{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:33:31Z","timestamp":1791725611523,"version":"4.3.4"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Previous studies have evaluated the roles of T and B cells in the pathogenesis of Sj\u00f6gren\u2019s syndrome (SS); however, their relationships with age-dependent and metabolic abnormalities remain unclear. We examined the impacts of changes associated with aging or metabolic abnormalities on populations of T and B cells and SS disease severity. We detected increased populations of IL-17-producing T and B cells, which regulate inflammation, in the salivary glands of NOD\/ShiLtJ mice. Inflammation-induced human submandibular gland cell death, determined based on p-MLKL and RIPK3 expression levels, was significantly increased by IL-17 treatment. Among IL-17-expressing cells in the salivary gland, peripheral blood, and spleen, the \u03b14\u03b27 (gut-homing integrin)-negative population was significantly increased in aged NOD\/ShiLtJ mice. The \u03b14\u03b27-positive population markedly increased in the intestines of aged NOD\/ShiLtJ mice following retinoic acid (RA) treatment. A significant increase in \u03b14\u03b27-negative IL-17-expressing cells in salivary glands may be involved in the onset and progression of SS. These results suggest the potential therapeutic utility of RA in SS treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2021.721453","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:36:16Z","timestamp":1630715776000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["IL-17 and CCR9+\u03b14\u03b27\u2013 Th17 Cells Promote Salivary Gland Inflammation, Dysfunction, and Cell Death in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.3389","volume":"12","author":[{"given":"Sun-Hee","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin 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