{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:28:16Z","timestamp":1793104096550,"version":"4.5.0"},"reference-count":148,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004396","name":"Thailand Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004396","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Adoptive cell therapy (ACT) using chimeric antigen receptor (CAR) T cells holds impressive clinical outcomes especially in patients who are refractory to other kinds of therapy. However, many challenges hinder its clinical applications. For example, patients who undergo chemotherapy usually have an insufficient number of autologous T cells due to lymphopenia. Long-term<jats:italic>ex vivo<\/jats:italic>expansion can result in T cell exhaustion, which reduces the effector function. There is also a batch-to-batch variation during the manufacturing process, making it difficult to standardize and validate the cell products. In addition, the process is labor-intensive and costly. Generation of universal off-the-shelf CAR T cells, which can be broadly given to any patient, prepared in advance and ready to use, would be ideal and more cost-effective. Human induced pluripotent stem cells (iPSCs) provide a renewable source of cells that can be genetically engineered and differentiated into immune cells with enhanced anti-tumor cytotoxicity. This review describes basic knowledge of T cell biology, applications in ACT, the use of iPSCs as a new source of T cells and current differentiation strategies used to generate T cells as well as recent advances in genome engineering to produce next-generation off-the-shelf T cells with improved effector functions. We also discuss challenges in the field and future perspectives toward the final universal off-the-shelf immunotherapeutic products.<\/jats:p>","DOI":"10.3389\/fimmu.2021.759558","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T06:17:58Z","timestamp":1632809878000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Advances in Adoptive Cell Therapy Using Induced Pluripotent Stem Cell-Derived T Cells"],"prefix":"10.3389","volume":"12","author":[{"given":"Ratchapong","family":"Netsrithong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methichit","family":"Wattanapanitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nrclinonc.2017.148","article-title":"Chimeric Antigen Receptor T-Cell Therapy\u2014Assessment and Management of Toxicities","volume":"15","author":"Neelapu","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/d41573-021-00031-9","article-title":"FDA Approves Fourth CAR-T Cell Therapy","volume":"20","author":"Asher","year":"2021","journal-title":"Nat Rev Drug Discovery"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.03.011","article-title":"New Cell Sources for T Cell Engineering and Adoptive Immunotherapy","volume":"16","author":"Themeli","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.smim.2015.10.007","article-title":"Reprogramming Away From the Exhausted T Cell State","volume":"28","author":"Karagiannis","year":"2016","journal-title":"Semin Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s13577-014-0089-8","article-title":"Rise of iPSCs as a Cell Source for Adoptive Immunotherapy","volume":"27","author":"Minagawa","year":"2014","journal-title":"Hum Cell"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1293","article-title":"An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells From Cord Blood and Peripheral Blood Cells","volume":"31","author":"Okita","year":"2013","journal-title":"Stem Cells"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.418","article-title":"Induction of Pluripotent Stem Cells From Fibroblast Cultures","volume":"2","author":"Takahashi","year":"2007","journal-title":"Nat Protoc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.12.006","article-title":"Regeneration of Human Tumor Antigen-Specific T Cells From iPSCs Derived From Mature CD8+ T Cells","volume":"12","author":"Vizcardo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.11.002","article-title":"Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation","volume":"12","author":"Nishimura","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2754","article-title":"Concise Review: Human Pluripotent Stem Cells to Produce Cell-Based Cancer Immunotherapy","volume":"36","author":"Zhu","year":"2018","journal-title":"Stem Cells"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.106","article-title":"Translational Implications for Off-The-Shelf Immune Cells Expressing Chimeric Antigen Receptors","volume":"24","author":"Torikai","year":"2016","journal-title":"Mol Ther"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090742","article-title":"Determinants of Lymphoid-Myeloid Lineage Diversification","volume":"24","author":"Laiosa","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-5323(03)00005-8","article-title":"Microenvironmental Regulation of Notch