{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:22:18Z","timestamp":1793762538743,"version":"4.6.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Patrolling monocytes (PMo) are the organism\u2019s preeminent intravascular guardians by their continuous search of damaged endothelial cells and harmful microparticles for their removal and to restore homeostasis. This surveillance is accomplished by PMo crawling on the apical side of the endothelium through regulated interactions of integrins and chemokine receptors with their endothelial ligands. We propose that the search mode governs the intravascular motility of PMo <jats:italic>in vivo<\/jats:italic> in a similar way to T cells looking for antigen in tissues. Signs of damage to the luminal side of the endothelium (local death, oxidized LDL, amyloid deposits, tumor cells, pathogens, abnormal red cells, etc.) will change the diffusive random towards a L\u00e8vy-like crawling enhancing their recognition and clearance by PMo damage receptors as the integrin \u03b1M\u03b22 and CD36. This new perspective can help identify new actors to promote unique PMo intravascular actions aimed at maintaining endothelial fitness and combating harmful microparticles involved in diseases as lung metastasis, Alzheimer\u2019s angiopathy, vaso-occlusive disorders, and sepsis.<\/jats:p>","DOI":"10.3389\/fimmu.2021.730835","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T06:08:20Z","timestamp":1631858900000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Intravascular Crawling of Patrolling Monocytes: A L\u00e8vy-Like Motility for Unique Search Functions?"],"prefix":"10.3389","volume":"12","author":[{"given":"Roc\u00edo","family":"Moreno-Ca\u00f1adas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Luque-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia G.","family":"Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142883","article-title":"Monitoring of Blood Vessels and Tissues by a Population of Monocytes With Patrolling Behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.010","article-title":"Nr4a1-Dependent Ly6C(low) Monocytes Monitor Endothelial Cells and Orchestrate Their Disposal","volume":"153","author":"Carlin","year":"2013","journal-title":"Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9407","article-title":"Patrolling Monocytes Control Tumor Metastasis to the Lung","volume":"350","author":"Hanna","year":"2015","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00080","article-title":"Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation","volume":"4","author":"Buscher","year":"2017","journal-title":"Front Cardiovasc Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00326.2020","article-title":"Nonclassical Monocytes in Cardiovascular Physiology and Disease","volume":"320","author":"Tahir","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/cr.2015.144","article-title":"Cancer Immunosurveillance: Role of Patrolling Monocytes","volume":"26","author":"Cassetta","year":"2016","journal-title":"Cell Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.012","article-title":"Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors","volume":"33","author":"Cros","year":"2010","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.010","article-title":"Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta","volume":"5","author":"Michaud","year":"2013","journal-title":"Cell Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229989","article-title":"Innate Immune Cells, Major Protagonists of Sickle Cell Disease Pathophysiology","volume":"105","author":"Allali","year":"2020","journal-title":"Haematologica"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900998","article-title":"Patrolling Monocytes Control NK Cell Expression of Activating and Stimulatory Receptors to Curtail Lung Metastases","volume":"204","author":"Narasimhan","year":"2020","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304650","article-title":"Nonclassical Patrolling Monocyte Function in the Vasculature","volume":"35","author":"Thomas","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/s41467-018-03351-4","article-title":"MT4-MMP Deficiency Increases Patrolling Monocyte Recruitment to Early Lesions and Accelerates Atherosclerosis","volume":"9","author":"Clemente","year":"2018","journal-title":"Nat Commun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41467-017-02610-0","article-title":"Angiogenic Factor-Driven Inflammation Promotes Extravasation of Human Proangiogenic Monocytes to Tumours","volume":"9","author":"Sidibe","year":"2018","journal-title":"Nat Commun"},{"key":"B14","doi-asserted-by":"publisher","first-page":"12597","DOI":"10.1038\/ncomms12597","article-title":"Regulation of Monocyte Cell Fate by Blood Vessels Mediated by Notch