{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T03:49:49Z","timestamp":1783050589030,"version":"3.54.6"},"reference-count":165,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Acute liver injuries have wide and varied etiologies and they occur both in patients with and without pre-existent chronic liver disease. Whilst the pathophysiological mechanisms remain distinct, both acute and acute-on-chronic liver injury is typified by deranged serum transaminase levels and if severe or persistent can result in liver failure manifest by a combination of jaundice, coagulopathy and encephalopathy. It is well established that platelets exhibit diverse functions as immune cells and are active participants in inflammation through processes including immunothrombosis or thromboinflammation. Growing evidence suggests platelets play a dualistic role in liver inflammation, shaping the immune response through direct interactions and release of soluble mediators modulating function of liver sinusoidal endothelial cells, stromal cells as well as migrating and tissue-resident leucocytes. Elucidating the pathways involved in initiation, propagation and resolution of the immune response are of interest to identify therapeutic targets. In this review the provocative role of platelets is outlined, highlighting beneficial and detrimental effects in a spatial, temporal and disease-specific manner.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1037645","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T05:28:57Z","timestamp":1666848537000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["The role of platelet mediated thromboinflammation in acute liver injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Sean M.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1208937","article-title":"Acute liver failure","volume":"369","author":"Bernal","year":"2013","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003328.pub3","article-title":"Interventions for paracetamol (acetaminophen) overdose","volume":"2","author":"Chiew","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.5500\/wjt.v11.i6.187","article-title":"Liver transplantation in acute liver failure: Dilemmas and challenges","volume":"11","author":"Kumar","year":"2021","journal-title":"World J Transplant"},{"key":"B4","doi-asserted-by":"crossref","unstructured":"AbbasN\n            RajoriyaN\n            ElsharkawyAM\n            ChauhanA\n          Acute-on-chronic liver failure (ACLF) in 2022: have novel treatment paradigms already arrived?2022","DOI":"10.1080\/17474124.2022.2097070"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.12.005","article-title":"Transition to decompensation and acute-on-chronic liver failure: Role of predisposing factors and precipitating events","volume":"75","author":"Gustot","year":"2021","journal-title":"J Hepatol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312670","article-title":"Acute-on-chronic liver failure: an update","volume":"66","author":"Hernaez","year":"2017","journal-title":"Gut"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00070","article-title":"Are platelets cells? and if yes, are they immune cells","volume":"6","author":"Garraud","year":"2015","journal-title":"Front Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01731","article-title":"Platelets and immune responses during thromboinflammation","volume":"10","author":"Mezger","year":"2019","journal-title":"Front Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/rth2.12266","article-title":"The dual role of platelet-innate immune cell interactions in thrombo-inflammation","volume":"4","author":"Rayes","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073868","article-title":"Beyond hemostasis: Platelet innate immune interactions and thromboinflammation","volume":"23","author":"Mandel","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-15584-3","article-title":"The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure","volume":"11","author":"Chauhan","year":"2020","journal-title":"Nat Commun"},{"key":"B13","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1172\/JCI79070","article-title":"Inflammation drives thrombosis after salmonella infection via CLEC-2 on platelets","volume":"125","author":"Hitchcock","year":"2015","journal-title":"J Clin Invest"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28526","article-title":"Platelets: No longer bystanders in liver disease","volume":"64","author":"Chauhan","year":"2016","journal-title":"Hepatology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"3113","DOI":"10.3390\/ijms22063113","article-title":"Till death do us part\u2013the multifaceted role of platelets in liver diseases","volume":"22","author":"Mussbacher","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.688643","article-title":"The role of CLEC-2 and its ligands in thromboinflammation","volume":"12","author":"Meng","year":"2021","journal-title":"Front Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.048","article-title":"Innate immune cell trafficking and function during sterile inflammation of the liver","volume":"151","author":"Mcdonald","year":"2016","journal-title":"Gastroenterology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Kono","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2970","article-title":"Molecular mechanisms of necroptosis: an ordered cellular explosion","volume":"11","author":"Vandenabeele","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.10.046","article-title":"Secondary necrosis: the natural outcome of the complete apoptotic program","volume":"584","author":"Silva","year":"2010","journal-title":"FEBS Lett"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28003","article-title":"Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice","volume":"62","author":"Slaba","year":"2015","journal-title":"Hepatology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28740","article-title":"Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure","volume":"64","author":"Cl\u00e0ria","year":"2016","journal-title":"Hepatology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/cells9122632","article-title":"Leukocytes, systemic