Signalling in T Cell Development","volume":"15","author":"Harman","year":"2003","journal-title":"Semin Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.2.127","article-title":"Mapping Precursor Movement Through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development","volume":"194","author":"Lind","year":"2001","journal-title":"J Exp Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nri3667","article-title":"Positive and Negative Selection of the T Cell Repertoire: What Thymocytes See (and Don't See)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nri2416","article-title":"Lineage Fate and Intense Debate: Myths, Models and Mechanisms of CD4- Versus CD8-Lineage Choice","volume":"8","author":"Singer","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nri2469","article-title":"Affinity Threshold for Thymic Selection Through a T-Cell Receptor\u2013Co-Receptor Zipper","volume":"9","author":"Palmer","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1874","article-title":"Autonomous Role of Medullary Thymic Epithelial Cells in Central CD4+ T Cell Tolerance","volume":"11","author":"Hinterberger","year":"2010","journal-title":"Nat Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological Memory and Protective Immunity: Understanding Their Relation","volume":"272","author":"Ahmed","year":"1996","journal-title":"Science"},{"key":"B20","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.138.3.989","article-title":"Identification of Specific Cytolytic Immune Responses Against Autologous Tumor in Humans Bearing Malignant Melanoma","volume":"138","author":"Muul","year":"1987","journal-title":"J Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.15.1159","article-title":"Treatment of Patients With Metastatic Melanoma With Autologous Tumor-Infiltrating Lymphocytes and Interleukin 2","volume":"86","author":"Rosenberg","year":"1994","journal-title":"J Natl Cancer Institute"},{"key":"B22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00002371-200205000-00007","article-title":"A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma","volume":"25","author":"Dudley","year":"2002","journal-title":"J Immunother (Hagerstown Md: 1997)"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/CJI.0b013e3181b88ffc","article-title":"Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-Specific T Cells","volume":"33","author":"Wrzesinski","year":"2010","journal-title":"J Immunother (Hagerstown Md: 1997)"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251102","article-title":"Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient With Epithelial Cancer","volume":"344","author":"Tran","year":"2014","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-211714","article-title":"Gene Therapy With Human and Mouse T-Cell Receptors Mediates Cancer Regression and Targets Normal Tissues Expressing Cognate Antigen","volume":"114","author":"Johnson","year":"2009","journal-title":"Blood"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129003","article-title":"Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes","volume":"314","author":"Morgan","year":"2006","journal-title":"Science"},{"key":"B27","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1200\/JCO.2010.32.2537","article-title":"Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1","volume":"29","author":"Robbins","year":"2011","journal-title":"J Clin Oncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2006.00356.x","article-title":"Loss or Down-Regulation of HLA Class I Expression at the Allelic Level in Freshly Isolated Leukemic Blasts","volume":"98","author":"Masuda","year":"2007","journal-title":"Cancer Sci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000043124.75633.ED","article-title":"Down-Regulation of HLA-A Expression Correlates With a Better Prognosis in Colorectal Cancer Patients","volume":"82","author":"Menon","year":"2002","journal-title":"Lab Invest"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.6.15.1464371","article-title":"Endowing T Cells With Antibody Specificity Using Chimeric T Cell Receptors","volume":"6","author":"Gross","year":"1992","journal-title":"FASEB J"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10024","article-title":"Expression of Immunoglobulin-T-Cell Receptor Chimeric Molecules as Functional Receptors With Antibody-Type Specificity","volume":"86","author":"Gross","year":"1989","journal-title":"Proc Natl Acad Sci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-immunol-032713-120136","article-title":"Adoptive Immunotherapy for Cancer or Viruses","volume":"32","author":"Maus","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.2072","article-title":"Economic Evaluation of Chimeric Antigen Receptor T-Cell Therapy by Site of Care Among Patients With Relapsed or Refractory Large B-Cell Lymphoma","volume":"3","author":"Lyman","year":"2020","journal-title":"JAMA Netw Open"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0956-8","article-title":"Value