{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:56:23Z","timestamp":1783850183799,"version":"3.55.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>X-linked severe combined immunodeficiency (X-SCID) is caused by mutations of <jats:italic>IL2RG<\/jats:italic>, the gene encoding the interleukin common gamma chain (IL-2R\u03b3 or \u03b3c) of cytokine receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Hypomorphic mutations of <jats:italic>IL2RG<\/jats:italic> may cause combined immunodeficiencies with atypical clinical and immunological presentations. Here, we report a clinical, immunological, and functional characterization of a missense mutation in exon 1 (c.115G&amp;gt;A; p. Asp39Asn) of <jats:italic>IL2RG<\/jats:italic> in a 7-year-old boy. The patient suffered from recurrent sinopulmonary infections and refractory eczema. His total lymphocyte counts have remained normal despite skewed T cell subsets, with a pronounced serum IgE elevation. Surface expression of IL-2R\u03b3 was reduced on his lymphocytes. Signal transducer and activator of transcription (STAT) phosphorylation in response to IL-2, IL-4, and IL-7 showed a partially preserved receptor function. T-cell proliferation in response to mitogens and anti-CD3\/anti-CD28 monoclonal antibodies was significantly reduced. Further analysis revealed a decreased percentage of CD4<jats:sup>+<\/jats:sup> T cells capable of secreting IFN-\u03b3, but not IL-4 or IL-17. Studies on the functional consequences of IL-2R\u03b3 variants are important to get more insight into the pathogenesis of atypical phenotypes which may lay the ground for novel therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fimmu.2021.696350","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T08:43:54Z","timestamp":1624524234000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome"],"prefix":"10.3389","volume":"12","author":[{"given":"Brahim","family":"Belaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Lamara Mahammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Mohand 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