{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:04:25Z","timestamp":1782144265600,"version":"3.54.5"},"reference-count":145,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup>Foxp3<jats:sup>+<\/jats:sup>regulatory T cells (Tregs) are functionally distinct subsets of mature T cells with broad suppressive activity and have been shown to play an important role in the establishment of immune tolerance after allogeneic hematopoietic stem cell transplantation (HSCT). Tregs exhibit an activated phenotype from the stage of emigration from the thymus and maintain continuous proliferation in the periphery. The distinctive feature in homeostasis enables Tregs to respond sensitively to small environmental changes and exert necessary and sufficient immune suppression; however, on the other hand, it also predisposes Tregs to be susceptible to apoptosis in the inflammatory condition post-transplant. Our studies have attempted to define the intrinsic and extrinsic factors affecting Treg homeostasis from the acute to chronic phases after allogeneic HSCT. We have found that altered cytokine environment in the prolonged post-HSCT lymphopenia or peri-transplant use of immune checkpoint inhibitors could hamper Treg reconstitution, leading to refractory graft-<jats:italic>versus<\/jats:italic>-host disease. Using murine models and clinical trials, we have also demonstrated that proper intervention with low-dose interleukin-2 or post-transplant cyclophosphamide could restore Treg homeostasis and further amplify the suppressive function after HSCT. The purpose of this review is to reconsider the distinctive characteristics of post-transplant Treg homeostasis and discuss how to harness Treg homeostasis to optimize posttransplant immunity for developing a safe and efficient therapeutic strategy.<\/jats:p>","DOI":"10.3389\/fimmu.2021.713358","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T16:48:41Z","timestamp":1630687721000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives"],"prefix":"10.3389","volume":"12","author":[{"given":"Shuntaro","family":"Ikegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic Stem-Cell Transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-Versus-Host Disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1609337","article-title":"Acute Graft-Versus-Host Disease - Biologic Process, Prevention, and Therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1703472","article-title":"Pathophysiology of Chronic Graft-Versus-Host Disease and Therapeutic Targets","volume":"377","author":"Zeiser","year":"2017","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic Self-Tolerance Maintained by Activated T Cells Expressing IL-2 Receptor Alpha-Chains (CD25). Breakdown of a Single Mechanism of Self-Tolerance Causes Various Autoimmune Diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490","article-title":"Control of Regulatory T Cell Development by the Transcription Factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/83784","article-title":"Disruption of a New Forkhead\/Winged-Helix Protein, Scurfin, Results in the Fatal Lymphoproliferative Disorder of the Scurfy Mouse","volume":"27","author":"Brunkow","year":"2001","journal-title":"Nat Genet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/83713","article-title":"The Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome (IPEX) Is Caused by Mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/ni.1818","article-title":"Regulatory T Cells Exert Checks and Balances on Self Tolerance and Autoimmunity","volume":"11","author":"Wing","year":"2010","journal-title":"Nat Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T Cells and Immune Tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.11.1311","article-title":"CD4(+)CD25(+) Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade","volume":"193","author":"Taylor","year":"2001","journal-title":"J Exp Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.10.3493","article-title":"The Infusion of Ex Vivo Activated and Expanded CD4(+)CD25(+) Immune Regulatory Cells Inhibits Graft-Versus-Host Disease Lethality","volume":"99","author":"Taylor","year":"2002","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-1040","article-title":"Association of Foxp3 Regulatory Gene Expression With Graft-Versus-Host Disease","volume":"104","author":"Miura","year":"2004","journal-title":"Blood"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1257","article-title":"Reduced Frequency of FOXP3+ CD4+CD25+ Regulatory T Cells in Patients With Chronic Graft-Versus-Host Disease","volume":"106","author":"Zorn","year":"2005","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-003996","article-title":"High Donor FOXP3-Positive Regulatory T-Cell (Treg) Content Is Associated With a Low Risk of GVHD Following HLA-Matched Allogeneic SCT","volume":"108","author":"Rezvani","year":"2006","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/jci41072","article-title":"Altered