{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:05:02Z","timestamp":1787061902217,"version":"build-2736575974"},"reference-count":107,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI60557 , R21 AI126172"],"award-info":[{"award-number":["R01 AI60557 , R21 AI126172"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007698","name":"University of Florida","doi-asserted-by":"publisher","award":["P0109858"],"award-info":[{"award-number":["P0109858"]}],"id":[{"id":"10.13039\/100007698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    is a major cause of gastric mucosal inflammation, peptic ulcers, and gastric cancer. Emerging antimicrobial-resistant\n                    <jats:italic>H. pylori<\/jats:italic>\n                    has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    . In this study, we employed a new innovative Protective Immunity Enhanced\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Vaccine (PIESV) vector strain to deliver and express multiple\n                    <jats:italic>H. pylori<\/jats:italic>\n                    antigen genes. Immunization of mice with our vaccine delivering the HpaA, Hp-NAP, UreA and UreB antigens, provided sterile protection against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    SS1 infection in 7 out of 10 tested mice. In comparison to the control groups that had received PBS or a PIESV carrying an empty vector, immunized mice exhibited specific and significant cellular recall responses and antigen-specific serum IgG1, IgG2c, total IgG and gastric IgA antibody titers. In conclusion, an improved\n                    <jats:italic>S.<\/jats:italic>\n                    Typhimurium-based live vaccine delivering four antigens shows promise as a safe and effective vaccine against\n                    <jats:italic>H. pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2022.1034683","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T02:45:35Z","timestamp":1668739535000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Protective immunity enhanced Salmonella vaccine vectors delivering Helicobacter pylori antigens reduce H. pylori stomach colonization in mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Amir","family":"Ghasemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Roy","family":"Curtiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"B1","first-page":"59","article-title":"Helicobacter pylori infection and gastric adenocarcinoma","volume":"7","author":"Correa","year":"2011","journal-title":"US Gastroenterol Hepatol Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.199","article-title":"Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease","volume":"81","author":"Blanchard","year":"2017","journal-title":"Pediatr Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90644-Z","article-title":"Epidemiology of Helicobacter pylori in an asymptomatic population in the united states. effect of age, race, and socioeconomic status","volume":"100","author":"Graham","year":"1991","journal-title":"Gastroenterology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.07.033","article-title":"Immunization with a recombinant fusion protein protects mice against Helicobacter pylori infection","volume":"36","author":"Ghasemi","year":"2018","journal-title":"Vaccine"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0975","article-title":"Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains","volume":"47","author":"Yamaoka","year":"2008","journal-title":"Intern Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i11.3150","article-title":"Vaccine against Helicobacter pylori: Inevitable approach","volume":"22","author":"Talebi Bezmin Abadi","year":"2016","journal-title":"World J Gastroenterol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1138","article-title":"New concepts of resistance in the treatment of Helicobacter pylori infections","volume":"5","author":"Graham","year":"2008","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0441-6","article-title":"VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1","volume":"4","author":"Capurro","year":"2019","journal-title":"Nat Microbiol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.022111","article-title":"H. pylori antibiotic resistance: prevalence, importance, and advances in testing","volume":"53","author":"Megraud","year":"2004","journal-title":"Gut"},{"key":"B10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s40139-013-0009-8","article-title":"Helicobacter, inflammation, and gastric cancer","volume":"1","author":"Sepulveda","year":"2013","journal-title":"Curr Pathobiol Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.12.2277","article-title":"Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses","volume":"188","author":"Ermak","year":"1998","journal-title":"J Exp Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.1.279-285.1999","article-title":"Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model","volume":"67","author":"Sawai","year":"1999","journal-title":"Infect