and Affordability of CAR T-Cell Therapy in the United States","volume":"55","author":"Fiorenza","year":"2020","journal-title":"Bone Marrow Transplant"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-486324","article-title":"Multicenter Study of Banked Third-Party Virus-Specific T Cells to Treat Severe Viral Infections After Hematopoietic Stem Cell Transplantation","volume":"121","author":"Leen","year":"2013","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nature21405","article-title":"Targeting a CAR to the TRAC Locus With CRISPR\/Cas9 Enhances Tumour Rejection","volume":"543","author":"Eyquem","year":"2017","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-405365","article-title":"A Foundation for Universal T-Cell Based Immunotherapy: T Cells Engineered to Express a CD19-Specific Chimeric-Antigen-Receptor and Eliminate Expression of Endogenous TCR","volume":"119","author":"Torikai","year":"2012","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901766","article-title":"The Optimal Antigen Response of Chimeric Antigen Receptors Harboring the CD3zeta Transmembrane Domain Is Dependent Upon Incorporation of the Receptor Into the Endogenous TCR\/CD3 Complex","volume":"184","author":"Bridgeman","year":"2010","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-14-3321","article-title":"Multiplex Genome-Edited T-Cell Manufacturing Platform for \"Off-The-Shelf\" Adoptive T-Cell Immunotherapies","volume":"75","author":"Poirot","year":"2015","journal-title":"Cancer Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaj2013","article-title":"Molecular Remission of Infant B-ALL After Infusion of Universal TALEN Gene-Edited CAR T Cells","volume":"9","author":"Qasim","year":"2017","journal-title":"Sci Trans Med"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0051-2","article-title":"'Off-the-Shelf' Allogeneic CAR T Cells: Development and Challenges","volume":"19","author":"Depil","year":"2020","journal-title":"Nat Rev Drug Discovery"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)32334-5","article-title":"Genome-Edited, Donor-Derived Allogeneic Anti-CD19 Chimeric Antigen Receptor T Cells in Paediatric and Adult B-Cell Acute Lymphoblastic Leukaemia: Results of Two Phase 1 Studies","volume":"396","author":"Benjamin","year":"2020","journal-title":"Lancet (London England)"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00485-1","article-title":"Will Allogeneic CAR T Cells for CD19(+) Malignancies Take Autologous CAR T Cells 'Off the Shelf'","volume":"18","author":"DiNofia","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-16-1149","article-title":"Regeneration of CD8alphabeta T Cells From T-Cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity","volume":"76","author":"Maeda","year":"2016","journal-title":"Cancer Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4061193","article-title":"The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases","volume":"4","author":"Hew","year":"2015","journal-title":"J Clin Med"},{"key":"B46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1365-2567.2005.02317.x","article-title":"Imbalance of Regulatory T Cells in Human Autoimmune Diseases","volume":"117","author":"Dejaco","year":"2006","journal-title":"Immunology"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.016","article-title":"Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction","volume":"28","author":"Tang","year":"2008","journal-title":"Immunity"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.4049\/jimmunol.1200633","article-title":"Programming of Regulatory T Cells From Pluripotent Stem Cells and Prevention of Autoimmunity","volume":"189","author":"Haque","year":"2012","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e126471","DOI":"10.1172\/jci.insight.126471","article-title":"Stem Cell-Derived Tissue-Associated Regulatory T Cells Suppress the Activity of Pathogenic Cells in Autoimmune Diabetes","volume":"4","author":"Haque","year":"2019","journal-title":"JCI Insight"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e97335","DOI":"10.1371\/journal.pone.0097335","article-title":"Broad T-Cell Receptor Repertoire in T-Lymphocytes Derived From Human Induced Pluripotent Stem Cells","volume":"9","author":"Chang","year":"2014","journal-title":"PloS One"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.02.005","article-title":"Lymphoid Regeneration From Gene-Corrected SCID-X1 Subject-Derived iPSCs","volume":"16","author":"Menon","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-676304","article-title":"Modeling Altered T-Cell Development With Induced Pluripotent Stem Cells From Patients With RAG1-Dependent Immune Deficiencies","volume":"128","author":"Brauer","year":"2016","journal-title":"Blood"},{"key":"B53","doi-asserted-by":"publisher","first-page":"4A. 3.1","DOI":"10.1002\/9780470151808.sc04a03s18","article-title":"Derivation of Induced Pluripotent