{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:08:18Z","timestamp":1792098498278,"version":"4.4.0"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the clinical validity of early Sj\u00f6gren\u2019s syndrome (SS) autoantibodies (eSjA), which were originally marketed for early diagnosis of SS, for juvenile SS (JSS) in a recently identified pediatric cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 105 symptomatic subjects with eSjA results available were evaluated at the Center for Orphaned Autoimmune Disorders at the University of Florida and enrolled for this study. JSS diagnosis was based on the 2016 ACR\/EULAR SS criteria. Demographic\/clinical\/laboratory parameters were compared between JSS (n = 27) and non-JSS (n = 78) for % positivity, sensitivity, and specificity of eSjA (SP1, anti-salivary protein; CA6, anti-carbonic anhydrase VI; PSP, anti-parotid secretory protein) and classic SS-autoantibodies (cSjA; ANA, SSA\/SSB, RF, and others) either alone or in combination. Associations between eSjA and diagnostic\/glandular parameters were also determined by Fisher\u2019s exact test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to non-JSS, JSS patients exhibited sicca symptoms demonstrating reduced unstimulated salivary flow rate (USFR) and abnormal glandular features revealed by salivary gland ultrasound (SGUS). Among cSjA, ANA demonstrated the highest sensitivity of 69.2%, while SSA, SSB, and RF showed around 95% specificities for JSS diagnosis. The % positive-SSA was notably higher in JSS than non-JSS (56% vs. 5%). Of eSjA, anti-CA6 IgG was the most prevalent without differentiating JSS (37%) from non-JSS (32%). Sensitivity and specificity of eSjA were 55.6 and 26.9%, respectively. Autoantibodies with potentially applicable specificity\/sensitivity for JSS were seen only in cSjA without a single eSjA included. There were no associations detected between eSjA and focus score (FS), USFR, SSA, SGUS, and parotitis\/glandular swelling analyzed in the entire cohort, JSS, and non-JSS. However, a negative association between anti-PSP and parotitis\/glandular swelling was found in a small group of positive-SSA (n = 19, p = 0.02) whereas no such association was found between anti-PSP-positive compared to anti-PSP-negative. JSS and non-JSS groups differed in FS, USFR, and EULAR SS Patient Reported Index Dryness\/Mean in CA6\/PSP\/ANA, SP1, and SSA-positive groups, respectively. Additionally, a higher FS was found in RF-positive than RF-negative individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>eSjA underperformed cSjS in differentiating JSS from non-JSS. The discovery of clinical impact of eSjA on early diagnosis of JSS necessitates a longitudinal study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2021.704193","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T01:38:36Z","timestamp":1624585116000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["The Diagnostic Performance of Early Sj\u00f6gren\u2019s Syndrome Autoantibodies in Juvenile Sj\u00f6gren\u2019s Syndrome: The University of Florida Pediatric Cohort Study"],"prefix":"10.3389","volume":"12","author":[{"given":"Akaluck","family":"Thatayatikom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inyoung","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indraneel","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoosik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abi","family":"Adewumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sthorn","family":"Thatayatikom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey","family":"Beal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Modica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa E.","family":"Elder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.clim.2017.04.005","article-title":"Sjogren\u2019s Syndrome: Clinical Aspects","volume":"182","author":"Vivino","year":"2017","journal-title":"Clin Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.07.002","article-title":"Juvenile Recurrent Parotitis: A Systematic Review of Treatment Studies","volume":"112","author":"Garavello","year":"2018","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B3","article-title":"International League of Associations for Rheumatology Classification of Juvenile Idiopathic Arthritis: Second Revision, Edmonton, 2001","volume":"31","author":"Petty","year":"2004","journal-title":"J\u00a0Rheumatol"},{"key":"B4","article-title":"Primary Sjogren\u2019s Syndrome in Children and Adolescents: Are Proposed Diagnostic Criteria