{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:43:09Z","timestamp":1792428189995,"version":"4.5.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Objective<\/jats:title>\n Evaluate the MRI evidence of active inflammatory and chronic structural damages in radiographic axial spondyloarthritis (r-axSpA) and non-radiographic axial spondyloarthritis (nr-axSpA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective review of 253 patients who underwent sacroiliac joint (SIJ) MRI between June 2014 and December 2019 was performed. MRI images including short tau inversion recovery scan and T1-weighted spin echo scans were assessed using the Spondyloarthritis Research Consortium of Canada (SPARCC) score and SPARCC MRI SIJ structural score by two independent readers.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Higher mean score of inflammatory (SPARCC) was seen in r-axSpA patients when compared with nr-axSpA patients (8.08\n vs<\/jats:italic>\n 4.37,\n P<\/jats:italic>\n &lt;0.05). Frequencies of MRI structural lesions in r-axSpA patients and nr-axSpA patients were as follows: erosion (65.84\n vs<\/jats:italic>\n 88.23%,\n P<\/jats:italic>\n =0.002), backfill (33.17\n vs<\/jats:italic>\n 13.73%,\n P<\/jats:italic>\n &lt;0.001), fat metaplasia (79.21\n vs<\/jats:italic>\n 60.78%,\n P<\/jats:italic>\n =0.01), and ankylosis (37.13\n vs<\/jats:italic>\n 1.96%,\n P<\/jats:italic>\n &lt;0.001). Patients with r-axSpA had a higher mean score for fat metaplasia (8.93\n vs<\/jats:italic>\n 4.06,\n P<\/jats:italic>\n =0.0003) and ankylosis (4.49\n vs<\/jats:italic>\n 0.04,\n P<\/jats:italic>\n &lt;0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n More active inflammatory and chronic structural damages except for erosion were seen in r-axSpA patients than nr-axSpA patients, while higher percentage of nr-axSpA patients presented with erosion in MRI.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fimmu.2021.700260","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T04:02:51Z","timestamp":1627358571000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Active Inflammatory and Chronic Structural Damages of Sacroiliac Joint in Patients With Radiographic Axial Spondyloarthritis and Non-Radiographic Axial Spondyloarthritis"],"prefix":"10.3389","volume":"12","author":[{"given":"Liudan","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Churong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieruo","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24483","article-title":"The 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