inflammation and immunopathology in acute-on-Chronic liver failure","volume":"9","author":"Casulleras","year":"2020","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314240","article-title":"Bacterial and fungal infections in acute-on-chronic liver failure: prevalence, characteristics and impact on prognosis","volume":"67","author":"Fern\u00e1ndez","year":"2018","journal-title":"Gut"},{"key":"B28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jhep.2013.07.044","article-title":"Pathological bacterial translocation in liver cirrhosis","volume":"60","author":"Wiest","year":"2014","journal-title":"J Hepatol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18486","article-title":"Cell death and liver disease","volume":"14","author":"Aizawa","year":"2020","journal-title":"Gut Liver"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02013","article-title":"Abnormal innate immunity in acute-on-Chronic liver failure: Immunotargets for therapeutics","volume":"11","author":"Khanam","year":"2020","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03259.x","article-title":"Altered immune function of monocytes in different stages of patients with acute on chronic liver failure","volume":"147","author":"Xing","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1053\/j.gastro.2014.11.045","article-title":"Patients with acute-on-Chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK","volume":"148","author":"Bernsmeier","year":"2015","journal-title":"Gastroenterology"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-283838","article-title":"Deciphering the human platelet sheddome","volume":"117","author":"Fong","year":"2011","journal-title":"Blood"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1358","article-title":"Platelets and platelet-derived extracellular vesicles in liver physiology and disease","volume":"3","author":"Balaphas","year":"2019","journal-title":"Hepatol Commun"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2015.1064881","article-title":"The role of platelets in the recruitment of leukocytes during vascular disease","volume":"26","author":"Ed Rainger","year":"2015","journal-title":"Platelets"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02712","article-title":"Role of platelets in leukocyte recruitment and resolution of inflammation","volume":"9","author":"Rossaint","year":"2018","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1786043","article-title":"Role of platelets and megakaryocytes in adaptive immunity","volume":"32","author":"Marcoux","year":"2021","journal-title":"Platelets"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142076","article-title":"Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia","volume":"212","author":"Hillgruber","year":"2015","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-12-617159","article-title":"Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice","volume":"126","author":"Gros","year":"2015","journal-title":"Blood"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000396","article-title":"Delayed but not early treatment with DNase reduces organ damage and improves outcome in a murine model of sepsis","volume":"44","author":"Mai","year":"2015","journal-title":"Shock"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"189","author":"Stark","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-287623","article-title":"Von willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models","volume":"117","author":"Brill","year":"2011","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1038\/s41582-019-0221-1","article-title":"Thrombo-inflammation in acute ischaemic stroke \u2014 implications for treatment","volume":"158","author":"Stoll","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-573915","article-title":"Thrombocytopenia impairs host defense in gram-negative pneumonia-derived sepsis in mice","volume":"124","author":"De Stoppelaar","year":"2014","journal-title":"Blood"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00023.2017","article-title":"Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse","volume":"313","author":"Lax","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"Rayes","year":"2017","journal-title":"Nat Commun"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000257","article-title":"Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice","volume":"4","author":"Lax","year":"2017","journal-title":"BMJ Open Respir Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.celrep.2019.06.062","article-title":"Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice","volume":"28","author":"Carestia","year":"2019","journal-title":"Cell Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1887842","article-title":"Platelets and viruses","volume":"32","author":"Antoniak","year":"2021","journal-title":"Platelets"},{"key":"B50","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/09537104.2020.1718633","article-title":"Alterations in platelet behavior after major trauma: adaptive or maladaptive","volume":"32","author":"Vulliamy","year":"2021","journal-title":"Platelets"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170","article-title":"The coagulopathy of chronic liver disease","volume":"365","author":"Tripodi","year":"2011","journal-title":"N Engl J Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.12.003","article-title":"EASL clinical practical guidelines on the management of acute (fulminant) liver failure","volume":"66","author":"Wendon","year":"2017","journal-title":"J Hepatol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300672","article-title":"Combined in vivo depletion of glycoprotein VI and c-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice","volume":"33","author":"Bender","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788067","article-title":"Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria","volume":"131","author":"Claushuis","year":"2018","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0020-y","article-title":"Liver sinusoidal endothelial cells \u2014 gatekeepers of hepatic