Applicable","volume":"32","author":"Houghton","year":"2005","journal-title":"J Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"109768","DOI":"10.1016\/j.ijporl.2019.109768","article-title":"Sj\u00f6gren\u2019s Syndrome in Children With Recurrent Parotitis","volume":"129","author":"Schiffer","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa757","article-title":"Childhood Sj\u00f6gren Syndrome: Features of an International Cohort and Application of the 2016 ACR\/EULAR Classification Criteria","volume":"6","author":"Basiaga","year":"2020","journal-title":"Rheumatol (Oxford)"},{"key":"B7","article-title":"Features of Childhood Sjogren\u2019s Syndrome in Comparison to Adult Sjogren\u2019s Syndrome: Considerations in Establishing Child-Specific Diagnostic Criteria","volume":"34","author":"Yokogawa","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3745-z","article-title":"A Systematic Review of Primary Sjogren\u2019s Syndrome in Male and Paediatric Populations","volume":"36","author":"Virdee","year":"2017","journal-title":"Clin Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1997.tb03597.x","article-title":"The Clinical Features of Sj\u00f6gren\u2019s Syndrome in Japanese Children","volume":"39","author":"Tomiita","year":"1997","journal-title":"Acta Paediatr Jpn"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554","article-title":"Classification Criteria for Sj\u00f6gren\u2019s Syndrome: A Revised Version of the European Criteria Proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591","article-title":"American College of Rheumatology Classification Criteria for Sj\u00f6gren\u2019s Syndrome: A Data-Driven, Expert Consensus Approach in the Sj\u00f6gren\u2019s International Collaborative Clinical Alliance Cohort","volume":"64","author":"Shiboski","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sjogren\u2019s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.09.013","article-title":"Novel Autoantibodies in Sjogren\u2019s Syndrome","volume":"145","author":"Shen","year":"2012","journal-title":"Clin Immunol"},{"key":"B14","article-title":"Early Detection of Sj\u00f6gren\u2019s Syndrome; Sensitivity and Specificity of the Sj\u00f6\u00ae Diagnostic Test","volume":"57","author":"Shen","year":"2016","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-eular.4216","article-title":"FRI0338\u2005Evaluation of The Sensitivity and Specificity of The Sj\u00f6\u00ae Diagnostic Test","volume":"75","author":"Shen","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e000022","DOI":"10.1136\/rmdopen-2014-000022","article-title":"Eular Sjogren\u2019s Syndrome Disease Activity Index (ESSDAI): A User Guide","volume":"1","author":"Seror","year":"2015","journal-title":"RMD Open"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22264","article-title":"Mandl T. Primary Sjogren\u2019s Syndrome: Diagnostic and Prognostic Value of Salivary Gland Ultrasonography Using a Simplified Scoring System","volume":"66","author":"Theander","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.010","article-title":"Outcome Measures for Primary Sjogren\u2019s Syndrome: A Comprehensive Review","volume":"51","author":"Seror","year":"2014","journal-title":"J Autoimmun"},{"key":"B19","doi-asserted-by":"publisher","first-page":"e205487","DOI":"10.1001\/jamapediatrics.2020.5487","article-title":"Association of Maternal Autoimmune Disease With Attention-Deficit\/Hyperactivity Disorder in Children","volume":"175","author":"Nielsen","year":"2021","journal-title":"JAMA Pediatr"},{"key":"B20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1097\/YPG.0000000000000212","article-title":"Familial Association of Attention-Deficit Hyperactivity Disorder With Autoimmune Diseases in the Population of Sweden","volume":"29","author":"Li","year":"2019","journal-title":"Psychiatr Genet"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/BF02396156","article-title":"Genetic and Tissue-Specific Variation in the Expression of a Closely Linked Murine Multigene Family on Chromosome 15 That Encodes Salivary and Lacrimal Proteins","volume":"27","author":"Dickinson","year":"1989","journal-title":"Biochem Genet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.clim.2017.12.008","article-title":"Shi G. Investigation of Autoantibodies to SP-1 in Chinese Patients With Primary Sj\u00f6gren\u2019s Syndrome","volume":"188","author":"Xuan","year":"2018","journal-title":"Clin Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1075958","article-title":"Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein","volume":"298","author":"Anderson","year":"2002","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1042\/bst0310815","article-title":"Expression