{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:17:03Z","timestamp":1793164623141,"version":"4.5.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004610","name":"Science and Technology Support Program of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Through long-term coevolution with its host,\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    ) uses multiple strategies to escape host defenses. The\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    Rv0927c protein is predicted to be a short-chain dehydrogenase\/reductase related to bacterial metabolism. However, the role of Rv0927c during\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    infection remains unclear. Here, we observed that Rv0927c inhibited the expression of IL-6, TNF-\u03b1, and IL-1\u03b2, an effect dependent on NF-\u03baB and p38 pathways. Western blot analysis of macrophages infected with recombinant\n                    <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n                    strains showed that Rv0927c attenuated NF-\u03baB activation by downregulating the phosphorylation of I\u03baB\u03b1. Additionally, Rv0927c enhanced intracellular survival of\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    and pathological effects in mice. In conclusion, our findings demonstrate that Rv0927c functions as a regulator of inflammatory genes and enhances the survival of\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2021.721370","type":"journal-article","created":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T18:25:28Z","timestamp":1630693528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Mycobacterium tuberculosis Rv0927c Inhibits NF-\u03baB Pathway by Downregulating the Phosphorylation Level of I\u03baB\u03b1 and Enhances Mycobacterial 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