{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:37:41Z","timestamp":1793342261013,"version":"4.5.0"},"reference-count":172,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ferroptosis requires not only the accumulation of iron ions, but also changes in many ferroptosis-related regulators, including a decrease in GPX4 and inhibition of SLC7A11 for classical ferroptosis, a deletion of FSP1 or GCH1. Surprisingly, adipose tissue (AT) in the obesity conditions is also accompanied by iron buildup, decreased GSH, and increased ROS. On the neurological side, the pro-inflammatory factor released by AT may have first caused ferroptosis in the vagus nerve by inhibiting of the NRF2-GPX4 pathway, resulting in disorders of the autonomic nervous system. On the immune side, obesity may cause M2 macrophages ferroptosis due to damage to iron-rich ATMs (MFe<jats:sup>hi<\/jats:sup>) and antioxidant ATMs (Mox), and lead to Treg cells ferroptosis through reductions in NRF2, GPX4, and GCH1 levels. At the same time, the reduction in GPX4 may also trigger the ferroptosis of B1 cells. In addition, some studies have also found the role of GPX4 in neutrophil autophagy, which is also worth pondering whether there is a connection with ferroptosis. In conclusion, this review summarizes the associations between neuroimmune regulation associated with obesity and ferroptosis, and on the basis of this, highlights their potential molecular mechanisms, proposing that ferroptosis in one or more cells in a multicellular tissue changes the fate of that tissue.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1049936","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:18:48Z","timestamp":1669011528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system"],"prefix":"10.3389","volume":"13","author":[{"given":"Sen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00063-2","article-title":"Chemistry and biology of eukaryotic iron metabolism","volume":"33","author":"Aisen","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0098-2997(00)00006-6","article-title":"The roles of iron in health and disease","volume":"22","author":"Lieu","year":"2001","journal-title":"Mol Aspects Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"B4","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydroperoxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.mam.2004.02.005","article-title":"Mitochondrial free radical production and cell signaling","volume":"25","author":"Cadenas","year":"2004","journal-title":"Mol Aspects Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408360701713104","article-title":"Oxidative stress and iron homeostasis: mechanistic and health aspects","volume":"45","author":"Galaris","year":"2008","journal-title":"Crit Rev Clin Lab Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1021\/tx060101w","article-title":"Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics","volume":"19","author":"Merkofer","year":"2006","journal-title":"Chem Res Toxicol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13020","article-title":"Iron and the liver","author":"Pietrangelo","year":"2016","journal-title":"Liver Int"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in alzheimer's disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J Neurochem"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.02.003","article-title":"Ferroptosis in parkinson's disease: glia-neuron crosstalk","volume":"28","author":"Wang","year":"2022","journal-title":"Trends Mol Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"173999","DOI":"10.1016\/j.ejphar.2021.173999","article-title":"Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis","volume":"898","author":"Tu","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13069","article-title":"Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice","volume":"25","author":"Xie","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"B14","doi-asserted-by":"publisher","first-page":"9911167","DOI":"10.1155\/2022\/9911167","article-title":"Postconditioning with irisin attenuates lung Ischemia\/Reperfusion injury by suppressing ferroptosis via induction of the Nrf2\/HO-1 signal axis","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14302","article-title":"Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis","volume":"23","author":"Huang","year":"2019","journal-title":"J Cell Mol Med"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-01004-z","article-title":"The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma","volume":"23","author":"Sun","year":"2020","journal-title":"Gastric Cancer"},{"key":"B17","doi-asserted-by":"publisher","first-page":"107992","DOI":"10.1016\/j.pharmthera.2021.107992","article-title":"Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression","volume":"232","author":"Sui","year":"2022","journal-title":"Pharmacol Ther"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat Chem Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010793200","article-title":"Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5. selective inhibition by triacsin c and thiazolidinediones","volume":"276","author":"Kim","year":"2001","journal-title":"J