{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:48:07Z","timestamp":1792097287461,"version":"4.4.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the Interaction between chronic endometritis (CE) caused endometrial microbiota disorder and endometrial immune environment change in recurrent implantation failure (RIF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Transcriptome sequencing analysis of the endometrial of 112 patients was preform by using High-Throughput Sequencing. The endometrial microbiota of 43 patients was analyzed by using 16s rRNA sequencing technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>In host endometrium, CD4 T cell and macrophage exhibited significant differences abundance between CE and non-CE patients. The enrichment analysis indicated differentially expressed genes mainly enriched in immune-related functional terms. <jats:italic>Phyllobacterium<\/jats:italic> and <jats:italic>Sphingomonas<\/jats:italic> were significantly high infiltration in CE patients, and active in pathways related to carbohydrate metabolism and\/or fat metabolism. The increased synthesis of lipopolysaccharide, an important immunomodulator, was the result of microbial disorders in the endometrium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The composition of endometrial microorganisms in CE and non-CE patients were significantly different. <jats:italic>Phyllobacterium<\/jats:italic> and <jats:italic>Sphingomonas<\/jats:italic> mainly regulated immune cells by interfering with the process of carbohydrate metabolism and\/or fat metabolism in the endometrium. CE endometrial microorganisms might regulate Th17 response and the ratio of Th1 to Th17 through lipopolysaccharide (LPS).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2021.748447","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T06:56:21Z","timestamp":1633330581000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":113,"title":["Interaction Between Chronic Endometritis Caused Endometrial Microbiota Disorder and Endometrial Immune Environment Change in Recurrent Implantation 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