{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:37Z","timestamp":1791232117019,"version":"4.1.0"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Severe fever with thrombocytopenia syndrome (SFTS) is a new tick-borne viral disease, and most SFTS virus (SFTSV) infections occur\n                    <jats:italic>via<\/jats:italic>\n                    bites from the tick\n                    <jats:italic>Haemaphysalis longicornis<\/jats:italic>\n                    ; however, SFTSV transmission can also occur through close contact with an infected patient. SFTS is characterized by acute high fever, thrombocytopenia, leukopenia, elevated serum hepatic enzyme levels, gastrointestinal symptoms, and multiorgan failure and has a 16.2 to 30% mortality rate. In this study, we found that age, dyspnea rates, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase, multiorgan dysfunction score (MODS), viral load, IL-6 levels, and IL-10 levels were higher in patients with fatal disease than in patients with nonfatal disease during the initial clinical course of SFTS. In addition, we found that IL-6 and IL-10 levels, rather than viral load and neutralizing antibody titers, in patients with an SFTSV infection strongly correlated with outcomes (for severe disease with an ultimate outcome of recovery or death).\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2021.711847","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T07:56:17Z","timestamp":1629186977000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":53,"title":["IL-6 and IL-10 Levels, Rather Than Viral Load and Neutralizing Antibody Titers, Determine the Fate of Patients With Severe Fever With Thrombocytopenia Syndrome Virus Infection in South Korea"],"prefix":"10.3389","volume":"12","author":[{"given":"Jeong Rae","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Taek","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ah","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjoo","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TaeHong","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Kyung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungjae","family":"Baek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Soo","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Mogg","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever With Thrombocytopenia Associated With a Novel Bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2411.170756","article-title":"Severe Fever With Thrombocytopenia Syndrome Virus Infection, South Korea, 2010","volume":"24","author":"Kim","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit603","article-title":"The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan","volume":"209","author":"Takahashi","year":"2014","journal-title":"J Infect Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181463","article-title":"Endemic Severe Fever With Thrombocytopenia Syndrome, Vietnam","volume":"25","author":"Tran","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3201\/eid2608.200135","article-title":"Genotypic Heterogeneity of Orientia Tsutsugamushi in Scrub Typhus Patients and Thrombocytopenia Syndrome Co-Infection, Myanmar","volume":"26","author":"Win","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200104","article-title":"Human Case of Severe Fever With Thrombocytopenia Syndrome Virus Infection, Taiwan, 2019","volume":"26","author":"Peng","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.31524\/bkkmedj.2020.22.001","article-title":"Severe Fever With Thrombocytopenia Syndrome Virus: The First Case Report in Thailand","volume":"16","author":"Ongkittikul","year":"2020","journal-title":"Bangkok Med J"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.190611","article-title":"Serologic Evidence of Severe Fever With Thrombocytopenia Syndrome Virus and Related Viruses in Pakistan","volume":"26","author":"Zohaib","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0527","article-title":"Family Cluster Analysis of Severe Fever With Thrombocytopenia Syndrome Virus Infection in Korea","volume":"95","author":"Yoo","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30293-7","article-title":"Epidemiological and Clinical Features of Laboratory-Diagnosed Severe Fever With Thrombocytopenia Syndrome in China, 2011-17: A Prospective Observational Study","volume":"18","author":"Li","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.649570","article-title":"Neutralizing Antibodies to Severe Fever With Thrombocytopenia Syndrome Virus Among Survivors, Non-Survivors and Healthy Residents in South Korea","volume":"11","author":"Yoo","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis452","article-title":"Host Cytokine Storm Is Associated With Disease Severity of Severe Fever With Thrombocytopenia Syndrome","volume":"206","author":"Sun","year":"2021","journal-title":"J Infect Dis"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir804","article-title":"Hemorrhagic Fever Caused by a Novel Bunyavirus in China: Pathogenesis and Correlates of Fatal Outcome","volume":"54","author":"Zhang","year":"2012","journal-title":"Clin Infect Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.711847\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T07:56:19Z","timestamp":1629186979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.711847\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":13,"alternative-id":["10.3389\/fimmu.2021.711847"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.711847","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]},"article-number":"711847"}}