Signalling","volume":"7","author":"Gamrekelashvili","year":"2016","journal-title":"Nat Commun"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.08.017","article-title":"Beta2-Adrenergic Receptor Signaling Mediates the Preferential Mobilization of Differentiated Subsets of CD8+ T-Cells, NK-Cells and Non-Classical Monocytes in Response to Acute Exercise in Humans","volume":"74","author":"Graff","year":"2018","journal-title":"Brain Behav Immun"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.3.C578","article-title":"Selective Mobilization of CD14(+)CD16(+) Monocytes by Exercise","volume":"279","author":"Steppich","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.009","article-title":"Triggering of NOD2 Receptor Converts Inflammatory Ly6C(high) Into Ly6C(low) Monocytes With Patrolling Properties","volume":"20","author":"Lessard","year":"2017","journal-title":"Cell Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1038\/s41467-017-01433-3","article-title":"Pre-Metastatic Cancer Exosomes Induce Immune Surveillance by Patrolling Monocytes at the Metastatic Niche","volume":"8","author":"Plebanek","year":"2017","journal-title":"Nat Commun"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1433s101","article-title":"Measuring Intravascular Migration of Mouse Ly6C(low) Monocytes In Vivo Using Intravital Microscopy","author":"Carlin","year":"2013","journal-title":"Curr Protoc Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304717","article-title":"Fractalkine Promotes Human Monocyte Survival via a Reduction in Oxidative Stress","volume":"34","author":"White","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309123","article-title":"Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis","volume":"37","author":"Marcovecchio","year":"2017","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4HI0420-098R","article-title":"Frontline Science: Kindlin-3 Is Essential for Patrolling and Phagocytosis Functions of Nonclassical Monocytes During Metastatic Cancer Surveillance","volume":"107","author":"Marcovecchio","year":"2020","journal-title":"J Leukoc Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nri.2015.16","article-title":"T Cell Migration, Search Strategies and Mechanisms","volume":"16","author":"Krummel","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"bio030106","DOI":"10.1242\/bio.030106","article-title":"Current Status and Future Directions of Levy Walk Research","volume":"7","author":"Reynolds","year":"2018","journal-title":"Biol Open"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401806","article-title":"Heterogeneity in the Locomotory Behavior of Human Monocyte Subsets Over Human Vascular Endothelium In Vitro","volume":"195","author":"Collison","year":"2015","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310739","article-title":"Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis","volume":"120","author":"Quintar","year":"2017","journal-title":"Circ Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001638","article-title":"LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ","volume":"185","author":"Sumagin","year":"2010","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41467-018-03181-4","article-title":"Effector CD4(+) T Cells Recognize Intravascular Antigen Presented by Patrolling Monocytes","volume":"9","author":"Westhorpe","year":"2018","journal-title":"Nat Commun"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1607710113","article-title":"CCN1\/CYR61-Mediated Meticulous Patrolling by Ly6Clow Monocytes Fuels Vascular Inflammation","volume":"113","author":"Imhof","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/s41467-017-01032-2","article-title":"ROCK Regulates the Intermittent Mode of Interstitial T Cell Migration in Inflamed Lungs","volume":"8","author":"Mrass","year":"2017","journal-title":"Nat Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1371\/journal.pbio.0030113","article-title":"Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids","volume":"3","author":"Geissmann","year":"2005","journal-title":"PloS Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/nature11098","article-title":"Generalized Levy Walks and the Role of Chemokines in Migration of Effector CD8+ T Cells","volume":"486","author":"Harris","year":"2012","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01514","article-title":"Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model","volume":"11","author":"Lau","year":"2020","journal-title":"Front Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"eaar3054","DOI":"10.1126\/sciimmunol.aar3054","article-title":"PD-L1 Expression on Nonclassical Monocytes Reveals Their Origin and Immunoregulatory Function","volume":"4","author":"Bianchini","year":"2019","journal-title":"Sci Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.cell.2014.05.044","article-title":"Detection of Rare