Immun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1186\/1471-2180-10-263","article-title":"Outer membrane protein a of Salmonella enterica serovar Typhimurium activates dendritic cells and enhances Th1 polarization","volume":"10","author":"Lee","year":"2010","journal-title":"BMC Microbiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nature08529","article-title":"Uptake through glycoprotein 2 of FimH(+) bacteria by m cells initiates mucosal immune response","volume":"462","author":"Hase","year":"2009","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1999.tb01340.x","article-title":"Live attenuated Salmonella: a paradigm of mucosal vaccines","volume":"171","author":"Sirard","year":"1999","journal-title":"Immunol Rev"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(89)90271-5","article-title":"Live Salmonella as vaccines and carriers of foreign antigenic determinants","volume":"7","author":"Chatfield","year":"1989","journal-title":"Vaccine"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.2.581-586.1998","article-title":"Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella Typhimurium phoPc expressing urease a and b subunits","volume":"66","author":"Corth\u00e9sy-Theulaz","year":"1998","journal-title":"Infect Immun"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(97)00247-8","article-title":"Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella Typhimurium producing urease subunits a and b","volume":"16","author":"G\u00f3mez-Duarte","year":"1998","journal-title":"Vaccine"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00246-7","article-title":"Safety and immunogenicity of phoP\/phoQ-deleted Salmonella Typhi expressing Helicobacter pylori urease in adult volunteers","volume":"18","author":"Dipetrillo","year":"1999","journal-title":"Vaccine"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00436-8","article-title":"The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases","volume":"17","author":"G\u00f3mez-Duarte","year":"1999","journal-title":"Vaccine"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00391-7","article-title":"Safety and immunogenicity of live recombinant Salmonella enterica serovar Typhi Ty21a expressing urease A and B from Helicobacter pylori in human volunteers","volume":"20","author":"Bumann","year":"2001","journal-title":"Vaccine"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00355-3","article-title":"Vaccination of mice with live recombinant Salmonella Typhimurium aroA against H. pylori: parameters associated with prophylactic and therapeutic vaccine efficacy","volume":"20","author":"Koesling","year":"2001","journal-title":"Vaccine"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.9.5096-5106.2002","article-title":"Attenuated Salmonella enterica serovar Typhi expressing urease effectively immunizes mice against Helicobacter pylori challenge as part of a heterologous mucosal priming-parenteral boosting vaccination regimen","volume":"70","author":"Londo\u00f1o-Arcila","year":"2002","journal-title":"Infect Immun"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2003.00182.x","article-title":"Immunization with attenuated Salmonella Typhimurium producing catalase in protection against gastric Helicobacter pylori infection in mice","volume":"8","author":"Chen","year":"2003","journal-title":"Helicobacter"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.11.6320-6328.2003","article-title":"Autodisplay: efficacious surface exposure of antigenic UreA fragments from Helicobacter pylori in Salmonella vaccine strains","volume":"71","author":"Rizos","year":"2003","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.020","article-title":"Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar Typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers","volume":"22","author":"Metzger","year":"2004","journal-title":"Vaccine"},{"key":"B27","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4049\/jimmunol.1600608","article-title":"Salmonella\n             vaccines: Conduits for protective antigens","volume":"200","author":"Clark-Curtiss","year":"2018","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1637\/aviandiseases-D-19-00159","article-title":"Mucosal delivery of a self-destructing Salmonella-based vaccine inducing immunity against Eimeria","volume":"64","author":"Kong","year":"2020","journal-title":"Avian Dis"},{"key":"B29","doi-asserted-by":"publisher","first-page":"101592","DOI":"10.1016\/j.psj.2021.101592","article-title":"A triple-sugar regulated Salmonella vaccine protects against Clostridium perfringens-induced necrotic enteritis in broiler chickens","volume":"101","author":"Wang","year":"2022","journal-title":"Poult Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.5.3.328","article-title":"Oral immunization using live attenuated Salmonella spp as carriers of foreign antigens","volume":"5","author":"Cardenas","year":"1992","journal-title":"Clin Microbiol Rev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216941","article-title":"Bacterial infectious disease control by vaccine development","volume":"110","author":"Curtiss","year":"2002","journal-title":"J Clin Invest."