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Immunol."],"abstract":"<jats:p><jats:italic>Burkholderia pseudomallei<\/jats:italic> (<jats:italic>B. pseudomallei<\/jats:italic>) causes melioidosis, a potentially fatal disease for which no licensed vaccine is available thus far. The host-pathogen interactions in <jats:italic>B. pseudomallei<\/jats:italic> infection largely remain the tip of the iceberg. The pathological manifestations are protean ranging from acute to chronic involving one or more visceral organs leading to septic shock, especially in individuals with underlying conditions similar to COVID-19. Pathogenesis is attributed to the intracellular ability of the bacterium to \u2018step into\u2019 the host cell\u2019s cytoplasm from the endocytotic vacuole, where it appears to polymerize actin filaments to spread across cells in the closer vicinity. <jats:italic>B. pseudomallei<\/jats:italic> effectively evades the host\u2019s surveillance armory to remain latent for prolonged duration also causing relapses despite antimicrobial therapy. Therefore, eradication of intracellular <jats:italic>B. pseudomallei<\/jats:italic> is highly dependent on robust cellular immune responses. However, it remains ambiguous why certain individuals in endemic areas experience asymptomatic seroconversion, whereas others succumb to sepsis-associated sequelae. Here, we propose key insights on how the host\u2019s surveillance radars get commandeered by <jats:italic>B. pseudomallei<\/jats:italic>.<\/jats:p>","DOI":"10.3389\/fimmu.2021.718719","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T05:07:49Z","timestamp":1628658469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Hijacking of the Host\u2019s Immune Surveillance Radars by Burkholderia pseudomallei"],"prefix":"10.3389","volume":"12","author":[{"given":"Vanitha","family":"Mariappan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumutha Malar","family":"Vellasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muttiah","family":"Barathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S. Smiline","family":"Girija","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esaki M.","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamuna","family":"Vadivelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.58.12.4011-4015.1992","article-title":"Evaluation of Culture Techniques for Isolation of Pseudomonas Pseudomallei From Soil","volume":"58","author":"Ashdown","year":"1992","journal-title":"Appl Environ Microbiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(99)00066-2","article-title":"Ecology of Burkholderia Pseudomallei and the Interactions Between Environmental Burkholderia Spp. And Human-Animal 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