{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:26:49Z","timestamp":1784874409343,"version":"3.55.0"},"reference-count":421,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"Background<\/jats:title>The recent emergence of COVID-19, rapid worldwide spread, and incomplete knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited development of therapeutic strategies. Our objective was to systematically investigate molecular regulatory mechanisms of COVID-19, using a combination of high throughput RNA-sequencing-based transcriptomics and systems biology approaches.<\/jats:p><\/jats:sec>Methods<\/jats:title>RNA-Seq data from peripheral blood mononuclear cells (PBMCs) of healthy persons, mild and severe 17 COVID-19 patients were analyzed to generate a gene expression matrix. Weighted gene co-expression network analysis (WGCNA) was used to identify co-expression modules in healthy samples as a reference set. For differential co-expression network analysis, module preservation and module-trait relationships approaches were used to identify key modules. Then, protein-protein interaction (PPI) networks, based on co-expressed hub genes, were constructed to identify hub genes\/TFs with the highest information transfer (hub-high traffic genes) within candidate modules.<\/jats:p><\/jats:sec>Results<\/jats:title>Based on differential co-expression network analysis, connectivity patterns and network density, 72% (15 of 21) of modules identified in healthy samples were altered by SARS-CoV-2 infection. Therefore, SARS-CoV-2 caused systemic perturbations in host biological gene networks. In functional enrichment analysis, among 15 non-preserved modules and two significant highly-correlated modules (identified by MTRs), 9 modules were directly related to the host immune response and COVID-19 immunopathogenesis. Intriguingly, systemic investigation of SARS-CoV-2 infection identified signaling pathways and key genes\/proteins associated with COVID-19\u2019s main hallmarks, e.g., cytokine storm, respiratory distress syndrome (ARDS), acute lung injury (ALI), lymphopenia, coagulation disorders, thrombosis, and pregnancy complications, as well as comorbidities associated with COVID-19, e.g., asthma, diabetic complications, cardiovascular diseases (CVDs), liver disorders and acute kidney injury (AKI). Topological analysis with betweenness centrality (BC) identified 290 hub-high traffic genes, central in both co-expression and PPI networks. We also identified several transcriptional regulatory factors, including NFKB1<\/jats:italic>, HIF1A<\/jats:italic>, AHR<\/jats:italic>, and TP53<\/jats:italic>, with important immunoregulatory roles in SARS-CoV-2 infection. Moreover, several hub-high traffic genes, including IL6<\/jats:italic>, IL1B<\/jats:italic>, IL10<\/jats:italic>, TNF<\/jats:italic>, SOCS1<\/jats:italic>, SOCS3<\/jats:italic>, ICAM1<\/jats:italic>, PTEN<\/jats:italic>, RHOA<\/jats:italic>, GDI2<\/jats:italic>, SUMO1<\/jats:italic>, CASP1<\/jats:italic>, IRAK3<\/jats:italic>, HSPA5<\/jats:italic>, ADRB2<\/jats:italic>, PRF1<\/jats:italic>, GZMB<\/jats:italic>, OASL<\/jats:italic>, CCL5<\/jats:italic>, HSP90AA1<\/jats:italic>, HSPD1<\/jats:italic>, IFNG<\/jats:italic>, MAPK1<\/jats:italic>, RAB5A<\/jats:italic>, and TNFRSF1A<\/jats:italic> had the highest rates of information transfer in 9 candidate modules and central roles in COVID-19 immunopathogenesis.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>This study provides comprehensive information on molecular mechanisms of SARS-CoV-2-host interactions and identifies several hub-high traffic genes as promising therapeutic targets for the COVID-19 pandemic.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2021.789317","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T07:36:38Z","timestamp":1639553798000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":60,"title":["Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic"],"prefix":"10.3389","volume":"12","author":[{"given":"Aliakbar","family":"Hasankhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl","family":"Bahrami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Sheybani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Aria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Hemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhang","family":"Fatehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Ghaem Maghami Farahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Javanmard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Kastelic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman W.","family":"Barkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical Characteristics of Coronavirus Disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v91i1.9397","article-title":"WHO Declares COVID-19 a Pandemic","volume":"91","author":"Cucinotta","year":"2020","journal-title":"Acta BioMed"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.02.034","article-title":"World Health Organization Declares Global Emergency: A Review of the 2019 Novel Coronavirus (COVID-19)","volume":"76","author":"Sohrabi","year":"2020","journal-title":"Int J Surg"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab120","article-title":"Bioinformatics and Machine Learning Approach Identifies Potential Drug Targets and Pathways in COVID-19","author":"Auwul","year":"2021","journal-title":"Briefings Bioinf"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Descriptive Study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6261","article-title":"Systems Biological Assessment of Immunity to Mild Versus Severe COVID-19 Infection in Humans","volume":"369","author":"Arunachalam","year":"2020","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86002-x","article-title":"Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"7052","DOI":"10.1038\/s41598-021-86002-x","article-title":"Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway","volume":"11","author":"Daamen","year":"2021","journal-title":"Sci Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.12.016","article-title":"Host Transcriptomic Profiling of COVID-19 Patients With Mild, Moderate, and Severe Clinical Outcomes","volume":"19","author":"Jain","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173594","article-title":"Integrative Transcriptomics Analysis of Lung Epithelial Cells and Identification of Repurposable Drug Candidates for COVID-19","volume":"887","author":"Islam","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/v13010082","article-title":"Transcriptomic Analysis of Respiratory Tissue and Cell Line Models to Examine Glycosylation Machinery During SARS-CoV-2 Infection","volume":"13","author":"Oommen","year":"2021","journal-title":"Viruses"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2020.03.24.004655","DOI":"10.1101\/2020.03.24.004655","article-title":"SARS-CoV-2 Launches a Unique Transcriptional Signature From In Vitro, Ex Vivo, and In Vivo Systems","author":"Blanco-Melo","year":"2020","journal-title":"bioRxiv"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102571","article-title":"Transcriptional Landscape of SARS-CoV-2 Infection Dismantles Pathogenic Pathways Activated by the Virus, Proposes Unique Sex-Specific Differences and Predicts Tailored Therapeutic Strategies","volume":"19","author":"Fagone","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.366","article-title":"Transcriptomic Analysis Reveals Novel Mechanisms of SARS-CoV-2 Infection in Human Lung Cells","volume":"8","author":"Yang","year":"2020","journal-title":"Immun Inflamm Dis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.chom.2020.03.021","article-title":"A Dynamic Immune Response Shapes COVID-19 Progression","volume":"27","author":"Ong","year":"2020","journal-title":"Cell Host Microbe"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00722","article-title":"Identification of Gene Modules and Hub Genes Involved in Mastitis Development Using a Systems Biology Approach","volume":"11","author":"Bakhtiarizadeh","year":"2020","journal-title":"Front Genet"},{"key":"B17","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1186\/s12864-020-07068-x","article-title":"Differential Network Analysis of Bovine Muscle Reveals Changes in Gene Coexpression Patterns in Response to Changes in Maternal Nutrition","volume":"21","author":"Liu","year":"2020","journal-title":"BMC Genomics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00477-1","article-title":"Systems Biology in Cardiovascular Disease: A Multiomics Approach","volume":"18","author":"Joshi","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: An R Package for Weighted Correlation Network Analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.12.017","article-title":"Weighted Gene Co-Expression Network Analysis Revealed Host Transcriptional Response to H1N1 Influenza A Virus Infection","volume":"82","author":"Guo","year":"2021","journal-title":"J Infect"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12926","article-title":"Identification Potential Epigenetic Biomarkers of a Human Immunodeficiency Virus\/Tuberculosis Co-Infection Based on Weighted Gene Co-Expression Network Analysis","volume":"65","author":"Xu","year":"2021","journal-title":"Microbiol Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s13721-016-0131-8","article-title":"Gene Co-Expression Network Analysis Reveals Common System-Level Properties of Genes Involved in Tuberculosis Across Independent Gene Expression Studies","volume":"5","author":"Jha","year":"2016","journal-title":"Network Model Anal Health Inf Bioinf"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-021-00357-4","article-title":"Identification of Key Genes in Hepatitis B Associated Hepatocellular Carcinoma Based on WGCNA","volume":"16","author":"Liu","year":"2021","journal-title":"Infect Agents Cancer"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e9687","DOI":"10.1097\/md.0000000000009687","article-title":"Identification of Key Candidate Genes and Pathways in Hepatitis B Virus-Associated Acute Liver Failure by Bioinformatical Analysis","volume":"97","author":"Lin","year":"2018","journal-title":"Medicine"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-017-0273-8","article-title":"Identification of Potential Gene Network Associated With HCV-Related Hepatocellular Carcinoma Using Microarray Analysis","volume":"24","author":"Cheng","year":"2018","journal-title":"Pathol Oncol Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"291","DOI":"10.20411\/pai.v5i1.376","article-title":"The Effects of Anti-Retroviral Therapy on Epigenetic Age Acceleration Observed in HIV-1-Infected Adults","volume":"5","author":"Sehl","year":"2020","journal-title":"Pathog Immun"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S258439","article-title":"Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA","volume":"13","author":"Tian","year":"2020","journal-title":"Onco Targets Ther"},{"key":"B28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s41065-019-0083-y","article-title":"Bladder Cancer Stage-Associated Hub Genes Revealed by WGCNA Co-Expression Network Analysis","volume":"156","author":"Di","year":"2019","journal-title":"Hereditas"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28377","article-title":"A Comprehensive Analysis of WGCNA and Serum Metabolomics Manifests the Lung Cancer-Associated Disordered Glucose Metabolism","volume":"120","author":"Ding","year":"2019","journal-title":"J Cell Biochem"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7412","article-title":"Colon Cancer Recurrence\u2212Associated Genes Revealed by WGCNA Co\u2212Expression Network Analysis","volume":"16","author":"Zhai","year":"2017","journal-title":"Mol Med Rep"},{"key":"B31","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.cels.2020.10.003","article-title":"Large-Scale Multi-Omic Analysis of COVID-19 Severity","volume":"12","author":"Overmyer","year":"2021","journal-title":"Cell Syst"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.716075","article-title":"Transcriptome Analysis of Peripheral Blood Mononuclear Cells Reveals Distinct Immune Response in Asymptomatic and Re-Detectable Positive COVID-19 Patients","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41392-020-00457-4","article-title":"Longitudinal Transcriptome Analyses Show Robust T Cell Immunity During Recovery From COVID-19","volume":"5","author":"Zheng","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1001057","DOI":"10.1371\/journal.pcbi.1001057","article-title":"Is My Network Module Preserved and Reproducible","volume":"7","author":"Langfelder","year":"2011","journal-title":"PloS Comput Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"753839","DOI":"10.1371\/journal.pone.0156006","article-title":"Integrated Network Analysis to Identify Key Modules and Potential Hub Genes Involved in Bovine Respiratory Disease: A Systems Biology Approach","volume":"12","author":"Hasankhani","year":"2021","journal-title":"Front Genet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0156006","DOI":"10.1371\/journal.pone.0156006","article-title":"Gene co-expression network analysis for identifying modules and functionally enriched pathways in type 1 diabetes","volume":"11","author":"Riquelme Medina","year":"2016","journal-title":"PloS One"},{"key":"B37","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s13104-015-1141-9","article-title":"Dysregulated Mechanisms Underlying Duchenne Muscular Dystrophy From Co-Expression Network Preservation Analysis","volume":"8","author":"Mukund","year":"2015","journal-title":"BMC Res Notes"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.668448","article-title":"Integrated