{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:14:48Z","timestamp":1787026488506,"version":"build-2736575974"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Interferon \u03bb (IFN-\u03bb) is critical for host viral defense at mucosal surfaces and stimulates immunomodulatory signals, acting on epithelial cells and few other cell types due to restricted IFN-\u03bb receptor expression. Epithelial cells of the intestine play a critical role in the pathogenesis of Inflammatory Bowel Disease (IBD), and the related type II interferons (IFN-\u03b3) have been extensively studied in the context of IBD. However, a role for IFN-\u03bb in IBD onset and progression remains unclear. Recent investigations of IFN-\u03bb in IBD are beginning to uncover complex and sometimes opposing actions, including pro-healing roles in colonic epithelial tissues and potentiation of epithelial cell death in the small intestine. Additionally, IFN-\u03bb has been shown to act through non-epithelial cell types, such as neutrophils, to protect against excessive inflammation. In most cases IFN-\u03bb demonstrates an ability to coordinate the host antiviral response without inducing collateral hyperinflammation, suggesting that IFN-\u03bb signaling pathways could be a therapeutic target in IBD. This mini review discusses existing data on the role of IFN-\u03bb in the pathogenesis of inflammatory bowel disease, current gaps in the research, and therapeutic potential of modulating the IFN-\u03bb-stimulated response.<\/jats:p>","DOI":"10.3389\/fimmu.2021.767505","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T13:44:44Z","timestamp":1634132684000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Interferon Lambda in the Pathogenesis of Inflammatory Bowel Diseases"],"prefix":"10.3389","volume":"12","author":[{"given":"Jonathan W.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Constant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy 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