and Anti-Bacterial Activity of Human Parotid Secretory Protein (PSP)","volume":"31","author":"Geetha","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1997.272.4.G863","article-title":"PSP Expression in Murine Lacrimal Glands and Function as a Bacteria Binding Protein in Exocrine Secretions","volume":"272","author":"Robinson","year":"1997","journal-title":"Am J Physiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1113\/EP088567","article-title":"The Parotid Secretory Protein BPIFA2 Is a Salivary Surfactant That Affects Lipopolysaccharide Action","volume":"105","author":"Nandula","year":"2020","journal-title":"Exp Physiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5359-5_131","article-title":"Aberrant Expression and Potential Function for Parotid Secretory Protein (PSP) in the NOD (Non-Obese Diabetic) Mouse","volume":"438","author":"Robinson","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/art.10258","article-title":"Two Nod Idd-associated Intervals Contribute Synergistically to the Development of Autoimmune Exocrinopathy (Sjogren\u2019s Syndrome) on a Healthy Murine Background","volume":"46","author":"Cha","year":"2002","journal-title":"Arthritis Rheumatol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467","article-title":"Carbonic Anhydrases: Novel Therapeutic Applications for Inhibitors and Activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discovery"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(20000301)258:3<269::AID-AR6>3.0.CO;2-Y","article-title":"Immunohistochemical Localization of Carbonic Anhydrases I, II, and VI in the Developing Rat Sublingual and Submandibular Glands","volume":"258","author":"Redman","year":"2000","journal-title":"Anat Rec"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/38.7.2113069","article-title":"Immunohistochemical Localization of Carbonic Anhydrase Isoenzymes VI, II, and I in Human Parotid and Submandibular Glands","volume":"38","author":"Parkkila","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S1590-8658(01)80138-9","article-title":"Carbonic Anhydrase Isozymes in the Human Pancreas","volume":"33","author":"Nishimori","year":"2001","journal-title":"Dig Liver Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121172598","article-title":"The Identification of Secreted Carbonic Anhydrase VI as a Constitutive Glycoprotein of Human and Rat Milk","volume":"98","author":"Karhumaa","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000608","article-title":"Characterization of Lacrimal Gland Carbonic Anhydrase VI","volume":"50","author":"Ogawa","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0716","article-title":"Recurrent Parotitis as a Presentation of Primary Pediatric Sj\u00f6gren Syndrome","volume":"129","author":"Baszis","year":"2012","journal-title":"Pediatrics"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3745-z","article-title":"A Systematic Review of Primary Sj\u00f6gren\u2019s Syndrome in Male and Paediatric Populations","volume":"36","author":"Virdee","year":"2017","journal-title":"Clin Rheumatol"},{"key":"B37","article-title":"Carbonic Anhydrase Autoantibodies and Sicca Symptoms in Primary Sj\u00f6gren\u2019s Syndrome","volume":"30","author":"Pertovaara","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"B38","first-page":"351","article-title":"Anti-carbonic Anhydrase Autoantibodies and Serum Beta-2 Microglobulin Correlate With the ClinESSDAI Score in Patients With Sj\u00f6gren\u2019s Syndrome","volume":"35","author":"Pertovaara","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000104873","article-title":"Induction of anti-carbonic-anhydrase-II Antibody Causes Renal Tubular Acidosis in a Mouse Model of Sjogren\u2019s Syndrome","volume":"106","author":"Takemoto","year":"2007","journal-title":"Nephron Physiol"},{"key":"B40","first-page":"26","article-title":"Carbonic Anhydrase I and II Autoantibodies in Beh\u00e7et\u2019s Disease","volume":"42","author":"Mentese","year":"2017","journal-title":"Acta Reumatol Port"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(91)90060-B","article-title":"A Novel Autoantibody Reactive With Carbonic Anhydrase in Sera From Patients With Systemic Lupus Erythematosus and Sj\u00f6gren\u2019s Syndrome","volume":"2","author":"Inagaki","year":"1991","journal-title":"J Dermatol Sci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/art.1780350112","article-title":"Antibodies to Carbonic