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Immunol."],"abstract":"<jats:p>Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint destruction, synovitis, and pannus formation. Gut microbiota dysbiosis may exert direct pathogenic effects on gut homeostasis. It may trigger the host\u2019s innate immune system and activate the \u201cgut\u2013joint axis\u201d, which exacerbates the RA. However, although the importance of the gut microbiota in the development and progression of RA is widely recognized, the mechanisms regulating the interactions between the gut microbiota and the host immune system remain incompletely defined. In this review, we discuss the role of gut microbiota-derived biological mediators, such as short-chain fatty acids, bile acids, and tryptophan metabolites, in maintaining intestinal barrier integrity, immune balance and bone destruction in RA patients as the bridge of the gut\u2013joint axis.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1007610","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T09:38:16Z","timestamp":1665049096000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":77,"title":["The bridge of the gut\u2013joint axis: Gut microbial metabolites in rheumatoid 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