{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:51:01Z","timestamp":1793490661830,"version":"4.5.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82071014, No.82271137, No. 81870700, No. 82000951"],"award-info":[{"award-number":["No. 82071014, No.82271137, No. 81870700, No. 82000951"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["No. 16ZR1426100"],"award-info":[{"award-number":["No. 16ZR1426100"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["No. 19411950700, No. 18DZ2260200"],"award-info":[{"award-number":["No. 19411950700, No. 18DZ2260200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common sinonasal inflammatory disorder with high heterogeneity. Increasing evidence have indicated that the infiltration of macrophages especially M2 macrophages play pivotal roles in the pathogenesis of CRSwNP, but the underlying mechanisms remain undetermined. This study sought to identify potential biomarkers related to M2 macrophages in CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression datasets of GSE136825 and GSE179265 were download from Gene Expression Omnibus (GEO) database and merged. Then, CIBERSORT and weighted gene co-expression network analysis (WGCNA) algorithms were applied to identify M2 macrophage-related gene modules. Thereafter, differentially expressed genes (DEGs) related to M2 macrophages were selected to perform functional enrichment analyses. A protein-protein interaction (PPI) network was built to identify hub genes and quantitative real-time reverse transcriptions PCR was used to verify the bioinformatics results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 92 DEGs associated with M2 macrophages were identified for further analysis. The results of Gene ontology (GO) and Kyoto Encyclopedia of genes and genomes (KEGG) analyses illustrated that M2 macrophage-associated DEGs primarily enriched in immune responses and extracellular matrix structure. PPI network analysis identified 18 hub genes related to M2 macrophages that might be pivotal in the pathogenesis of CRSwNP. After verification, AIF1, C1QA, C1QB, C3AR1, CCR1, CD163, CD4, CD53, CD86, CSF1R, CYBB, FCER1G, FCGR3A, IL10RA, ITGB2, LAPTM5, PLEK, TYROBP were identified as potential M2 macrophage-related biomarkers for CRSwNP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings yield new insights into the hub genes and mechanisms related to M2 macrophages in the pathogenesis of CRSwNP. Further studies of these hub genes would help better understand the disease progression and identify potential treatment targets.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.1047930","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T05:05:12Z","timestamp":1668661512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":58,"title":["M2 macrophage-related gene signature in chronic rhinosinusitis with nasal polyps"],"prefix":"10.3389","volume":"13","author":[{"given":"Ying","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.12.021","article-title":"Phenotypes of chronic rhinosinusitis","volume":"8","author":"Cho","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.jaci.2009.05.017","article-title":"Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese","volume":"124","author":"Cao","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12016-021-08844-7","article-title":"Eosinophils in the field of nasal polyposis: Towards a better understanding of biologic therapies","volume":"62","author":"Vanderhaegen","year":"2022","journal-title":"Clin Rev Allergy Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41572-020-00218-1","article-title":"Adult chronic rhinosinusitis","volume":"6","author":"Bachert","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/all.14706","article-title":"Role of microRNAs in inflammatory upper airway diseases","volume":"76","author":"Tubita","year":"2021","journal-title":"Allergy"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.928134","article-title":"Advances in the regulation of macrophage polarization by mesenchymal stem cells and implications for ALI\/ARDS treatment","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00541-3","article-title":"Macrophages and the maintenance of homeostasis","volume":"18","author":"Mosser","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/0194599814528672","article-title":"Macrophage infiltrate is elevated in CRSwNP sinonasal tissue regardless of atopic status","volume":"151","author":"Banks","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B10","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1398-9995.2010.02498.x","article-title":"Alternatively activated macrophages and impaired phagocytosis of s","volume":"66","author":"Krysko","year":"2011","journal-title":"aureus chronic rhinosinusitis Allergy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1016\/j.jaci.2018.09.041","article-title":"IFN-\u03bb1 enhances staphylococcus aureus clearance in healthy nasal mucosa but not in nasal polyps","volume":"143","author":"Lan","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22218","article-title":"Deficiency in interleukin-10 production by M2 macrophages in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"8","author":"Wang","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J