{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:02:42Z","timestamp":1793930562931,"version":"4.8.0"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>S100A9\/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the pathogenesis of rheumatoid arthritis (RA), as it triggers chemotaxis, phagocyte migration and modulation of neutrophils and macrophages. Higher calprotectin levels have been found in synovial fluid, plasma, and serum from RA patients. Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity indexes than c-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR). Calprotectin serum levels decreased after treatment, independently of the DMARD type or strategy. Calprotectin has shown the strongest correlations with other sensitive techniques to detect inflammation, such as ultrasound. Calprotectin independently predicts radiographic progression. However, its value as a biomarker of treatment response and flare after tapering is unclear. This update reviews the current understanding of calprotectin in RA and discusses possible applications as a biomarker in clinical practice.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1001025","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T09:29:40Z","timestamp":1672306180000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":134,"title":["From bench to bedside: Calprotectin (S100A8\/S100A9) as a biomarker in rheumatoid arthritis"],"prefix":"10.3389","volume":"13","author":[{"given":"Jos\u00e9","family":"Inciarte-Mundo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Frade-Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimon","family":"Sanmart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J Autoimmun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/SQB.1989.054.01.003","article-title":"Approaching the asymptote? evolution and revolution in immunology","author":"Janeway","year":"1989","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/art.11079","article-title":"Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis","volume":"48","author":"Ryckman","year":"2003","journal-title":"Arthritis Rheumatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3233","article-title":"Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8\/A9 induce neutrophil chemotaxis and adhesion","volume":"170","author":"Ryckman","year":"2003","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.160.3.1427","article-title":"The human S100 protein MRP-14 is a novel activator of the beta 2 integrin mac-1 on neutrophils","volume":"160","author":"Newton","year":"1998","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(65)90320-7","article-title":"A soluble protein characteristic of the nervous system","volume":"19","author":"Moore","year":"1965","journal-title":"Biochem Biophys Res Commun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00046-2","article-title":"S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles","volume":"33","author":"Donato","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-010-9211-9","article-title":"S100A1: a multifaceted therapeutic target in cardiovascular disease","volume":"3","author":"Rohde","year":"2010","journal-title":"J Cardiovasc Transl Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<325::AID-IJC10>3.0.CO;2-7","article-title":"Expression pattern of sloo calcium-binding proteins in human tumors","volume":"68","author":"Ilg","year":"1996"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.10.002","article-title":"Posttranslational modifications affect the interaction of S100 proteins with tumor suppressor p53","volume":"394","author":"van Dieck","year":"2009","journal-title":"J Mol Biol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709357200","article-title":"Specific citrullination causes assembly of a globular S100A3 homotetramer: a putative Ca2+ modulator matures human hair cuticle","volume":"283","author":"Kizawa","year":"2008","journal-title":"J Biol Chem"},{"key":"B13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nrc3893","article-title":"S100 proteins in cancer","volume":"15","author":"Bresnick","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1369\/0022155417727263","article-title":"Expression and functional analysis of tumor-related factor S100A4 in antler stem cells","volume":"65","author":"Wang","year":"2017","journal-title":"J Histochem Cytochem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1046\/j.0305-1846.2003.00525.x","article-title":"S100A5: a marker of recurrence in WHO grade I meningiomas","volume":"30","author":"Hancq","year":"2004","journal-title":"Neuropathol Appl Neurobiol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197402","article-title":"Aberrant S100A16 expression might be an independent prognostic indicator of unfavorable survival in non-small cell lung adenocarcinoma","volume":"13","author":"Chen","year":"2018","journal-title":"PloS One"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113979","article-title":"S100A6 and its brain ligands in neurodegenerative disorders","volume":"21","author":"Filipek","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i17.1973","article-title":"S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis","volume":"27","author":"Dong","year":"2021","journal-title":"World J Gastroenterol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3639","article-title":"S100A6 represses calu-6 lung cancer cells growth via inhibiting cell proliferation, migration, invasion and enhancing apoptosis","volume":"39","author":"Wang","year":"2021","journal-title":"Cell Biochem Funct"},{"key":"B20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.2174\/156652413804486214","article-title":"Functions of S100 proteins","volume":"13","author":"Donato R","year":"2013","journal-title":"Curr