immunity","volume":"15","author":"Shetty","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240311","article-title":"Expression of e-selectin and e-selectin ligands in human liver inflammation","volume":"24","author":"Adams","year":"1996","journal-title":"Hepatology"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.1.255","article-title":"Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells","volume":"134","author":"Campbell","year":"1996","journal-title":"J Cell Biol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0379-5","article-title":"Platelet GPIb\u03b1 is a mediator and potential interventional target for NASH and subsequent liver cancer","volume":"25","author":"Malehmir","year":"2019","journal-title":"Nat Med"},{"key":"B59","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s10353-015-0363-3","article-title":"Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation","volume":"48","author":"Miyashita","year":"2016","journal-title":"Eur Surg"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.2.507","article-title":"Platelet-endothelial cell interactions during Ischemia\/Reperfusion: The role of p-selectin","volume":"92","author":"Massberg","year":"1998","journal-title":"Blood"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nm1317","article-title":"Platelets mediate cytotoxic T lymphocyte\u2013induced liver damage","volume":"11","author":"Iannacone","year":"2005","journal-title":"Nat Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"G469","DOI":"10.1152\/ajpgi.00407.2012","article-title":"Hepatic sinusoidal endothelium avidly binds platelets in an integrin-dependent manner, leading to platelet and endothelial activation and leukocyte recruitment","volume":"304","author":"Lalor","year":"2013","journal-title":"Am J Physiol - Gastrointest Liver Physiol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24755","article-title":"Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers","volume":"55","author":"Russo","year":"2012","journal-title":"Hepatology"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50069","article-title":"Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells","volume":"37","author":"Upadhya","year":"2003","journal-title":"Hepatology"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70427-6","article-title":"Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver","volume":"118","author":"Sindram","year":"2000","journal-title":"Gastroenterology"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707578","article-title":"Platelet-dependent accumulation of leukocytes in sinusoids mediates hepatocellular damage in bile duct ligation-induced cholestasis","volume":"153","author":"Laschke","year":"2008","journal-title":"Br J Pharmacol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.05.009","article-title":"Platelet c-type lectin-like receptor 2 reduces cholestatic liver injury in mice","volume":"190","author":"Maruyama","year":"2020","journal-title":"Am J Pathol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"R107","DOI":"10.1186\/cc6133","article-title":"Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction","volume":"11","author":"Gambim","year":"2007","journal-title":"Crit Care"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26307","article-title":"Role of procoagulant microparticles in mediating complications and outcome of acute liver injury\/acute liver failure","volume":"58","author":"Stravitz","year":"2013","journal-title":"Hepatology"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097945","article-title":"Characterization of microparticles after hepatic ischemia-reperfusion injury","volume":"9","author":"Freeman","year":"2014","journal-title":"PloS One"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104376","article-title":"Microparticles mediate hepatic ischemia-reperfusion injury and are the targets of diannexin (ASP8597)","volume":"9","author":"Teoh","year":"2014","journal-title":"PloS One"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21017","article-title":"CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets","volume":"43","author":"Khandoga","year":"2006","journal-title":"Hepatology"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.20529","article-title":"Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced p-selectin up-regulation in the rat","volume":"33","author":"Peralta","year":"2001","journal-title":"Hepatology"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nm1780","article-title":"Aggravation of viral hepatitis by platelet-derived serotonin","volume":"14","author":"Lang","year":"2008","journal-title":"Nat Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/12447","article-title":"Targeted disruption of cd39\/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation","volume":"5","author":"Enjyoji","year":"1999","journal-title":"Nat Med"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711580211","article-title":"Hepatic sinusoidal cell destruction in the development of intravascular coagulation in acute liver failure of rats","volume":"158","author":"Hirata","year":"1989","journal-title":"J Pathol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.09.030","article-title":"Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice","volume":"72","author":"Groeneveld","year":"2020","journal-title":"J Hepatol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.10.018","article-title":"Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure","volume":"64","author":"Mookerjee","year":"2016","journal-title":"J Hepatol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1016\/j.cgh.2021.07.012","article-title":"Decreasing von willebrand factor levels upon nonselective beta blocker therapy indicate a decreased risk of further decompensation, acute-on-chronic liver failure, and death","volume":"20","author":"Jachs","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.005","article-title":"Severity of systemic inflammation is the main predictor of ACLF and bleeding in patients with acutely decompensated cirrhosis","author":"Zanetto","year":"2022","journal-title":"J Hepatol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319044","article-title":"Role