Analysis of lncRNAs, mRNAs, and TFs to Identify Regulatory Networks Underlying MAP Infection in Cattle","volume":"12","author":"Heidari","year":"2021","journal-title":"Front Genet"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw139","article-title":"Gene Co-Expression Analysis for Functional Classification and Gene\u2013Disease Predictions","volume":"19","author":"van Dam","year":"2017","journal-title":"Briefings Bioinf"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A Flexible Trimmer for Illumina Sequence Data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-Based Genome Alignment and Genotyping With HISAT2 and HISAT-Genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python Framework to Work With High-Throughput Sequencing Data","volume":"31","author":"Anders","year":"2014","journal-title":"Bioinformatics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"Voom: Precision Weights Unlock Linear Model Analysis Tools for RNA-Seq Read Counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"B44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","article-title":"Limma: Linear Models for Microarray Data","volume-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor","author":"Smyth","year":"2005"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-327","article-title":"Signed Weighted Gene Co-Expression Network Analysis of Transcriptional Regulation in Murine Embryonic Stem Cells","volume":"10","author":"Mason","year":"2009","journal-title":"BMC Genomics"},{"key":"B46","doi-asserted-by":"publisher","first-page":"17","DOI":"10.18637\/jss.v046.i11","article-title":"Fast R Functions for Robust Correlations and Hierarchical Clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J Stat Software"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-328","article-title":"Comparison of Co-Expression Measures: Mutual Information, Correlation, and Model Based Indices","volume":"13","author":"Song","year":"2012","journal-title":"BMC Bioinf"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: Interactive and Collaborative HTML5 Gene List Enrichment Analysis Tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.1038\/s41598-020-61162-4","article-title":"Identification of the Key Genes and Pathways Involved in the Tumorigenesis and Prognosis of Kidney Renal Clear Cell Carcinoma","volume":"10","author":"Cui","year":"2020","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01081","article-title":"Identification of Hub Genes and Key Pathways Associated With Bipolar Disorder Based on Weighted Gene Co-Expression Network Analysis","volume":"10","author":"Liu","year":"2019","journal-title":"Front Physiol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01142","article-title":"Identifying Key Genes and Functionally Enriched Pathways in Sj\u00f6gren\u2019s Syndrome by Weighted Gene Co-Expression Network Analysis","volume":"10","author":"Yao","year":"2019","journal-title":"Front Genet"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701361104","article-title":"The Human Disease Network","volume":"104","author":"Goh","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"B53","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41598-017-18705-z","article-title":"Application of Weighted Gene Co-Expression Network Analysis for Data From Paired Design","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e94868","DOI":"10.1371\/journal.pone.0094868","article-title":"Rat Hepatocytes Weighted Gene Co-Expression Network Analysis Identifies Specific Modules and Hub Genes Related to Liver Regeneration After Partial Hepatectomy","volume":"9","author":"Zhou","year":"2014","journal-title":"PloS One"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131","article-title":"STRING V11: Protein\u2013Protein Association Networks With Increased Coverage, Supporting Functional Discovery in Genome-Wide Experimental Datasets","volume":"47","author":"Szklarczyk","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky822","article-title":"AnimalTFDB 3.0: A Comprehensive Resource for Annotation and Prediction of Animal Transcription Factors","volume":"47","author":"Hu","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.627623","article-title":"Whole-Blood Transcriptome Analysis of Feedlot Cattle With and Without Bovine Respiratory Disease","volume":"12","author":"Jiminez","year":"2021","journal-title":"Front Genet"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12071809","article-title":"Identification of GSN and LAMC2 as Key Prognostic Genes of Bladder Cancer by Integrated Bioinformatics Analysis","volume":"12","author":"Yang","year":"2020","journal-title":"Cancers"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-28","article-title":"Topological Analysis of Protein Co-Abundance Networks Identifies Novel Host Targets Important for HCV Infection and Pathogenesis","volume":"6","author":"McDermott","year":"2012","journal-title":"BMC Syst Biol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e28438","DOI":"10.1371\/journal.pone.0028438","article-title":"Correlation Network Analysis Applied to Complex Biofilm Communities","volume":"6","author":"Duran-Pinedo","year":"2011","journal-title":"PloS One"},{"key":"B61","doi-asserted-by":"publisher","first-page":"3747","DOI":"10.1073\/pnas.0400087101","article-title":"The Architecture of Complex Weighted Networks","volume":"101","author":"Barrat","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8081160","article-title":"Identification of Prognostic Candidate Genes in Breast Cancer by Integrated Bioinformatic Analysis","volume":"8","author":"Wang","year":"2019","journal-title":"J Clin Med"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"Cytohubba: Identifying Hub Objects and Sub-Networks From Complex Interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2212","article-title":"A Travel Guide to Cytoscape Plugins","volume":"9","author":"Saito","year":"2012","journal-title":"Nat Methods"},{"key":"B65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12272-020-01301-7","article-title":"Overview of COVID-19 Inflammatory Pathogenesis From the Therapeutic Perspective","volume":"44","author":"Lee","year":"2021","journal-title":"Arch Pharmacal Res"},{"key":"B66","doi-asserted-by":"publisher","first-page":"eabc8511","DOI":"10.1126\/science.abc8511","article-title":"Deep Immune Profiling of COVID-19 Patients Reveals Distinct Immunotypes With Therapeutic Implications","volume":"369","author":"Mathew","year":"2020","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00281","article-title":"A Perspective on Emerging Therapeutic Interventions for COVID-19","volume":"8","author":"Torequl Islam","year":"2020","journal-title":"Front Public Health"},{"key":"B68","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s40495-020-00216-7","article-title":"An Update on Current Therapeutic Drugs Treating COVID-19","volume":"6","author":"Wu","year":"2020","journal-title":"Curr Pharmacol Rep"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.05.044","article-title":"COVID-19: Transmission, Prevention, and Potential Therapeutic Opportunities","volume":"508","author":"Lotfi","year":"2020","journal-title":"Clinica Chimica Acta"},{"key":"B70","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bbi.2020.04.046","article-title":"Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis","volume":"87","author":"Zhang","year":"2020","journal-title":"Brain Behavior Immun"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-Like Receptors and the Control of Immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001115R","article-title":"Genetic Gateways to COVID-19 Infection: Implications for Risk, Severity, and Outcomes","volume":"34","author":"Debnath","year":"2020","journal-title":"FASEB J"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26826","article-title":"Role of Toll-Like Receptors in the Pathogenesis of COVID-19","volume":"93","author":"Khanmohammadi","year":"2021","journal-title":"J Med Virol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26387","article-title":"Targeting Human TLRs to Combat COVID-19: A Solution","volume":"93","author":"Patra","year":"2021","journal-title":"J Med Virol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2020.09.002","article-title":"Is Toll-Like Receptor 4 Involved in the Severity of COVID-19 Pathology in Patients With Cardiometabolic Comorbidities","volume":"58","author":"Brand\u00e3o","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.23812\/conti-e","article-title":"Induction of Pro-Inflammatory Cytokines (IL-1 and IL-6) and Lung Inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): Anti-Inflammatory Strategies","volume":"34","author":"Conti","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"key":"B77","doi-asserted-by":"publisher","first-page":"e12771","DOI":"10.1111\/sji.12771","article-title":"Toll-Like Receptor Polymorphism in Host Immune Response to Infectious Diseases: A Review","volume":"90","author":"Mukherjee","year":"2019","journal-title":"Scand J Immunol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1016\/j.immuni.2021.05.006","article-title":"SARS-CoV-2 Exacerbates Proinflammatory Responses in Myeloid Cells Through C-Type Lectin Receptors and Tweety Family Member 2","volume":"54","author":"Lu","year":"2021","journal-title":"Immunity"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz483","article-title":"Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages","volume":"221","author":"Zhao","year":"2019","journal-title":"J Infect Dis"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102293","article-title":"ORF8 Contributes to Cytokine Storm During SARS-CoV-2 Infection by Activating IL-17 Pathway","volume":"24","author":"Lin","year":"2021","journal-title":"iScience"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0311-8","article-title":"The Trinity of COVID-19: Immunity, Inflammation and Intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102537","article-title":"The Role of Cytokines Including Interleukin-6 in COVID-19 Induced Pneumonia and Macrophage Activation Syndrome-Like Disease","volume":"19","author":"McGonagle","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B83","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10787-020-00773-9","article-title":"The Role and Therapeutic Potential of NF-Kappa-B Pathway in Severe COVID-19 Patients","volume":"29","author":"Hariharan","year":"2021","journal-title":"Inflammopharmacology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cytogfr.2020.04.002","article-title":"Cytokine Storm Intervention in the Early Stages of COVID-19 Pneumonia","volume":"53","author":"Sun","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.598444","article-title":"NF-\u03bab Pathway as a Potential Target for Treatment of Critical Stage COVID-19 Patients","volume":"11","author":"Kircheis","year":"2020","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.648250","article-title":"A Computational Approach Identified Andrographolide as a Potential Drug for Suppressing COVID-19-Induced Cytokine Storm","volume":"12","author":"Rehan","year":"2021","journal-title":"Front Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590459","article-title":"A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection","volume":"11","author":"Ahmed","year":"2020","journal-title":"Front Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202437","article-title":"TNF-Induced Death Signaling Triggers Alveolar Epithelial Dysfunction in Acute Lung Injury","volume":"190","author":"Patel","year":"2013","journal-title":"J Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"609","DOI":"10.12688\/f1000research.23996.2","article-title":"Prediction of Repurposed Drugs for Treating Lung Injury in COVID-19","volume":"9","author":"He","year":"2020","journal-title":"F1000Research"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26505","article-title":"Apoptosis and Immunophenotyping of Peripheral Blood Lymphocytes in Iranian COVID-19 Patients: Clinical and Laboratory Characteristics","volume":"93","author":"Taghiloo","year":"2021","journal-title":"J Med Virol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv380","article-title":"Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways","volume":"213","author":"Chu","year":"2016","journal-title":"J Infect Dis"},{"key":"B92","doi-asserted-by":"publisher","first-page":"20533","DOI":"10.1038\/s41598-020-77525-w","article-title":"Longitudinal Proteomic Profiling Reveals Increased Early Inflammation and Sustained Apoptosis Proteins in Severe COVID-19","volume":"10","author":"Haljasm\u00e4gi","year":"2020","journal-title":"Sci Rep"},{"key":"B93","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26742","article-title":"Apoptosis-Induced T-Cell Lymphopenia is Related to COVID-19 Severity","volume":"93","author":"Cizmecioglu","year":"2021","journal-title":"J Med Virol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108863","article-title":"Metabolic Programs Define Dysfunctional Immune Responses in Severe COVID-19 Patients","volume":"34","author":"Thompson","year":"2021","journal-title":"Cell Rep"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00827","article-title":"Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)","volume":"11","author":"Diao","year":"2020","journal-title":"Front Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1747363","article-title":"Transcriptomic Characteristics of Bronchoalveolar Lavage Fluid and Peripheral Blood Mononuclear Cells in COVID-19 Patients","volume":"9","author":"Xiong","year":"2020","journal-title":"Emerging Microbes