Mol Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.10.150","article-title":"S100A6 - new facts and features","volume":"390","author":"Le\u015bniak","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.268","article-title":"The antimicrobial protein psorias in (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption","volume":"129","author":"Gl\u00e4ser","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004183","article-title":"S100A7, a novel alzheimer\u2019s disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10","volume":"4","author":"Qin","year":"2009","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02782.x","article-title":"Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation","volume":"124","author":"Zheng","year":"2008","journal-title":"Immunology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1499","article-title":"Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15","volume":"181","author":"Wolf","year":"2008","journal-title":"J Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"290","DOI":"10.2174\/187152309789838975","article-title":"Anti-infective protective properties of s100 calgranulins","volume":"8","author":"Hsu","year":"2009","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000041594.36418.f6","article-title":"Induction of S100A9 gene expression by cytokine oncostatin m in breast cancer cells through the STAT3 signaling cascade","volume":"87","author":"Li","year":"2004","journal-title":"Breast Cancer Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0313-4","article-title":"S100A10\/p11: family, friends and functions","volume":"455","author":"Rescher","year":"2008","journal-title":"Pflugers Arch"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-298851","article-title":"Regulation of S100A10 by the PML-RAR-\u03b1 oncoprotein","volume":"117","author":"O\u2019Connell","year":"2011","journal-title":"Blood"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.12.8296","article-title":"Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products","volume":"175","author":"Cecil","year":"2005","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1091\/mbc.e07-07-0682","article-title":"S100A11, an dual mediator for growth regulation of human keratinocytes","volume":"19","author":"Sakaguchi","year":"2008","journal-title":"Mol Biol Cell"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0528-0","article-title":"Inflammation-associated S100 proteins: new mechanisms that regulate function","volume":"41","author":"Goyette","year":"2011","journal-title":"Amino Acids"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.217745","article-title":"S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein e-null mice by activating an osteogenic gene regulatory program","volume":"31","author":"Bowman","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.jri.2005.07.001","article-title":"FGF-1 and S100A13 possibly contribute to angiogenesis in endometriosis","volume":"67","author":"Hayrabedyan","year":"2005","journal-title":"J Reprod Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019375","article-title":"S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)","volume":"6","author":"Jin","year":"2011","journal-title":"PloS One"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.326975","article-title":"Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation","volume":"287","author":"Chen","year":"2012","journal-title":"J Biol Chem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00587.x","article-title":"Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium","volume":"16","author":"Wolf","year":"2007","journal-title":"Exp Dermatol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700946","article-title":"S100A15, an antimicrobial protein of the skin: regulation by e. coli through toll-like receptor 4","volume":"127","author":"B\u00fcchau","year":"2007","journal-title":"J Invest Dermatol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605798200","article-title":"S100A16, a novel calcium-binding protein of the EF-hand superfamily","volume":"281","author":"Sturchler","year":"2006","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1059","article-title":"Identification of S100A16 as a novel adipogenesis promoting factor in 3T3-L1 cells","volume":"152","author":"Liu","year":"2011","journal-title":"Endocrinology"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.11.009","article-title":"S100B\u2019s double life: intracellular regulator and extracellular signal","volume":"1793","author":"Donato","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.1185","article-title":"A critical analysis of the role of the neurotrophic protein S100B in acute brain injury","volume":"23","author":"Kleindienst","year":"2006","journal-title":"J Neurotrauma"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806145200","article-title":"Characterization of the Ca2+ -regulated ezrin-S100P interaction and its role in tumor cell migration","volume":"283","author":"Austermann","year":"2008","journal-title":"J Biol Chem"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.349787","article-title":"S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration","volume":"287","author":"Du","year":"2012","journal-title":"J Biol Chem"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1021\/bi0114731","article-title":"Molecular characterization and tissue distribution of a novel member of the S100 family of EF-hand proteins","volume":"40","author":"Gribenko","year":"2001","journal-title":"Biochemistry"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/art.30290","article-title":"S100A8 enhances osteoclastic bone resorption in vitro through activation of toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis","volume":"63","author":"Grevers","year":"2011","journal-title":"Arthritis Rheumatol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e0120971","DOI":"10.1371\/journal.pone.0120971","article-title":"S100A8\/A9 stimulates keratinocyte proliferation in the development of squamous cell carcinoma of the skin via the receptor for advanced glycation-end products","volume":"10","author":"Iotzova-Weiss","year":"2015","journal-title":"PloS One"},{"key":"B48","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/jlb.53.2.197","article-title":"MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes","volume":"53","author":"Hessian","year":"1993","journal-title":"J Leukoc Biol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90027-R","article-title":"Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3","volume":"8","author":"Dorin","year":"1990","journal-title":"Genomics"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.8.6.2402-2410.1988","article-title":"Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation","volume":"8","author":"Lagasse","year":"1988","journal-title":"Mol Cell Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb02754.x","article-title":"Release and quantitation of a leukocyte derived protein (L1)","volume":"24","author":"Fagerhol","year":"1980","journal-title":"Scand J Haematol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0009-8981(73)90346-X","article-title":"Demonstration of serum protein differences in cystic fibrosis by isoelectric focusing in thin-layer polyacrylamide gels","volume":"49","author":"Wilson","year":"1973","journal-title":"Clin Chim Acta"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.91.2.221","article-title":"Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues","volume":"91","author":"Wilkinson","year":"1988","journal-title":"J Cell Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/326614a0","article-title":"A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene","volume":"326","author":"Dorin","year":"1987","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3310\/hta17550","article-title":"Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation","volume":"17","author":"Waugh","year":"2013","journal-title":"Health Technol Assess"},{"key":"B56","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.cgh.2013.06.028","article-title":"Effectiveness and cost-effectiveness of measuring fecal calprotectin in diagnosis of inflammatory bowel disease in adults and children","volume":"12","author":"Yang","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22917","article-title":"Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease","volume":"18","author":"D\u2019Haens","year":"2012","journal-title":"Inflammation Bowel Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.08.025","article-title":"Calprotectin in inflammatory bowel disease","volume":"510","author":"Khaki-Khatibi","year":"2020","journal-title":"Clinica Chimica Acta"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.6","article-title":"A meta-analysis of the utility of c-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS","volume":"110","author":"Menees","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/330080a0","article-title":"Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis","volume":"330","author":"Odink","year":"1987","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0446","article-title":"MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes","volume":"104","author":"Vogl","year":"2004","journal-title":"Blood"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2741\/A846","article-title":"S100 proteins: structure, functions and pathology","volume":"7","author":"Heizmann","year":"2002","journal-title":"Front Biosci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.6.1875.1875","article-title":"MRP8 and MRP14, s-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner","volume":"82","author":"Roth","year":"1993","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2010.06.009","article-title":"NETs formed by human neutrophils inhibit growth of the pathogenic mold aspergillus fumigatus","volume":"12","author":"McCormick","year":"2010","journal-title":"Microbes Infect"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2520","article-title":"Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells","volume":"105","author":"Viemann","year":"2005","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.7.4678","article-title":"Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells","volume":"166","author":"Srikrishna","year":"2001","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1042\/bj3090419","article-title":"Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration inhibitory factor-related protein 8 (MRP8) and MRP14 to keratin intermediate filaments","volume":"309","author":"Goebeler","year":"1995","journal-title":"Biochem J"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00062-0","article-title":"Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules","volume":"24","author":"Roth","year":"2003","journal-title":"Trends Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1126\/science.1152449","article-title":"Metal chelation and inhibition of bacterial growth in tissue abscesses","volume":"319","author":"Corbin","year":"2008","journal-title":"Science"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.07.004","article-title":"Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of staphylococcus aureus","volume":"10","author":"Kehl-Fie","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0058-9","article-title":"S100 proteins in rheumatic diseases","volume":"14","author":"Austermann","year":"2018","journal-title":"Nat Rev Rheumatol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/art.41062","article-title":"A