title":"Erythropoietin Protects the Kidneys Against Ischemia Reperfusion Injury by Activating Hypoxia Inducible Factor-1alpha","volume":"83","author":"Imamura","year":"2007","journal-title":"Transplantation"},{"key":"B257","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.1371\/journal.pmed.0050137","article-title":"The Reno-Vascular A2B Adenosine Receptor Protects the Kidney From Ischemia","volume":"5","author":"Grenz","year":"2008","journal-title":"PloS Med"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199401001-00010","article-title":"The Beneficial Effect of Human Recombinant Superoxide Dismutase on Acute and Chronic Rejection Events in Recipients of Cadaveric Renal Transplants","volume":"57","author":"Land","year":"1994","journal-title":"Transplantation"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2011.02.020","article-title":"Protective Effect of N-Acetylcysteine on Early Outcomes of Deceased Renal Transplantation","volume":"43","author":"Danilovic","year":"2011","journal-title":"Transplant Proc"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000438622.89310.95","article-title":"Powerful Protection Against Renal Ischemia Reperfusion Injury by T Cell-Specific NF-\u03bab Inhibition","volume":"97","author":"Xue","year":"2014","journal-title":"Transplantation"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.968495","article-title":"On the Edge: Targeting Toll-Like Receptor 2 in Ischemia\/Reperfusion Injury","volume":"5","author":"Lepper","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"key":"B262","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/clpt.2013.150","article-title":"Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody","volume":"94","author":"Reilly","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007111267","article-title":"Complement 5a Receptor Inhibition Improves Renal Allograft Survival","volume":"19","author":"Gueler","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1023-z","article-title":"Renoprotective Effects of Novel Interleukin-1 Receptor-Associated Kinase 4 Inhibitor AS2444697 Through Anti-Inflammatory Action in 5\/6 Nephrectomized Rats","volume":"387","author":"Kondo","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12121","article-title":"Managing Renal Transplant Ischemia Reperfusion Injury: Novel Therapies in the Pipeline","volume":"27","author":"Powell","year":"2013","journal-title":"Clin Transplant"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14717","article-title":"Donor Pretreatment With Nebulized Complement C3a Receptor Antagonist Mitigates Brain-Death Induced Immunological Injury Post-Lung Transplant","volume":"18","author":"Cheng","year":"2018","journal-title":"Am J Transplant"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.06.026","article-title":"Carbon Monoxide-Saturated Preservation Solution Protects Lung Grafts From Ischemia-Reperfusion Injury","volume":"136","author":"Kohmoto","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.02.032","article-title":"Inhaled Nitric Oxide Reduces Ischemia-Reperfusion Injury in Rat Lungs From Non-Heart-Beating Donors","volume":"132","author":"Takashima","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.12.025","article-title":"Inhaled Nitric Oxide Attenuates Apoptosis in Ischemia-Reperfusion Injury of the Rabbit Lung","volume":"78","author":"Yamashita","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.37","article-title":"Human Amniotic Mesenchymal Stem Cells Alleviate Lung Injury Induced by Ischemia and Reperfusion After Cardiopulmonary Bypass in Dogs","volume":"96","author":"Qiang","year":"2016","journal-title":"Lab Invest"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.07.006","article-title":"Mesenchymal Stromal Cell Therapy During Ex Vivo Lung Perfusion Ameliorates Ischemia-Reperfusion Injury in Lung Transplantation","volume":"38","author":"Nakajima","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2018.12.003","article-title":"Hypothermic Perfusion of Donor Heart With a Preservation Solution Supplemented by Mesenchymal Stem Cells","volume":"38","author":"Korkmaz-Ic\u00f6z","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2015.1128997","article-title":"Human Mesenchymal Stromal Cells Improve Cardiac Perfusion in an Ovine Immunocompetent Animal Model","volume":"29","author":"Dayan","year":"2016","journal-title":"J Invest Surg"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3695-3","article-title":"Acute Kidney Injury: Emerging Pharmacotherapies in Current Clinical