Stem Cells From Human Peripheral Circulating T Cells","volume":"18","author":"Seki","year":"2011","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nprot.2012.015","article-title":"Generation of Induced Pluripotent Stem Cells From a Small Amount of Human Peripheral Blood Using a Combination of Activated T Cells and Sendai Virus","volume":"7","author":"Seki","year":"2012","journal-title":"Nat Protoc"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e97397","DOI":"10.1371\/journal.pone.0097397","article-title":"Derivation of Transgene-Free Human Induced Pluripotent Stem Cells From Human Peripheral T Cells in Defined Culture Conditions","volume":"9","author":"Kishino","year":"2014","journal-title":"PloS One"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2678","article-title":"Generation of Tumor-Targeted Human T Lymphocytes From Induced Pluripotent Stem Cells for Cancer Therapy","volume":"31","author":"Themeli","year":"2013","journal-title":"Nat Biotechnol"},{"key":"B57","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.stem.2018.10.005","article-title":"Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy","volume":"23","author":"Minagawa","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217729","article-title":"Generation of Functional NKT Cells In Vitro From Embryonic Stem Cells Bearing Rearranged Invariant V\u03b114-J\u03b118 Tcr\u03b1 Gene","volume":"115","author":"Watarai","year":"2010","journal-title":"Blood"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.04.025","article-title":"Generation of TCR-Expressing Innate Lymphoid-Like Helper Cells That Induce Cytotoxic T Cell-Mediated Anti-Leukemic Cell Response","volume":"10","author":"Ueda","year":"2018","journal-title":"Stem Cell Rep"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2465","article-title":"Efficient Regeneration of Human V\u03b124+ Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo","volume":"34","author":"Yamada","year":"2016","journal-title":"Stem Cells"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.01.005","article-title":"Cellular Adjuvant Properties, Direct Cytotoxicity of Re-Differentiated V\u03b124 Invariant NKT-Like Cells From Human Induced Pluripotent Stem Cells","volume":"6","author":"Kitayama","year":"2016","journal-title":"Stem Cell Rep"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/22780","article-title":"Creation of Human Tumour Cells With Defined Genetic Elements","volume":"400","author":"Hahn","year":"1999","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.07.004","article-title":"Sustainable Tumor-Suppressive Effect of iPSC-Derived Rejuvenated T Cells Targeting Cervical Cancers","volume":"28","author":"Honda","year":"2020","journal-title":"Mol Ther"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3584","article-title":"Origins and Implications of Pluripotent Stem Cell Variability and Heterogeneity","volume":"14","author":"Cahan","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2019.12.006","article-title":"High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells","volume":"16","author":"Nagano","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.973","article-title":"Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question","volume":"166","author":"Suchin","year":"2001","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02742.x","article-title":"Contribution of Na\u00efve and Memory T-Cell Populations to the Human Alloimmune Response","volume":"9","author":"Macedo","year":"2009","journal-title":"Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surgeons"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061442","article-title":"Hierarchy of Notch-Delta Interactions Promoting T Cell Lineage Commitment and Maturation","volume":"204","author":"Besseyrias","year":"2007","journal-title":"J Exp Med"},{"key":"B70","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ymeth.2015.10.001","article-title":"Directed Differentiation of Definitive Hemogenic Endothelium and Hematopoietic Progenitors From Human Pluripotent Stem Cells","volume":"101","author":"Ditadi","year":"2016","journal-title":"Methods (San Diego Calif)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13059-020-02058-4","article-title":"Analysis of Endothelial-to-Haematopoietic Transition at the Single Cell Level Identifies Cell Cycle Regulation as a Driver of Differentiation","volume":"21","author":"Canu","year":"2020","journal-title":"Genome Biol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.11.003","article-title":"T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures","volume":"2","author":"Kennedy","year":"2012","journal-title":"Cell Rep"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2915","article-title":"Wnt Signaling Controls the Specification of Definitive and Primitive Hematopoiesis From Human Pluripotent Stem Cells","volume":"32","author":"Sturgeon","year":"2014","journal-title":"Nat