neutrophil activation biomarker panel in prognosis and monitoring of patients with rheumatoid arthritis","volume":"72","author":"Bach","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1319729","article-title":"Calprotectin levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis","volume":"129","author":"Bae","year":"2017","journal-title":"Postgrad Med"},{"key":"B75","article-title":"Clinical significance of serum calprotectin level for the disease activity in active rheumatoid arthritis with normal c-reactive protein","volume":"12","author":"Wang","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2019-0508","article-title":"Pre-analytical and analytical confounders of serum calprotectin as a biomarker in rheumatoid arthritis","volume":"58","author":"Van Hoovels","year":"2019","journal-title":"Clin Chem Lab Med"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2021.1980223","article-title":"Plasma calprotectin in the emergency department: a potential clinical biomarker for patients with infectious diseases","volume":"81","author":"Wollmer","year":"2021","journal-title":"Scand J Clin Lab Invest"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-61094-z","article-title":"Calprotectin, a new biomarker for diagnosis of acute respiratory infections","volume":"10","author":"Havelka","year":"2020","journal-title":"Sci Rep"},{"key":"B79","first-page":"59","article-title":"A longitudinal study of calprotectin as an inflammatory marker in patients with reactive arthritis","volume":"13","author":"Hammer","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1519103","article-title":"Serum calprotectin correlates with risk and disease severity of ankylosing spondylitis and its change during first month might predict favorable response to treatment","volume":"29","author":"Hu","year":"2019","journal-title":"Mod Rheumatol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3448-x","article-title":"Elevated levels of serum MRP8\/14 in ankylosing spondylitis: associated with peripheral arthritis and active disease","volume":"35","author":"Gupta","year":"2016","journal-title":"Clin Rheumatol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/s13075-014-0413-4","article-title":"Calprotectin (S100A8\/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis","volume":"16","author":"Turina","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"B83","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13075-020-2111-8","article-title":"A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal, and joint disease in the absence of c-reactive protein and its link to clinical disease manifestations","volume":"22","author":"Sokolova","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/696415","article-title":"S-calprotectin (S100A8\/S100A9): A potential marker of inflammation in patients with psoriatic arthritis","volume":"2014","author":"Hansson","year":"2014"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200598","article-title":"The toll-like receptor 4 agonist MRP8\/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis","volume":"71","author":"Holzinger","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/art.11177","article-title":"Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis","volume":"48","author":"Frosch","year":"2003","journal-title":"Arthritis Rheumatol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2017.05.011","article-title":"New markers for adult-onset still\u2019s disease","volume":"85","author":"Mitrovic","year":"2018","journal-title":"Joint Bone Spine"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1615449","article-title":"The role of damage-associated molecular pattern for pathogenesis and biomarkers in adult-onset still\u2019s disease","volume":"19","author":"Jung","year":"2019","journal-title":"Expert Rev Mol Diagn"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/art.38369","article-title":"Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout","volume":"66","author":"Holzinger","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1186\/s13075-017-1444-4","article-title":"Urine S100 proteins as potential biomarkers of lupus nephritis activity","volume":"19","author":"Turnier","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B91","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1177\/096120339300200108","article-title":"Calprotectin in patients with systemic lupus erythematosus: relation to clinical and laboratory parameters of disease activity","volume":"2","author":"Haga","year":"1993","journal-title":"Lupus"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1996.tb04953.x","article-title":"Immunohistochemical characterization of the cellular infiltrates in sj\u00f6gren\u2019s syndrome, rheumatoid arthritis and osteoarthritis with special reference to calprotectin-producing cells","volume":"104","author":"Cuida","year":"1996","journal-title":"APMIS"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2013.848930","article-title":"Calprotectin (S100A8\/A9), S100A12, and EDTA-resistant S100A12 complexes (ERAC) in primary sj\u00f6gren\u2019s syndrome","volume":"43","author":"Nordal","year":"2014","journal-title":"Scand J Rheumatol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2305-4","article-title":"Increased expression of S100A8 and S100A9 in patients with diffuse cutaneous systemic sclerosis. a correlation with organ involvement and immunological abnormalities","volume":"32","author":"Xu","year":"2013","journal-title":"Clin Rheumatol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2013.03.015","article-title":"Biomarkers from bronchoalveolar lavage fluid in systemic sclerosis patients with interstitial lung disease relate to severity of lung