{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:54:39Z","timestamp":1779256479365,"version":"3.51.4"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of na\u00efve CD4+ T cells and the IFN-\u03b3 production of CD4+ T cells without increasing regulatory T cells. BMP4 could also moderate glycolysis of T cells and regulate Hif1\u03b1 expression. Furthermore, BMP4 showed a suppressive function on the IFN-\u03b3 production of CD4+ T cells <jats:italic>in vivo<\/jats:italic>. These findings indicating a mechanism by which BMP-4 may regulate activation and IFN-\u03b3 production in CD4+ T cells <jats:italic>via<\/jats:italic> metabolism moderation and suggests that BMP4 may be a potential therapeutic supplement in autoinflammatory diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2021.702211","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T04:34:10Z","timestamp":1627965250000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T 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