Biol Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nat Chem Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.10.002","article-title":"Mammalian lipoxygenases and their biological relevance","volume":"1851","author":"Kuhn","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0472-6","article-title":"Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis","volume":"16","author":"Zou","year":"2020","journal-title":"Nat Chem Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metab"},{"key":"B26","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol Cell"},{"key":"B27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/A:1006841228483","article-title":"NADPH-initiated cytochrome P450-dependent free iron-independent microsomal lipid peroxidation: Specific prevention by ascorbic acid","volume":"166","author":"Ghosh","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90921.2008","article-title":"Dysregulated glutathione metabolism links to impaired insulin action in adipocytes","volume":"296","author":"Kobayashi","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione peroxidase 4 senses and translates oxidative stress into 12\/15-lipoxygenase dependent- and AIF-mediated cell death","volume":"8","author":"Seiler","year":"2008","journal-title":"Cell Metab"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.680090","article-title":"Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis","volume":"290","author":"Chen","year":"2015","journal-title":"J Biol Chem"},{"key":"B35","doi-asserted-by":"publisher","first-page":"129539","DOI":"10.1016\/j.bbagen.2020.129539","article-title":"Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy","volume":"1864","author":"Wei","year":"2020","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B36","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11154-013-9281-5","article-title":"Risk of postprandial insulin resistance: the liver\/vagus rapport","volume":"15","author":"Macedo","year":"2014","journal-title":"Rev Endocr Metab Disord"},{"key":"B37","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1146\/annurev.pharmtox.42.092501.104328","article-title":"The biochemistry and physiology of s-nitrosothiols","volume":"42","author":"Hogg","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0556","article-title":"A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism","volume":"29","author":"Villette","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1159\/000368833","article-title":"Association of genetic polymorphisms for glutathione peroxidase genes with obesity in Spanish children","volume":"7","author":"Ruperez","year":"2014","journal-title":"J Nutrigenet Nutrigenomics"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0942","article-title":"Adipocyte turnover: Relevance to human adipose tissue morphology","volume":"59","author":"Arner","year":"2010","journal-title":"Diabetes"},{"key":"B42","doi-asserted-by":"publisher","first-page":"101020","DOI":"10.1016\/j.plipres.2019.101020","article-title":"A global perspective on the crosstalk between saturated fatty acids and toll-like receptor 4 in the etiology of inflammation and insulin resistance","volume":"77","author":"Li","year":"2020","journal-title":"Prog Lipid Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-022-01064-9","article-title":"Adipocyte GPX4 protects against inflammation, hepatic insulin resistance and metabolic dysregulation","volume":"46","author":"Schwarzler","year":"2022","journal-title":"Int J Obes (Lond)"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.05.030","article-title":"High-fat diet induces changes in adipose tissue trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels in a depot-specific manner","volume":"63","author":"Long","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat Commun"},{"key":"B49","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","article-title":"GTP cyclohydrolase 1\/Tetrahydrobiopterin counteract ferroptosis through lipid remodeling","volume":"6","author":"Kraft","year":"2020","journal-title":"ACS Cent Sci"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nat Chem Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"B52","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3390\/antiox10020317","article-title":"xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers","volume":"10","author":"Lee","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-022-00642-w","article-title":"The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis","volume":"32","author":"Yan","year":"2022","journal-title":"Cell Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.5.3009","article-title":"4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer","volume":"274","author":"Nakamura","year":"1999","journal-title":"J Biol Chem"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11455","article-title":"Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins","volume":"274","author":"Sato","year":"1999","journal-title":"J Biol Chem"},{"key":"B56","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun (Lond)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35926-4","article-title":"Exchange of cystine and glutamate across plasma membrane of human