Trials","volume":"33","author":"Benoit","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215511","article-title":"Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury","volume":"20","author":"Oliva","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B276","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12967-018-1422-x","article-title":"Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial","volume":"16","author":"Sun","year":"2018","journal-title":"J Transl Med"},{"key":"B277","doi-asserted-by":"publisher","first-page":"e24777","DOI":"10.1097\/MD.0000000000024777","article-title":"Comparison of the Treatment Results of Knee Osteoarthritis Using Adipose Tissue Mesenchymal Stromal Cells Derived Through Enzymatic Digestion and Mechanically Fragmented Adipose Tissue","volume":"100","author":"Krze\u015bniak","year":"2021","journal-title":"Med (Baltimore)"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011440","article-title":"Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke","volume":"96","author":"Chung","year":"2021","journal-title":"Neurology"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0472","article-title":"Umbilical Cord Mesenchymal Stem Cells for COVID-19 Acute Respiratory Distress Syndrome: A Double-Blind, Phase 1\/2a, Randomized Controlled Trial","volume":"10","author":"Lanzoni","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(95)70125-7","article-title":"Successful Treatment of Life-Threatening Acute Reperfusion Injury After Lung Transplantation With Inhaled Nitric Oxide","volume":"110","author":"Macdonald","year":"1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E228","article-title":"Role of Inhaled Nitric Oxide in Adult Heart or Lung Transplant Recipients","volume":"39","author":"Rea","year":"2005","journal-title":"Ann Pharmacother"},{"key":"B282","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jss.2012.06.037","article-title":"Inhaled Hydrogen Sulfide Improves Graft Function in an Experimental Model of Lung Transplantation","volume":"178","author":"George","year":"2012","journal-title":"J Surg Res"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31892","article-title":"Inhaled NO Accelerates Restoration of Liver Function in Adults Following Orthotopic Liver Transplantation","volume":"117","author":"Lang","year":"2007","journal-title":"J Clin Invest"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2014.10.001","article-title":"Anesthetics Attenuate Ischemia-Reperfusion Induced Renal Injury: Effects and Mechanisms","volume":"52","author":"Khajuria","year":"2014","journal-title":"Acta Anaesthesiol Taiwan"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00251.2010","article-title":"Lung Ischemia-Reperfusion Injury: A Molecular and Clinical View on a Complex Pathophysiological Process","volume":"299","author":"den Hengst","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000232","article-title":"Primary Graft Dysfunction: Lessons Learned About the First 72\u200aH After Lung Transplantation","volume":"20","author":"Porteous","year":"2015","journal-title":"Curr Opin Organ Transplant"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13606","article-title":"Early Pulmonary Function and Mid Term Outcome in Lung Transplantation After Ex Vivo Lung Perfusion- a Single-Center, Retrospective, Observational, Cohort Study","volume":"20","author":"Fumagalli","year":"2020","journal-title":"Transpl Int"},{"key":"B288","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21037\/acs.2020.01.02","article-title":"Ex-Vivo Lung Perfusion Versus Standard Protocol Lung Transplantation-Mid-Term Survival and Meta-Analysis","volume":"9","author":"Chakos","year":"2020","journal-title":"Ann Cardiothorac Surg"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2017.02.011","article-title":"Standard Donor Lung Procurement With Normothermic Ex Vivo Lung Perfusion: A Prospective Randomized Clinical Trial","volume":"36","author":"Slama","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014597","article-title":"Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation","volume":"364","author":"Cypel","year":"2011","journal-title":"N Engl J Med"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.06.043","article-title":"Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion","volume":"102","author":"Charles","year":"2016","journal-title":"Ann Thorac Surg"},{"key":"B292","article-title":"Normothermic Ex Vivo Lung Perfusion in Brain-Dead Donors Reduces Inflammatory Cytokines and Toll-Like Receptor Expression","volume":"15","author":"Shafaghi","year":"2016","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003338","article-title":"Ex