{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:18:26Z","timestamp":1792225106128,"version":"4.4.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Deoxynivalenol (DON), a highly prevalent contaminant of grain-based products, is known to induce reproductive- and immunotoxicities. Considering the importance of immune development in early life, the present study investigated the effects of perinatal DON exposure on allergy development and vaccine responsiveness in the offspring. Pregnant mice received control or DON-contaminated diets (12.5 mg\/kg diet) during pregnancy and lactation. After weaning, female offspring were sensitized to ovalbumin (OVA) by oral administration of OVA with cholera toxin (CT). Male offspring were injected with Influvac vaccine. OVA-specific acute allergic skin response (ASR) in females and vaccine-specific delayed-type hypersensitivity (DTH) in males were measured upon intradermal antigen challenge. Immune cell populations in spleen and antigen-specific plasma immunoglobulins were analyzed. In female CT+OVA-sensitized offspring of DON-exposed mothers ASR and OVA-specific plasma immunoglobulins were significantly higher, compared to the female offspring of control mothers. In vaccinated male offspring of DON-exposed mothers DTH and vaccine-specific antibody levels were significantly lower, compared to the male offspring of control mothers. In both models a significant reduction in regulatory T cells, Tbet<jats:sup>+<\/jats:sup> Th1 cells and Th1-related cytokine production of the offspring of DON-exposed mothers was observed. In conclusion, early life dietary exposure to DON can adversely influence immune development in the offspring. Consequently, the immune system of the offspring may be skewed towards an imbalanced state, resulting in an increased allergic immune response to food allergens and a decreased immune response to vaccination against influenza virus in these models.<\/jats:p>","DOI":"10.3389\/fimmu.2021.797152","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:30:46Z","timestamp":1639726246000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Exposure to Deoxynivalenol During Pregnancy and Lactation Enhances Food Allergy and Reduces Vaccine Responsiveness in the Offspring in a Mouse Model"],"prefix":"10.3389","volume":"12","author":[{"given":"Negisa","family":"Seyed Toutounchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Braber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"van\u2019t Land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Thijssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Garssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aletta D.","family":"Kraneveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gert","family":"Folkerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Hogenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108322436","article-title":"Environmental Exposures and Adverse Pregnancy Outcomes: A Review of the Science","volume":"15","author":"Stillerman","year":"2008","journal-title":"Reprod Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.scitotenv.2013.03.100","article-title":"Exposure to Food Contaminants During Pregnancy","author":"Chan-Hon-Tong","year":"2013","journal-title":"Sci Total Environ"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108s3483","article-title":"Workshop to Identify Critical Windows of Exposure for Children\u2019s Health: Immune and Respiratory Systems Work Group Summary","volume":"108","author":"Dietert","year":"2000","journal-title":"Environ Health Perspect"},{"key":"B4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.taap.2004.03.003","article-title":"Symposium Summary: Children\u2019s Health Risk\u2014What\u2019s So Special About the Developing Immune System","volume":"199","author":"Holsapple","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311427709","article-title":"Current Status of Developmental Immunotoxicity: Early-Life Patterns and Testing","volume":"40","author":"DeWitt","year":"2012","journal-title":"Toxicol Pathol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"867805","DOI":"10.1155\/2014\/867805","article-title":"Developmental Immunotoxicity, Perinatal Programming, and Noncommunicable Diseases: Focus on Human Studies","volume":"2014","author":"Dietert","year":"2014","journal-title":"Adv Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20170","article-title":"Early-Life Environment, Developmental Immunotoxicology, and the Risk of Pediatric Allergic Disease Including Asthma","volume":"83","author":"Dietert","year":"2008","journal-title":"Birth Defects Res Part B: Dev Reprod Toxicol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.2174\/157339609787587591","article-title":"Pediatric Immune Dysfunction and Health Risks Following Early-Life Immune Insult","volume":"5","author":"Dietert","year":"2009","journal-title":"Curr Pediatr Rev"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0342-2","article-title":"Interaction