Pathol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1900732","DOI":"10.1183\/13993003.00732-2019","article-title":"Whole-transcriptome sequencing reveals heightened inflammation and defective host defence responses in chronic rhinosinusitis with nasal polyps","volume":"54","author":"Peng","year":"2019","journal-title":"Eur Respir J"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1016\/j.jaci.2021.11.017","article-title":"Inflammatory molecular endotypes of nasal polyps derived from white and Japanese populations","volume":"149","author":"Nakayama","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1101\/060012","article-title":"Fast gene set enrichment analysis","volume":"60012","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an r package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Gene Ontol Consortium Nat Genet"},{"key":"B24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an r package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: an r package for visually combining expression data with functional analysis","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq675","article-title":"Cytoscape 2.8: new features for data integration and network visualization","volume":"27","author":"Smoot","year":"2011","journal-title":"Bioinformatics"},{"key":"B29","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","author":"Chin","year":"2014","journal-title":"BMC Syst Biol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2278OC","article-title":"Cytokines in chronic rhinosinusitis. role in eosinophilia and aspirin-exacerbated respiratory disease","volume":"192","author":"Stevens","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e11450","DOI":"10.1371\/journal.pone.0011450","article-title":"Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis","volume":"5","author":"Plager","year":"2010","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/all.14287","article-title":"Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps","volume":"76","author":"Shi","year":"2021","journal-title":"Allergy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21419","article-title":"Role of platelet-derived growth factor-\u03b1 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps","volume":"4","author":"Lin","year":"2014","journal-title":"Int Forum Allergy Rhinol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jaci.2009.04.013","article-title":"TGF-beta signaling and collagen deposition in chronic rhinosinusitis","volume":"124","author":"Van Bruaene","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin20.564","article-title":"Mucin 5AC is significantly upregulated in exosomes from the nasal lavage fluid and may promote the expression of COX-2, VEGF and MMP-9: an implication in nasal polyp pathogenesis","volume":"59","author":"Wang","year":"2021","journal-title":"Rhinology"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140315","article-title":"Macrophage-mediated vascular permeability via VLA4\/VCAM1 pathway dictates ascites development in ovarian cancer","volume":"131","author":"Zhang","year":"2021","journal-title":"J Clin Invest"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00934","article-title":"Corrigendum: Coagulation factor X regulated by CASC2c recruited macrophages and induced M2 polarization in glioblastoma multiforme","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jaci.2013.02.003","article-title":"Increased expression of factor XIII-a in patients with chronic rhinosinusitis with nasal polyps","volume":"132","author":"Takabayashi","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.310333","article-title":"IL-1\u03b2 (Interleukin-1\u03b2) and TNF-\u03b1 (Tumor necrosis factor-\u03b1) impact abdominal aortic aneurysm formation by differential effects on macrophage polarization","volume":"38","author":"Batra","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12929-015-0151-1","article-title":"Complement and macrophage crosstalk during process of angiogenesis in tumor progression","volume":"22","author":"Khan","year":"2015","journal-title":"J BioMed Sci"},{"key":"B43","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/alr.20046","article-title":"Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis","volume":"1","author":"Ayers","year":"2011","journal-title":"Int Forum Allergy Rhinol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218412","article-title":"CC chemokines in a tumor: A review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jaci.2011.03.017","article-title":"Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"128","author":"Poposki","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947983","article-title":"IL-10 family cytokines in chronic rhinosinusitis with nasal polyps: From experiments to the clinic","volume":"13","author":"Xuan","year":"2022","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/cea.12304","article-title":"Increased local IgE production induced by common aeroallergens and phenotypic alteration of mast cells in Chinese eosinophilic, but not non-eosinophilic, chronic rhinosinusitis with nasal polyps","volume":"44","author":"Cao","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/all.13567","article-title":"The