Vivo Lung Perfusion Improves the Inflammatory Signaling Profile of the Porcine Donor Lung Following Transplantation","volume":"104","author":"Stone","year":"2020","journal-title":"Transplantation"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2017.03.016","article-title":"Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury","volume":"2","author":"Demirjian","year":"2017","journal-title":"Kidney Int Rep"},{"key":"B295","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s13063-017-1972-x","article-title":"A Double-Blind Randomised Controlled Investigation Into the Efficacy of Mirococept (APT070) for Preventing Ischaemia Reperfusion Injury in the Kidney Allograft (EMPIRIKAL): Study Protocol for a Randomised Controlled Trial","volume":"18","author":"Kassimatis","year":"2017","journal-title":"Trials"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13899","article-title":"Prophylactic Orthosteric Inhibition of Leukocyte Integrin CD11b\/CD18 Prevents Long-Term Fibrotic Kidney Failure in Cynomolgus Monkeys","volume":"8","author":"Dehnadi","year":"2017","journal-title":"Nat Commun"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12179","article-title":"Renal Transplantation After Ex Vivo Normothermic Perfusion: The First Clinical Study","volume":"13","author":"Nicholson","year":"2013","journal-title":"Am J Transplant"},{"key":"B298","doi-asserted-by":"publisher","first-page":"e012237","DOI":"10.1136\/bmjopen-2016-012237","article-title":"Protocol of a Randomised Controlled, Open-Label Trial of Ex Vivo Normothermic Perfusion Versus Static Cold Storage in Donation After Circulatory Death Renal Transplantation","volume":"7","author":"Hosgood","year":"2017","journal-title":"BMJ Open"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1590\/s1679-45082016rw3585","article-title":"Primary Graft Dysfunction of the Liver: Definitions, Diagnostic Criteria and Risk Factors","volume":"14","author":"Neves","year":"2016","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.03.080","article-title":"Emerging Innovations in Liver Preservation and Resuscitation","volume":"50","author":"Kim","year":"2018","journal-title":"Transplant Proc"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25023","article-title":"Hypothermic Oxygenated Machine Perfusion Reduces Bile Duct Reperfusion Injury After Transplantation of Donation After Circulatory Death Livers","volume":"24","author":"Van Rijn","year":"2018","journal-title":"Liver Transplantation"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-0956-6","article-title":"Study Protocol for a Multicenter Randomized Controlled Trial to Compare the Efficacy of End-Ischemic Dual Hypothermic Oxygenated Machine Perfusion With Static Cold Storage in Preventing Non-Anastomotic Biliary Strictures After Transplantation of Liver Gra","volume":"19","author":"Van Rijn","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000003540","article-title":"Transplantation of High-Risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial","volume":"270","author":"van Leeuwen","year":"2019","journal-title":"Ann Surg"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13708","article-title":"Liver Transplantation AfterEx VivoNormothermic Machine Preservation: A Phase 1 (First-In-Man) Clinical Trial","volume":"16","author":"Ravikumar","year":"2016","journal-title":"Am J Transplantation"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.01.011","article-title":"Does Hypothermic Machine Perfusion of Human Donor Livers Affect Risks of Sinusoidal Endothelial Injury and Microbial Infection","volume":"45","author":"Jomaa","year":"2013","journal-title":"A Feasibility Study Assessing Flow Parameters Sterility Sinusoidal Endothelial Ultrastructure"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04086.x","article-title":"Hypothermic Machine Preservation Reduces Molecular Markers of Ischemia\/Reperfusion Injury in Human Liver Transplantation","volume":"12","author":"Henry","year":"2012","journal-title":"Am J Transplant"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25362","article-title":"Pilot, Open, Randomized, Prospective Trial for Normothermic Machine Perfusion Evaluation in Liver Transplantation From Older Donors","volume":"25","author":"Ghinolfi","year":"2019","journal-title":"Liver Transplantation"},{"key":"B308","doi-asserted-by":"publisher","first-page":"e017558","DOI":"10.1136\/bmjopen-2017-017558","article-title":"Hypothermic Oxygenated Machine Perfusion (HOPE) for Orthotopic Liver Transplantation of Human Liver Allografts From Extended Criteria Donors (ECD) in Donation After