Biotechnol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e97335","DOI":"10.1371\/journal.pone.0097335","article-title":"Broad T-Cell Receptor Repertoire in T-Lymphocytes Derived From Human Induced Pluripotent Stem Cells","volume":"9","author":"Chang","year":"2014","journal-title":"PloS One"},{"key":"B75","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41467-020-20658-3","article-title":"A Clinically Applicable and Scalable Method to Regenerate T-Cells From iPSCs for Off-the-Shelf T-Cell Immunotherapy","volume":"12","author":"Iriguchi","year":"2021","journal-title":"Nat Commun"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.09.011","article-title":"Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes From iPSCs Transduced With Exogenous TCR Genes","volume":"19","author":"Maeda","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.100998","article-title":"Cytotoxic T Lymphocytes Regenerated From iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model","volume":"23","author":"Kashima","year":"2020","journal-title":"iScience"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801027","article-title":"NOTCH Activation at the Hematovascular Mesoderm Stage Facilitates Efficient Generation of T Cells With High Proliferation Potential From Human Pluripotent Stem Cells","volume":"202","author":"Kumar","year":"2019","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B79","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.stem.2018.12.011","article-title":"Organoid-Induced Differentiation of Conventional T Cells From Human Pluripotent Stem Cells","volume":"24","author":"Montel-Hagen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01997-w","article-title":"Multilineage Differentiation Potential of Hematoendothelial Progenitors Derived From Human Induced Pluripotent Stem Cells","volume":"11","author":"Netsrithong","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.05.016","article-title":"Generation of Highly Proliferative Rejuvenated Cytotoxic T Cell Clones Through Pluripotency Reprogramming for Adoptive Immunotherapy","volume":"21","author":"Kawai","year":"2021","journal-title":"Mol Ther J Am Soc Gene Ther"},{"key":"B82","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.stemcr.2015.07.011","article-title":"A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy","volume":"5","author":"Ando","year":"2015","journal-title":"Stem Cell Rep"},{"key":"B83","doi-asserted-by":"publisher","first-page":"796","DOI":"10.3324\/haematol.2019.223511","article-title":"Long-Term Eradication of Extranodal Natural Killer\/T-Cell Lymphoma, Nasal Type, by Induced Pluripotent Stem Cell-Derived Epstein-Barr Virus-Specific Rejuvenated T Cells In Vivo","volume":"105","author":"Miki","year":"2020","journal-title":"Haematologica"},{"key":"B84","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s42003-021-02195-x","article-title":"The Therapeutic Potential of Multiclonal Tumoricidal T Cells Derived From Tumor Infiltrating Lymphocyte-Derived iPS Cells","volume":"4","author":"Ito","year":"2021","journal-title":"Commun Biol"},{"key":"B85","article-title":"Involvement of the C-Kit Receptor in the Adhesion of Hematopoietic Stem Cells to Stromal Cells","volume":"22","author":"Kodama","year":"1994","journal-title":"Exp Hematol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1126\/science.8066449","article-title":"Generation of Lymphohematopoietic Cells From Embryonic Stem Cells in Culture","volume":"265","author":"Nakano","year":"1994","journal-title":"Science"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00474-0","article-title":"Induction of T Cell Development From Hematopoietic Progenitor Cells by Delta-Like-1 In Vitro","volume":"17","author":"Schmitt","year":"2002","journal-title":"Immunity"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1293","article-title":"Induction of T-Cell Development From Human Cord Blood Hematopoietic Stem Cells by Delta-Like 1 In Vitro","volume":"105","author":"La Motte-Mohs","year":"2005","journal-title":"Blood"},{"key":"B89","doi-asserted-by":"publisher","first-page":"e50495","DOI":"10.1371\/journal.pone.0050495","article-title":"Assessment of Human Multi-Potent Hematopoietic Stem\/Progenitor Cell Potential Using a Single In Vitro Screening System","volume":"7","author":"Calvo","year":"2012","journal-title":"PloS One"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v97.7.1960","article-title":"Human Homologues of Delta-1 and Delta-4 Function as Mitogenic Regulators of Primitive Human Hematopoietic Cells","volume":"97","author":"Karanu","year":"2001","journal-title":"Blood J Am Soc Hematol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1038\/ni1075","article-title":"Delta-Like 1 Is Necessary for the Generation of Marginal Zone B Cells But Not T Cells In