Infect"},{"key":"B98","doi-asserted-by":"publisher","first-page":"11886","DOI":"10.1038\/s41598-021-91417-7","article-title":"Regulation of the Acetylcholine\/\u03b17nachr Anti-Inflammatory Pathway in COVID-19 Patients","volume":"11","author":"Courties","year":"2021","journal-title":"Sci Rep"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01446","article-title":"The COVID-19 Cytokine Storm; What We Know So Far","volume":"11","author":"Ragab","year":"2020","journal-title":"Front Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological Inflammation in Patients With COVID-19: A Key Role for Monocytes and Macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: Immunopathology and its Implications for Therapy","volume":"20","author":"Cao","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin Infect Dis"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00299","article-title":"Leucocyte Subsets Effectively Predict the Clinical Outcome of Patients With COVID-19 Pneumonia: A Retrospective Case-Control Study","volume":"8","author":"Gan","year":"2020","journal-title":"Front Public Health"},{"key":"B104","doi-asserted-by":"publisher","first-page":"20834","DOI":"10.1038\/s41598-020-77641-7","article-title":"Clinical Characteristics and Predictors of Mortality Associated With COVID-19 in Elderly Patients From a Long-Term Care Facility","volume":"10","author":"Trecarichi","year":"2020","journal-title":"Sci Rep"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103378","article-title":"Clinical Features and Prognostic Factors in Covid-19: A Prospective Cohort Study","volume":"67","author":"de Bruin","year":"2021","journal-title":"EBioMedicine"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106995","article-title":"Correlation Between Premorbid IL-6 Levels and COVID-19 Mortality: Potential Role for Vitamin D","volume":"88","author":"Silberstein","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1186\/s12890-020-01343-z","article-title":"Broncho-Alveolar Inflammation in COVID-19 Patients: A Correlation With Clinical Outcome","volume":"20","author":"Pandolfi","year":"2020","journal-title":"BMC Pulm Med"},{"key":"B108","doi-asserted-by":"publisher","first-page":"6357","DOI":"10.1038\/s41598-021-85877-0","article-title":"Proteomic Blood Profiling in Mild, Severe and Critical COVID-19 Patients","volume":"11","author":"Patel","year":"2021","journal-title":"Sci Rep"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.581469","article-title":"Risk Factors for Mortality of COVID-19 Patient Based on Clinical Course: A Single Center Retrospective Case-Control Study","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"e23582","DOI":"10.1097\/md.0000000000023582","article-title":"Anti-IL6 Treatment of Serious COVID-19 Disease: A Monocentric Retrospective Experience","volume":"100","author":"Castelnovo","year":"2021","journal-title":"Medicine"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.615972","article-title":"Current Evidence of Interleukin-6 Signaling Inhibitors in Patients With COVID-19: A Systematic Review and Meta-Analysis","volume":"11","author":"Han","year":"2020","journal-title":"Front Pharmacol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.598799","article-title":"Upregulated IL-6 Indicates a Poor COVID-19 Prognosis: A Call for Tocilizumab and Convalescent Plasma Treatment","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081583","article-title":"Tocilizumab Improves the Prognosis of COVID-19 in Patients With High IL-6","volume":"10","author":"Flisiak","year":"2021","journal-title":"J Clin Med"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106560","article-title":"Towards Treatment Planning of COVID-19: Rationale and Hypothesis for the Use of Multiple Immunosuppressive Agents: Anti-Antibodies, Immunoglobulins, and Corticosteroids","volume":"84","author":"Saghazadeh","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.07.008","article-title":"Safety and Efficacy of Anti-Il6-Receptor Tocilizumab Use in Severe and Critical Patients Affected by Coronavirus Disease 2019: A Comparative Analysis","volume":"81","author":"Rossotti","year":"2020","journal-title":"J Infect"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1051-9","article-title":"An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival","volume":"26","author":"Del Valle","year":"2020","journal-title":"Nat Med"},{"key":"B117","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.medj.2020.11.005","article-title":"The Potential for Repurposing Anti-TNF as a Therapy for the Treatment of COVID-19","volume":"1","author":"Robinson","year":"2020","journal-title":"Med"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3146-4","article-title":"Effect of Anti-Tumor Necrosis Factor Alpha Treatment of Rheumatoid Arthritis and Chronic Kidney Disease","volume":"35","author":"Kim","year":"2015","journal-title":"Rheumatol Int"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2391::AID-ANR3>3.0.CO;2-F","article-title":"Systemic Anti\u2013Tumor Necrosis Factor \u03b1 Therapy in Rheumatoid Arthritis Down-Regulates Synovial Tumor Necrosis Factor \u03b1 Synthesis","volume":"43","author":"Ulfgren","year":"2000","journal-title":"Arthritis Rheumatism"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.4.443","article-title":"Tumour Necrosis Factor and Crohn's Disease","volume":"40","author":"Van Deventer","year":"1997","journal-title":"Gut"},{"key":"B121","doi-asserted-by":"publisher","first-page":"R326","DOI":"10.1186\/ar1182","article-title":"Deactivation of Endothelium and Reduction in Angiogenesis in Psoriatic Skin and Synovium by Low Dose Infliximab Therapy in Combination With Stable Methotrexate Therapy: A Prospective Single-Centre Study","volume":"6","author":"Goedkoop","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12382","article-title":"Anti-TNF-\u03b1 Therapy for Patients With Sepsis: A Systematic Meta-Analysis","volume":"68","author":"Lv","year":"2014","journal-title":"Int J Clin Pract"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1258::AID-ART17>3.0.CO;2-1","article-title":"Modulation of Angiogenic Vascular Endothelial Growth Factor by Tumor Necrosis Factor \u03b1 and Interleukin-1 in Rheumatoid Arthritis","volume":"41","author":"Paleolog","year":"1998","journal-title":"Arthritis Rheumatism"},{"key":"B124","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/1529-0131(200001)43:1<38::AID-ANR6>3.0.CO;2-L","article-title":"Reduction of Chemokine Levels and Leukocyte Traffic to Joints by Tumor Necrosis Factor \u03b1 Blockade in Patients With Rheumatoid Arthritis","volume":"43","author":"Taylor","year":"2000","journal-title":"Arthritis Rheumatism"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.8.723","article-title":"Anti-Tumour Necrosis Factor (TNF) \u03b1 Treatment of Rheumatoid Arthritis (Infliximab) Selectively Down Regulates the Production of Interleukin (IL) 18 But Not of IL12 and IL13","volume":"61","author":"Pittoni","year":"2002","journal-title":"Ann Rheumatic Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390702","article-title":"Decrease in Cellularity and Expression of Adhesion Molecules by Anti\u2013Tumor Necrosis Factor \u03b1 Monoclonal Antibody Treatment in Patients With Rheumatoid Arthritis","volume":"39","author":"Tak","year":"1996","journal-title":"Arthritis Rheumatism"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh178","article-title":"Long-Term Treatment With Etanercept Significantly Reduces the Number of Proinflammatory Cytokine-Secreting Peripheral Blood Mononuclear Cells in Patients With Rheumatoid Arthritis","volume":"43","author":"Schotte","year":"2004","journal-title":"Rheumatology"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30858-8","article-title":"Trials of Anti-Tumour Necrosis Factor Therapy for COVID-19 are Urgently Needed","volume":"395","author":"Feldmann","year":"2020","journal-title":"Lancet"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30309-X","article-title":"Accumulating Evidence Suggests Anti-TNF Therapy Needs to be Given Trial Priority in COVID-19 Treatment","volume":"2","author":"Robinson","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03bab Signaling in Inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13627","article-title":"NFKB1: A Suppressor of Inflammation, Ageing and Cancer","volume":"283","author":"Cartwright","year":"2016","journal-title":"FEBS J"},{"key":"B132","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/s41392-021-00709-x","article-title":"Multimodal Single-Cell Omics Analysis Identifies Epithelium\u2013Immune Cell Interactions and Immune Vulnerability Associated With Sex Differences in COVID-19","volume":"6","author":"Hou","year":"2021","journal-title":"Signal Transduction Targeted Ther"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00455-9","article-title":"Discriminating Mild From Critical COVID-19 by Innate and Adaptive Immune Single-Cell Profiling of Bronchoalveolar Lavages","volume":"31","author":"Wauters","year":"2021","journal-title":"Cell Res"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-021-00681-2","article-title":"Single-Cell RNA Sequencing of Blood Antigen-Presenting Cells in Severe COVID-19 Reveals Multi-Process Defects in Antiviral Immunity","volume":"23","author":"Saichi","year":"2021","journal-title":"Nat Cell Biol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.104126","article-title":"Determining Crucial Genes Associated With COVID-19 Based on COPD Findings\u2736,\u2736\u2736","volume":"128","author":"Sharma","year":"2021","journal-title":"Comput Biol Med"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.590870","article-title":"The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link to Inflammation","volume":"11","author":"Meydan","year":"2020","journal-title":"Front Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108071","article-title":"Prediction and Analysis of microRNAs Involved in COVID-19 Inflammatory Processes Associated With the NF-kB and JAK\/STAT Signaling Pathways","volume":"100","author":"Amini-Farsani","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000004315","article-title":"Mesenchymal Stem Cell\u2013Derived Extracellular Vesicles Alleviate Acute Lung Injury via Transfer of miR-27a-3p*","volume":"48","author":"Wang","year":"2020","journal-title":"Crit Care Med"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9050556","article-title":"Predicting COVID-19\u2014Comorbidity Pathway Crosstalk-Based Targets and Drugs: Towards Personalized COVID-19 Management","volume":"9","author":"Barh","year":"2021","journal-title":"Biomedicines"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111437","article-title":"Fluoxetine as an Anti-Inflammatory Therapy in SARS-CoV-2 Infection","volume":"138","author":"Creeden","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.3390\/v12070776","article-title":"Tiotropium is Predicted to be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway Analysis","volume":"12","author":"Kang","year":"2020","journal-title":"Viruses"},{"key":"B142","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12950-020-00263-3","article-title":"Hypoxia: A Key Feature of COVID-19 Launching Activation of HIF-1 and Cytokine Storm","volume":"17","author":"Jahani","year":"2020","journal-title":"J\u00a0Inflamm"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111354","article-title":"Improved Motor Nerve Regeneration by SIRT1\/Hif1a-Mediated Autophagy","volume":"8","author":"Romeo-Guitart","year":"2019","journal-title":"Cells"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2020.100317","article-title":"Hypoxia-Inducible Factor (HIF): The Link Between Obesity and COVID-19","volume":"22","author":"AbdelMassih","year":"2021","journal-title":"Obes Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.673485","article-title":"Therapeutic Targeting of Transcription Factors to Control the Cytokine Release Syndrome in COVID-19","volume":"12","author":"Santoso","year":"2021","journal-title":"Front Pharmacol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-021-00181-x","article-title":"Comparative Transcriptome Analysis Reveals Key Epigenetic Targets in SARS-CoV-2 Infection","volume":"7","author":"Salgado-Albarr\u00e1n","year":"2021","journal-title":"NPJ Syst Biol Appl"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101611","article-title":"Ppar\u03b3 Cistrome Repression During Activation of Lung Monocyte-Macrophages in Severe COVID-19","volume":"23","author":"Desterke","year":"2020","journal-title":"iScience"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2021.08.007","article-title":"Drug Repurposing for COVID-19 Using Computational Screening: Is Fostamatinib\/R406 a Potential Candidate","author":"Saha","year":"2021","journal-title":"Methods"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11070681","article-title":"Evaluation of Cytokines as Robust Diagnostic Biomarkers for COVID-19 Detection","volume":"11","author":"Tamayo-Velasco","year":"2021","journal-title":"J Pers Med"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.650465","article-title":"Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics","volume":"12","author":"Laudanski","year":"2021","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.545089","article-title":"Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19","volume":"8","author":"Stolfi","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa173","article-title":"Pathogenetic Profiling of COVID-19 and SARS-Like Viruses","volume":"22","author":"Nain","year":"2020","journal-title":"Briefings Bioinf"},{"key":"B153","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12964-021-00754-7","article-title":"Single-Cell Analysis Reveals Cell Communication Triggered