Brain Death (DBD): A Prospective Multicentre Randomised Controlled Trial (HOPE ECD-DBD)","volume":"7","author":"Czigany","year":"2017","journal-title":"BMJ Open"},{"key":"B309","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1111\/ajt.14049","article-title":"Preliminary Single Centre Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial","volume":"17","author":"Bral","year":"2016","journal-title":"Am J Transplant"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02932.x","article-title":"Hypothermic Machine Preservation in Human Liver Transplantation: The First Clinical Series","volume":"10","author":"Guarrera","year":"2010","journal-title":"Am J Transplantation"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.023","article-title":"HOPE for Human Liver Grafts Obtained From Donors After Cardiac Death","volume":"60","author":"Dutkowski","year":"2014","journal-title":"J Hepatol"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13875","article-title":"Transplantation of Declined Liver Allografts Following Normothermic Ex-Situ Evaluation","volume":"16","author":"Mergental","year":"2016","journal-title":"Am J Transplant"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14583","article-title":"The First Case of Ischemia-Free Organ Transplantation in Humans: A Proof of Concept","volume":"18","author":"He","year":"2018","journal-title":"Am J Transplant"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-019-09794-1","article-title":"Primary Graft Dysfunction After Heart Transplantation: A Thorn Amongst the Roses","volume":"24","author":"Singh","year":"2019","journal-title":"Heart Fail Rev"},{"key":"B315","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1177\/1089253219867694","article-title":"Early Graft Dysfunction Following Heart Transplant: Prevention and Management","volume":"24","author":"Subramani","year":"2020","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw171","article-title":"Effect of a Single Dose of the Interleukin-6 Receptor Antagonist Tocilizumab on Inflammation and Troponin T Release in Patients With Non-ST-Elevation Myocardial Infarction: A Double-Blind, Randomized, Placebo-Controlled Phase 2 Trial","volume":"37","author":"Kleveland","year":"2016","journal-title":"Eur Heart J"},{"key":"B317","doi-asserted-by":"publisher","first-page":"e108024","DOI":"10.1371\/journal.pone.0108024","article-title":"Etanercept Attenuates Myocardial Ischemia\/Reperfusion Injury by Decreasing Inflammation and Oxidative Stress","volume":"9","author":"Yang","year":"2014","journal-title":"PloS One"},{"key":"B318","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2018.12.031","article-title":"Recombinant Human Interleukin-1 Receptor Antagonist Treatment Protects Rats From Myocardial Ischemia-Reperfusion Injury","volume":"111","author":"Zhu","year":"2019","journal-title":"BioMed Pharmacother"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60261-6","article-title":"Ex-Vivo Perfusion of Donor Hearts for Human Heart Transplantation (PROCEED II): A Prospective, Open-Label, Multicentre, Randomised Non-Inferiority Trial","volume":"385","author":"Ardehali","year":"2015","journal-title":"Lancet"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2016.08.015","article-title":"Intermediate Outcomes With Ex-Vivo Allograft Perfusion for Heart Transplantation","volume":"36","author":"Chan","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"B321","doi-asserted-by":"publisher","first-page":"75","DOI":"10.21037\/acs.2018.01.08","article-title":"Heart Transplantation From Donation After Circulatory Determined Death","volume":"7","author":"Page","year":"2018","journal-title":"Ann Cardiothorac Surg"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.01.090","article-title":"First to 50: Early Outcomes Following Heart Transplantation at Royal Papworth Hospital From Donation After Circulatory Determined Death (DCD) Donors","volume":"12","author":"Messer","year":"2019","journal-title":"J Heart Lung Transplant"},{"key":"B323","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.1038\/s41467-020-16782-9","article-title":"A Nonrandomized Open-Label Phase 2 Trial of Nonischemic Heart Preservation for Human Heart Transplantation","volume":"11","author":"Nilsson","year":"2020","journal-title":"Nat Commun"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.103900","article-title":"Will the Pig Solve the Transplantation Backlog","volume":"53","author":"Cooper","year":"2002","journal-title":"Annu Rev Med"},{"key":"B325","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/xen.12133","article-title":"Systemic