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.12.046","article-title":"Recombinant Salmonella vaccines for biodefence","volume":"24","author":"Atkins","year":"2006","journal-title":"Vaccine"},{"key":"B33","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ijmm.2007.08.006","article-title":"Rational design of Salmonella recombinant vaccines","volume":"298","author":"Cheminay","year":"2008","journal-title":"Int J Med Microbiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v30.i3.30","article-title":"New technologies in using recombinant attenuated Salmonella vaccine vectors","volume":"30","author":"Curtiss","year":"2010","journal-title":"Crit Rev Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.micpath.2012.10.006","article-title":"New technologies in developing recombinant attenuated Salmonella vaccine vectors","volume":"58","author":"Wang","year":"2013","journal-title":"Microbial Pathogenesis"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(99)01468-1","article-title":"Regional specialization in the mucosal immune system: primed cells do not always home along the same track","volume":"20","author":"Brandtzaeg","year":"1999","journal-title":"Immunol Today"},{"key":"B37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1600-065X.1999.tb01342.x","article-title":"The b-cell system of human mucosae and exocrine glands","volume":"171","author":"Brandtzaeg","year":"1999","journal-title":"Immunol Rev"},{"key":"B38","first-page":"39","article-title":"Role of mucosal immunity in influenza","volume":"115","author":"Brandtzaeg","year":"2003","journal-title":"Dev Biol (Basel)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1078\/1438-4221-00241","article-title":"Role of secretory antibodies in the defence against infections","volume":"293","author":"Brandtzaeg","year":"2003","journal-title":"Int J Med Microbiol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/j.0105-2896.2005.00290.x","article-title":"Mucosal immunoglobulins","volume":"206","author":"Woof","year":"2005","journal-title":"Immunol Rev"},{"key":"B41","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3109\/08820131003622635","article-title":"Secretory IgA: arresting microbial pathogens at epithelial borders","volume":"39","author":"Mantis","year":"2010","journal-title":"Immunol Invest"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.9.3279-3286.1995","article-title":"A recombinant Salmonella Typhimurium vaccine induces local immunity by four different routes of immunization","volume":"63","author":"Hopkins","year":"1995","journal-title":"Infect Immun"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod53.2.462","article-title":"Oral immunization with attenuated Salmonella expressing human sperm antigen induces antibodies in serum and the reproductive tract","volume":"53","author":"Srinivasan","year":"1995","journal-title":"Biol Reprod"},{"key":"B44","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00005-006-0003-5","article-title":"Activation of Salmonella-specific immune responses in the intestinal mucosa","volume":"54","author":"Srinivasan","year":"2006","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00679.x","article-title":"Early cellular responses to Salmonella infection: dendritic cells, monocytes, and more","volume":"225","author":"Tam","year":"2008","journal-title":"Immunol Rev"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-93864-4_8","article-title":"Tracking the dynamics of Salmonella specific T cell responses","volume":"334","author":"Moon","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00413-09","article-title":"Immunogenicity of a live recombinant Salmonella enterica serovar Typhimurium vaccine expressing pspA in neonates and infant mice born from naive and immunized mothers","volume":"17","author":"Shi","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2011.2","article-title":"Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda","volume":"4","author":"Griffin","year":"2011","journal-title":"Mucosal Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4161\/gmic.19141","article-title":"Innate immune response to Salmonella Typhimurium, a model enteric pathogen","volume":"3","author":"Broz","year":"2012","journal-title":"Gut Microbes"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0688-693","article-title":"Construction of an ASD+ expression-cloning vector: Stable maintenance and high level expression of cloned genes in a Salmonella vaccine strain","volume":"6","author":"Nakayama","year":"1988","journal-title":"Nat Biotech"},{"key":"B51","article-title":"Protective immunity enhanced Salmonella vaccine (PIESV) against brucella spp","author":"Curtiss","year":"2018","journal-title":"US patent