by Macrophages Associated With the Reduction and Exhaustion of CD8+ T Cells in COVID-19","volume":"19","author":"He","year":"2021","journal-title":"Cell Commun Signaling"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.677008","article-title":"Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action","volume":"12","author":"Islam","year":"2021","journal-title":"Front Immunol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1002\/ctm2.200","article-title":"The Noncoding and Coding Transcriptional Landscape of the Peripheral Immune Response in Patients With COVID-19","volume":"10","author":"Tang","year":"2020","journal-title":"Clin Trans Med"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.582102","article-title":"SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19","volume":"11","author":"Johnson","year":"2020","journal-title":"Front Immunol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijid.2021.02.019","article-title":"The Unbalanced P53\/SIRT1 Axis may Impact Lymphocyte Homeostasis in COVID-19 Patients","volume":"105","author":"Bordoni","year":"2021","journal-title":"Int J Infect Dis"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110917","article-title":"Irisin Modulates Genes Associated With Severe Coronavirus Disease (COVID-19) Outcome in Human Subcutaneous Adipocytes Cell Culture","volume":"515","author":"de Oliveira","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"B159","doi-asserted-by":"publisher","first-page":"eabh2624","DOI":"10.1126\/scitranslmed.abh2624","article-title":"Type I Interferon Autoantibodies are Associated With Systemic Immune Alterations in Patients With COVID-19","author":"Wijst","year":"2021","journal-title":"Sci Trans Med"},{"key":"B160","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/j.cmet.2021.05.013","article-title":"SARS-CoV-2 Infects Human Pancreatic \u03b2 Cells and Elicits \u03b2 Cell Impairment","volume":"33","author":"Wu","year":"2021","journal-title":"Cell Metab"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.07.004","article-title":"SARS-CoV-2 and Pancreas: A Potential Pathological Interaction","volume":"32","author":"Geravandi","year":"2021","journal-title":"Trends Endocrinol Metab"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.595150","article-title":"Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients","volume":"12","author":"Hammoudeh","year":"2021","journal-title":"Front Immunol"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001325","article-title":"Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients","volume":"206","author":"Yan","year":"2021","journal-title":"J Immunol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.224","article-title":"Dysbalance of ACE2 Levels \u2013 a Possible Cause for Severe COVID-19 Outcome in COPD","volume":"7","author":"Flie\u00dfer","year":"2021","journal-title":"J Pathol: Clin Res"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01095","article-title":"Pathological Aspects of COVID-19 as a Conformational Disease and the Use of Pharmacological Chaperones as a Potential Therapeutic Strategy","volume":"11","author":"Aoe","year":"2020","journal-title":"Front Pharmacol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12967-020-02695-0","article-title":"Transcriptome of Nasopharyngeal Samples From COVID-19 Patients and a Comparative Analysis With Other SARS-CoV-2 Infection Models Reveal Disparate Host Responses Against SARS-CoV-2","volume":"19","author":"Islam","year":"2021","journal-title":"J Trans Med"},{"key":"B167","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1038\/s41467-020-17834-w","article-title":"Single-Cell Analysis of Two Severe COVID-19 Patients Reveals a Monocyte-Associated and Tocilizumab-Responding Cytokine Storm","volume":"11","author":"Guo","year":"2020","journal-title":"Nat Commun"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa349","article-title":"Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients","volume":"222","author":"Tong","year":"2020","journal-title":"J Infect Dis"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.631206","article-title":"Glycyrrhizic Acid for COVID-19: Findings of Targeting Pivotal Inflammatory Pathways Triggered by SARS-CoV-2","volume":"12","author":"Zheng","year":"2021","journal-title":"Front Pharmacol"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2020.1826510","article-title":"Chemical Composition and Pharmacological Mechanism of Shenfu Decoction in the Treatment of Novel Coronavirus Pneumonia (COVID-19)","volume":"46","author":"Li","year":"2020","journal-title":"Drug Dev Ind Pharm"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092239","article-title":"NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease","volume":"4","author":"Chen","year":"2009","journal-title":"Annu Rev Pathol: Mech Dis"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.104123","article-title":"Comparative Transcriptome Analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to Identify Potential Pathways for Drug Repurposing","volume":"128","author":"Krishnamoorthy","year":"2021","journal-title":"Comput Biol Med"},{"key":"B173","doi-asserted-by":"publisher","first-page":"e13024","DOI":"10.1111\/cpr.13024","article-title":"Bioinformatic Analyses Hinted at Augmented T Helper 17 Cell Differentiation and Cytokine Response as the Central Mechanism of COVID-19\u2013Associated Guillain-Barr\u00e9 Syndrome","volume":"54","author":"Li","year":"2021","journal-title":"Cell Proliferation"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01518","article-title":"Targeting the NLRP3 Inflammasome in Severe COVID-19","volume":"11","author":"Freeman","year":"2020","journal-title":"Front Immunol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105051","article-title":"Targeting Inflammation and Cytokine Storm in COVID-19","volume":"159","author":"Huang","year":"2020","journal-title":"Pharmacol Res"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.584057","article-title":"Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19","volume":"11","author":"Liu","year":"2020","journal-title":"Front Pharmacol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41418-018-0172-x","article-title":"Necroptosis in Anti-Viral Inflammation","volume":"26","author":"Nailwal","year":"2019","journal-title":"Cell Death Differ"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2019.4244","article-title":"RIP1\/RIP3-Regulated Necroptosis as a Target for Multifaceted Disease Therapy (Review)","volume":"44","author":"Liu","year":"2019","journal-title":"Int J Mol Med"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00762-0","article-title":"FNDC4 and FNDC5 Reduce SARS-CoV-2 Entry Points and Spike Glycoprotein S1-Induced Pyroptosis, Apoptosis, and Necroptosis in Human Adipocytes","volume":"18","author":"Fr\u00fchbeck","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B180","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"B181","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41392-020-00334-0","article-title":"SARS-CoV-2 Triggers Inflammatory Responses and Cell Death Through Caspase-8 Activation","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduction Targeted Ther"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319117","article-title":"SARS-CoV-2 Initiates Programmed Cell Death in Platelets","volume":"129","author":"Koupenova","year":"2021","journal-title":"Circ Res"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105297","article-title":"Necrostatin-1 and Necroptosis Inhibition: Pathophysiology and Therapeutic Implications","volume":"163","author":"Cao","year":"2021","journal-title":"Pharmacol Res"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.01.007","article-title":"Human T Cell Development, Localization, and Function Throughout Life","volume":"48","author":"Kumar","year":"2018","journal-title":"Immunity"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149298","article-title":"Maturation Signatures of Conventional Dendritic Cell Subtypes in COVID-19 Suggest Direct Viral Sensing","author":"Marongiu","year":"2021","journal-title":"Eur J Immunol"},{"key":"B186","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41392-020-0148-4","article-title":"Lymphopenia Predicts Disease Severity of COVID-19: A Descriptive and Predictive Study","volume":"5","author":"Tan","year":"2020","journal-title":"Signal Transduction Targeted Ther"},{"key":"B187","doi-asserted-by":"publisher","first-page":"e20200678","DOI":"10.1084\/jem.20200678","article-title":"The Many Faces of the Anti-COVID Immune responseA Review of the Anti-COVID Immune Response","volume":"217","author":"Vardhana","year":"2020","journal-title":"J Exp Med"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0402-2","article-title":"Functional Exhaustion of Antiviral Lymphocytes in COVID-19 Patients","volume":"17","author":"Zheng","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa141","article-title":"Integrative Pharmacological Mechanism of Vitamin C Combined With Glycyrrhizic Acid Against COVID-19: Findings of Bioinformatics Analyses","volume":"22","author":"Li","year":"2020","journal-title":"Briefings Bioinf"},{"key":"B190","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/imm.13262","article-title":"T-Cell Responses and Therapies Against SARS-CoV-2 Infection","volume":"162","author":"Toor","year":"2021","journal-title":"Immunology"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2018030117","article-title":"Transcriptional and Proteomic Insights Into the Host Response in Fatal COVID-19 Cases","volume":"117","author":"Wu","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02063","article-title":"Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19","volume":"11","author":"Wang","year":"2020","journal-title":"Front Immunol"},{"key":"B193","doi-asserted-by":"publisher","first-page":"e20201012","DOI":"10.1084\/jem.20201012","article-title":"Neutrophil Extracellular Traps Infiltrate the Lung Airway, Interstitial, and Vascular Compartments in Severe COVID-19","volume":"217","author":"Radermecker","year":"2020","journal-title":"J Exp Med"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201129","article-title":"SARS-CoV-2\u2013Triggered Neutrophil Extracellular Traps Mediate COVID-19 Pathology","volume":"217","author":"Veras","year":"2020","journal-title":"J Exp Med"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102925","article-title":"Vascular Occlusion by Neutrophil Extracellular Traps in COVID-19","volume":"58","author":"Leppkes","year":"2020","journal-title":"EBioMedicine"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02324-z","article-title":"Neutrophil Extracellular Traps and Thrombosis in COVID-19","volume":"51","author":"Zuo","year":"2021","journal-title":"J Thromb Thrombolysis"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007008","article-title":"Neutrophil Extracellular Traps Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome","volume":"136","author":"Middleton","year":"2020","journal-title":"Blood"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3704","article-title":"Mitochondria are the Powerhouses of Immunity","volume":"18","author":"Mills","year":"2017","journal-title":"Nat Immunol"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1177\/1073858420960443","article-title":"The COVID-19 Effect on the Immune System and Mitochondrial Dynamics in Diabetes, Obesity, and Dementia","volume":"27","author":"Holder","year":"2021","journal-title":"Neuroscientist"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.614650","article-title":"Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases","volume":"12","author":"Ganji","year":"2021","journal-title":"Front Aging Neurosci"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00224.2020","article-title":"Decoding SARS-CoV-2 Hijacking of Host Mitochondria in COVID-19 Pathogenesis","volume":"319","author":"Singh","year":"2020","journal-title":"Am J Physiol-Cell Physiol"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1937144","article-title":"Of Mitochondrion and COVID-19","volume":"36","author":"Alfarouk","year":"2021","journal-title":"J Enzyme Inhib Med Chem"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.110161","article-title":"Mitochondrial-Targeted Ubiquinone: A Potential Treatment for COVID-19","volume":"144","author":"Ouyang","year":"2020","journal-title":"Med Hypotheses"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive Oxygen Species in Inflammation and Tissue Injury","volume":"20","author":"Mittal","year":"2013","journal-title":"Antioxid Redox Signaling"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.04.014","article-title":"Reactive Oxygen Species (ROS) Induced Cytokine Production and Cytotoxicity of PAMAM Dendrimers in J774A.1 Cells","volume":"246","author":"Naha","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mito.2020.06.008","article-title":"Mitochondria and Microbiota Dysfunction in COVID-19 Pathogenesis","volume":"54","author":"Saleh","year":"2020","journal-title":"Mitochondrion"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.598925","article-title":"In Silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19","volume":"12","author":"L\u00f3pez-Cort\u00e9s","year":"2021","journal-title":"Front Pharmacol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.10.027","article-title":"Potential SARS-CoV-2 Interactions With Proteins Involved in Trophoblast Functions \u2013 An in-Silico Study","volume":"103","author":"Seethy","year":"2021","journal-title":"Placenta"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2021.104921","article-title":"Analyzing Host-Viral Interactome of SARS-CoV-2 for Identifying