Regulatory T Cell Homeostasis in Patients With CD4+ Lymphopenia Following Allogeneic Hematopoietic Stem Cell Transplantation","volume":"120","author":"Matsuoka","year":"2010","journal-title":"J Clin Invest"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-672345","article-title":"Unbalanced Recovery of Regulatory and Effector T Cells After Allogeneic Stem Cell Transplantation Contributes to Chronic GVHD","volume":"127","author":"Alho","year":"2016","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nm915","article-title":"CD4+CD25+ Regulatory T Cells Preserve Graft-Versus-Tumor Activity While Inhibiting Graft-Versus-Host Disease After Bone Marrow Transplantation","volume":"9","author":"Edinger","year":"2003","journal-title":"Nat Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.141176","article-title":"A Phase I Study of CD25\/regulatory T-Cell-Depleted Donor Lymphocyte Infusion for Relapse After Allogeneic Stem Cell Transplantation","volume":"101","author":"Nikiforow","year":"2016","journal-title":"Haematologica"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nri3605","article-title":"Homeostatic Control of Regulatory T Cell Diversity","volume":"14","author":"Liston","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2649","article-title":"Antiapoptotic Mcl-1 Is Critical for the Survival and Niche-Filling Capacity of Foxp3(+) Regulatory T Cells","volume":"14","author":"Pierson","year":"2013","journal-title":"Nat Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28941","article-title":"Human CD4+ CD25hi Foxp3+ Regulatory T Cells Are Derived by Rapid Turnover of Memory Populations In Vivo","volume":"116","author":"Vukmanovic-Stejic","year":"2006","journal-title":"J Clin Invest"},{"key":"B23","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1600-065x.1997.tb00974.x","article-title":"Pathways of T-Cell Regeneration in Mice and Humans: Implications for Bone Marrow Transplantation and Immunotherapy","volume":"157","author":"Mackall","year":"1997","journal-title":"Immunol Rev"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-334623","article-title":"Thymic T-Cell Development in Allogeneic Stem Cell Transplantation","volume":"117","author":"Krenger","year":"2011","journal-title":"Blood"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070795","article-title":"Proliferative Arrest and Rapid Turnover of Thymic Epithelial Cells Expressing Aire","volume":"204","author":"Gray","year":"2007","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300657","article-title":"Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-Versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells","volume":"191","author":"Wu","year":"2013","journal-title":"J Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.1.347","article-title":"Thymic Atrophy in Murine Acute Graft-Versus-Host Disease Is Effected by Impaired Cell Cycle Progression of Host Pro-T and Pre-T Cells","volume":"96","author":"Krenger","year":"2000","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.004","article-title":"T Cell Immune Reconstitution Following Lymphodepletion","volume":"19","author":"Williams","year":"2007","journal-title":"Semin Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of Naive and Memory T Cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570550","article-title":"Maturation and Phenotypic Heterogeneity of Human CD4+ Regulatory T Cells From Birth to Adulthood and After Allogeneic Stem Cell Transplantation","volume":"11","author":"Matos","year":"2020","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12175","article-title":"Lineage Stability and Phenotypic Plasticity of Foxp3(+) Regulatory T Cells","volume":"259","author":"Hori","year":"2014","journal-title":"Immunol Rev"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3347","article-title":"Instability of Foxp3 Expression Limits the Ability of Induced Regulatory T Cells to Mitigate Graft Versus Host Disease","volume":"17","author":"Beres","year":"2011","journal-title":"Clin Cancer Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.027","article-title":"STAT3 Transcription Factor Promotes Instability of Ntreg Cells and Limits Generation of Itreg Cells During Acute Murine Graft-Versus-Host Disease","volume":"37","author":"Laurence","year":"2012","journal-title":"Immunity"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0312-3","article-title":"Loss of Lkb1 Impairs Treg Function and Stability to Aggravate Graft-Versus-Host Disease After Bone Marrow Transplantation","volume":"17","author":"Su","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702004104","article-title":"Full Restoration of Peripheral Foxp3+ Regulatory T Cell Pool by Radioresistant Host Cells in Scurfy Bone Marrow Chimeras","volume":"104","author":"Komatsu","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-173179","article-title":"Host CD4+CD25+ T Cells can Expand and Comprise a Major Component of the Treg Compartment After Experimental HCT","volume":"113","author":"Bayer","year":"2009","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-017-2386-y","article-title":"Low-Dose Interleukin-2 as a Modulator of Treg Homeostasis After HSCT: Current Understanding and Future Perspectives","volume":"107","author":"Matsuoka","year":"2018","journal-title":"Int J Hematol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nature10664","article-title":"Response to Self Antigen Imprints Regulatory Memory in Tissues","volume":"480","author":"Rosenblum","year":"2011","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362137","article-title":"Low Telomerase Activity in CD4+ Regulatory T Cells in Patients With Severe Chronic GVHD After Hematopoietic Stem Cell Transplantation","volume":"118","author":"Kawano","year":"2011","journal-title":"Blood"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.104166","article-title":"Increased Mitochondrial Apoptotic Priming of Human Regulatory T Cells After Allogeneic Hematopoietic Stem Cell Transplantation","volume":"99","author":"Murase","year":"2014","journal-title":"Haematologica"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-044529","article-title":"In Vivo Dynamics of Regulatory T-Cell Trafficking and Survival Predict Effective Strategies to Control Graft-Versus-Host Disease Following Allogeneic Transplantation","volume":"109","author":"Nguyen","year":"2007","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-2044","article-title":"Only the CD62L+ Subpopulation of CD4+CD25+ Regulatory T Cells Protects From Lethal Acute GVHD","volume":"105","author":"Ermann","year":"2005","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)80067-o","article-title":"Ulcerative Colitis-Like Disease in Mice With a Disrupted Interleukin-2 Gene","volume":"75","author":"Sadlack","year":"1993","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.7770771","article-title":"Deregulated T Cell Activation and Autoimmunity in Mice Lacking Interleukin-2 Receptor Beta","volume":"268","author":"Suzuki","year":"1995","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041982","article-title":"Homeostatic Maintenance of Natural Foxp3(+) CD25(+) CD4(+) Regulatory T Cells by Interleukin (IL)-2 and Induction of Autoimmune Disease by IL-2 Neutralization","volume":"201","author":"Setoguchi","year":"2005","journal-title":"J Exp Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.5979","article-title":"Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease","volume":"168","author":"McHugh","year":"2002","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"eaat1482","DOI":"10.1126\/sciimmunol.aat1482","article-title":"Revisiting IL-2: Biology and Therapeutic Prospects","volume":"3","author":"Abbas","year":"2018","journal-title":"Sci Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nri3156","article-title":"The Role of Interleukin-2 During Homeostasis and Activation of the Immune System","volume":"12","author":"Boyman","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.004","article-title":"Interleukin-2 Receptor Signaling: At the Interface Between Tolerance and Immunity","volume":"33","author":"Malek","year":"2010","journal-title":"Immunity"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.3.964.964","article-title":"Effect of Low-Dose Interleukin-2 on Disease Relapse After T-Cell-Depleted Allogeneic Bone Marrow Transplantation","volume":"84","author":"Soiffer","year":"1994","journal-title":"Blood"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.12.494","article-title":"Combined CD4+ Donor Lymphocyte Infusion and Low-Dose Recombinant IL-2 Expand FOXP3+ Regulatory T Cells Following Allogeneic Hematopoietic Stem Cell Transplantation","volume":"15","author":"Zorn","year":"2009","journal-title":"Biol Blood Marrow Transpl"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1709436","article-title":"The Role of Regulatory T Cells in Graft-Versus-Host Disease Management","volume":"13","author":"Whangbo","year":"2020","journal-title":"Expert Rev Hematol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1108188","article-title":"Interleukin-2 and Regulatory T Cells in Graft-Versus-Host Disease","volume":"365","author":"Koreth","year":"2011","journal-title":"N Engl J Med"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-702852","article-title":"Efficacy, Durability, and Response Predictors of Low-Dose Interleukin-2 Therapy for Chronic Graft-Versus-Host Disease","volume":"128","author":"Koreth","year":"2016","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","first-page":"179ra43","DOI":"10.1126\/scitranslmed.3005265","article-title":"Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients With Chronic Graft-Versus-Host Disease","volume":"5","author":"Matsuoka","year":"2013","journal-title":"Sci