Between Dendritic Cells and Natural Killer Cells During Pregnancy in Mice","volume":"86","author":"Blois","year":"2008","journal-title":"J Mol Med (Berlin Germany)"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.01.013","article-title":"Deoxynivalenol, Gut Microbiota and Immunotoxicity: A Potential Approach","volume":"112","author":"Liao","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3109\/15569541003598553","article-title":"An Overview of Mycotoxin Contamination in Foods and Its Implications for Human Health","volume":"29","author":"Reddy","year":"2010","journal-title":"Toxin Rev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.foodcont.2018.12.014","article-title":"Deoxynivalenol in Cereal-Based Baby Food Production Process. A Review","volume":"99","author":"Pascari","year":"2019","journal-title":"Food Control"},{"key":"B13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/10937400590889458","article-title":"Deoxynivalenol: Toxicology and Potential Effects on Humans","volume":"8","author":"Pestka","year":"2005","journal-title":"J Toxicol Environ Health Part B"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7103845","article-title":"Deoxynivalenol Exposure Assessment for Pregnant Women in Bangladesh","volume":"7","author":"Ali","year":"2015","journal-title":"Toxins"},{"key":"B15","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3390\/toxins8110306","article-title":"Determination of Deoxynivalenol in the Urine of Pregnant Women in the UK","volume":"8","author":"Wells","year":"2016","journal-title":"Toxins"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.04.016","article-title":"The Effect of Feeding a Diet Naturally Contaminated With Deoxynivalenol (DON) and Zearalenone (ZON) on the Spleen and Liver of Sow and Fetus From Day 35 to 70 of Gestation","volume":"179","author":"Tiemann","year":"2008","journal-title":"Toxicol Lett"},{"key":"B17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.toxlet.2007.04.003","article-title":"On the Transfer of the Fusarium Toxins Deoxynivalenol (DON) and Zearalenone (ZON) From Sows to Their Fetuses During Days 35\u201370 of Gestation","volume":"171","author":"Goyarts","year":"2007","journal-title":"Toxicol Lett"},{"key":"B18","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3390\/toxins10120517","article-title":"Transfer of Deoxynivalenol (DON) Through Placenta, Colostrum and Milk From Sows to Their Offspring During Late Gestation and Lactation","volume":"10","author":"Sayyari","year":"2018","journal-title":"Toxins"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2015.01.020","article-title":"Presence of Mycotoxins in Animal Milk: A Review","volume":"53","author":"Flores-Flores","year":"2015","journal-title":"Food Control"},{"key":"B20","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3390\/toxins5040784","article-title":"From the Gut to the Brain: Journey and Pathophysiological Effects of the Food-Associated Trichothecene Mycotoxin Deoxynivalenol","volume":"5","author":"Maresca","year":"2013","journal-title":"Toxins"},{"key":"B21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.toxlet.2004.04.023","article-title":"Cellular and Molecular Mechanisms for Immune Modulation by Deoxynivalenol and Other Trichothecenes: Unraveling a Paradox","volume":"153","author":"Pestka","year":"2004","journal-title":"Toxicol Lett"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.12.012","article-title":"Deoxynivalenol Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes","volume":"64","author":"Yang","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00029-1","article-title":"Deoxynivalenol-Induced Immunomodulation of Human Lymphocyte Proliferation and Cytokine Production","volume":"39","author":"Meky","year":"2001","journal-title":"Food Chem Toxicol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.13","article-title":"The Mycotoxin Deoxynivalenol Facilitates Allergic Sensitization to Whey in Mice","volume":"9","author":"Bol-Schoenmakers","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi225","article-title":"Modulation of Murine Host Response to Enteric Reovirus Infection by the Trichothecene Deoxynivalenol","volume":"87","author":"Li","year":"2005","journal-title":"Toxicol Sci"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl153","article-title":"Deoxynivalenol Exacerbates Viral Bronchopneumonia Induced by Respiratory Reovirus Infection","volume":"95","author":"Li","year":"2006","journal-title":"Toxicol Sci"},{"key":"B27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3390\/toxins12100615","article-title":"Maternal Exposure Results in Long-Term Deoxynivalenol Persistence in Piglets\u2019 Plasma and Modulates the Immune System","volume":"12","author":"\u0160t\u011bp\u00e1nov\u00e1","year":"2020","journal-title":"Toxins"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 Diets as Improvements in the AIN-76A Diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr"},{"key":"B29","doi-asserted-by":"publisher","first-page":"5602","DOI":"10.3390\/ijerph17155602","article-title":"Assessment of Deoxynivalenol in Wheat, Corn and Its Products and Estimation of Dietary Intake","volume":"17","author":"Iqbal","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1080\/19393210.2014.926397","article-title":"Co-Occurrence of Type A and B Trichothecenes and Zearalenone in Wheat Grown in Northern Italy Over the Years 2009\u20132011","volume":"7","author":"Bertuzzi","year":"2014","journal-title":"Food Addit Contam: Part B"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3390\/toxins5081353","article-title":"Occurrence of Deoxynivalenol in Wheat in Slovakia During 2010 and 2011","volume":"5","author":"\u0160likov\u00e1","year":"2013","journal-title":"Toxins"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/19440040903567232","article-title":"Fusarium Head Blight and Associated Mycotoxin Occurrence on Winter Wheat in Luxembourg in 2007\/2008","volume":"27","author":"Giraud","year":"2010","journal-title":"Food Addit Contam: Part A"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2019.1571479","article-title":"Global Occurrence of Deoxynivalenol in Food Commodities and Exposure Risk Assessment in Humans in the Last Decade: A Survey","volume":"60","author":"Mishra","year":"2020","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B34","doi-asserted-by":"publisher","first-page":"996","DOI":"10.3945\/jn.115.210401","article-title":"Supplementation of Mice With Specific Nondigestible Oligosaccharides During Pregnancy or Lactation Leads to Diminished Sensitization and Allergy in the Female Offspring","volume":"145","author":"Hogenkamp","year":"2015","journal-title":"J Nutr"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2009.00924.x","article-title":"Acute Allergic Skin Response as a New Tool to Evaluate the Allergenicity of Whey Hydrolysates in a Mouse Model of Orally Induced Cow\u2019s Milk Allergy","volume":"21","author":"Van Esch","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1017\/S204017441000067X","article-title":"Perinatal Programming of Murine Immune Responses by Polyunsaturated Fatty Acids","volume":"2","author":"Van Vlies","year":"2011","journal-title":"J Dev Origins Health Dis"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-238717","article-title":"Deoxynivalenol: A Trigger for Intestinal Integrity Breakdown","volume":"28","author":"Akbari","year":"2014","journal-title":"FASEB J"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00452","article-title":"Human Milk Oligosaccharide 2\u2032-Fucosyllactose Improves Innate and Adaptive Immunity in an Influenza-Specific Murine Vaccination Model","volume":"9","author":"Xiao","year":"2018","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.03.010","article-title":"A Specific Prebiotic Oligosaccharide Mixture Stimulates Delayed-Type Hypersensitivity in a Murine Influenza Vaccination Model","volume":"6","author":"Vos","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s12550-017-0304-z","article-title":"Exposure of Pregnant Sows to Deoxynivalenol During 35\u201370 Days of Gestation Does Not Affect Pathomorphological and Immunohistochemical Properties of Fetal Organs","volume":"34","author":"Wippermann","year":"2018","journal-title":"Mycotoxin Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"7761","DOI":"10.1073\/pnas.1231488100","article-title":"Mast Cells Disrupt Epithelial Barrier Function During Enteric Nematode Infection","volume":"100","author":"McDermott","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa168","article-title":"Acute and Subacute Oral Toxicity of Deoxynivalenol Exposure in a Dermatophagoides Farinae-Induced Murine Asthma Model","volume":"179","author":"Ookawara","year":"2021","journal-title":"Toxicol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1554","article-title":"TNF-\u03b1 Contributes to the Development of Allergic Rhinitis in Mice","volume":"112","author":"Iwasaki","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.7.953","article-title":"Tumor Necrosis Factor \u03b1 Is a Critical Component of Interleukin 13\u2013Mediated Protective T Helper Cell Type 2 Responses During Helminth Infection","volume":"190","author":"Artis","year":"1999","journal-title":"J Exp Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/ni941","article-title":"CpG Directly Induces T-Bet Expression and Inhibits IgG1 and IgE Switching in B Cells","volume":"4","author":"Liu","year":"2003","journal-title":"Nat Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1463","article-title":"Genetic Susceptibility to Food Allergy is Linked to Differential TH2-TH1 Responses in C3H\/HeJ and BALB\/c Mice","volume":"111","author":"Morafo","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.8542","article-title":"Interferon Gamma Induction During Oral Tolerance Reduces T-Cell Migration to Sites of