Anhydrase in Systemic Lupus Erythematosus and Other Rheumatic Diseases","volume":"35","author":"Itoh","year":"1992","journal-title":"Arthritis Rheumatol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90143-4","article-title":"Antibodies to Carbonic Anhydrase in Patients With Immune Cholangiopathies","volume":"108","author":"Gordon","year":"1995","journal-title":"Gastroenterology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613065","article-title":"Serum Antibodies to Carbonic Anhydrase I and II in Patients With Idiopathic Chronic Pancreatitis and Sj\u00f6gren\u2019s Syndrome","volume":"110","author":"Kino-Ohsaki","year":"1996","journal-title":"Gastroenterology"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-200005000-00008","article-title":"Elevated Serum Levels of Antibodies to Carbonic Anhydrase I and II in Patients With Chronic Pancreatitis","volume":"20","author":"Frulloni","year":"2000","journal-title":"Pancreas"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.07.049","article-title":"Autoantibodies Against Carbonic Anhydrase II Are Increased in Renal Tubular Acidosis Associated With Sjogren Syndrome","volume":"118","author":"Takemoto","year":"2005","journal-title":"Am J Med"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.154.9.4865","article-title":"Induction of Experimental Autoimmune Sialoadenitis by Immunization of PL\/J Mice With Carbonic Anhydrase II","volume":"154","author":"Nishimori","year":"1995","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker118","article-title":"Novel Carbonic Anhydrase Autoantibodies and Renal Manifestations in Patients With Primary Sjogren\u2019s Syndrome","volume":"50","author":"Pertovaara","year":"2011","journal-title":"Rheumatol (Oxford)"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001471","article-title":"Utility of Novel Autoantibodies in the Diagnosis of Sj\u00f6gren\u2019s Syndrome Among Patients With Dry Eye","volume":"37","author":"Karakus","year":"2018","journal-title":"Cornea"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2545-4","article-title":"Clinical and Diagnostic Significance of Serum Immunoglobulin A Rheumatoid Factor in Primary Sjogren\u2019s Syndrome","volume":"23","author":"Lee","year":"2019","journal-title":"Clin Oral Investig"},{"key":"B51","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s12886-015-0023-1","article-title":"Investigation of Novel Autoantibodies in Sjogren\u2019s Syndrome Utilizing Sera From the Sjogren\u2019s International Collaborative Clinical Alliance Cohort","volume":"15","author":"Suresh","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002171","article-title":"Association Between Early Sj\u00f6gren Markers and Symptoms and Signs of Dry Eye","volume":"39","author":"Hubschman","year":"2020","journal-title":"Cornea"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002147","article-title":"Prevalence of Novel Candidate Sj\u00f6gren Syndrome Autoantibodies in the Penn Sj\u00f6gren\u2019s International Collaborative Clinical Alliance Cohort","volume":"38","author":"Bunya","year":"2019","journal-title":"Cornea"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001714","article-title":"Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Dry Eye Assessment and Management (Dream) Study","volume":"37","author":"Bunya","year":"2018","journal-title":"Cornea"},{"key":"B55","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12886-017-0412-8","article-title":"Analysis of Novel Sjogren\u2019s Syndrome Autoantibodies in Patients With Dry Eyes","volume":"17","author":"Everett","year":"2017","journal-title":"BMC Ophthalmol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.08.009","article-title":"Evaluation of Salivary Gland Protein 1 Antibodies in Patients With Primary and Secondary Sjogren\u2019s Syndrome","volume":"155","author":"Shen","year":"2014","journal-title":"Clin Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901711010010","article-title":"Evaluation of Autoantibodies in Patients With Primary and Secondary Sjogren\u2019s Syndrome","volume":"11","author":"De Langhe","year":"2017","journal-title":"Open Rheumatol J"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.704193\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T07:56:49Z","timestamp":1672559809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.704193\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2021.704193"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.704193","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"article-number":"704193"}}