Transl Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"e89278","DOI":"10.1172\/jci.insight.89278","article-title":"Low-Dose IL-2 Selectively Activates Subsets of CD4(+) Tregs and NK Cells","volume":"1","author":"Hirakawa","year":"2016","journal-title":"JCI Insight"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122224799","article-title":"Specificity Requirements for Selection and Effector Functions of CD25+4+ Regulatory T Cells in Anti-Myelin Basic Protein T Cell Receptor Transgenic Mice","volume":"99","author":"Hori","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B58","doi-asserted-by":"publisher","first-page":"56","DOI":"10.4049\/jimmunol.0902379","article-title":"CD4(+) CD25(+) Foxp3(+) T Regulatory Cells With Limited TCR Diversity in Control of\u00a0Autoimmunity","volume":"184","author":"Adeegbe","year":"2010","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141986","article-title":"High TCR Diversity Ensures Optimal Function and Homeostasis of Foxp3+ Regulatory T Cells","volume":"41","author":"Fohse","year":"2011","journal-title":"Eur J Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018027474","article-title":"Functional Analysis of Clinical Response to Low-Dose IL-2 in Patients With Refractory Chronic Graft-Versus-Host Disease","volume":"3","author":"Whangbo","year":"2019","journal-title":"Blood Adv"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1182\/blood.V126.23.1928.1928","article-title":"Interval of IL-2 Administration Has a Major Impact on Treatment Efficacy for Regulatory T Cell Expansion and Homeostasis","volume":"126","author":"Kishi","year":"2015","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.18926\/AMO\/54608","article-title":"Phase I\/IIa Study of Low Dose Subcutaneous Interleukin-2 (IL-2) for Treatment of Refractory Chronic Graft Versus Host Disease","volume":"70","author":"Asano","year":"2016","journal-title":"Acta Med Okayama"},{"key":"B63","doi-asserted-by":"publisher","first-page":"S175","DOI":"10.1016\/j.bbmt.2019.12.732","article-title":"Sustained Immunogenic and Clinical Effects of Low-Dose Interleukin-2 Therapy With an Intermittent Maintenance Method for Refractory Chronic Graft-Versus-Host Disease: Results of Phase1\/2a LDIL2-01 Study","volume":"26","author":"Meguri","year":"2020","journal-title":"Biol Blood Marrow Transplant: J Am Soc Blood Marrow Transplant"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.10.017","article-title":"A Long-Lived IL-2 Mutein That Selectively Activates and Expands Regulatory T Cells as a Therapy for Autoimmune Disease","volume":"95","author":"Peterson","year":"2018","journal-title":"J Autoimmun"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05481.x","article-title":"Induced Expression of PD-1, a Novel Member of the Immunoglobulin Gene Superfamily, Upon Programmed Cell Death","volume":"11","author":"Ishida","year":"1992","journal-title":"EMBO J"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608873113","article-title":"Nonoverlapping Roles of PD-1 and FoxP3 in Maintaining Immune Tolerance in a Novel Autoimmune Pancreatitis Mouse Model","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e85935","DOI":"10.1172\/jci.insight.85935","article-title":"PD-1 Marks Dysfunctional Regulatory T Cells in Malignant Gliomas","volume":"1","author":"Lowther","year":"2016","journal-title":"JCI Insight"},{"key":"B68","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1073\/pnas.1822001116","article-title":"PD-1(+) Regulatory T Cells Amplified by PD-1 Blockade Promote Hyperprogression of Cancer","volume":"116","author":"Kamada","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401936","article-title":"PD-1 Upregulated on Regulatory T Cells During Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction With PD-L1 Expressed on CD8+ T Cells","volume":"194","author":"Park","year":"2015","journal-title":"J Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0175-7","article-title":"Regulatory T Cells in Cancer Immunosuppression - Implications for Anticancer Therapy","volume":"16","author":"Togashi","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.0105-2896.2006.00427.x","article-title":"Foxp3+ CD25+ CD4+ Natural Regulatory T Cells in Dominant Self-Tolerance and Autoimmune Disease","volume":"212","author":"Sakaguchi","year":"2006","journal-title":"Immunol Rev"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.459","article-title":"CD28 and CTLA-4 Have Opposing Effects on the Response of T Cells to Stimulation","volume":"182","author":"Krummel","year":"1995","journal-title":"J Exp Med"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.cell.2017.07.024","article-title":"Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade","volume":"170","author":"Wei","year":"2017","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2762","article-title":"A Rheostat for Immune Responses: The Unique Properties of PD-1 and Their Advantages for Clinical