Vivo","volume":"5","author":"Hozumi","year":"2004","journal-title":"Nat Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"867","DOI":"10.4049\/jimmunol.1000782","article-title":"Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes","volume":"185","author":"Mohtashami","year":"2010","journal-title":"J Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.454850","article-title":"Intrinsic Selectivity of Notch 1 for Delta-Like 4 Over Delta-Like 1","volume":"288","author":"Andrawes","year":"2013","journal-title":"J Biol Chem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2009.09.005","article-title":"T Lineage Differentiation From Induced Pluripotent Stem Cells","volume":"260","author":"Lei","year":"2009","journal-title":"Cell Immunol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1007\/7651_2021_355","article-title":"Efficient Generation of iPSC-Derived Hematoendothelial Progenitors and Specification Toward T Cell Lineage","author":"Suwanpitak","year":"2021","journal-title":"Methods Mol Biol (Clifton NJ)"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803670","article-title":"Generation of T Cells From Human Embryonic Stem Cell-Derived Hematopoietic Zones","volume":"182","author":"Timmermans","year":"2009","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B97","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-4939-8938-6_3","article-title":"Generation of Antigen-Specific T Cells From Human Induced Pluripotent Stem Cells","volume":"1899","author":"Nishimura","year":"2019","journal-title":"Methods Mol Biol (Clifton NJ)"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-15-1742","article-title":"Adoptive Transfer of CD8+ T Cells Generated From Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along With Immunological Memory","volume":"76","author":"Saito","year":"2016","journal-title":"Cancer Res"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1731","article-title":"Engineering the Human Thymic Microenvironment to Support Thymopoiesis In Vivo","volume":"32","author":"Chung","year":"2014","journal-title":"Stem Cells"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4237","article-title":"Generation of Mature T Cells From Human Hematopoietic Stem and Progenitor Cells in Artificial Thymic Organoids","volume":"14","author":"Seet","year":"2017","journal-title":"Nat Methods"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-122193","article-title":"Guided Polarization of iPSC-Derived CD4SP Helper T Cells By CRISPR\/Cas9-Based Genome-Editing","volume":"134","author":"Yano","year":"2019","journal-title":"Blood"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt027","article-title":"Induction of T-Cell Development by Delta-Like 4-Expressing Fibroblasts","volume":"25","author":"Mohtashami","year":"2013","journal-title":"Int Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069572","article-title":"A Simple Model System Enabling Human CD34(+) Cells to Undertake Differentiation Towards T Cells","volume":"8","author":"Lapenna","year":"2013","journal-title":"PloS One"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1862","article-title":"Combined Effects of Notch Signaling and Cytokines Induce a Multiple Log Increase in Precursors With Lymphoid and Myeloid Reconstituting Ability","volume":"101","author":"Varnum-Finney","year":"2003","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188995","article-title":"An Essential Developmental Checkpoint for Production of the T Cell Lineage","volume":"329","author":"Ikawa","year":"2010","journal-title":"Science"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30916","article-title":"Biomaterial-Based Notch Signaling for the Differentiation of Hematopoietic Stem Cells Into T Cells","volume":"79","author":"Taqvi","year":"2006","journal-title":"J Biomed Mater Res Part A"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4258","article-title":"Progenitor T-Cell Differentiation From Hematopoietic Stem Cells Using Delta-Like-4 and VCAM-1","volume":"14","author":"Shukla","year":"2017","journal-title":"Nat Methods"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0064-x","article-title":"Next-Generation Stem Cells - Ushering in a New Era of Cell-Based Therapies","volume":"19","author":"Kimbrel","year":"2020","journal-title":"Nat Rev Drug Discovery"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0290-5","article-title":"Calibration of CAR Activation Potential Directs Alternative T Cell Fates and Therapeutic Potency","volume":"25","author":"Feucht","year":"2019","journal-title":"Nat Med"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-142894","article-title":"NOTCH and CAR Signaling Control T Cell Lineage Commitment From Pluripotent Stem Cells","volume":"136","author":"van der Stegen","year":"2020","journal-title":"Blood"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2020-3245","article-title":"Abstract 3245: FT819 Path to IND: First-Of-Kind Off-the-Shelf CAR19 T-Cell for B Cell Malignancies","volume":"80","author":"Mandal","year":"2020","journal-title":"Cancer