Appl 17 \/ 273,801"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.3.1079-1085.1991","article-title":"Mutations at rfc or pmi attenuate Salmonella Typhimurium virulence for mice","volume":"59","author":"Collins","year":"1991","journal-title":"Infect Immun"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803801105","article-title":"Regulated programmed lysis of recombinant Salmonella in host tissues to release protective antigens and confer biological containment","volume":"105","author":"Kong","year":"2008","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00693-08","article-title":"Salmonella enterica serovar Typhimurium strains with regulated delayed attenuation in vivo","volume":"77","author":"Curtiss","year":"2009","journal-title":"Infect Immun"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.03.094","article-title":"Multiple antigens of yersinia pestis delivered by live recombinant attenuated Salmonella vaccine strains elicit protective immunity against plague","volume":"34","author":"Sanapala","year":"2016","journal-title":"Vaccine"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1637\/11094-041715-Reg","article-title":"Protection against necrotic enteritis in broiler chickens by regulated delayed lysis Salmonella vaccines","volume":"59","author":"Jiang","year":"2015","journal-title":"Avian Dis"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.1739-1749.2002","article-title":"Immune responses to recombinant pneumococcal PspA antigen delivered by live attenuated Salmonella enterica serovar Typhimurium vaccine","volume":"70","author":"Kang","year":"2002","journal-title":"Infect Immun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00950-10","article-title":"Immunization with Salmonella enterica serovar Typhimurium-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae","volume":"79","author":"Muralinath","year":"2011","journal-title":"Infect Immun"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.9.1467","article-title":"The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor","volume":"191","author":"Satin","year":"2000","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.2.920-926.2006","article-title":"HpaA is essential for Helicobacter pylori colonization in mice","volume":"74","author":"Carlsohn","year":"2006","journal-title":"Infect Immun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1586\/erv.09.62","article-title":"Development of vaccines against Helicobacter pylori","volume":"8","author":"Del Giudice","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3390\/biology2031110","article-title":"The role of Helicobacter pylori outer membrane proteins in adherence and pathogenesis","volume":"2","author":"Oleastro","year":"2013","journal-title":"Biol (Basel)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.008","article-title":"Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis","volume":"15","author":"Hatakeyama","year":"2014","journal-title":"Cell Host Microbe"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02281-14","article-title":"Dynamics of Lewis b binding and sequence variation of the babA adhesin gene during chronic Helicobacter pylori infection in humans","volume":"5","author":"Nell","year":"2014","journal-title":"MBio"},{"key":"B65","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2174\/1874285801610010097","article-title":"In silico design of a chimeric protein containing antigenic fragments of Helicobacter pylori; a bioinformatic approach","volume":"10","author":"Mohammad","year":"2016","journal-title":"Open Microbiol J"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8060181","article-title":"Use of VacA as a vaccine antigen","volume":"8","author":"Moyat","year":"2016","journal-title":"Toxins (Basel)"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.171","article-title":"Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer","volume":"15","author":"Gagnaire","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2018.01.001","article-title":"Immunization with recombinant FliD confers protection against Helicobacter pylori infection in mice","volume":"94","author":"Ghasemi","year":"2018","journal-title":"Mol Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.10.033","article-title":"Evaluation of Psn, HmuR and a modified LcrV protein delivered to mice by live attenuated Salmonella as a vaccine against bubonic and pneumonic Yersinia pestis challenge","volume":"29","author":"Branger","year":"2010","journal-title":"Vaccine"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.09.013","article-title":"Simultaneous immunization of mice with Omp31 and TF provides protection against Brucella melitensis infection","volume":"33","author":"Ghasemi","year":"2015","journal-title":"Vaccine"},{"key":"B71","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41419-019-1859-8","article-title":"SIRT1-targeted miR-543 autophagy inhibition and epithelial-mesenchymal transition promotion in Helicobacter