of portal venous platelet activation in patients with decompensated cirrhosis and TIPS","volume":"69","author":"Queck","year":"2020","journal-title":"Gut"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21175","article-title":"Neutrophil depletion protects against murine acetaminophen hepatotoxicity","volume":"43","author":"Liu","year":"2006","journal-title":"Hepatology"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15142-15150.2005","article-title":"Blockade of neutrophil elastase attenuates severe liver injury in hepatitis b transgenic mice","volume":"79","author":"Takai","year":"2005","journal-title":"J Virol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(02)00200-8","article-title":"Neutrophil-mediated tissue injury in alcoholic hepatitis","volume":"27","author":"Jaeschke","year":"2002","journal-title":"Alcohol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052411","article-title":"Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice","volume":"7","author":"Rensen","year":"2012","journal-title":"PloS One"},{"key":"B86","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/labinvest.2017.90","article-title":"Neutrophils: a cornerstone of liver ischemia and reperfusion injury","volume":"98","author":"De Oliveira","year":"2018","journal-title":"Lab Invest"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200012073432307","article-title":"Immunodeficiency diseases caused by defects in phagocytes","volume":"343","author":"Lekstrom-Himes","year":"2000","journal-title":"N Engl J Med"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701584163","article-title":"Role of neutrophils in the pathogenesis of acute inflammatory liver injury","volume":"35","author":"Ramaiah","year":"2007","journal-title":"Toxicol Pathol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902485","article-title":"Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death","volume":"184","author":"Kono","year":"2010","journal-title":"J Immunol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195491","article-title":"Intravascular danger signals guide neutrophils to sites of sterile inflammation","volume":"330","author":"McDonald","year":"2010","journal-title":"Science"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779","article-title":"Phagocyte partnership during the onset and resolution of inflammation","volume":"10","author":"Soehnlein","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1172\/JCI35958","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J Clin Invest"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 release induced by liver ischemia involves toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"Tsung","year":"2007","journal-title":"J Exp Med"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26748","article-title":"Opposing effects of prednisolone treatment on T\/NKT cell- and hepatotoxin-mediated hepatitis in mice","volume":"59","author":"Kwon","year":"2014","journal-title":"Hepatology"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep38250","article-title":"Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients","volume":"6","author":"Huang","year":"2016","journal-title":"Sci Rep"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.12.005","article-title":"Impaired intracellular signaling, myeloperoxidase release and bactericidal activity of neutrophils from patients with alcoholic cirrhosis","volume":"64","author":"Boussif","year":"2016","journal-title":"J Hepatol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/srep38714","article-title":"Low expression of CXCR1\/2 on neutrophils predicts poor survival in patients with hepatitis b virus-related acute-on-chronic liver failure","volume":"6","author":"Xu","year":"2016","journal-title":"Sci Rep"},{"key":"B99","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/jvh.12160","article-title":"Neutrophil-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis b liver failure","volume":"21","author":"Liu","year":"2014","journal-title":"J Viral Hepat"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1159\/000347132","article-title":"Damage-associated molecular patterns control neutrophil recruitment","volume":"5","author":"Pittman","year":"2013","journal-title":"J Innate Immun"},{"key":"B101","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.blre.2006.06.001","article-title":"Platelet-neutrophil-interactions: Linking hemostasis and inflammation","volume":"21","author":"Zarbock","year":"2007","journal-title":"Blood Rev"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2727-4","article-title":"Platelet-neutrophil interactions as drivers of inflammatory and thrombotic disease","volume":"371","author":"Lisman","year":"2018","journal-title":"Cell Tissue Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"Sreeramkumar","year":"2014","journal-title":"Science"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290505","article-title":"P-selectin mediates reperfusion injury through neutrophil and platelet sequestration in the warm ischemic mouse liver","volume":"29","author":"Yadav","year":"1999","journal-title":"Hepatology"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119742","article-title":"Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor","volume":"100","author":"Weber","year":"1997","journal-title":"J Clin Invest"},{"key":"B106","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.thromres.2019.08.019","article-title":"The role of PSGL-1 in pathogenesis of systemic inflammatory response and coagulopathy in endotoxemic mice","volume":"182","author":"Wang","year":"2019","journal-title":"Thromb Res"},{"key":"B107","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.cell.2022.01.010","article-title":"GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA","volume":"185","author":"De Giovanni","year":"2022","journal-title":"Cell"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1715474","article-title":"Netting liver disease: Neutrophil extracellular traps in the initiation and exacerbation of liver pathology","volume":"46","author":"Meijenfeldt","year":"2020","journal-title":"Semin Thromb