fibrosis","volume":"107","author":"Hesselstrand","year":"2013","journal-title":"Respir Med"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-205013","article-title":"Proteomic analysis of plasma identifies the toll-like receptor agonists S100A8\/A9 as a novel possible marker for systemic sclerosis phenotype","volume":"73","author":"Van Bon","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"B97","first-page":"504","article-title":"THU0610 serum calprotectin levels in bechet\u2019s disease: relationships between disease activity and clinical parameters","volume":"77","author":"Torgutalp","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1186\/ar4311","article-title":"Myeloid related protein induces muscle derived inflammatory mediators in juvenile dermatomyositis","volume":"15","author":"Nistala","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63454-2","article-title":"Expression of calcium-binding proteins MRP8 and MRP14 in inflammatory muscle diseases","volume":"163","author":"Seeliger","year":"2003","journal-title":"Am J Pathol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2019.06.044","article-title":"Targeted proteomics reveals serum amyloid a variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis","volume":"204","author":"Nys","year":"2019","journal-title":"Talanta"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1097\/JIM.0000000000000095","article-title":"Elevated serum levels of calprotectin (myeloid-related protein 8\/14) in patients with ankylosing spondylitis and its association with disease activity and quality of life","volume":"62","author":"Oktayoglu","year":"2014","journal-title":"J Investig Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.06.008","article-title":"Serum calprotectin as a biomarker for crohn\u2019s disease","volume":"7","author":"Meuwis","year":"2013","journal-title":"J Crohns Colitis"},{"key":"B103","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/1471-2261-14-196","article-title":"Plasma calprotectin and its association with cardiovascular disease manifestations, obesity and the metabolic syndrome in type 2 diabetes mellitus patients","volume":"14","author":"Pedersen","year":"2014","journal-title":"BMC Cardiovasc Disord"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/852723","article-title":"Clinicians\u2019 guide to the use of fecal calprotectin to identify and monitor disease activity in inflammatory bowel disease","volume":"29","author":"Bressler","year":"2015","journal-title":"Can J Gastroenterol Hepatol"},{"key":"B105","doi-asserted-by":"publisher","first-page":"R122","DOI":"10.1186\/ar3426","article-title":"Decreases in serum levels of S100A8\/9 (calprotectin) correlate with improvements in total swollen joint count in patients with recent-onset rheumatoid arthritis","volume":"13","author":"Andr\u00e9s Cerezo","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B106","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.abd.2018.12.001","article-title":"Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it","volume":"94","author":"Resende","year":"2019","journal-title":"Bras Dermatol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.9.1003","article-title":"Microscopic measurement of cellular infiltration in the rheumatoid arthritis synovial membrane: a comparison of semiquantitative and quantitative analysis","volume":"37","author":"Youssef","year":"1998","journal-title":"Br J Rheumatol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"B109","doi-asserted-by":"publisher","first-page":"580295","DOI":"10.4061\/2011\/580295","article-title":"Myeloid-related protein activity in rheumatoid arthritis","volume":"2011","author":"Malemud","year":"2011","journal-title":"Int J Inflam"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.2174\/157436209789057467","article-title":"Targeting JAK\/STAT signaling pathway in inflammatory diseases","volume":"4","author":"Malemud","year":"2009","journal-title":"Curr Signal Transduct Ther"},{"key":"B111","article-title":"Expression of myeloid related proteins (MRP) 8 and 14 and the MRP8\/14 heterodimer in rheumatoid arthritis synovial membrane","volume":"26","author":"Youssef","year":"1999","journal-title":"J Rheumatol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket315","article-title":"IL-22\/IL-22R1 axis and S100A8\/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts","volume":"52","author":"Carri\u00f3n","year":"2013","journal-title":"Rheumatol (Oxford)"},{"key":"B113","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3109\/03009749109165280","article-title":"The leukocyte protein L1 in plasma and synovial fluid from patients with rheumatoid arthritis and osteoarthritis","volume":"20","author":"Berntzen","year":"1991","journal-title":"Scand J Rheumatol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1021\/pr025531w","article-title":"Application of a novel protein biochip technology for detection and identification of rheumatoid arthritis biomarkers in synovial fluid","volume":"1","author":"Uchida","year":"2002","journal-title":"J Proteome Res"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1419371","article-title":"Calprotectin (S100A8\/A9) should preferably be measured in EDTA-plasma; results from a longitudinal study of patients with rheumatoid arthritis","volume":"78","author":"Nordal","year":"2018"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2009.10.435","article-title":"Prot\u00e9ines S100A8, S100A9 et S100A12: marqueurs inflammatoires ou acteurs physiopathologiques de la polyarthrite rhumato\u00efde","volume":"31","author":"Baillet","year":"2010","journal-title":"Rev Medecine Interne"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep452","article-title":"Synovial fluid proteomic fingerprint: S100A8, S100A9 and S100A12 proteins