soluble isoform of human Fc\u03b5RI is an endogenous inhibitor of IgE-mediated mast cell responses","volume":"74","author":"Mo\u00f1ino-Romero","year":"2019","journal-title":"Allergy"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0129-x","article-title":"Fc\u03b3RIII stimulation breaks the tolerance of human nasal epithelial cells to bacteria through cross-talk with TLR4","volume":"12","author":"Golebski","year":"2019","journal-title":"Mucosal Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0239","article-title":"Activation of tumor-promoting type 2 macrophages by EGFR-targeting antibody cetuximab","volume":"17","author":"Pander","year":"2011","journal-title":"Clin Cancer Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-021-00892-7","article-title":"Tipping the balance: intricate roles of the complement system in disease and therapy","volume":"43","author":"Pouw","year":"2021","journal-title":"Semin Immunopathol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2980","article-title":"Innate responses to aspergillus: role of C1q and pentraxin 3 in nasal polyposis","volume":"21","author":"Baruah","year":"2007","journal-title":"Am J Rhinol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0048-x","article-title":"C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis","volume":"11","author":"Mulligan","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-719757","article-title":"C1q and HMGB1 reciprocally regulate human macrophage polarization","volume":"128","author":"Son","year":"2016","journal-title":"Blood"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.609754","article-title":"Transcriptomic signatures and functional network analysis of chronic rhinosinusitis with nasal polyps","volume":"12","author":"Hao","year":"2021","journal-title":"Front Genet"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4193\/Rhin19.407","article-title":"Analysis of expression profiling data suggests explanation for difficulties in finding biomarkers for nasal polyps","volume":"58","author":"Lee","year":"2020","journal-title":"Rhinology"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150660","article-title":"NOX2-dependent regulation of inflammation","volume":"130","author":"Singel","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22530","article-title":"Expression of nicotinamide adenine dinucleotide phosphate oxidase in chronic rhinosinusitis with nasal polyps","volume":"10","author":"Zheng","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073532","article-title":"Withholding of m-CSF supplement reprograms macrophages to M2-like via endogenous CSF-1 activation","volume":"22","author":"Chen","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002683","article-title":"The transition of m-CSF-derived human macrophages to a growth-promoting phenotype","volume":"4","author":"Hamidzadeh","year":"2020","journal-title":"Blood Adv"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200900060","article-title":"Proteomic identification of pleckstrin-associated proteins in platelets: possible interactions with actin","volume":"9","author":"Baig","year":"2009","journal-title":"Proteomics"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-178913","article-title":"Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis","volume":"113","author":"Lian","year":"2009","journal-title":"Blood"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47901","article-title":"ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S307197","article-title":"Cell adhesion molecules are upregulated and may drive inflammation in chronic rhinosinusitis with nasal polyposis","volume":"14","author":"Blight","year":"2021","journal-title":"J Asthma Allergy"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8811-9","article-title":"TYROBP in alzheimer's disease","volume":"51","author":"Ma","year":"2015","journal-title":"Mol Neurobiol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"19315","DOI":"10.1038\/s41598-021-98637-x","article-title":"TYROBP, TLR4 and ITGAM regulated macrophages polarization and immune checkpoints expression in osteosarcoma","volume":"11","author":"Liang","year":"2021","journal-title":"Sci Rep"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.769727","article-title":"Development and validation of a prognostic gene signature correlated with M2 macrophage infiltration in esophageal squamous cell carcinoma","volume":"11","author":"Yao","year":"2021","journal-title":"Front Oncol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.355917","article-title":"LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages","volume":"287","author":"Glowacka","year":"2012","journal-title":"J Biol Chem"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1047930\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T05:05:17Z","timestamp":1668661517000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1047930\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,17]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2022.1047930"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1047930","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,17]]},"article-number":"1047930"}}