Hemost"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1718631","article-title":"Platelets and extracellular traps in infections","volume":"32","author":"G\u00f3mez","year":"2021","journal-title":"Platelets"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27841","article-title":"Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury","volume":"62","author":"Huang","year":"2015","journal-title":"Hepatology"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.06.006","article-title":"Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death","volume":"584","author":"Gupta","year":"2010","journal-title":"FEBS Lett"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0415-161R","article-title":"Mediators and molecular pathways involved in the regulation of neutrophil extracellular trap formation mediated by activated platelets","volume":"99","author":"Carestia","year":"2016","journal-title":"J Leukoc Biol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-624023","article-title":"P-selectin promotes neutrophil extracellular trap formation in mice","volume":"126","author":"Etulain","year":"2015","journal-title":"Blood"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice","volume":"129","author":"McDonald","year":"2017","journal-title":"Blood"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-343061","article-title":"Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4","volume":"118","author":"Semeraro","year":"2011","journal-title":"Blood"},{"key":"B118","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam8897","article-title":"Host DNases prevent vascular occlusion by neutrophil extracellular traps","volume":"358","author":"Jim\u00e9nez-Alc\u00e1zar","year":"2017","journal-title":"Sci (80- )"},{"key":"B120","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jcmgh.2022.05.012","article-title":"Neutrophil extracellular traps mediate acute liver failure in regulation of miR-223\/Neutrophil elastase signaling in mice","volume":"14","author":"Ye","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2019.06.002","article-title":"Plasma levels of circulating DNA are associated with outcome, but not with activation of coagulation in decompensated cirrhosis and ACLF","volume":"1","author":"Blasi","year":"2019","journal-title":"JHEP Rep Innov Hepatol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32174","article-title":"Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome","volume":"75","author":"von Meijenfeldt","year":"2022","journal-title":"Hepatology"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00085","article-title":"Platelet-neutrophil interplay: Insights into neutrophil extracellular trap (NET)-driven coagulation in infection","volume":"6","author":"Zucoloto","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002783","article-title":"Acetylsalicylic acid inhibits intravascular coagulation during staphylococcus aureus-induced sepsis in mice","volume":"135","author":"Carestia","year":"2020","journal-title":"Blood"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2019.1704711","article-title":"Inhibition of immunothrombosis does not affect pathogen capture and does not promote bacterial dissemination in a mouse model of sepsis","volume":"31","author":"Carestia","year":"2020","journal-title":"Platelets"},{"key":"B126","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28682","article-title":"Chemokine (C-c motif) receptor 2\u2013positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury","volume":"64","author":"Mossanen","year":"2016","journal-title":"Hepatology"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086660","article-title":"The monocyte to macrophage transition in the murine sterile wound","volume":"9","author":"Crane","year":"2014","journal-title":"PloS One"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"Wong","year":"2013","journal-title":"Nat Immunol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68571.sa2","article-title":"Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment","volume":"10","author":"Shan","year":"2021","journal-title":"Elife"},{"key":"B131","doi-asserted-by":"publisher","first-page":"110680","DOI":"10.1016\/j.biopha.2020.110680","article-title":"CHI3L1 in the pathophysiology and diagnosis of liver diseases","volume":"131","author":"Wang","year":"2020","journal-title":"BioMed Pharmacother"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-598656","article-title":"Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice","volume":"126","author":"Miyakawa","year":"2015","journal-title":"Blood"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.916346","article-title":"Monocytes: protagonists of infarct inflammation and repair after myocardial infarction","volume":"121","author":"Nahrendorf","year":"2010","journal-title":"Circulation"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20141539","article-title":"A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury","volume":"212","author":"Dal-Secco","year":"2015","journal-title":"J Exp Med"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.009","article-title":"A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"B138","doi-asserted-by":"publisher","first-page":"7294","DOI":"10.1038\/s41467-021-27614-9","article-title":"Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury","volume":"12","author":"Honda","year":"2021","journal-title":"Nat Commun"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-23197-7","article-title":"Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe0595","article-title":"Primordial GATA6 macrophages function as extravascular platelets in sterile injury","volume":"371","author":"Zindel","year":"2021","journal-title":"Sci (80- )"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-314184","article-title":"CD14 + CD15 - HLA-DR - myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure","volume":"67","author":"Bernsmeier","year":"2018","journal-title":"Gut"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-316888","article-title":"Inhibition of glutamine synthetase in monocytes from patients with acute-on-chronic liver failure resuscitates their antibacterial