Inflammation","volume":"119","author":"Lee","year":"2000","journal-title":"Gastroenterology"},{"key":"B48","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jaci.2016.03.023","article-title":"Allergen Endotoxins Induce T-Cell\u2013Dependent and non\u2013IgE-Mediated Nasal Hypersensitivity in Mice","volume":"139","author":"Iwasaki","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041498","article-title":"Beyond IgE: Alternative Mast Cell Activation Across Different Disease States","volume":"21","author":"Lyons","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1515\/bmc-2018-0007","article-title":"Interferon-Gamma (IFN-\u03b3): Exploring its Implications in Infectious Diseases","volume":"9","author":"Kak","year":"2018","journal-title":"Biomol Concepts"},{"key":"B51","doi-asserted-by":"publisher","first-page":"0","DOI":"10.4110\/in.2018.18.e33","article-title":"Direct Antiviral Mechanisms of Interferon-Gamma","volume":"18","author":"Kang","year":"2018","journal-title":"Immune Network"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.069","article-title":"Deoxynivalenol (DON) Naturally Contaminated Feed Impairs the Immune Response Induced by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Live Attenuated Vaccine","volume":"33","author":"Savard","year":"2015","journal-title":"Vaccine"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e75148","DOI":"10.1371\/journal.pone.0075148","article-title":"Alterations in Regulatory T Cells Induced by Specific Oligosaccharides Improve Vaccine Responsiveness in Mice","volume":"8","author":"Schijf","year":"2013","journal-title":"PloS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.046","article-title":"Regulatory T-Cells Have a Prominent Role in the Immune Modulated Vaccine Response by Specific Oligosaccharides","volume":"28","author":"van\u2019t Land","year":"2010","journal-title":"Vaccine"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.197707","article-title":"Supplementing Pregnant Mice With a Specific Mixture of Nondigestible Oligosaccharides Reduces Symptoms of Allergic Asthma in Male Offspring","volume":"145","author":"Hogenkamp","year":"2014","journal-title":"J Nutr"},{"key":"B56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1479-5876-12-125","article-title":"Subsets of Regulatory T Cells and Their Roles in Allergy","volume":"12","author":"Zhang","year":"2014","journal-title":"J Trans Med"},{"key":"B57","article-title":"Foxp3 Expressing Regulatory T-Cells in Allergic Disease","volume-title":"Forkhead Transcription Factors: Vital Elements in Biology and Medicine","author":"Nouri-Aria","year":"2010"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.6.2.121","article-title":"T Regulatory Cells and the Control of Allergic Disease","volume":"6","author":"Xystrakis","year":"2006","journal-title":"Expert Opin Biol Ther"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2005.05.005","article-title":"Oral Probiotic Bacterial Administration Suppressed Allergic Responses in an Ovalbumin-Induced Allergy Mouse Model","volume":"45","author":"Kim","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3945\/jn.110.135863","article-title":"Dietary Fatty Acids Affect the Immune System in Male Mice Sensitized to Ovalbumin or Vaccinated With Influenza","volume":"141","author":"Hogenkamp","year":"2011","journal-title":"J Nutr"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.02.014","article-title":"Specific Prebiotic Oligosaccharides Modulate the Early Phase of a Murine Vaccination Response","volume":"10","author":"Vos","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/1541-4337.12545","article-title":"Deoxynivalenol: Masked Forms, Fate During Food Processing, and Potential Biological Remedies","volume":"19","author":"Guo","year":"2020","journal-title":"Food Sci Food Safety"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.04.046","article-title":"Combined Toxic Effects of Mycotoxins","volume":"153","author":"Speijers","year":"2004","journal-title":"Toxicol Lett"},{"key":"B64","doi-asserted-by":"publisher","first-page":"495","DOI":"10.3390\/toxins12080495","article-title":"Individual and Combined In Vitro Effects of Deoxynivalenol and Zearalenone on Boar Semen","volume":"12","author":"Tassis","year":"2020","journal-title":"Toxins"},{"key":"B65","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.tifs.2018.03.008","article-title":"Mycotoxin Risks Under a Climate Change Scenario in Europe","volume":"84","author":"Moretti","year":"2019","journal-title":"Trends Food Sci Technol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.797152\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:30:49Z","timestamp":1639726249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2021.797152\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,17]]},"references-count":65,"alternative-id":["10.3389\/fimmu.2021.797152"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2021.797152","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,17]]},"article-number":"797152"}}