Application","volume":"14","author":"Okazaki","year":"2013","journal-title":"Nat Immunol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1158\/1078-0432.CCR-18-3740","article-title":"Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3(+) Regulatory T Cells (Tregs) in Human Cancers-Letter","volume":"25","author":"Ferrara","year":"2019","journal-title":"Clin Cancer Res"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-741629","article-title":"PD-1 Modulates Regulatory T-Cell Homeostasis During Low-Dose Interleukin-2 Therapy","volume":"129","author":"Asano","year":"2017","journal-title":"Blood"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060","article-title":"Cancer Immunotherapy Using Checkpoint Blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.76.0793","article-title":"Nivolumab for Relapsed\/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial","volume":"36","author":"Armand","year":"2018","journal-title":"J Clin Oncol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30167-X","article-title":"Nivolumab for Classical Hodgkin\u2019s Lymphoma After Failure of Both Autologous Stem-Cell Transplantation and Brentuximab Vedotin: A Multicentre, Multicohort, Single-Arm Phase 2 Trial","volume":"17","author":"Younes","year":"2016","journal-title":"Lancet Oncol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.3.1272","article-title":"Blockade of Programmed Death-1 Engagement Accelerates Graft-Versus-Host Disease Lethality by an IFN-Gamma-Dependent Mechanism","volume":"171","author":"Blazar","year":"2003","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-500801","article-title":"Host Programmed Death Ligand 1 Is Dominant Over Programmed Death Ligand 2 Expression in Regulating Graft-Versus-Host Disease Lethality","volume":"122","author":"Saha","year":"2013","journal-title":"Blood"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-738385","article-title":"Safety and Efficacy of Allogeneic Hematopoietic Stem Cell Transplant After PD-1 Blockade in Relapsed\/Refractory Lymphoma","volume":"129","author":"Merryman","year":"2017","journal-title":"Blood"},{"key":"B83","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1182\/blood-2018-02-811174","article-title":"Recommendations for Managing PD-1 Blockade in the Context of Allogeneic HCT in Hodgkin Lymphoma: Taming a Necessary Evil","volume":"132","author":"Herbaux","year":"2018","journal-title":"Blood"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.08.028","article-title":"Significant Risk of Graft-Versus-Host Disease With Exposure to Checkpoint Inhibitors Before and After Allogeneic Transplantation","volume":"25","author":"Ijaz","year":"2019","journal-title":"Biol Blood Marrow Transpl"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0851-8","article-title":"Posttransplant Cyclophosphamide After Allogeneic Hematopoietic Cell Transplantation Mitigates the Immune Activation Induced by Previous Nivolumab Therapy","volume":"34","author":"Nieto","year":"2020","journal-title":"Leukemia"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000134","article-title":"PTCy Ameliorates GVHD by Restoring Regulatory and Effector T-Cell Homeostasis in Recipients With PD-1 Blockade","volume":"3","author":"Ikegawa","year":"2019","journal-title":"Blood Adv"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01167-8","article-title":"Pretransplant Nivolumab Further Enhanced Treg Expansion After Posttransplant Cyclophosphamide; Another Aspect for Immune Tolerance by PTCy After Nivolumab","volume":"35","author":"Ikegawa","year":"2021","journal-title":"Leukemia"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32796","article-title":"Posttransplantation Cyclophosphamide Improves Transplantation Outcomes in Patients With AML\/MDS Who Are Treated With Checkpoint Inhibitors","volume":"126","author":"Oran","year":"2020","journal-title":"Cancer"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.06.012","article-title":"Non-Myeloablative Allogeneic Transplantation With Post-Transplant Cyclophosphamide After Immune Checkpoint Inhibition for Classic Hodgkin Lymphoma: A Retrospective Cohort Study","volume":"26","author":"Paul","year":"2020","journal-title":"Biol Blood Marrow Transpl"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001336","article-title":"Checkpoint Inhibition Before Haploidentical Transplantation With Posttransplant Cyclophosphamide in Hodgkin Lymphoma","volume":"4","author":"De Philippis","year":"2020","journal-title":"Blood Adv"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01193-6","article-title":"Allogeneic Transplantation After PD-1 Blockade for Classic Hodgkin Lymphoma","author":"Merryman","year":"2021","journal-title":"Leukemia"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2012.09.005","article-title":"Post-Transplantation Cyclophosphamide for Tolerance Induction in HLA-Haploidentical Bone Marrow Transplantation","volume":"39","author":"Luznik","year":"2012","journal-title":"Semin