discriminate rheumatoid arthritis from other inflammatory joint diseases","volume":"49","author":"Baillet","year":"2010","journal-title":"Rheumatol (Oxford)"},{"key":"B118","article-title":"Calprotectin in patients with rheumatoid arthritis: relation to clinical and laboratory variables of disease activity","volume":"19","author":"Brun","year":"1992","journal-title":"J Rheumatol"},{"key":"B119","article-title":"Measurement of plasma calprotectin as an indicator of arthritis and disease activity in patients with inflammatory rheumatic diseases","volume":"21","author":"Brun","year":"1994","journal-title":"J Rheumatol"},{"key":"B120","article-title":"A longitudinal study of the leukocyte protein L1 as an indicator of disease activity in patients with rheumatoid arthritis","volume":"16","author":"Berntzen","year":"1989","journal-title":"J Rheumatol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.099549","article-title":"Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis","volume":"54","author":"De Seny","year":"2008","journal-title":"Clin Chem"},{"key":"B122","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s40291-013-0016-9","article-title":"Calprotectin in rheumatoid arthritis: association with disease activity in a cross-sectional and a longitudinal cohort","volume":"17","author":"Garc\u00eda-Arias","year":"2013","journal-title":"Mol Diagn Ther"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.064741","article-title":"Calprotectin (a major leucocyte protein) is strongly and independently correlated with joint inflammation and damage in rheumatoid arthritis","volume":"66","author":"Hammer","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"B124","doi-asserted-by":"publisher","first-page":"R39","DOI":"10.1186\/ar2645","article-title":"Serum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis","volume":"11","author":"Chen","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.103739","article-title":"Calprotectin (a major S100 leucocyte protein) predicts 10-year radiographic progression in patients with rheumatoid arthritis","volume":"69","author":"Berner Hammer","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3109\/03009748809102976","article-title":"The major leukocyte protein L1 as an indicator of inflammatory joint disease","volume":"76","author":"Berntzen","year":"1988","journal-title":"Scand J Rheumatol Suppl"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.2174\/138161211795049741","article-title":"Critical determinants of cardiovascular risk in rheumatoid arthritis","volume":"17","author":"Bisoendial","year":"2011","journal-title":"Curr Pharm Des"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029751","article-title":"Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis","volume":"64","author":"Haringman","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev251","article-title":"Calprotectin more accurately discriminates the disease status of rheumatoid arthritis patients receiving tocilizumab than acute phase reactants","volume":"54","author":"Inciarte-Mundo","year":"2015","journal-title":"Rheumatol (United Kingdom)"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211695","article-title":"Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis","volume":"76","author":"Jonsson","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183420","article-title":"Relationship between serum calprotectin (S100A8\/9) and clinical, laboratory and ultrasound parameters of disease activity in rheumatoid arthritis: A large cohort study","volume":"12","author":"Hurnakova","year":"2017","journal-title":"PloS One"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmu.2016.11.001","article-title":"Serum calprotectin in rheumatoid arthritis: A promising diagnostic marker, how far is it related to activity and sonographic findings","volume":"25","author":"Mansour","year":"2017","journal-title":"J Med Ultrasound"},{"key":"B133","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/acr.22795","article-title":"Serum calprotectin more accurately discriminates the inflammatory disease activity of rheumatoid arthritis patients receiving TNF inhibitors than acute phase reactants","volume":"68","author":"Inciarte-Mundo","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B134","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/art.27740","article-title":"Interleukin-6 receptor inhibition with tocilizumab and attainment of disease remission in rheumatoid arthritis: The role of acute-phase reactants","volume":"63","author":"Smolen","year":"2011","journal-title":"Arthritis Rheumatol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98255-7","article-title":"Serum calprotectin: a promising biomarker in rheumatoid arthritis and axial spondyloarthritis","volume":"22","author":"Jarlborg","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2017.1413591","article-title":"Calprotectin in patients with chronic rheumatoid arthritis correlates with disease activity and responsiveness to methotrexate","volume":"78","author":"Nielsen","year":"2018","journal-title":"Scand J Clin Lab Invest"},{"key":"B137","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/path.1758","article-title":"Differential expression and response to anti-TNF? treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis","volume":"206","author":"De Rycke","year":"2005","journal-title":"J Pathol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/68362","article-title":"Fibulin-3 and other cartilage metabolism biomarkers in relationship to calprotectin (MRP8\/14) and disease activity in rheumatoid arthritis patients treated with anti-TNF therapy","volume":"27","author":"Kopec-Medrek","year":"2018","journal-title":"Adv Clin Exp Med"},{"key":"B139","article-title":"Clinical