Vulnerable Host Proteins During COVID-19 Pathogenesis","volume":"93","author":"Das","year":"2021","journal-title":"Infect Genet Evol"},{"key":"B210","doi-asserted-by":"publisher","first-page":"19395","DOI":"10.1038\/s41598-020-76404-8","article-title":"Lung Transcriptome of a COVID-19 Patient and Systems Biology Predictions Suggest Impaired Surfactant Production Which may be Druggable by Surfactant Therapy","volume":"10","author":"Islam","year":"2020","journal-title":"Sci Rep"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109055","article-title":"SARS-CoV-2 Infection of Primary Human Lung Epithelium for COVID-19 Modeling and Drug Discovery","volume":"35","author":"Mulay","year":"2021","journal-title":"Cell Rep"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26824","article-title":"A Parsimonious Approach for Recognizing SARS-CoV-2 and Host Interactions","volume":"93","author":"Ganguly","year":"2021","journal-title":"J Med Virol"},{"key":"B213","doi-asserted-by":"publisher","first-page":"5152","DOI":"10.1038\/s41467-021-25040-5","article-title":"Tracheal Aspirate RNA Sequencing Identifies Distinct Immunological Features of COVID-19 ARDS","volume":"12","author":"Sarma","year":"2021","journal-title":"Nat Commun"},{"key":"B214","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1038\/s41467-021-21213-4","article-title":"A Genome-Wide CRISPR Screen Identifies Host Factors That Regulate SARS-CoV-2 Entry","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat Commun"},{"key":"B215","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cell.2020.10.030","article-title":"Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells","volume":"184","author":"Daniloski","year":"2021","journal-title":"Cell"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.653110","article-title":"Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 may Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism","volume":"12","author":"Shao","year":"2021","journal-title":"Front Immunol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202100002","article-title":"Proteomic and Metabolomic Investigation of Serum Lactate Dehydrogenase Elevation in COVID-19 Patients","volume":"21","author":"Yan","year":"2021","journal-title":"Proteomics"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.06.018","article-title":"Upregulation of Oxidative Stress Gene Markers During SARS-COV-2 Viral Infection","volume":"172","author":"Saheb Sharif-Askari","year":"2021","journal-title":"Free Radical Biol Med"},{"key":"B219","doi-asserted-by":"publisher","first-page":"e0255335","DOI":"10.1371\/journal.pone.0255335","article-title":"Impaired Immune Response Mediated by Prostaglandin E2 Promotes Severe COVID-19 Disease","volume":"16","author":"Ricke-Hoch","year":"2021","journal-title":"PloS One"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15206","article-title":"Non-Steroidal Anti-Inflammatory Drugs, Prostaglandins, and COVID-19","volume":"177","author":"Robb","year":"2020","journal-title":"Br J Pharmacol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-020-00895-4","article-title":"Neurological Manifestations of COVID-19: Available Evidences and a New Paradigm","volume":"26","author":"Khatoon","year":"2020","journal-title":"J NeuroVirol"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104808","article-title":"Plausibility of Therapeutic Effects of Rho Kinase Inhibitors Against Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19)","volume":"156","author":"Abedi","year":"2020","journal-title":"Pharmacol Res"},{"key":"B223","doi-asserted-by":"publisher","first-page":"20848","DOI":"10.1038\/s41598-020-77632-8","article-title":"Investigation of COVID-19 Comorbidities Reveals Genes and Pathways Coincident With the SARS-CoV-2 Viral Disease","volume":"10","author":"Dolan","year":"2020","journal-title":"Sci Rep"},{"key":"B224","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cell.2020.12.006","article-title":"Genome-Scale Identification of SARS-CoV-2 and Pan-Coronavirus Host Factor Networks","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102823","article-title":"Multi-Omics Analysis of Respiratory Specimen Characterizes Baseline Molecular Determinants Associated With SARS-CoV-2 Outcome","volume":"24","author":"Maras","year":"2021","journal-title":"iScience"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.582399","article-title":"Molecular Basis of Cardiac and Vascular Injuries Associated With COVID-19","volume":"7","author":"Hachim","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1093\/immadv\/ltab013","article-title":"Targeting Immunometabolism to Treat COVID-19","volume":"1","author":"O\u2019Carroll","year":"2021","journal-title":"Immunother Adv"},{"key":"B228","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41421-020-00231-4","article-title":"Initial Whole-Genome Sequencing and Analysis of the Host Genetic Contribution to COVID-19 Severity and Susceptibility","volume":"6","author":"Wang","year":"2020","journal-title":"Cell Discov"},{"key":"B229","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/07391102.2021.1874532","article-title":"Structural Similarity-Based Prediction of Host Factors Associated With SARS-CoV-2 Infection and Pathogenesis","volume":"28","author":"Tiwari","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjaa033","article-title":"Proteome-Wide Data Analysis Reveals Tissue-Specific Network Associated With SARS-CoV-2 Infection","volume":"12","author":"Feng","year":"2020","journal-title":"J Mol Cell Biol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.12688\/f1000research.27287.2","article-title":"'The Long Tail of Covid-19' - The Detection of a Prolonged Inflammatory Response After a SARS-CoV-2 Infection in Asymptomatic and Mildly Affected Patients","volume":"9","author":"Doykov","year":"2021","journal-title":"F1000Research"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab003","article-title":"Diseasome and Comorbidities Complexities of SARS-CoV-2 Infection With Common Malignant Diseases","volume":"22","author":"Satu","year":"2021","journal-title":"Briefings Bioinf"},{"key":"B233","doi-asserted-by":"publisher","first-page":"e885","DOI":"10.1097\/pr9.0000000000000885","article-title":"Neurobiology of SARS-CoV-2 Interactions With the Peripheral Nervous System: Implications for COVID-19 and Pain","volume":"6","author":"McFarland","year":"2021","journal-title":"Pain Rep"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc6027","article-title":"Impaired Type I Interferon Activity and Inflammatory Responses in Severe COVID-19 Patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"key":"B235","doi-asserted-by":"publisher","first-page":"e20201707","DOI":"10.1084\/jem.20201707","article-title":"Inflammasomes are Activated in Response to SARS-CoV-2 Infection and are Associated With COVID-19 Severity in Patients","volume":"218","author":"Rodrigues","year":"2020","journal-title":"J Exp Med"},{"key":"B236","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41419-021-04012-z","article-title":"RBM15-Mediated N6-Methyladenosine Modification Affects COVID-19 Severity by Regulating the Expression of Multitarget Genes","volume":"12","author":"Meng","year":"2021","journal-title":"Cell Death Dis"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.06.009","article-title":"Innate Immune Response Analysis in COVID-19 and Kawasaki Disease Reveals MIS-C Predictors","author":"Yang","year":"2021","journal-title":"J Formosan Med Assoc"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4COVHR0221-093RR","article-title":"Inflammasome Regulation in Driving COVID-19 Severity in Humans and Immune Tolerance in Bats","author":"Nagaraja","year":"2021","journal-title":"J Leukocyte Biol"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102567","article-title":"Should We Stimulate or Suppress Immune Responses in COVID-19? Cytokine and Anti-Cytokine Interventions","volume":"19","author":"Jamilloux","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.040","article-title":"Active Caspase-1 is a Regulator of Unconventional Protein Secretion","volume":"132","author":"Keller","year":"2008","journal-title":"Cell"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05190-5","article-title":"Cytokine Storm in COVID-19: Pathogenesis and Overview of Anti-Inflammatory Agents Used in Treatment","volume":"39","author":"Soy","year":"2020","journal-title":"Clin Rheumatol"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by Inflammatory Caspases Determines Pyroptotic Cell Death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2021-0101","article-title":"NLRP3 Inflammasome Activation and Oxidative Stress Status in the Mild and Moderate SARS-CoV-2 Infected Patients: Impact of Melatonin as a Medicinal Supplement","author":"Ghaleh","year":"2021","journal-title":"Z f\u00fcr Naturforsch C"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106232","article-title":"Endocrine Disrupting Chemicals and COVID-19 Relationships: A Computational Systems Biology Approach","volume":"157","author":"Wu","year":"2021","journal-title":"Environ Int"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.646701","article-title":"Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis","volume":"12","author":"Crespo-Facorro","year":"2021","journal-title":"Front Pharmacol"},{"key":"B246","doi-asserted-by":"publisher","first-page":"14601","DOI":"10.1038\/s41598-021-94256-8","article-title":"Proteomics and Metabonomics Analyses of Covid-19 Complications in Patients With Pulmonary Fibrosis","volume":"11","author":"Yang","year":"2021","journal-title":"Sci Rep"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108723","article-title":"Treatment of B-Cell Depleted COVID-19 Patients With Convalescent Plasma and Plasma-Based Products","volume":"227","author":"Kenig","year":"2021","journal-title":"Clin Immunol"},{"key":"B248","doi-asserted-by":"publisher","first-page":"20836","DOI":"10.1038\/s41598-020-77945-8","article-title":"Depletion of Circulating IgM Memory B Cells Predicts Unfavourable Outcome in COVID-19","volume":"10","author":"Lenti","year":"2020","journal-title":"Sci Rep"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.611004","article-title":"B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients","volume":"11","author":"Sosa-Hern\u00e1ndez","year":"2020","journal-title":"Front Immunol"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2020.1816076","article-title":"Exploration of Turn-Positive RT-PCR Results and Factors Related to Treatment Outcome in COVID-19: A Retrospective Cohort Study","volume":"11","author":"Xiao","year":"2020","journal-title":"Virulence"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107586","article-title":"The Contributory Role of Lymphocyte Subsets, Pathophysiology of Lymphopenia and its Implication as Prognostic and Therapeutic Opportunity in COVID-19","volume":"95","author":"Delshad","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B252","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41421-020-0168-9","article-title":"Immune Cell Profiling of COVID-19 Patients in the Recovery Stageby Single-Cell Sequencing","volume":"6","author":"Wen","year":"2020","journal-title":"Cell Discov"},{"key":"B253","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.cell.2020.06.010","article-title":"Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment","volume":"182","author":"Sun","year":"2020","journal-title":"Cell"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26506","article-title":"Role of Eosinophils in the Diagnosis and Prognostic Evaluation of COVID-19","volume":"93","author":"Tan","year":"2021","journal-title":"J Med Virol"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01329-2","article-title":"Single-Cell Multi-Omics Analysis of the Immune Response in COVID-19","volume":"27","author":"Stephenson","year":"2021","journal-title":"Nat Med"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6635925","article-title":"Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients","volume":"2021","author":"Li","year":"2021","journal-title":"Mediators Inflamm"},{"key":"B257","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.cell.2021.01.053","article-title":"COVID-19 Immune Features Revealed by a Large-Scale Single-Cell Transcriptome Atlas","volume":"184","author":"Ren","year":"2021","journal-title":"Cell"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105954","article-title":"Cytokine Release Syndrome in Severe COVID-19: Interleukin-6 Receptor Antagonist Tocilizumab may be the Key to Reduce Mortality","volume":"55","author":"Zhang","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"B259","doi-asserted-by":"publisher","first-page":"3434","DOI":"10.1038\/s41467-020-17292-4","article-title":"Marked T Cell Activation, Senescence, Exhaustion and Skewing Towards TH17 in Patients With COVID-19 Pneumonia","volume":"11","author":"De Biasi","year":"2020","journal-title":"Nat Commun"},{"key":"B260","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.coi.2018.09.002","article-title":"IL-6: A Cytokine at the Crossroads of Autoimmunity","volume":"55","author":"Jones","year":"2018","journal-title":"Curr Opin Immunol"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753","article-title":"Reciprocal Developmental Pathways for the Generation of Pathogenic Effector TH17 and Regulatory T Cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-15567-x","article-title":"Bioinformatic Analyses Suggest Augmented Interleukin-17 Signaling as the Mechanism of COVID-19-Associated Herpes Zoster","volume":"28","author":"Yu","year":"2021","journal-title":"Environ Sci Pollut