pylori CagA-associated gastric cancer","volume":"10","author":"Shi","year":"2019","journal-title":"Cell Death Dis"},{"key":"B72","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41419-019-1312-z","article-title":"Decreased IL-17RB expression impairs CD11b","volume":"10","author":"Teng","year":"2019","journal-title":"Cell Death Dis"},{"key":"B73","first-page":"71","article-title":"An improvement of the 2\u02c6(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis","volume":"3","author":"Rao","year":"2013","journal-title":"Biostat Bioinforma Biomath"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401366200","article-title":"Investigation of the structural requirements in the lipopolysaccharide core acceptor for ligation of O antigens in the genus Salmonella: WaaL \"ligase\" is not the sole determinant of acceptor specificity","volume":"279","author":"Kaniuk","year":"2004","journal-title":"J Biol Chem"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.074","article-title":"Regulated delayed expression of rfc enhances the immunogenicity and protective efficacy of a heterologous antigen delivered by live attenuated Salmonella enterica vaccines","volume":"28","author":"Kong","year":"2010","journal-title":"Vaccine"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00097-13","article-title":"A colanic acid operon deletion mutation enhances induction of early antibody responses by live attenuated Salmonella vaccine strains","volume":"81","author":"Wang","year":"2013","journal-title":"Infect Immun"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01623-07","article-title":"Analysis of type II secretion of recombinant pneumococcal PspA and PspC in a Salmonella enterica serovar Typhimurium vaccine with regulated delayed antigen synthesis","volume":"76","author":"Xin","year":"2008","journal-title":"Infect Immun"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00444-10","article-title":"Salmonella vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity","volume":"78","author":"Wang","year":"2010","journal-title":"Infect Immun"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05526-11","article-title":"Live attenuated Salmonella vaccines displaying regulated delayed lysis and delayed antigen synthesis to confer protection against Mycobacterium tuberculosis","volume":"80","author":"Ju\u00e1rez-Rodr\u00edguez","year":"2012","journal-title":"Infect Immun"},{"key":"B80","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2180-11-31","article-title":"Improving Salmonella vector with rec mutation to stabilize the DNA cargoes","volume":"11","author":"Zhang","year":"2011","journal-title":"BMC Microbiol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1016\/j.vaccine.2011.03.066","article-title":"Protective cellular responses elicited by vaccination with influenza nucleoprotein delivered by a live recombinant attenuated Salmonella vaccine","volume":"29","author":"Ashraf","year":"2011","journal-title":"Vaccine"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217554109","article-title":"Turning self-destructing Salmonella into a universal DNA vaccine delivery platform","volume":"109","author":"Kong","year":"2012","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.2174\/0929866521666140708092032","article-title":"Role of antimicrobial peptides expressed by host cells upon infection by Helicobacter pylori","volume":"21","author":"Gopal","year":"2014","journal-title":"Protein Pept Lett"},{"key":"B84","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/978-3-030-15138-6_8","article-title":"Carbohydrate-dependent and antimicrobial peptide defence mechanisms against Helicobacter pylori infections","volume":"421","author":"Padra","year":"2019","journal-title":"Curr Top Microbiol Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60588","article-title":"Cxcr2 and Cxcl5 regulate the IL-17\/G-CSF axis and neutrophil homeostasis in mice","volume":"122","author":"Mei","year":"2012","journal-title":"J Clin Invest"},{"key":"B86","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s41419-019-1312-z","article-title":"Decreased IL-17RB expression impairs CD11b+CD11c- myeloid cell accumulation in gastric mucosa and host defense during the early-phase of Helicobacter pylori infection","volume":"10","author":"Teng","year":"2019","journal-title":"Cell Death Dis"},{"key":"B87","article-title":"Proliferative lesions of the non-glandular and glandular stomach in rats, GI-3","volume-title":"Guides for toxologic pathology, STP\/ARP\/AFIP","author":"Frantz Jd","year":"1991"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.06.099","article-title":"Therapeutic efficacy of oral immunization with attenuated Salmonella Typhimurium expressing Helicobacter pylori CagA, VacA and UreB fusion proteins in mice model","volume":"29","author":"Liu","year":"2011","journal-title":"Vaccine"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.4.2135-2141.2000","article-title":"Pilot study of