Oncol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-251595","article-title":"High-Dose Cyclophosphamide as Single-Agent, Short-Course Prophylaxis of Graft-Versus-Host Disease","volume":"115","author":"Luznik","year":"2010","journal-title":"Blood"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-587477","article-title":"Single-Agent GVHD Prophylaxis With Posttransplantation Cyclophosphamide After Myeloablative, HLA-Matched BMT for AML, ALL, and MDS","volume":"124","author":"Kanakry","year":"2014","journal-title":"Blood"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.0625","article-title":"Multi-Institutional Study of Post-Transplantation Cyclophosphamide as Single-Agent Graft-Versus-Host Disease Prophylaxis After Allogeneic Bone Marrow Transplantation Using Myeloablative Busulfan and Fludarabine Conditioning","volume":"32","author":"Kanakry","year":"2014","journal-title":"J Clin Oncol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124218","article-title":"Post-Transplantation Cyclophosphamide Prevents Graft-Versus-Host Disease by Inducing Alloreactive T Cell Dysfunction and Suppression","volume":"129","author":"Wachsmuth","year":"2019","journal-title":"J Clin Invest"},{"key":"B97","doi-asserted-by":"publisher","first-page":"211ra157","DOI":"10.1126\/scitranslmed.3006960","article-title":"Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide","volume":"5","author":"Kanakry","year":"2013","journal-title":"Sci Transl Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-525873","article-title":"Donor CD4+ Foxp3+ Regulatory T Cells Are Necessary for Posttransplantation Cyclophosphamide-Mediated Protection Against GVHD in Mice","volume":"124","author":"Ganguly","year":"2014","journal-title":"Blood"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/tri.13494","article-title":"A Prospective Observational Study of Immune Reconstitution Following Transplantation With Post-Transplant Reduced-Dose Cyclophosphamide From HLA-Haploidentical Donors","volume":"32","author":"Nakamae","year":"2019","journal-title":"Transpl Int"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2019.03.005","article-title":"Immune Reconstitution After T-Cell Replete HLA-Haploidentical Transplantation","volume":"56","author":"McCurdy","year":"2019","journal-title":"Semin Hematol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003005","article-title":"Impaired T- and NK-Cell Reconstitution After Haploidentical HCT With Posttransplant Cyclophosphamide","volume":"5","author":"Rambaldi","year":"2021","journal-title":"Blood Adv"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-01100-0","article-title":"Post-Transplantation Cyclophosphamide Restores Early B-Cell Lymphogenesis That Suppresses Subsequent Chronic Graft-Versus-Host Disease","volume":"56","author":"Iwamoto","year":"2021","journal-title":"Bone Marrow Transpl"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.3472","article-title":"Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study","volume":"30","author":"Ishida","year":"2012","journal-title":"J Clin Oncol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.3575","article-title":"Phase I Study of KW-0761, A Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma","volume":"28","author":"Yamamoto","year":"2010","journal-title":"J Clin Oncol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.8250","article-title":"Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia\/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality","volume":"34","author":"Fuji","year":"2016","journal-title":"J Clin Oncol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00501","article-title":"Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report","volume":"37","author":"Cook","year":"2019","journal-title":"J Clin Oncol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.05.011","article-title":"Plasma Exchange Eliminates Residual Mogamulizumab But Does Not Warrant Prompt Recovery of Peripheral Treg Levels","volume":"58","author":"Sugiura","year":"2019","journal-title":"Transfus Apher Sci"},{"key":"B108","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.1841","article-title":"Raising the NKT Cell Family","volume":"11","author":"Godfrey","year":"2010","journal-title":"Nat Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/35097097","article-title":"A Synthetic Glycolipid Prevents Autoimmune Encephalomyelitis by Inducing TH2 Bias of Natural Killer T Cells","volume":"413","author":"Miyamoto","year":"2001","journal-title":"Nature"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.025","article-title":"Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.551","article-title":"Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-Versus-Host Disease by Inducing Th2 Polarization of Donor T Cells","volume":"174","author":"Hashimoto","year":"2005","journal-title":"J