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In general, asthma prevails in developed countries than developing countries, and its prevalence is increasing in the latter. For instance, the hygiene hypothesis demonstrated that this phenomenon resulted from higher household hygienic standards that decreased the chances of infections, which would subsequently increase the occurrence of allergy. In this review, we attempted to integrate our knowledge with the hygiene hypothesis into beneficial preventive approaches for allergic asthma. Therefore, we highlighted the studies that investigated the correlation between allergic asthma and the two different types of infections that induce the two major antagonizing arms of T cells. This elucidation reflects the association between various types of natural infections and the immune system, which is predicted to support the main objective of the current research on investigating of the benefits of natural infections, regardless their immune pathways for the prevention of allergic asthma. We demonstrated that natural infection with <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (Mtb) prevents the development of allergic asthma, thus Bacille Calmette-Gu\u00e9rin (BCG) vaccine is suggested at early age to mediate the same prevention particularly with increasing its efficiency through genetic engineering-based modifications. Likewise, natural helminth infections might inhabit the allergic asthma development. Therefore, helminth-derived proteins at early age are good candidates for designing vaccines for allergic asthma and it requires further investigation. Finally, we recommend imitation of natural infections as a general strategy for preventing allergic asthma that increased dramatically over the past decades.<\/jats:p>","DOI":"10.3389\/fimmu.2021.696734","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T05:21:51Z","timestamp":1627968111000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Mycobacterium-Induced Th1, Helminths-Induced Th2 Cells and the Potential Vaccine Candidates for Allergic Asthma: Imitation of Natural Infection"],"prefix":"10.3389","volume":"12","author":[{"given":"Mohamed Hamed","family":"Abdelaziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma A.","family":"Abouelnazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayed F.","family":"Abdelwahab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246","article-title":"Epidemiology of Asthma in Children and Adults","volume":"7","author":"Dharmage","year":"2019","journal-title":"Front Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12967-020-02251-w","article-title":"Alternatively Activated Macrophages; A Double-Edged Sword in Allergic Asthma","volume":"18","author":"Abdelaziz","year":"2020","journal-title":"J Transl Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0091-6749(00)90044-7","article-title":"Prevalence and Etiology of Asthma","volume":"105","author":"Beasley","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"B4","first-page":"91","article-title":"Serum IgE Levels in White and Metis Communities in Saskatchewan","volume":"37","author":"Gerrard","year":"1976","journal-title":"Ann Allergy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay Fever, Hygiene, and Household Size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70771-6","article-title":"Helminth Therapy or Elimination: Epidemiological, Immunological, and Clinical Considerations","volume":"14","author":"Wammes","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37132007000300016","article-title":"Interrelationship Among Asthma, Atopy, and Helminth Infections","volume":"33","author":"Ponte","year":"2007","journal-title":"J Bras Pneumol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00109-009-0546-0","article-title":"Regulation of Type 1 Diabetes, Tuberculosis, and Asthma by Parasites","volume":"88","author":"Liu","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2019.03.009","article-title":"Helminths and Asthma: Risk and Protection","volume":"39","author":"Fernandes","year":"2019","journal-title":"Immunol Allergy Clin North Am"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.coi.2018.05.007","article-title":"Helminth-Induced Regulatory T Cells and Suppression of Allergic Responses","volume":"54","author":"Logan","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s13071-019-3561-1","article-title":"Preventive and Therapeutic Effects of Trichinella Spiralis Adult Extracts on Allergic Inflammation in an Experimental Asthma Mouse Model","volume":"12","author":"Sun","year":"2019","journal-title":"Parasit Vectors"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-015-0074-3","article-title":"Human Helminth Therapy to Treat Inflammatory Disorders - 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