phoP\/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers","volume":"68","author":"Angelakopoulos","year":"2000","journal-title":"Infect Immun"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.12.016","article-title":"Contributions of humoral and cellular immunity to vaccine-induced protection in humans","volume":"411","author":"Amanna","year":"2011","journal-title":"Virology"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4155-4168.2000","article-title":"Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein families","volume":"68","author":"Alm","year":"2000","journal-title":"Infect Immun"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/nature11684","article-title":"Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori","volume":"493","author":"Strugatsky","year":"2013","journal-title":"Nature"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01003","article-title":"Protection against Helicobacter pylori infection in BALB\/c mouse model by oral administration of multivalent epitope-based vaccine of cholera toxin b subunit-HUUC","volume":"9","author":"Pan","year":"2018","journal-title":"Front Immunol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1006\/mpat.2001.0466","article-title":"HpaA shows variable surface localization but the gene expression is similar in different Helicobacter pylori strains","volume":"31","author":"Lundstr\u00f6m","year":"2001","journal-title":"Microb Pathog"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1080\/00016350152509238","article-title":"T-Cell-mediated mucosal immunity in the absence of antibody: lessons from Helicobacter pylori infection","volume":"59","author":"Ernst","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.001","article-title":"CD25+\/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo","volume":"131","author":"Rad","year":"2006","journal-title":"Gastroenterology"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.12.007","article-title":"The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer","volume":"14","author":"Naugler","year":"2008","journal-title":"Trends Mol Med"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004","article-title":"The biological functions of T helper 17 cell effector cytokines in inflammation","volume":"28","author":"Ouyang","year":"2008","journal-title":"Immunity"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.4.1958","article-title":"CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism","volume":"170","author":"Chung","year":"2003","journal-title":"J Immunol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2013.03.011","article-title":"Th17 cell based vaccines in mucosal immunity","volume":"25","author":"Kumar","year":"2013","journal-title":"Curr Opin Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801308","article-title":"IL-22 preserves gut epithelial integrity and promotes disease remission during chronic","volume":"202","author":"Lo","year":"2019","journal-title":"J Immunol"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203421","article-title":"Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration","volume":"191","author":"Al-Alwan","year":"2013","journal-title":"J Immunol"},{"key":"B103","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1099\/ijs.0.63083-0","article-title":"Lactobacillus gastricus sp. nov., lactobacillus antri sp. nov., lactobacillus kalixensis sp. nov. and Lactobacillus ultunensis sp. nov., isolated from human stomach mucosa","volume":"55","author":"Roos","year":"2005","journal-title":"Int J Syst Evol Microbiol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-765X.2008.02416.x","article-title":"Isolation of lactobacilli with probiotic properties from the human stomach","volume":"47","author":"Ryan","year":"2008","journal-title":"Lett Appl Microbiol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.149","article-title":"Structure of the human gastric bacterial community in relation to Helicobacter pylori status","volume":"5","author":"Maldonado-Contreras","year":"2011","journal-title":"ISME J"},{"key":"B106","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/srep00170","article-title":"Bacterial biogeography of the human digestive tract","volume":"1","author":"Stearns","year":"2011","journal-title":"Sci Rep"},{"key":"B107","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1136\/gutjnl-2013-305178","article-title":"Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis","volume":"63","author":"Lertpiriyapong","year":"2014","journal-title":"Gut"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1034683\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T02:45:42Z","timestamp":1668739542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1034683\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":107,"alternative-id":["10.3389\/fimmu.2022.1034683"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1034683","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"article-number":"1034683"}}