Immunol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165506","article-title":"Host Natural Killer T Cells Induce an Interleukin-4-Dependent Expansion of Donor CD4+CD25+Foxp3+ T Regulatory Cells That Protects Against Graft-Versus-Host Disease","volume":"113","author":"Pillai","year":"2009","journal-title":"Blood"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.2741\/3149","article-title":"Alpha-Galactosylceramide-Driven Immunotherapy for Allergy","volume":"13","author":"Ishii","year":"2008","journal-title":"Front Biosci"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.11.022","article-title":"Pharmacologic Expansion of Donor-Derived, Naturally Occurring CD4(+)Foxp3(+) Regulatory T Cells Reduces Acute Graft-Versus-Host Disease Lethality Without Abrogating the Graft-Versus-Leukemia Effect in Murine Models","volume":"17","author":"Duramad","year":"2011","journal-title":"Biol Blood Marrow Transpl"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-576017","article-title":"CD4+ Invariant Natural Killer T Cells Protect From Murine GVHD Lethality Through Expansion of Donor CD4+CD25+FoxP3+ Regulatory T Cells","volume":"124","author":"Schneidawind","year":"2014","journal-title":"Blood"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.425","article-title":"Donor Treg Expansion by Liposomal Alpha-Galactosylceramide Modulates Tfh Cells and Prevents Sclerodermatous Chronic Graft-Versus-Host Disease","volume":"9","author":"Sugiura","year":"2021","journal-title":"Immun Inflammation Dis"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.01.069","article-title":"Increased Foxp3(+)Helios(+) Regulatory T Cells and Decreased Acute Graft-Versus-Host Disease After Allogeneic Bone Marrow Transplantation in Patients Receiving Sirolimus and RGI-2001, an Activator of Invariant Natural Killer T Cells","volume":"23","author":"Chen","year":"2017","journal-title":"Biol Blood Marrow Transpl"},{"key":"B118","doi-asserted-by":"publisher","first-page":"13125","DOI":"10.1038\/s41598-021-92526-z","article-title":"Reduced Dose of PTCy Followed by Adjuvant Alpha-Galactosylceramide Enhances GVL Effect Without Sacrificing GVHD Suppression","volume":"11","author":"Nakamura","year":"2021","journal-title":"Sci Rep"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.005","article-title":"Prophylactic Effects of Interleukin-2 Receptor Antagonists Against Graft-Versus-Host Disease Following Unrelated Donor Peripheral Blood Stem Cell Transplantation","volume":"18","author":"Fang","year":"2012","journal-title":"Biol Blood Marrow Transpl"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.12.624","article-title":"CD25 Blockade Delays Regulatory T Cell Reconstitution and Does Not Prevent Graft-Versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation","volume":"23","author":"Locke","year":"2017","journal-title":"Biol Blood Marrow Transpl"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.83","article-title":"Daclizumab, a Humanized Anti-Interleukin-2 Receptor Alpha Chain Antibody, for Treatment of Acute Graft-Versus-Host Disease","volume":"95","author":"Przepiorka","year":"2000","journal-title":"Blood"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0854","article-title":"Effect of Up-Front Daclizumab When Combined With Steroids for the Treatment of Acute Graft-Versus-Host Disease: Results of a Randomized Trial","volume":"104","author":"Lee","year":"2004","journal-title":"Blood"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0028","article-title":"Safety and Efficacy of Denileukin Diftitox in Patients With Steroid-Refractory Acute Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation","volume":"104","author":"Ho","year":"2004","journal-title":"Blood"},{"key":"B124","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.bbmt.2006.05.005","article-title":"Denileukin Diftitox as Prophylaxis Against Graft-Versus-Host Disease in the Canine Hematopoietic Cell Transplantation Model","volume":"12","author":"Mielcarek","year":"2006","journal-title":"Biol Blood Marrow Transpl"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2011.11.009","article-title":"Upfront Denileukin Diftitox as In Vivo Regulatory T-Cell Depletion in Order to Enhance Vaccination Effects in a Canine Allogeneic Hematopoietic Stem Cell Transplantation Model","volume":"145","author":"Knueppel","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.03.008","article-title":"Fatal Hyperacute Graft-Versus-Host Disease Following Denileukin Diftitox Treatment for Recurrent T Cell Lymphoma After Allogeneic Stem Cell Transplantation","volume":"15","author":"Khubchandani","year":"2009","journal-title":"Biol Blood Marrow Transpl"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0329","article-title":"Inhibition of CD4+CD25+ Regulatory T-Cell Function by Calcineurin-Dependent Interleukin-2 Production","volume":"108","author":"Zeiser","year":"2006","journal-title":"Blood"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-543736","article-title":"Activity