{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:01:31Z","timestamp":1794315691345,"version":"4.9.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772167, 81772167"],"award-info":[{"award-number":["81772167, 81772167"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome (HFRS). The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the susceptibility of <jats:italic>Nlrc3<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice to HTNV infection in order to establish a new model of HFRS. <jats:italic>Nlrc3<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice developed weight loss, renal hemorrhage, and tubule dilation after HTNV infection, recapitulating many clinical symptoms of human HFRS. Moreover, infected <jats:italic>Nlrc3<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice showed higher viral loads in serum, spleen, and kidney than wild type C57BL\/6 (WT) mice, and some of them manifested more hematological disorders and significant pathological changes within multiple organs than WT mice. Our results identify that HTNV infected <jats:italic>Nlrc3<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice can develop clinical symptoms and pathological changes resembling patients with HFRS, suggesting a new model for studying the pathogenesis and testing of candidate vaccines and therapeutics.<\/jats:p>","DOI":"10.3389\/fimmu.2021.692509","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T11:49:42Z","timestamp":1626436182000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV 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