and inflammatory capacity","volume":"68","author":"Korf","year":"2019","journal-title":"Gut"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.611133","article-title":"Activated platelets convert CD14+CD16- into CD14+CD16+ monocytes with enhanced Fc\u03b3R-mediated phagocytosis and skewed M2 polarization","volume":"11","author":"Lee","year":"2021","journal-title":"Front Immunol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1631-3","article-title":"Resolving the fibrotic niche of human liver cirrhosis at single-cell level","volume":"575","author":"Ramachandran","year":"2019","journal-title":"Nature"},{"key":"B145","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1053\/j.gastro.2004.12.039","article-title":"Liver regeneration, growth factors, and amphiregulin","volume":"128","author":"Michalopoulos","year":"2005","journal-title":"Gastroenterology"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-006-0772-3","article-title":"Platelets promote liver regeneration in early period after hepatectomy in mice","volume":"31","author":"Murata","year":"2007","journal-title":"World J Surg"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9493-0","article-title":"Platelets promote liver regeneration under conditions of kupffer cell depletion after hepatectomy in mice","volume":"32","author":"Murata","year":"2008","journal-title":"World J Surg"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.04.019","article-title":"Role of platelets on liver regeneration after 90% hepatectomy in mice","volume":"49","author":"Myronovych","year":"2008","journal-title":"J Hepatol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2019.01.016","article-title":"Systematic review and meta-analysis of thrombocytopenia as a predictor of post-hepatectomy liver failure","volume":"21","author":"Meyer","year":"2019","journal-title":"HPB (Oxford)"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1257786","article-title":"The cellular basis of platelet secretion: Emerging structure\/function relationships","volume":"28","author":"Yadav","year":"2017","journal-title":"Platelets"},{"key":"B151","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3748\/wjg.v28.i9.897","article-title":"Dualistic role of platelets in living donor liver transplantation: Are they harmful","volume":"28","author":"Liang","year":"2022","journal-title":"World J Gastroenterol"},{"key":"B152","doi-asserted-by":"publisher","first-page":"8053","DOI":"10.3390\/ijms22158053","article-title":"Critical role of LSEC in post-hepatectomy liver regeneration and failure","volume":"22","author":"De Rudder","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B153","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3390\/cells9051243","article-title":"Platelet interactions with liver sinusoidal endothelial cells and hepatic stellate cells lead to hepatocyte proliferation","volume":"9","author":"Meyer","year":"2020","journal-title":"Cells"},{"key":"B154","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1111\/jth.13672","article-title":"The platelet-activating receptor c-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice","volume":"15","author":"Kono","year":"2017","journal-title":"J Thromb Haemost"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13386","article-title":"Transient von willebrand factor-mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice","volume":"37","author":"Kirschbaum","year":"2017","journal-title":"Liver Int"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3390\/cells9051311","article-title":"Platelet transforming growth factor-\u03b21 induces liver sinusoidal endothelial cells to secrete interleukin-6","volume":"9","author":"Balaphas","year":"2020","journal-title":"Cells"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12446","article-title":"Sphingosine 1-phosphate has anti-apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human","volume":"45","author":"Nowatari","year":"2015","journal-title":"Hepatol Res"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23262","article-title":"Role of acid sphingomyelinase of kupffer cells in cholestatic liver injury in mice","volume":"51","author":"Osawa","year":"2010","journal-title":"Hepatology"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21814","article-title":"Depletion of kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl\/6 mice","volume":"29","author":"Owumi","year":"2014","journal-title":"Environ Toxicol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Sci (80- )"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9452-4","article-title":"Decreased hepatic 5-HT1A receptors during liver regeneration and neoplasia in rats","volume":"33","author":"Sulaiman","year":"2008","journal-title":"Neurochem Res"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31601","article-title":"Consequences of perioperative serotonin reuptake inhibitor treatment during hepatic surgery","volume":"73","author":"Starlinger","year":"2021","journal-title":"Hepatology"},{"key":"B163","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1182\/blood-2014-09-600312","article-title":"Horizontal RNA transfer mediates platelet-induced hepatocyte proliferation","volume":"126","author":"Kirschbaum","year":"2015","journal-title":"Blood"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-869057","article-title":"Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans","volume":"133","author":"Groeneveld","year":"2019","journal-title":"Blood"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.12.006","article-title":"Liver regeneration after acetaminophen hepatotoxicity: Mechanisms and therapeutic opportunities","volume":"189","author":"Bhushan","year":"2019","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1037645\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T05:29:02Z","timestamp":1666848542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1037645\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":165,"alternative-id":["10.3389\/fimmu.2022.1037645"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1037645","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"article-number":"1037645"}}