of Therapeutic JAK 1\/2 Blockade in Graft-Versus-Host Disease","volume":"123","author":"Spoerl","year":"2014","journal-title":"Blood"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917635","article-title":"Ruxolitinib for Glucocorticoid-Refractory Acute Graft-Versus-Host Disease","volume":"382","author":"Zeiser","year":"2020","journal-title":"N Engl J Med"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75328","article-title":"Ibrutinib Treatment Ameliorates Murine Chronic Graft-Versus-Host Disease","volume":"124","author":"Dubovsky","year":"2014","journal-title":"J Clin Invest"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-07-793786","article-title":"Ibrutinib for Chronic Graft-Versus-Host Disease After Failure of Prior Therapy","volume":"130","author":"Miklos","year":"2017","journal-title":"Blood"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131459","article-title":"Itk-Mediated Integration of T Cell Receptor and Cytokine Signaling Regulates the Balance Between Th17 and Regulatory T Cells","volume":"211","author":"Gomez-Rodriguez","year":"2014","journal-title":"J Exp Med"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.593863","article-title":"Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT","volume":"11","author":"Mammadli","year":"2020","journal-title":"Front Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2100042","article-title":"Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-Versus-Host Disease by Inhibiting Effector T Cell Differentiation While Sparing Regulatory T Cells","volume":"5","author":"Kondo","year":"2021","journal-title":"Immunohorizons"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of Ex Vivo Expanded T Regulatory Cells in Adults Transplanted With Umbilical Cord Blood: Safety Profile and Detection Kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-653667","article-title":"Umbilical Cord Blood-Derived T Regulatory Cells to Prevent GVHD: Kinetics, Toxicity Profile, and Clinical Effect","volume":"127","author":"Brunstein","year":"2016","journal-title":"Blood"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-564401","article-title":"HLA-Haploidentical Transplantation With Regulatory and Conventional T-Cell Adoptive Immunotherapy Prevents Acute Leukemia Relapse","volume":"124","author":"Martelli","year":"2014","journal-title":"Blood"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003739","article-title":"Haploidentical Age-Adapted Myeloablative Transplant and Regulatory and Effector T Cells for Acute Myeloid Leukemia","volume":"5","author":"Pierini","year":"2021","journal-title":"Blood Adv"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.06.001","article-title":"First-In-Man Clinical Results of the Treatment of Patients With Graft Versus Host Disease With Human Ex Vivo Expanded CD4+CD25+CD127- T Regulatory Cells","volume":"133","author":"Trzonkowski","year":"2009","journal-title":"Clin Immunol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2014.11.005","article-title":"Adoptive Transfer of Allogeneic Regulatory T Cells Into Patients With Chronic Graft-Versus-Host Disease","volume":"17","author":"Theil","year":"2015","journal-title":"Cytotherapy"},{"key":"B141","first-page":"511","article-title":"Phase I Trial of Regulatory T-Cell Donor Lymphocyte Infusion Plus Daily Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-Versus-Host Disease","volume":"130","author":"Nikiforow","year":"2017","journal-title":"Blood"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-0356-4","article-title":"Dissecting the Biology of Allogeneic HSCT to Enhance the GvT Effect Whilst Minimizing GvHD","volume":"17","author":"Blazar","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/s41591-021-01232-w","article-title":"Identification of Resistance Pathways and Therapeutic Targets in Relapsed Multiple Myeloma Patients Through Single-Cell Sequencing","volume":"27","author":"Cohen","year":"2021","journal-title":"Nat Med"},{"key":"B144","doi-asserted-by":"publisher","first-page":"eaaz0316","DOI":"10.1126\/scitranslmed.aaz0316","article-title":"RNA-Seq of Human T Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity","volume":"13","author":"Peltier","year":"2021","journal-title":"Sci Transl Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.587014","article-title":"Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses","volume":"11","author":"Kidman","year":"2020","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.713358\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T15:23:50Z","timestamp":1673191430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.713358\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":145,"alternative-id":["10.3389\/fimmu.2021.713358"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.713358","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,30]]},"article-number":"713358"}}