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Immunol."],"abstract":"<jats:p>Mucosal-associated invariant T (MAIT) cells are an innate-like population of T cells that display a TCR V\u03b17.2+ CD161+ phenotype and are restricted by the nonclassical MHC-related molecule 1 (MR1). Although B cells control MAIT cell development and function, little is known about the mechanisms underlying their interaction(s). Here, we report, for the first time, that during<jats:italic>Salmonella enterica<\/jats:italic>serovar Typhi (<jats:italic>S<\/jats:italic>. Typhi) infection, HLA-G expression on B cells downregulates IFN-\u03b3 production by MAIT cells. In contrast, blocking HLA-G expression on<jats:italic>S<\/jats:italic>. Typhi-infected B cells increases IFN-\u03b3 production by MAIT cells. After interacting with MAIT cells, kinetic studies show that B cells upregulate HLA-G expression and downregulate the inhibitory HLA-G receptor CD85j on MAIT cells resulting in their loss. These results provide a new role for HLA-G as a negative feedback loop by which B cells control MAIT cell responses to antigens.<\/jats:p>","DOI":"10.3389\/fimmu.2021.728685","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T11:18:50Z","timestamp":1633087130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["B Cells Control Mucosal-Associated Invariant T Cell Responses to Salmonella enterica Serovar Typhi Infection Through the CD85j HLA-G 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