fibroblasts","volume":"261","author":"Bannai","year":"1986","journal-title":"J Biol Chem"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0867-5","article-title":"The oxidative stress-inducible cystine\/glutamate antiporter, system x (c) (-) : Cystine supplier and beyond","volume":"42","author":"Conrad","year":"2012","journal-title":"Amino Acids"},{"key":"B59","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.3390\/ijms21155529","article-title":"Iron metabolism in obesity and metabolic syndrome","volume":"21","author":"Gonzalez-Dominguez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B60","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour","year":"2014","journal-title":"J Res Med Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179889","article-title":"Iron elevation and adipose tissue remodeling in the epididymal depot of a mouse model of polygenic obesity","volume":"12","author":"Ma","year":"2017","journal-title":"PloS One"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1159\/000336423","article-title":"Macrophages and systemic iron homeostasis","volume":"4","author":"Ganz","year":"2012","journal-title":"J Innate Immun"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.023879","article-title":"Polarization dictates iron handling by inflammatory and alternatively activated macrophages","volume":"95","author":"Corna","year":"2010","journal-title":"Haematologica"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0213","article-title":"Obesity alters adipose tissue macrophage iron content and tissue iron distribution","volume":"63","author":"Orr","year":"2014","journal-title":"Diabetes"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0604-5","article-title":"Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study","volume":"50","author":"Forouhi","year":"2007","journal-title":"Diabetologia"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00033.2011","article-title":"Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice","volume":"302","author":"Tajima","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4106","article-title":"Variations in the size of the major omentum are primarily determined by fat cell number","volume":"98","author":"Arner","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B69","doi-asserted-by":"publisher","first-page":"111315","DOI":"10.1016\/j.biopha.2021.111315","article-title":"Adipose tissue and insulin resistance in obese","volume":"137","author":"Ahmed","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802502","article-title":"Inflammatory pathways and insulin action","author":"Hotamisligil","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J Clin Invest"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48032-5","article-title":"Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization","volume":"262","author":"Tanner","year":"1987","journal-title":"J Biol Chem"},{"key":"B73","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.lfs.2017.11.019","article-title":"Mitochondrial dysfunction in obesity","volume":"192","author":"de Mello","year":"2018","journal-title":"Life Sci"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00109","article-title":"Diet impact on mitochondrial bioenergetics and dynamics","volume":"6","author":"Putti","year":"2015","journal-title":"Front Physiol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2009.02.004","article-title":"Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes","volume":"41","author":"Zorzano","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.05603-11","article-title":"Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle","volume":"32","author":"Jheng","year":"2012","journal-title":"Mol Cell Biol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"165838","DOI":"10.1016\/j.bbadis.2020.165838","article-title":"Mitochondrial dysfunction in metabolic syndrome","volume":"1866","author":"Prasun","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"12407","DOI":"10.1038\/s41598-020-69016-9","article-title":"Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals","volume":"10","author":"Bohm","year":"2020","journal-title":"Sci Rep"},{"key":"B79","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.molmet.2018.06.004","article-title":"Three-dimensional volume fluorescence-imaging of vascular plasticity in adipose tissues","volume":"14","author":"Cao","year":"2018","journal-title":"Mol Metab"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16606","article-title":"alphaMSH prevents ROS-induced apoptosis by inhibiting Foxo1\/mTORC2 in mice adipose tissue","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b01632","article-title":"Self-assembled redox dual-responsive prodrug-nanosystem formed by single thioether-bridged paclitaxel-fatty acid conjugate for cancer chemotherapy","volume":"16","author":"Luo","year":"2016","journal-title":"Nano Lett"},{"key":"B82","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13045-022-01297-1","article-title":"Mammary adipocytes protect triple-negative breast cancer cells from