Res"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-130584","article-title":"FT819: Translation of Off-The-Shelf TCR-Less Trac-1xx CAR-T Cells in Support of First-Of-Kind Phase I Clinical Trial","volume":"134","author":"Chang","year":"2019","journal-title":"Blood"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-116843","article-title":"Pluripotent Cell-Derived Off-The-Shelf TCR-Less CAR-Targeted Cytotoxic T Cell Therapeutic for the Allogeneic Treatment of B Cell Malignancies","volume":"132","author":"Clarke","year":"2018","journal-title":"Blood"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-142423","article-title":"A Phase I Study of FT819, a First-Of-Kind, Off-The-Shelf, iPSC-Derived TCR-Less CD19 CAR T Cell Therapy for the Treatment of Relapsed\/Refractory B-Cell Malignancies","volume":"136","author":"Park","year":"2020","journal-title":"Blood"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0016-3","article-title":"Hypoimmunogenic Derivatives of Induced Pluripotent Stem Cells Evade Immune Rejection in Fully Immunocompetent Allogeneic Recipients","volume":"37","author":"Deuse","year":"2019","journal-title":"Nat Biotechnol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3860","article-title":"HLA-E-Expressing Pluripotent Stem Cells Escape Allogeneic Responses and Lysis by NK Cells","volume":"35","author":"Gornalusse","year":"2017","journal-title":"Nat Biotechnol"},{"key":"B117","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.stem.2019.02.005","article-title":"Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs With Enhanced Immune Compatibility","volume":"24","author":"Xu","year":"2019","journal-title":"Cell Stem Cell"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3269","article-title":"Generation of Hypoimmunogenic Human Pluripotent Stem Cells via Expression of Membrane-Bound and Secreted \u03b22m-HLA-G Fusion Proteins","volume":"38","author":"Shi","year":"2020","journal-title":"Stem Cells"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00730-z","article-title":"Generation of Hypoimmunogenic T Cells From Genetically Engineered Allogeneic Human Induced Pluripotent Stem Cells","volume":"5","author":"Wang","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1007\/7651_2021_352","article-title":"CRISPR\/Cas9 Ribonucleoprotein Complex-Mediated Efficient B2M Knockout in Human Induced Pluripotent Stem Cells (iPSCs)","author":"Thongsin","year":"2021","journal-title":"Methods Mol Biol (Clifton NJ)"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902566116","article-title":"Generation of Hypoimmunogenic Human Pluripotent Stem Cells","volume":"116","author":"Han","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.2217\/rme-2019-0117","article-title":"Engineering Strategies for Generating Hypoimmunogenic Cells With High Clinical and Commercial Value","volume":"14","author":"Malik","year":"2019","journal-title":"Regener Med"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-020-00132-9","article-title":"Current Status and Future Perspectives of HLA-Edited Induced Pluripotent Stem Cells","volume":"40","author":"Koga","year":"2020","journal-title":"Inflammation Regener"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0200-1","article-title":"Engineering Universal Cells That Evade Immune Detection","volume":"19","author":"Lanza","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22703","article-title":"Natural Killer Cell Inhibition by HLA-E Molecules on Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells","volume":"59","author":"Sugita","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.9.6010","article-title":"Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype","volume":"181","author":"Fauriat","year":"2008","journal-title":"J\u00a0Immunol (Baltimore Md 1950)"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-138930","article-title":"Generation of Multiplexed Engineered, Off-The-Shelf CAR T Cells Uniformly Carrying Multiple Anti-Tumor Modalities to Prevent Tumor Relapse","volume":"136","author":"Chang","year":"2020","journal-title":"Blood"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0578-8","article-title":"Genome-Wide CRISPR\u2013Cas9 Screening Reveals Ubiquitous T Cell Cancer Targeting via the Monomorphic MHC Class I-Related Protein MR1","volume":"21","author":"Crowther","year":"2020","journal-title":"Nat Immunol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-141507","article-title":"Multiplexed Engineered, Off-The-Shelf T Cells Carrying Three Tumor-Associated Antigen-Targeting Modalities: CAR + Pan-Tumor Targeting TCR + CD16 Fc Receptor","volume":"136","author":"Nguyen","year":"2020","journal-title":"Blood"},{"key":"B130","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.exphem.2016.10.009","article-title":"'Off-the-Shelf' Immunotherapy With iPSC-Derived Rejuvenated Cytotoxic T Lymphocytes","volume":"47","author":"Ando","year":"2017","journal-title":"Exp Hematol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01965","article-title":"Use