Antigen-Presenting Cells Through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g","volume":"158","author":"Gerard","year":"2014","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.12.020","article-title":"Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin","volume":"30","author":"Shulman","year":"2009","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.05.003","article-title":"Mechanical Modes of 'Amoeboid' Cell Migration","volume":"21","author":"Lammermann","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606253113","article-title":"Patrolling Monocytes Promote Intravascular Neutrophil Activation and Glomerular Injury in the Acutely Inflamed Glomerulus","volume":"113","author":"Finsterbusch","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1515389","DOI":"10.1155\/2017\/1515389","article-title":"Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion","volume":"2017","author":"Babendreyer","year":"2017","journal-title":"Mediators Inflammation"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203179","article-title":"Integrin Regulation During Leukocyte Recruitment","volume":"190","author":"Herter","year":"2013","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4313","article-title":"CX3C-Chemokine, Fractalkine-Enhanced Adhesion of THP-1 Cells to Endothelial Cells Through Integrin-Dependent and -Independent Mechanisms","volume":"164","author":"Goda","year":"2000","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200112126","article-title":"Dynamic Interaction of VCAM-1 and ICAM-1 With Moesin and Ezrin in a Novel Endothelial Docking Structure for Adherent Leukocytes","volume":"157","author":"Barreiro","year":"2002","journal-title":"J Cell Biol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802638200","article-title":"Functional Adhesiveness of the CX3CL1 Chemokine Requires Its Aggregation. Role of the Transmembrane Domain","volume":"283","author":"Hermand","year":"2008","journal-title":"J Biol Chem"},{"key":"B44","doi-asserted-by":"publisher","first-page":"9069","DOI":"10.1038\/s41598-020-65988-w","article-title":"CX3CL1 Homo-Oligomerization Drives Cell-to-Cell Adherence","volume":"10","author":"Ostuni","year":"2020","journal-title":"Sci Rep"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e0146598","DOI":"10.1371\/journal.pone.0146598","article-title":"Nanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters","volume":"11","author":"Franz","year":"2016","journal-title":"PloS One"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.29.177816","article-title":"Shear Forces Induce ICAM-1 Nanoclustering on Endothelial Cells That Impact on T Cell Migration","volume":"120","author":"Piechocka","year":"2021","journal-title":"Biophys J"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.619925","article-title":"Beta2 Integrin Signaling Cascade in Neutrophils: More Than a Single Function","volume":"11","author":"Bouti","year":"2020","journal-title":"Front Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.014","article-title":"Impaired Integrin-Dependent Function in Wiskott-Aldrich Syndrome Protein-Deficient Murine and Human Neutrophils","volume":"25","author":"Zhang","year":"2006","journal-title":"Immunity"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e07847","DOI":"10.7554\/eLife.07847","article-title":"Immune Surveillance of the Lung by Migrating Tissue Monocytes","volume":"4","author":"Rodero","year":"2015","journal-title":"Elife"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.5.1626","article-title":"Hydrodynamic Shear Shows Distinct Roles for LFA-1 and Mac-1 in Neutrophil Adhesion to Intercellular Adhesion Molecule-1","volume":"92","author":"Neelamegham","year":"1998","journal-title":"Blood"},{"key":"B51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s40035-020-00195-1","article-title":"Peripheral Clearance of Brain-Derived Abeta in Alzheimer's Disease: Pathophysiology and Therapeutic Perspectives","volume":"9","author":"Cheng","year":"2020","journal-title":"Transl Neurodegener"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-819870","article-title":"HO-1(Hi) Patrolling Monocytes Protect Against Vaso-Occlusion in Sickle Cell Disease","volume":"131","author":"Liu","year":"2018","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000172","article-title":"Patrolling Monocytes Scavenge Endothelial-Adherent Sickle RBCs: A Novel Mechanism of Inhibition of Vaso-Occlusion in SCD","volume":"134","author":"Liu","year":"2019","journal-title":"Blood"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.3390\/ijms21041402","article-title":"Beta2 Integrins-Multi-Functional Leukocyte Receptors in Health and Disease","volume":"21","author":"Bednarczyk","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"re3","DOI":"10.1126\/scisignal.272re3","article-title":"CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior","volume":"2","author":"Silverstein","year":"2009","journal-title":"Sci