{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:03:43Z","timestamp":1787457823251,"version":"build-2736575974"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>CD11c, also named integrin \u03b1X, has been deemed solely as a dendritic cell marker for decades while the delineation of its biological function was limited. In the current study, we observed in mice that CD11c deficiency led to a defect in T cell development, demonstrated by the loss of CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup>double positive (DP) T cells, CD4<jats:sup>+<\/jats:sup>CD8<jats:sup>-<\/jats:sup>, and CD4<jats:sup>-<\/jats:sup>CD8<jats:sup>+<\/jats:sup>single positive (SP) T cells in the thymus and less mature T cells in the periphery. By using bone marrow chimera, we confirmed that CD11c regulated T cell development in the thymus. We further showed that CD11c deficiency led to an accelerated apoptosis of CD3 positive thymocytes, but not CD4<jats:sup>-<\/jats:sup>CD8<jats:sup>-<\/jats:sup>double negative (DN) T cells. Overall, this study added one more layer of knowledge on the regulatory mechanism of late-stage T cell development that the presence of CD11c in the thymus is critical for maintaining T cell survival.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1040818","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T06:36:38Z","timestamp":1668062198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["CD11c regulates late-stage T cell development in the 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