of Cell and Genome Modification Technologies to Generate Improved \u201cOff-The-Shelf\u201d CAR T and CAR NK Cells","volume":"11","author":"Morgan","year":"2020","journal-title":"Front Immunol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-019-00528-6","article-title":"Induced Pluripotent Stem Cell (iPSC)-Derived Lymphocytes for Adoptive Cell Immunotherapy: Recent Advances and Challenges","volume":"14","author":"Nianias","year":"2019","journal-title":"Curr Hematol Malig Rep"},{"key":"B133","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1038\/s41467-020-17165-w","article-title":"Pre-Clinical Study of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitor Cells for Parkinson\u2019s Disease","volume":"11","author":"Doi","year":"2020","journal-title":"Nat Commun"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-019-0106-0","article-title":"Overview: An iPS Cell Stock at CiRA","volume":"39","author":"Umekage","year":"2019","journal-title":"Inflammation Regener"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5171032","article-title":"Recent Updates on Induced Pluripotent Stem Cells in Hematological Disorders","volume":"2019","author":"Wattanapanitch","year":"2019","journal-title":"Stem Cells Int"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4136473","article-title":"Genome Editing Redefines Precision Medicine in the Cardiovascular Field","volume":"2018","author":"Dzilic","year":"2018","journal-title":"Stem Cells Int"},{"key":"B137","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.exphem.2018.12.001","article-title":"From Pluripotent Stem Cells to T Cells","volume":"71","author":"Montel-Hagen","year":"2019","journal-title":"Exp Hematol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000037","article-title":"T Cell Regeneration: An Update on Progress and Challenges","volume":"2","author":"Guo","year":"2020","journal-title":"Blood Sci"},{"key":"B139","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.reth.2020.06.002","article-title":"iPS Cell-Based Therapy for Parkinson's Disease: A Kyoto Trial","volume":"13","author":"Takahashi","year":"2020","journal-title":"Regenerative Ther"},{"key":"B140","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.stemcr.2015.07.011","article-title":"A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy","volume":"5","author":"Ando","year":"2015","journal-title":"Stem Cell Rep"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/nature22395","article-title":"Therapeutic T Cell Engineering","volume":"545","author":"Sadelain","year":"2017","journal-title":"Nature"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.2147\/cmar.S260915","article-title":"EGLIF-CAR-T Cells Secreting PD-1 Blocking Antibodies Significantly Mediate the Elimination of Gastric Cancer","volume":"12","author":"Zhou","year":"2020","journal-title":"Cancer Manag Res"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00803","article-title":"Augmenting the Effectiveness of CAR-T Cells by Enhanced Self-Delivery of PD-1-Neutralizing scFv","volume":"8","author":"Ping","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.215","article-title":"IL-12-Secreting CD19-Targeted Cord Blood-Derived T Cells for the Immunotherapy of B-Cell Acute Lymphoblastic Leukemia","volume":"29","author":"Pegram","year":"2015","journal-title":"Leukemia"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.063","article-title":"CAR T Cells Releasing IL-18 Convert to T-Bet(high) FoxO1(low) Effectors That Exhibit Augmented Activity Against Advanced Solid Tumors","volume":"21","author":"Chmielewski","year":"2017","journal-title":"Cell Rep"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-18-1811","article-title":"Eradication of Neuroblastoma by T Cells Redirected With an Optimized GD2-Specific Chimeric Antigen Receptor and Interleukin-15","volume":"25","author":"Chen","year":"2019","journal-title":"Clin Cancer Res"},{"key":"B147","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2147\/btt.S291768","article-title":"Armored CAR T-Cells: The Next Chapter in T-Cell Cancer Immunotherapy","volume":"15","author":"Hawkins","year":"2021","journal-title":"Biologics"},{"key":"B148","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13045-020-00983-2","article-title":"Pluripotent Stem Cell-Derived CAR-Macrophage Cells With Antigen-Dependent Anti-Cancer Cell Functions","volume":"13","author":"Zhang","year":"2020","journal-title":"J Hematol Oncol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.759558\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T11:28:14Z","timestamp":1673350094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.759558\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":148,"alternative-id":["10.3389\/fimmu.2021.759558"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.759558","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]},"article-number":"759558"}}