Signal"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4348","DOI":"10.1038\/srep04348","article-title":"The Plasma Protein Fibrinogen Stabilizes Clusters of Red Blood Cells in Microcapillary Flows","volume":"4","author":"Brust","year":"2014","journal-title":"Sci Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208877200","article-title":"A Molecular Basis for Integrin Alphambeta 2 Ligand Binding Promiscuity","volume":"277","author":"Yakubenko","year":"2002","journal-title":"J Biol Chem"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905217106","article-title":"Hotspots of GPI-Anchored Proteins and Integrin Nanoclusters Function as Nucleation Sites for Cell Adhesion","volume":"106","author":"van Zanten","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.056","article-title":"Actin Flows Mediate a Universal Coupling Between Cell Speed and Cell Persistence","volume":"161","author":"Maiuri","year":"2015","journal-title":"Cell"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16-12-0827","article-title":"Ligand-Specific Binding Forces of LFA-1 and Mac-1 in Neutrophil Adhesion and Crawling","volume":"29","author":"Li","year":"2018","journal-title":"Mol Biol Cell"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-017-0950-2","article-title":"Structural Alteration of the Endothelial Glycocalyx: Contribution of the Actin Cytoskeleton","volume":"17","author":"Li","year":"2018","journal-title":"Biomech Model Mechanobiol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1161\/ATVBAHA.117.309907","article-title":"Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins","volume":"38","author":"Le Master","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e1000314","DOI":"10.1371\/journal.ppat.1000314","article-title":"Extracellular Bacterial Pathogen Induces Host Cell Surface Reorganization to Resist Shear Stress","volume":"5","author":"Mikaty","year":"2009","journal-title":"PloS Pathog"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300739","article-title":"Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1\/ICAM-1","volume":"191","author":"Katakai","year":"2013","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"107798","DOI":"10.1016\/j.celrep.2020.107798","article-title":"Stabilization of Endothelial Receptor Arrays by a Polarized Spectrin Cytoskeleton Facilitates Rolling and Adhesion of Leukocytes","volume":"31","author":"Mylvaganam","year":"2020","journal-title":"Cell Rep"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00948","article-title":"Current Concepts on 6-Sulfo LacNAc Expressing Monocytes (slanMo)","volume":"10","author":"Ahmad","year":"2019","journal-title":"Front Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02052","article-title":"6-Sulfo LacNAc (Slan) as a Marker for Non-Classical Monocytes","volume":"10","author":"Hofer","year":"2019","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0716-317RR","article-title":"Fluid Shear-Induced Cathepsin B Release in the Control of Mac1-Dependent Neutrophil Adhesion","volume":"102","author":"Akenhead","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M800449-MCP200","article-title":"MMP-9 Sheds the Beta2 Integrin Subunit (CD18) From Macrophages","volume":"8","author":"Vaisar","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287722","article-title":"Cleavage of the CD11b Extracellular Domain by the Leukocyte Serprocidins is Critical for Neutrophil Detachment During Chemotaxis","volume":"117","author":"Zen","year":"2011","journal-title":"Blood"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02752-19","article-title":"Three-Dimensional Light Sheet Fluorescence Microscopy of Lungs To Dissect Local Host Immune-Aspergillus Fumigatus Interactions","volume":"11","author":"Amich","year":"2020","journal-title":"mBio"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01073","article-title":"High-Speed Single-Molecule Tracking of CXCL13 in the B-Follicle","volume":"9","author":"Miller","year":"2018","journal-title":"Front Immunol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00278.2013","article-title":"NOX2 in Lung Inflammation: Quantum Dot Based in Situ Imaging of NOX2-Mediated Expression of Vascular Cell Adhesion Molecule-1","volume":"306","author":"Orndorff","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.730835\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T06:08:23Z","timestamp":1631858903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.730835\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,17]]},"references-count":73,"alternative-id":["10.3389\/fimmu.2021.730835"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.730835","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,17]]},"article-number":"730835"}}