Inflammation in Xenograft Recipients Precedes Activation of Coagulation","volume":"22","author":"Ezzelarab","year":"2015","journal-title":"Xenotransplantation"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a3a52b","article-title":"Activation of the Lectin Pathway of Complement in Pig-to-Human Xenotransplantation Models","volume":"96","author":"Bongoni","year":"2013","journal-title":"Transplantation"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-07419-5","article-title":"Success for Pig-to-Baboon Heart Transplants","volume":"564","author":"Knosalla","year":"2018","journal-title":"Nature"},{"key":"B328","doi-asserted-by":"publisher","first-page":"e12636","DOI":"10.1111\/xen.12636","article-title":"Cold Non-Ischemic Heart Preservation With Continuous Perfusion Prevents Early Graft Failure in Orthotopic Pig-to-Baboon Xenotransplantation","volume":"28","author":"L\u00e4ngin","year":"2021","journal-title":"Xenotransplantation"},{"key":"B329","doi-asserted-by":"publisher","first-page":"e12391","DOI":"10.1111\/xen.12391","article-title":"GalT-KO Pig Lungs Are Highly Susceptible to Acute Vascular Rejection in Baboons, Which may be Mitigated by Transgenic Expression of Hcd47 on Porcine Blood Vessels","volume":"25","author":"Watanabe","year":"2018","journal-title":"Xenotransplantation"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14341","article-title":"Prolonged Survival Following Pig-To-Primate Liver Xenotransplantation Utilizing Exogenous Coagulation Factors and Costimulation Blockade","volume":"17","author":"Shah","year":"2017","journal-title":"Am J Transplant"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.03.008","article-title":"Loss of Ecto-5\u2019nucleotidase From Porcine Endothelial Cells After Exposure to Human Blood: Implications for Xenotransplantation","volume":"1741","author":"Khalpey","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"B332","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1126\/sciimmunol.aau6298","article-title":"Transplanting Organs From Pigs to Humans","volume":"4","author":"Sykes","year":"2019","journal-title":"Sci Immunol"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11138","article-title":"Chimeric 2C10R4 Anti-CD40 Antibody Therapy Is Critical for Long-Term Survival of GTKO.hCD46.hTBM Pig-to-Primate Cardiac Xenograft","volume":"7","author":"Mohiuddin","year":"2016","journal-title":"Nat Commun"},{"key":"B334","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1097\/TP.0000000000001452","article-title":"Interleukin-6, A Cytokine Critical to Mediation of Inflammation, Autoimmunity and Allograft Rejection: Therapeutic Implications of IL-6 Receptor Blockade","volume":"101","author":"Jordan","year":"2017","journal-title":"Transplantation"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1172\/JCI93537","article-title":"Inflammasomes and IL-1 Biology in the Pathogenesis of Allograft Dysfunction","volume":"127","author":"Weigt","year":"2017","journal-title":"J Clin Invest"},{"key":"B336","doi-asserted-by":"publisher","first-page":"e12502","DOI":"10.1111\/xen.12502","article-title":"Potential Pathological Role of Pro-Inflammatory Cytokines (IL-6, TNF-\u03b1, and IL-17) in Xenotransplantation","volume":"26","author":"Zhao","year":"2019","journal-title":"Xenotransplantation"},{"key":"B337","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3109\/14017431.2016.1154598","article-title":"Safe Orthotopic Transplantation of Hearts Harvested 24\u2009Hours After Brain Death and Preserved for 24\u2009Hours","volume":"50","author":"Steen","year":"2016","journal-title":"Scand Cardiovasc J"},{"key":"B338","doi-asserted-by":"publisher","first-page":"14","DOI":"10.5500\/wjt.v9.i1.14","article-title":"Machine Perfusion of the Liver: Which Is the Best Technique to Mitigate Ischaemia-Reperfusion Injury","volume":"9","author":"Boteon","year":"2019","journal-title":"World J Transplant"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.2014332","article-title":"Normothermic Ex Vivo Allograft Blood Perfusion in Clinical Heart Transplantation","volume":"17","author":"Koerner","year":"2014","journal-title":"Heart Surg Forum"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-020-03345-z","article-title":"Aloin Antagonizes Stimulated Ischemia\/Reperfusion-Induced Damage and Inflammatory Response in Cardiomyocytes by Activating the Nrf2\/HO-1 Defense Pathway","volume":"3","author":"Sun","year":"2021","journal-title":"Cell Tissue Res"},{"key":"B341","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1016\/j.ijbiomac.2018.11.190","article-title":"Involvement of Nrf2 