Res"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2020.03.005","article-title":"TH17 Responses in Cytokine Storm of COVID-19: An Emerging Target of JAK2 Inhibitor Fedratinib","volume":"53","author":"Wu","year":"2020","journal-title":"J Microbiol Immunol Infect"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2009.07.003","article-title":"STAT3 in CD4+ T Helper Cell Differentiation and Inflammatory Diseases","volume":"47","author":"Egwuagu","year":"2009","journal-title":"Cytokine"},{"key":"B265","doi-asserted-by":"publisher","first-page":"e13304","DOI":"10.1111\/aji.13304","article-title":"COVID-19 and Treg\/Th17 Imbalance: Potential Relationship to Pregnancy Outcomes","volume":"84","author":"Muyayalo","year":"2020","journal-title":"Am J Reprod Immunol"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040391","article-title":"IL-6: Regulator of Treg\/Th17 Balance","volume":"40","author":"Kimura","year":"2010","journal-title":"Eur J Immunol"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30233","article-title":"Immunomodulatory Effects of Nanocurcumin on Th17 Cell Responses in Mild and Severe COVID-19 Patients","volume":"236","author":"Tahmasebi","year":"2021","journal-title":"J Cell Physiol"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.651656","article-title":"Single-Cell RNA Sequencing Analysis of the Immunometabolic Rewiring and Immunopathogenesis of Coronavirus Disease 2019","volume":"12","author":"Qi","year":"2021","journal-title":"Front Immunol"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22137127","article-title":"Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 Pathologies","volume":"22","author":"Joshi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B270","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.immuni.2020.11.017","article-title":"Longitudinal Multi-Omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19","volume":"53","author":"Bernardes","year":"2020","journal-title":"Immunity"},{"key":"B271","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1080\/08830185.2020.1840567","article-title":"How Could We Forget Immunometabolism in SARS-CoV2 Infection or COVID-19","volume":"40","author":"Kumar","year":"2021","journal-title":"Int Rev Immunol"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0944-y","article-title":"A Single-Cell Atlas of the Peripheral Immune Response in Patients With Severe COVID-19","volume":"26","author":"Wilk","year":"2020","journal-title":"Nat Med"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6793","article-title":"Covid-19 and Thymoquinone: Connecting the Dots","volume":"34","author":"Ahmad","year":"2020","journal-title":"Phytother Res"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa703","article-title":"Autoantigens That may Explain Postinfection Autoimmune Manifestations in Patients With Coronavirus Disease 2019 Displaying Neurological Conditions","volume":"223","author":"Mohkhedkar","year":"2020","journal-title":"J Infect Dis"},{"key":"B275","doi-asserted-by":"publisher","first-page":"e3000970","DOI":"10.1371\/journal.pbio.3000970","article-title":"A Network Medicine Approach to Investigation and Population-Based Validation of Disease Manifestations and Drug Repurposing for COVID-19","volume":"18","author":"Zhou","year":"2020","journal-title":"PloS Biol"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.588508","article-title":"Current Prevention of COVID-19: Natural Products and Herbal Medicine","volume":"11","author":"Huang","year":"2020","journal-title":"Front Pharmacol"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1761881","article-title":"Natural Products may Interfere With SARS-CoV-2 Attachment to the Host Cell","volume":"39","author":"Elfiky","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab126","article-title":"Bioinformatics and System Biology Approaches to Identify the Diseasome and Comorbidities Complexities of SARS-CoV-2 Infection With the Digestive Tract Disorders","author":"Nashiry","year":"2021","journal-title":"Briefings Bioinf"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1086\/518259","article-title":"IRAK-M is Involved in the Pathogenesis of Early-Onset Persistent Asthma","volume":"80","author":"Balaci","year":"2007","journal-title":"Am J Hum Genet"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.46378","article-title":"Investigating the Mechanism of ShuFeng JieDu Capsule for the Treatment of Novel Coronavirus Pneumonia (COVID-19) Based on Network Pharmacology","volume":"17","author":"Chen","year":"2020","journal-title":"Int J Med Sci"},{"key":"B281","doi-asserted-by":"publisher","first-page":"5148","DOI":"10.1038\/s41467-021-25412-x","article-title":"AHR Signaling is Induced by Infection With Coronaviruses","volume":"12","author":"Giovannoni","year":"2021","journal-title":"Nat Commun"},{"key":"B282","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41590-020-00840-x","article-title":"Untuned Antiviral Immunity in COVID-19 Revealed by Temporal Type I\/III Interferon Patterns and Flu Comparison","volume":"22","author":"Galani","year":"2021","journal-title":"Nat Immunol"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0762-x","article-title":"Single-Cell Landscape of Immunological Responses in Patients With COVID-19","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat Immunol"},{"key":"B284","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41392-020-00263-y","article-title":"Adaptive Immune Responses to SARS-CoV-2 Infection in Severe Versus Mild Individuals","volume":"5","author":"Zhang","year":"2020","journal-title":"Signal Transduction Targeted Ther"},{"key":"B285","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41421-020-00225-2","article-title":"The Differential Immune Responses to COVID-19 in Peripheral and Lung Revealed by Single-Cell RNA Sequencing","volume":"6","author":"Xu","year":"2020","journal-title":"Cell Discov"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 Severity Correlates With Airway Epithelium\u2013Immune Cell Interactions Identified by Single-Cell Analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat Biotechnol"},{"key":"B287","doi-asserted-by":"publisher","first-page":"14151","DOI":"10.1038\/s41598-021-93743-2","article-title":"Discovery of Potential Imaging and Therapeutic Targets for Severe Inflammation in COVID-19 Patients","volume":"11","author":"Lee","year":"2021","journal-title":"Sci Rep"},{"key":"B288","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1038\/s41467-020-17240-2","article-title":"Immunological and Inflammatory Profiles in Mild and Severe Cases of COVID-19","volume":"11","author":"Song","year":"2020","journal-title":"Nat Commun"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.701085","article-title":"A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients","volume":"12","author":"Bieberich","year":"2021","journal-title":"Front Immunol"},{"key":"B290","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.cell.2020.10.001","article-title":"Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19","volume":"183","author":"Meckiff","year":"2020","journal-title":"Cell"},{"key":"B291","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.cell.2020.10.037","article-title":"Multi-Omics Resolves a Sharp Disease-State Shift Between Mild and Moderate COVID-19","volume":"183","author":"Su","year":"2020","journal-title":"Cell"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2053","article-title":"Modulation of Expression of the MHC Class I-Binding Natural Killer Cell Receptors, and NK Activity in Relation to Viral Load in HIV-Infected\/AIDS Patients","volume":"65","author":"Ahmad","year":"2001","journal-title":"J Med Virol"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1309\/wpk7y2xknf4cbf3r","article-title":"The Involvement of Natural Killer Cells in the Pathogenesis of Severe Acute Respiratory Syndrome","volume":"121","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01512","article-title":"Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies","volume":"11","author":"Market","year":"2020","journal-title":"Front Immunol"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2007.04.011","article-title":"Delivering the Kiss of Death: Progress on Understanding How Perforin Works","volume":"19","author":"Pipkin","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1038\/nri1983","article-title":"Perforin-Mediated Target-Cell Death and Immune Homeostasis","volume":"6","author":"Voskoboinik","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B297","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and Granzymes: Function, Dysfunction and Human Pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1038\/nri911","article-title":"Functional Significance of the Perforin\/Granzyme Cell Death Pathway","volume":"2","author":"Trapani","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01020-4","article-title":"Integrated Analysis of Plasma and Single Immune Cells Uncovers Metabolic Changes in Individuals With COVID-19","author":"Lee","year":"2021","journal-title":"Nat Biotechnol"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062967","article-title":"Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis","volume":"22","author":"Chu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B301","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00296-020-04636-y","article-title":"Hemophagocytic Lymphohistiocytosis: A Review Inspired by the COVID-19 Pandemic","volume":"41","author":"Soy","year":"2021","journal-title":"Rheumatol Int"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00167","article-title":"Familial Hemophagocytic Lymphohistiocytosis: When Rare Diseases Shed Light on Immune System Functioning","volume":"5","author":"Sieni","year":"2014","journal-title":"Front Immunol"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.586765","article-title":"Can Natural Killer Cells be a Principal Player in Anti-SARS-CoV-2 Immunity","volume":"11","author":"Ahmed","year":"2020","journal-title":"Front Immunol"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.556984","article-title":"In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression Analysis","volume":"11","author":"Ge","year":"2020","journal-title":"Front Pharmacol"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.625881","article-title":"Epigenetic Landscapes of Single-Cell Chromatin Accessibility and Transcriptomic Immune Profiles of T Cells in COVID-19 Patients","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.686699","article-title":"Case Report: Systemic Sclerosis After Covid-19 Infection","volume":"12","author":"Fineschi","year":"2021","journal-title":"Front Immunol"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.589380","article-title":"T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis","volume":"11","author":"Kalfaoglu","year":"2020","journal-title":"Front Immunol"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2020.1112","article-title":"Prediction of SARS-CoV Interaction With Host Proteins During Lung Aging Reveals a Potential Role for TRIB3 in COVID-19","volume":"12","author":"de Moraes","year":"2021","journal-title":"Aging Dis"},{"key":"B309","doi-asserted-by":"publisher","first-page":"eabe4282","DOI":"10.1126\/scitranslmed.abe4282","article-title":"Lung Transplantation for Patients With Severe COVID-19","volume":"12","author":"Bharat","year":"2020","journal-title":"Sci Trans Med"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.601080","article-title":"Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities","volume":"12","author":"Chu","year":"2021","journal-title":"Front Immunol"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.700782","article-title":"Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning","volume":"12","author":"Patterson","year":"2021","journal-title":"Front Immunol"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063184","article-title":"Exosomes From COVID-19 Patients Carry Tenascin-C and Fibrinogen-\u03b2 in Triggering Inflammatory Signals in Cells of Distant Organ","volume":"22","author":"Sur","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108125","article-title":"Increased LPS Levels Coexist With Systemic Inflammation and Result in Monocyte Activation in Severe COVID-19 Patients","volume":"100","author":"Teixeira","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B314","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ijid.2020.10.101","article-title":"CCR5 Inhibition in Critical COVID-19 Patients Decreases Inflammatory Cytokines, Increases CD8 T-Cells, and Decreases SARS-CoV2 RNA in Plasma by Day 14","volume":"103","author":"Patterson","year":"2021","journal-title":"Int J Infect Dis"},{"key":"B315","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1186\/s12967-020-02646-9","article-title":"The Dysregulated Innate Immune Response in Severe COVID-19 Pneumonia That Could Drive Poorer Outcome","volume":"18","author":"Blot","year":"2020","journal-title":"J Trans Med"},{"key":"B316","doi-asserted-by":"publisher","first-page":"e139834","DOI":"10.1172\/jci.insight.139834","article-title":"Longitudinal COVID-19 Profiling Associates IL-1RA and IL-10 With Disease Severity and RANTES With Mild Disease","volume":"5","author":"Zhao","year":"2020","journal-title":"JCI Insight"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-021-00945-6","article-title":"Histomorphological Patterns of Regional Lymph Nodes in COVID-19 Lungs","author":"Haslbauer","year":"2021","journal-title":"Der Pathologe"},{"key":"B318","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.livres.2020.01.002","article-title":"Functional Roles of CCL5\/RANTES in Liver Disease","volume":"4","author":"Chen","year":"2020","journal-title":"Liver