ferroptosis","volume":"15","author":"Xie","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0165-y","article-title":"Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus","volume":"15","author":"Guilherme","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3306-14.2015","article-title":"Brown adipose tissue has sympathetic-sensory feedback circuits","volume":"35","author":"Ryu","year":"2015","journal-title":"J Neurosci"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.06.013","article-title":"Lipolysis sensation by white fat afferent nerves triggers brown fat thermogenesis","volume":"5","author":"Garretson","year":"2016","journal-title":"Mol Metab"},{"key":"B86","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.physbeh.2017.07.008","article-title":"Denervation as a tool for testing sympathetic control of white adipose tissue","volume":"190","author":"Harris","year":"2018","journal-title":"Physiol Behav"},{"key":"B87","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/intimm\/dxab023","article-title":"Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation","volume":"34","author":"Imai","year":"2022","journal-title":"Int Immunol"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2011.00102","article-title":"Beta-adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure","volume":"2","author":"Collins","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/nm1611","article-title":"Neuropeptide y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome","volume":"13","author":"Kuo","year":"2007","journal-title":"Nat Med"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A1214-626R","article-title":"Purinergic signaling modulates human visceral adipose inflammatory responses: implications in metabolically unhealthy obesity","volume":"97","author":"Pandolfi","year":"2015","journal-title":"J Leukoc Biol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1205750","article-title":"Purinergic signaling during inflammation","volume":"367","author":"Eltzschig","year":"2012","journal-title":"N Engl J Med"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.705786","article-title":"Progress in understanding ferroptosis and its targeting for therapeutic benefits in traumatic brain and spinal cord injuries","volume":"9","author":"Hu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B93","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 reasons why the brain is susceptible to oxidative stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10990.x","article-title":"Reactive oxygen species and the central nervous system","volume":"59","author":"Halliwell","year":"1992","journal-title":"J Neurochem"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated fatty acids and their metabolites in brain function and disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B96","doi-asserted-by":"publisher","first-page":"80","DOI":"10.4239\/wjd.v6.i1.80","article-title":"Diabetes and cardiac autonomic neuropathy: Clinical manifestations, cardiovascular consequences, diagnosis and treatment","volume":"6","author":"Balcioglu","year":"2015","journal-title":"World J Diabetes"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.046","article-title":"The vagus nerve in appetite regulation, mood, and intestinal inflammation","volume":"152","author":"Browning","year":"2017","journal-title":"Gastroenterology"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1113\/JP271538","article-title":"Role of the vagus nerve in the development and treatment of diet-induced obesity","volume":"594","author":"de Lartigue","year":"2016","journal-title":"J Physiol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-1082","article-title":"Autonomic nervous system balance in children and adolescents with craniopharyngioma and hypothalamic obesity","volume":"168","author":"Cohen","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-016-0501-9","article-title":"Vagotomy diminishes obesity in cafeteria rats by decreasing cholinergic potentiation of insulin release","volume":"72","author":"Balbo","year":"2016","journal-title":"J Physiol Biochem"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.672027","article-title":"The vagus nerve and spleen: Influence on white adipose mass and histology of obese and non-obese rats","volume":"12","author":"Kuchler","year":"2021","journal-title":"Front Physiol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1001\/archsurg.2011.237","article-title":"Vagus nerve and postinjury inflammatory response","volume":"147","author":"Peterson","year":"2012","journal-title":"Arch Surg"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1079129","DOI":"10.1155\/2020\/1079129","article-title":"Vagus nerve stimulation alleviates hepatic ischemia and reperfusion injury by regulating glutathione production and transformation","volume":"2020","author":"Xia","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.832432","article-title":"Electroacupuncture alleviates LPS-induced ARDS through alpha7 nicotinic acetylcholine receptor-mediated inhibition of ferroptosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.189","article-title":"The vagus nerve and the inflammatory reflex\u2013linking immunity and metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-14-4-251","article-title":"Cardiac autonomic neuropathy in diabetes