in Myocardial Ischemia and Reperfusion Injury","volume":"125","author":"Shen","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1038\/2063","article-title":"Expression of Heme Oxygenase-1 can Determine Cardiac Xenograft Survival","volume":"4","author":"Soares","year":"1998","journal-title":"Nat Med"},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01158.x","article-title":"Role of Heme Oxygenase-1 in Transplantation","volume":"23","author":"\u00d6llinger","year":"2010","journal-title":"Transpl Int"},{"key":"B344","doi-asserted-by":"publisher","first-page":"e46646","DOI":"10.1371\/journal.pone.0046646","article-title":"Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs","volume":"7","author":"Yeom","year":"2012","journal-title":"PloS One"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2016.1258704","article-title":"Immunomodulation of Cell-Penetrating Tat-Metallothionein for Successful Outcome of Xenotransplanted Pancreatic Islet","volume":"25","author":"Kim","year":"2017","journal-title":"J Drug Targeting"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1007\/s00147-002-0394-0","article-title":"Prevention of Free-Radical Induced Apoptosis by Induction of Human Recombinant Cu, Zn-SOD in Pig Endothelial Cells","volume":"15","author":"Yokoyama","year":"2002","journal-title":"Transpl Int"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02602.x","article-title":"Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation","volume":"9","author":"Knosalla","year":"2009","journal-title":"Am J Transplant"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12173","article-title":"Human Thrombomodulin Regulates Complement Activation as Well as the Coagulation Cascade in Xeno-Immune Response","volume":"22","author":"Kim","year":"2015","journal-title":"Xenotransplantation"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12149","article-title":"Meta-Analysis of the Independent and Cumulative Effects of Multiple Genetic Modifications on Pig Lung Xenograft Performance During Ex Vivo Perfusion With Human Blood","volume":"22","author":"Harris","year":"2015","journal-title":"Xenotransplantation"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12236","article-title":"Platelet Sequestration and Activation During GalTKO.hCD46 Pig Lung Perfusion by Human Blood Is Primarily Mediated by GPIb, GPIIb\/IIIa, and Von Willebrand Factor","volume":"23","author":"Burdorf","year":"2016","journal-title":"Xenotransplantation"},{"key":"B351","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.trim.2013.08.001","article-title":"The Suppression of Inflammatory Macrophage-Mediated Cytotoxicity and Proinflammatory Cytokine Production by Transgenic Expression of HLA-E","volume":"29","author":"Maeda","year":"2013","journal-title":"Transpl Immunol"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1803530","article-title":"Immune Vulnerability of Ovarian Cancer Stem-Like Cells Due to Low CD47 Expression Is Protected by Surrounding Bulk Tumor Cells","volume":"9","author":"Chang","year":"2020","journal-title":"Oncoimmunol"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000571","article-title":"Functional Difference Between Membrane-Bound and Soluble Human Thrombomodulin","volume":"99","author":"Miwa","year":"2015","journal-title":"Transplantation"},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7355","article-title":"Porcine Endothelial Cells and Iliac Arteries Transduced With AdenoIL-4 Are Intrinsically Protected, Through Akt Activation, Against Immediate Injury Caused by Human Complement","volume":"177","author":"Black","year":"2006","journal-title":"J Immunol"},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2696","article-title":"CD47 Enhances Ex Vivo Functionality of Artificial Antigen-Presenting Cells","volume":"21","author":"Bruns","year":"2015","journal-title":"Clin Cancer Res"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14049","article-title":"Preliminary Single-Center Canadian Experience of Human Normothermic Ex Vivo Liver Perfusion: Results of a Clinical Trial","volume":"17","author":"Bral","year":"2017","journal-title":"Am J Transplant"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.681504\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T21:57:46Z","timestamp":1673215066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.681504\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":356,"alternative-id":["10.3389\/fimmu.2021.681504"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.681504","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,9]]},"article-number":"681504"}}