Res"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.6.2684-2693.2006","article-title":"Modeling the Early Events of Severe Acute Respiratory Syndrome Coronavirus Infection In Vitro","volume":"80","author":"Yen","year":"2006","journal-title":"J Virol"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4166","article-title":"Chemokine Up-Regulation in SARS-Coronavirus\u2013Infected, Monocyte-Derived Human Dendritic Cells","volume":"106","author":"Law","year":"2005","journal-title":"Blood"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26232","article-title":"The Cytokine Storm and COVID-19","volume":"93","author":"Hu","year":"2021","journal-title":"J Med Virol"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01708","article-title":"Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies","volume":"11","author":"Tang","year":"2020","journal-title":"Front Immunol"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400593111","article-title":"Mapping the Innate Signaling Cascade Essential for Cytokine Storm During Influenza Virus Infection","volume":"111","author":"Teijaro","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048724","article-title":"Immune Response in Children With COVID-19 is Characterized by Lower Levels of T-Cell Activation Than Infected Adults","volume":"50","author":"Moratto","year":"2020","journal-title":"Eur J Immunol"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1038\/srep18424","article-title":"RANTES Mediates Kidney Ischemia Reperfusion Injury Through a Possible Role of HIF-1\u03b1 and LncRNA PRINS","volume":"6","author":"Yu","year":"2016","journal-title":"Sci Rep"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.12.004","article-title":"2\u2032-5\u2032-Oligoadenylate Synthetase-Like Protein Inhibits Intracellular M. Tuberculosis Replication and Promotes Proinflammatory Cytokine Secretion","volume":"118","author":"Leisching","year":"2020","journal-title":"Mol Immunol"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27093","article-title":"Genome-Wide Screening of SARS-CoV-2 Infection-Related Genes Based on the Blood Leukocytes Sequencing Data Set of Patients With COVID-19","volume":"93","author":"Gao","year":"2021","journal-title":"J Med Virol"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00619-0","article-title":"Ribosome Structure and the Mechanism of Translation","volume":"108","author":"Ramakrishnan","year":"2002","journal-title":"Cell"},{"key":"B329","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1038\/s41467-021-23621-y","article-title":"Clinical and Molecular Characteristics of COVID-19 Patients With Persistent SARS-CoV-2 Infection","volume":"12","author":"Yang","year":"2021","journal-title":"Nat Commun"},{"key":"B330","doi-asserted-by":"publisher","first-page":"e2017715118","DOI":"10.1073\/pnas.2017715118","article-title":"Dynamic Competition Between SARS-CoV-2 NSP1 and mRNA on the Human Ribosome Inhibits Translation Initiation","volume":"118","author":"Lapointe","year":"2021","journal-title":"Proc Natl Acad Sci"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8665","article-title":"Structural Basis for Translational Shutdown and Immune Evasion by the Nsp1 Protein of SARS-CoV-2","volume":"369","author":"Thoms","year":"2020","journal-title":"Science"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0511-8","article-title":"SARS-CoV-2 Nsp1 Binds the Ribosomal mRNA Channel to Inhibit Translation","volume":"27","author":"Schubert","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.558557","article-title":"Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database","volume":"11","author":"Li","year":"2020","journal-title":"Front Genet"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1771694","article-title":"Emerging Therapies for COVID-19 Pneumonia","volume":"29","author":"Battaglini","year":"2020","journal-title":"Expert Opin Invest Drugs"},{"key":"B335","doi-asserted-by":"publisher","first-page":"5048","DOI":"10.1038\/s41467-020-18710-3","article-title":"Many Small Steps Towards a COVID-19 Drug","volume":"11","author":"Erlanson","year":"2020","journal-title":"Nat Commun"},{"key":"B336","doi-asserted-by":"publisher","first-page":"e1009687","DOI":"10.1371\/journal.ppat.1009687","article-title":"The Endogenous Cellular Protease Inhibitor SPINT2 Controls SARS-CoV-2 Viral Infection and is Associated to Disease Severity","volume":"17","author":"Ramirez Alvarez","year":"2021","journal-title":"PloS Pathog"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00130-21","article-title":"Human Nasal and Lung Tissues Infected Ex Vivo With SARS-CoV-2 Provide Insights Into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract","volume":"95","author":"Alfi","year":"2021","journal-title":"J Virol"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101526","article-title":"Integrative Network Biology Framework Elucidates Molecular Mechanisms of SARS-CoV-2 Pathogenesis","volume":"23","author":"Kumar","year":"2020","journal-title":"iScience"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.623012","article-title":"Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19","volume":"7","author":"Jha","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102151","article-title":"Transcriptomic Profiling of SARS-CoV-2 Infected Human Cell Lines Identifies HSP90 as Target for COVID-19 Therapy","volume":"24","author":"Wyler","year":"2021","journal-title":"iScience"},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16714","article-title":"Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates With COVID-19 Severity","volume":"25","author":"Ma","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202000278","article-title":"Longitudinal Proteomic Profiling Provides Insights Into Host Response and Proteome Dynamics in COVID-19 Progression","volume":"21","author":"Lee","year":"2021","journal-title":"Proteomics"},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.3390\/v13061018","article-title":"COVID-19 Severity Potentially Modulated by Cardiovascular-Disease-Associated Immune Dysregulation","volume":"13","author":"Lee","year":"2021","journal-title":"Viruses"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113743","article-title":"ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients With Cardiovascular Risk Factors","volume":"9","author":"Wicik","year":"2020","journal-title":"J\u00a0Clin Med"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.652799","article-title":"Proteomics and Machine Learning Approaches Reveal a Set of Prognostic Markers for COVID-19 Severity With Drug Repurposing Potential","volume":"12","author":"Suvarna","year":"2021","journal-title":"Front Physiol"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.04.010","article-title":"EZH2-Mediated H3K27me3 Inhibits ACE2 Expression","volume":"526","author":"Li","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02266-w","article-title":"Brain Disease Network Analysis to Elucidate the Neurological Manifestations of COVID-19","volume":"58","author":"Prasad","year":"2021","journal-title":"Mol Neurobiol"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189684","article-title":"Computational Methods to Study Human Transcript Variants in COVID-19 Infected Lung Cancer Cells","volume":"22","author":"Sun","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.06.013","article-title":"Lymphopenia During the COVID-19 Infection: What it Shows and What can be Learned","volume":"225","author":"Tavakolpour","year":"2020","journal-title":"Immunol Lett"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa462","article-title":"Downregulated Gene Expression Spectrum and Immune Responses Changed During the Disease Progression in Patients With COVID-19","volume":"71","author":"Ouyang","year":"2020","journal-title":"Clin Infect Dis"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168663","article-title":"Anti-SARS-CoV-2 Strategies and the Potential Role of miRNA in the Assessment of COVID-19 Morbidity, Recurrence, and Therapy","volume":"22","author":"Naro\u017cna","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040982","article-title":"Master Regulator Analysis of the SARS-CoV-2\/Human Interactome","volume":"9","author":"Guzzi","year":"2020","journal-title":"J Clin Med"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.637642","article-title":"Severe Clinical Worsening in COVID-19 and Potential Mechanisms of Immune-Enhanced Disease","volume":"8","author":"Hussman","year":"2021","journal-title":"Front Med"},{"key":"B354","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41392-021-00526-2","article-title":"Dynamic Blood Single-Cell Immune Responses in Patients With COVID-19","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduction Targeted Ther"},{"key":"B355","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s42003-021-02095-0","article-title":"Genome-Wide Bioinformatic Analyses Predict Key Host and Viral Factors in SARS-CoV-2 Pathogenesis","volume":"4","author":"Ferrarini","year":"2021","journal-title":"Commun Biol"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00846-z","article-title":"The SARS-CoV-2 RNA\u2013protein Interactome in Infected Human Cells","volume":"6","author":"Schmidt","year":"2021","journal-title":"Nat Microbiol"},{"key":"B357","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa300","article-title":"Network Pharmacology and Bioinformatics Analyses Identify Intersection Genes of Niacin and COVID-19 as Potential Therapeutic Targets","volume":"22","author":"Li","year":"2020","journal-title":"Briefings Bioinf"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8040673","article-title":"SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated From CD4+ Cells From Healthy, Unexposed Polish Donors","volume":"8","author":"Sa\u0142kowska","year":"2020","journal-title":"Vaccines"},{"key":"B359","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bbrc.2020.11.115","article-title":"Overexpression of SARS-CoV-2 Protein ORF6 Dislocates RAE1 and NUP98 From the Nuclear Pore Complex","volume":"536","author":"Kato","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"B360","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.599261","article-title":"Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection","volume":"12","author":"Singh","year":"2021","journal-title":"Front Genet"},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109583","article-title":"Computational Analysis of TMPRSS2 Expression in Normal and SARS-CoV-2-Infected Human Tissues","volume":"346","author":"Cao","year":"2021","journal-title":"Chem-Bio Interact"},{"key":"B362","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122679","article-title":"Taming the Autophagy as a Strategy for Treating COVID-19","volume":"9","author":"Garc\u00eda-P\u00e9rez","year":"2020","journal-title":"Cells"},{"key":"B363","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.45498","article-title":"Targeting the Endocytic Pathway and Autophagy Process as a Novel Therapeutic Strategy in COVID-19","volume":"16","author":"Yang","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B364","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.716208","article-title":"ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication","volume":"9","author":"Qu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1953847","article-title":"Manipulation of Autophagy by SARS-CoV-2 Proteins","volume":"17","author":"Koepke","year":"2021","journal-title":"Autophagy"},{"key":"B366","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082022","article-title":"The Molecular Interplay Between Human Coronaviruses and Autophagy","volume":"10","author":"Shroff","year":"2021","journal-title":"Cells"},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.675419","article-title":"Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection","volume":"12","author":"Maity","year":"2021","journal-title":"Front Microbiol"},{"key":"B368","doi-asserted-by":"publisher","first-page":"6725","DOI":"10.1038\/s41598-021-86110-8","article-title":"Mining of High Throughput Screening Database Reveals AP-1 and Autophagy Pathways as Potential Targets for COVID-19 Therapeutics","volume":"11","author":"Zhu","year":"2021","journal-title":"Sci Rep"},{"key":"B369","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.173928","article-title":"Chloroquine: Autophagy Inhibitor, Antimalarial, Bitter Taste Receptor Agonist in Fight Against COVID-19, a Reality Check","volume":"897","author":"Sharma","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"B370","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071619","article-title":"Canonical and Noncanonical Autophagy as Potential Targets for COVID-19","volume":"9","author":"Bello-Perez","year":"2020","journal-title":"Cells"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1779467","article-title":"Autophagy as an Emerging Target for COVID-19: Lessons From an Old Friend, Chloroquine","volume":"16","author":"Bonam","year":"2020","journal-title":"Autophagy"},{"key":"B372","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1817280","article-title":"Coronavirus Interactions With the Cellular Autophagy Machinery","volume":"16","author":"Miller","year":"2020","journal-title":"Autophagy"},{"key":"B373","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.569849","article-title":"Autophagy Modulation in Lymphocytes From COVID-19 Patients: New Therapeutic Target in SARS-COV-2 Infection","volume":"11","author":"Vomero","year":"2020","journal-title":"Front Pharmacol"},{"key":"B374","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.624006","article-title":"Potentials