significance of myeloid-related protein 8\/14 as a predictor for biological treatment and disease activity in rheumatoid arthritis","volume":"48","author":"Yunchun","year":"2018","journal-title":"Ann Clin Lab Sci"},{"key":"B140","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.semarthrit.2006.04.009","article-title":"Power Doppler ultrasound in musculoskeletal disease: a systematic review","volume":"36","author":"Joshua","year":"2006","journal-title":"Semin Arthritis Rheumatol"},{"key":"B141","doi-asserted-by":"publisher","first-page":"R178","DOI":"10.1186\/ar3503","article-title":"The soluble biomarker calprotectin (a S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab","volume":"13","author":"Hammer","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"B142","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s13075-015-0764-5","article-title":"Serum calprotectin (S100A8\/9): an independent predictor of ultrasound synovitis in patients with rheumatoid arthritis","volume":"17","author":"Hurnakova","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"B143","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s13075-016-1201-0","article-title":"Calprotectin (S100A8\/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis","volume":"19","author":"Nordal","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"B144","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13075-016-1032-z","article-title":"Calprotectin and TNF trough serum levels identify power Doppler ultrasound synovitis in rheumatoid arthritis and psoriatic arthritis patients in remission or with low disease activity","volume":"18","author":"Inciarte-Mundo","year":"2016"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1002\/art.30418","article-title":"Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis","volume":"63","author":"Koenders","year":"2011","journal-title":"Arthritis Rheumatol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.04.007","article-title":"Clinical and sonographic biomarkers of structural damage progression in RA patients in clinical remission: A prospective study with 12 months follow-up","volume":"47","author":"Ram\u00edrez","year":"2017","journal-title":"Semin Arthritis Rheumatol"},{"key":"B147","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jbspin.2019.07.001","article-title":"Calprotectin alone is not sufficient to predict response to methotrexate in early ACR\/EULAR 2010 rheumatoid arthritis: Analysis of the ESPOIR cohort","volume":"87","author":"Bernardy","year":"2020","journal-title":"Joint Bone Spine"},{"key":"B148","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1136\/annrheumdis-2013-203923","article-title":"MRP8\/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis","volume":"74","author":"Choi","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152362","article-title":"A personalized approach to biological therapy using prediction of clinical response based on MRP8\/14 serum complex levels in rheumatoid arthritis patients","volume":"11","author":"Nair","year":"2016","journal-title":"PloS One"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1669813","article-title":"Low serum calprotectin levels correlate with the presence of biological drugs after the first year of treatment in patients with rheumatoid arthritis","volume":"79","author":"Mart\u00ednez-Feito","year":"2019","journal-title":"Scand J Clin Lab Invest"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140628","article-title":"Calprotectin as a biomarker for rheumatoid arthritis: a systematic review","volume":"42","author":"Abildtrup","year":"2015","journal-title":"J Rheumatol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.2174\/1573397115666190122113221","article-title":"Evaluation of serum calprotectin level and disease activity in patients with rheumatoid arthritis","volume":"15","author":"Aghdashi","year":"2019","journal-title":"Curr Rheumatol Rev"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.171375","article-title":"Flares in rheumatoid arthritis patients with low disease activity: Predictability and association with worse clinical outcomes","volume":"45","author":"Bechman","year":"2018","journal-title":"J Rheumatol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000654","article-title":"Predictive value of serum calprotectin (S100A8\/A9) for clinical response after starting or tapering anti-TNF treatment in patients with rheumatoid arthritis","volume":"4","author":"Tweehuysen","year":"2018","journal-title":"RMD Open"},{"key":"B155","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13075-019-2064-y","article-title":"Circulating calprotectin (S100A8\/A9) is higher in rheumatoid arthritis patients that relapse within 12 months of tapering anti-rheumatic drugs","volume":"21","author":"De Moel","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045478","article-title":"An inflammation loop orchestrated by S100A9 and calprotectin is critical for development of arthritis","volume":"7","author":"Cesaro","year":"2012","journal-title":"PloS One"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1330411","article-title":"S100-alarmins: potential therapeutic targets for arthritis","volume":"21","author":"Austermann","year":"2017","journal-title":"Expert Opin Ther Targets"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1001025\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T07:28:50Z","timestamp":1679210930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1001025\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,3]]},"references-count":157,"alternative-id":["10.3389\/fimmu.2022.1001025"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1001025","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,3]]},"article-number":"1001025"}}