of Antitussive Traditional Persian Functional Foods for COVID-19 Therapy\u2020","volume":"12","author":"Mosleh","year":"2021","journal-title":"Front Pharmacol"},{"key":"B375","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00143","article-title":"Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral Mpro Protease Target Host Selenoproteins and Glutathione Synthesis","volume":"7","author":"Taylor","year":"2020","journal-title":"Front Nutr"},{"key":"B376","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa332","article-title":"ACE2 Expression is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19","volume":"222","author":"Pinto","year":"2020","journal-title":"J Infect Dis"},{"key":"B377","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s40001-021-00544-4","article-title":"The Relative Expression of miR-31, miR-29, miR-126, and miR-17 and Their mRNA Targets in the Serum of COVID-19 Patients With Different Grades During Hospitalization","volume":"26","author":"Keikha","year":"2021","journal-title":"Eur J Med Res"},{"key":"B378","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-021-00886-x","article-title":"Germline Variants in UNC13D and AP3B1 are Enriched in COVID-19 Patients Experiencing Severe Cytokine Storms","volume":"29","author":"Luo","year":"2021","journal-title":"Eur J Hum Genet"},{"key":"B379","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00304-9","article-title":"Impact of Sex and Gender on COVID-19 Outcomes in Europe","volume":"11","author":"Gebhard","year":"2020","journal-title":"Biol Sex Dif"},{"key":"B380","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00367-20","article-title":"COVID-19 Hyperinflammation: What About Neutrophils","volume":"5","author":"Didangelos","year":"2020","journal-title":"mSphere"},{"key":"B381","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.688227","article-title":"Identification of Novel Gene Signatures Using Next-Generation Sequencing Data From COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics","volume":"12","author":"Pushparaj","year":"2021","journal-title":"Front Pharmacol"},{"key":"B382","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221910198","article-title":"Severity of COVID-19 Patients Predicted by Serum Sphingolipids Signature","volume":"22","author":"Torretta","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B383","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115992","article-title":"Autophagy, Unfolded Protein Response, and Neuropilin-1 Cross-Talk in SARS-CoV-2 Infection: What can be Learned From Other Coronaviruses","volume":"22","author":"Siri","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B384","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12920-021-01079-7","article-title":"Lung Disease Network Reveals Impact of Comorbidity on SARS-CoV-2 Infection and Opportunities of Drug Repurposing","volume":"14","author":"Das","year":"2021","journal-title":"BMC Med Genomics"},{"key":"B385","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab197","article-title":"Transcriptomic Studies Revealed Pathophysiological Impact of COVID-19 to Predominant Health Conditions","author":"Nain","year":"2021","journal-title":"Briefings Bioinf"},{"key":"B386","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13020-021-00427-0","article-title":"The Important Herbal Pair for the Treatment of COVID-19 and its Possible Mechanisms","volume":"16","author":"Xia","year":"2021","journal-title":"Chin Med"},{"key":"B387","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab373","article-title":"Identification of Potential Therapeutic Targets and Mechanisms of COVID-19 Through Network Analysis and Screening of Chemicals and Herbal Ingredients","author":"Wang","year":"2021","journal-title":"Briefings Bioinf"},{"key":"B388","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13040-020-00229-4","article-title":"Exploring Active Ingredients and Function Mechanisms of Ephedra-Bitter Almond for Prevention and Treatment of Corona Virus Disease 2019 (COVID-19) Based on Network Pharmacology","volume":"13","author":"Gao","year":"2020","journal-title":"BioData Min"},{"key":"B389","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(20)60031-0","article-title":"Recent Advances of Traditional Chinese Medicine on the Prevention and Treatment of COVID-19","volume":"18","author":"Dai","year":"2020","journal-title":"Chin J Nat Med"},{"key":"B390","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa079","article-title":"Therapeutic Targets and Signaling Mechanisms of Vitamin C Activity Against Sepsis: A Bioinformatics Study","volume":"22","author":"Li","year":"2020","journal-title":"Briefings Bioinf"},{"key":"B391","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26743","article-title":"Dysregulation of the Mevalonate Pathway During SARS-CoV-2 Infection: An in Silico Study","volume":"93","author":"Gomez Marti","year":"2021","journal-title":"J Med Virol"},{"key":"B392","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/s41421-020-00208-3","article-title":"SARS-CoV-2 N Protein Antagonizes Type I Interferon Signaling by Suppressing Phosphorylation and Nuclear Translocation of STAT1 and STAT2","volume":"6","author":"Mu","year":"2020","journal-title":"Cell Discov"},{"key":"B393","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1038\/s41423-020-0514-8","article-title":"SARS-CoV-2 Orf9b Suppresses Type I Interferon Responses by Targeting TOM70","volume":"17","author":"Jiang","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B394","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108234","article-title":"Evasion of Type I Interferon by SARS-CoV-2","volume":"33","author":"Xia","year":"2020","journal-title":"Cell Rep"},{"key":"B395","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0346-x","article-title":"Dysregulation of Type I Interferon Responses in COVID-19","volume":"20","author":"Acharya","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B396","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"B397","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104791","article-title":"Type 1 Interferons as a Potential Treatment Against COVID-19","volume":"178","author":"Sallard","year":"2020","journal-title":"Antiviral Res"},{"key":"B398","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2021.104892","article-title":"The Differences in SARS-CoV and SARS-CoV-2 Specific Co-Expression Network Mediated Biological Process in Human Gut Enterocytes","volume":"92","author":"Nayak","year":"2021","journal-title":"Infect Genet Evol"},{"key":"B399","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103262","article-title":"Temporal Dynamics of the Host Molecular Responses Underlying Severe COVID-19 Progression and Disease Resolution","volume":"65","author":"Ong","year":"2021","journal-title":"EBioMedicine"},{"key":"B400","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107777","article-title":"Insights on the Mechanisms of Action of Ozone in the Medical Therapy Against COVID-19","volume":"96","author":"Chirumbolo","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B401","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157963","article-title":"The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19","volume":"22","author":"Emanuele","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B402","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091440","article-title":"Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients","volume":"10","author":"Liao","year":"2021","journal-title":"Antioxidants"},{"key":"B403","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2021.06.005","article-title":"The miRNA Neuroinflammatory Biomarkers in COVID-19 Patients With Different Severity of Illness","author":"Keikha","year":"2021","journal-title":"Neurolog\u00eda"},{"key":"B404","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40360-020-00444-z","article-title":"A Protein Interaction Map Identifies Existing Drugs Targeting SARS-CoV-2","volume":"21","author":"Cava","year":"2020","journal-title":"BMC Pharmacol Toxicol"},{"key":"B405","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-Cell Landscape of Bronchoalveolar Immune Cells in Patients With COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat Med"},{"key":"B406","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00274-1","article-title":"Integrating Longitudinal Clinical Laboratory Tests With Targeted Proteomic and Transcriptomic Analyses Reveal the Landscape of Host Responses in COVID-19","volume":"7","author":"Tan","year":"2021","journal-title":"Cell Discov"},{"key":"B407","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168423","article-title":"Severe COVID-19 Patients Show an Increase in Soluble TNFR1 and ADAM17, With a Relationship to Mortality","volume":"22","author":"Palacios","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B408","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103500","article-title":"SARS-CoV-2 Activates Lung Epithelial Cell Proinflammatory Signaling and Leads to Immune Dysregulation in COVID-19 Patients","volume":"70","author":"Chen","year":"2021","journal-title":"EBioMedicine"},{"key":"B409","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-021-02485-9","article-title":"Genetic Exchange of Lung-Derived Exosome to Brain Causing Neuronal Changes on COVID-19 Infection","author":"Ahmed","year":"2021","journal-title":"Mol Neurobiol"},{"key":"B410","doi-asserted-by":"publisher","first-page":"e0256899","DOI":"10.1371\/journal.pone.0256899","article-title":"Statins Use and COVID-19 Outcomes in Hospitalized Patients","volume":"16","author":"Ayeh","year":"2021","journal-title":"PloS One"},{"key":"B411","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1844433","article-title":"A Multifactorial Score Including Autophagy for Prognosis and Care of COVID-19 Patients","volume":"16","author":"Domdom","year":"2020","journal-title":"Autophagy"},{"key":"B412","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01332-z","article-title":"An Evidence That SARS-Cov-2\/COVID-19 Spike Protein (SP) Damages Hematopoietic Stem\/Progenitor Cells in the Mechanism of Pyroptosis in Nlrp3 Inflammasome-Dependent Manner","volume":"35","author":"Kucia","year":"2021","journal-title":"Leukemia"},{"key":"B413","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.07.074","article-title":"Integrated Multi-Omics Approach Identified Molecular Mechanism and Pathogenetic Processes of COVID-19 That Affect Patient With Parkinson\u2019s Disorder","author":"Zhao","year":"2021","journal-title":"Saudi J Biol Sci"},{"key":"B414","doi-asserted-by":"publisher","first-page":"e144455","DOI":"10.1172\/jci.insight.144455","article-title":"An Immune-Based Biomarker Signature is Associated With Mortality in COVID-19 Patients","volume":"6","author":"Abers","year":"2021","journal-title":"JCI Insight"},{"key":"B415","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110316","article-title":"Analysis of the Molecular Mechanism of Pudilan (PDL) Treatment for COVID-19 by Network Pharmacology Tools","volume":"128","author":"Kong","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"B416","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1879313","article-title":"Study on Mechanism of Matrine in Treatment of COVID-19 Combined With Liver Injury by Network Pharmacology and Molecular Docking Technology","volume":"28","author":"Liu","year":"2021","journal-title":"Drug Deliv"},{"key":"B417","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102909","article-title":"The Mechanism Behind Flaring\/Triggering of Autoimmunity Disorders Associated With COVID-19","volume":"20","author":"Redwan","year":"2021","journal-title":"Autoimmun Rev"},{"key":"B418","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7012","article-title":"Exploring the Treatment of COVID-19 With Yinqiao Powder Based on Network Pharmacology","volume":"35","author":"Lin","year":"2021","journal-title":"Phytother Res"},{"key":"B419","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113871","article-title":"Dissecting the Novel Mechanism of Reduning Injection in Treating Coronavirus Disease 2019 (COVID-19) Based on Network Pharmacology and Experimental Verification","volume":"273","author":"Jia","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"B420","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11030-021-10244-0","article-title":"Investigating the Active Compounds and Mechanism of HuaShi XuanFei Formula for Prevention and Treatment of COVID-19 Based on Network Pharmacology and Molecular Docking Analysis","volume":"9","author":"Wang","year":"2021","journal-title":"Mol Divers"},{"key":"B421","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.581277","article-title":"\u201cFei Yan No. 1\u201d as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study","volume":"11","author":"Ai","year":"2020","journal-title":"Front Pharmacol"}],"updated-by":[{"DOI":"10.3389\/fimmu.2025.1572273","type":"corrigendum","label":"Corrigendum","source":"publisher","updated":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000}}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.789317\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:29:09Z","timestamp":1741350549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.789317\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":421,"alternative-id":["10.3389\/fimmu.2021.789317"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.789317","relation":{"corrigendum":[{"id-type":"doi","id":"10.3389\/fimmu.2025.1572273","asserted-by":"object"}]},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,15]]},"article-number":"789317"}}