mellitus","volume":"14","author":"Agashe","year":"2018","journal-title":"Methodist Debakey Cardiovasc J"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05691-9","article-title":"Unravelling innervation of pancreatic islets","volume":"65","author":"Hampton","year":"2022","journal-title":"Diabetologia"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00679.2005","article-title":"White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation","volume":"291","author":"Giordano","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00428.2006","article-title":"Vagaries of adipose tissue innervation","volume":"291","author":"Berthoud","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510002400","article-title":"High-fat diet results in postprandial insulin resistance that involves parasympathetic dysfunction","volume":"104","author":"Afonso","year":"2010","journal-title":"Br J Nutr"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.09.001","article-title":"Satellite glial cells in sensory ganglia: from form to function","volume":"48","author":"Hanani","year":"2005","journal-title":"Brain Res Brain Res Rev"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.04.009","article-title":"Satellite glial cells in sympathetic and parasympathetic ganglia: in search of function","volume":"64","author":"Hanani","year":"2010","journal-title":"Brain Res Rev"},{"key":"B113","doi-asserted-by":"publisher","first-page":"3425617","DOI":"10.1155\/2016\/3425617","article-title":"Diabetic polyneuropathy in type 2 diabetes mellitus: Inflammation, oxidative stress, and mitochondrial function","volume":"2016","author":"Roman-Pintos","year":"2016","journal-title":"J Diabetes Res"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023265","article-title":"Oxidative stress as an underlying contributor in the development of chronic complications in diabetes mellitus","volume":"14","author":"de","year":"2013","journal-title":"Int J Mol Sci"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28726","article-title":"P2Y14 receptor is functionally expressed in satellite glial cells and mediates interleukin-1beta and chemokine CCL2 secretion","volume":"234","author":"Lin","year":"2019","journal-title":"J Cell Physiol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00267","article-title":"Nrf2 and ferroptosis: A new research direction for neurodegenerative diseases","volume":"14","author":"Song","year":"2020","journal-title":"Front Neurosci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.873090","article-title":"Naringin relieves diabetic cardiac autonomic neuropathy mediated by P2Y14 receptor in superior cervical ganglion","volume":"13","author":"Tang","year":"2022","journal-title":"Front Pharmacol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"341583","DOI":"10.1155\/2015\/341583","article-title":"Relevance of sympathetic nervous system activation in obesity and metabolic syndrome","volume":"2015","author":"Thorp","year":"2015","journal-title":"J Diabetes Res"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.113175","article-title":"Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins","volume":"285","author":"Hall","year":"2010","journal-title":"J Biol Chem"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00426.2010","article-title":"Imbalance of central nitric oxide and reactive oxygen species in the regulation of sympathetic activity and neural mechanisms of hypertension","volume":"300","author":"Hirooka","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226999","article-title":"Post mortem evaluation of inflammation, oxidative stress, and PPARgamma activation in a nonhuman primate model of cardiac sympathetic neurodegeneration","volume":"15","author":"Metzger","year":"2020","journal-title":"PloS One"},{"key":"B122","doi-asserted-by":"publisher","first-page":"120405","DOI":"10.1016\/j.lfs.2022.120405","article-title":"Antioxidant therapy reverses sympathetic dysfunction, oxidative stress, and hypertension in male hyperadipose rats","volume":"295","author":"Lopes","year":"2022","journal-title":"Life Sci"},{"key":"B123","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1023\/A:1022899115220","article-title":"A biofeedback system of baroreceptor cardiac reflex sensitivity","volume":"24","author":"Reyes del Paso","year":"1999","journal-title":"Appl Psychophysiol Biofeedback"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J Neurosci"},{"key":"B125","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12944-015-0123-1","article-title":"The role of fatty acids in insulin resistance","volume":"14","author":"Sears","year":"2015","journal-title":"Lipids Health Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.179192","article-title":"Hormone and glucose signalling in POMC and AgRP neurons","volume":"587","author":"Belgardt","year":"2009","journal-title":"J Physiol"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.11.002","article-title":"Central orchestration of peripheral nutrient partitioning and substrate utilization: Implications for the metabolic syndrome","volume":"40","author":"Denis","year":"2014","journal-title":"Diabetes Metab"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00411.2020","article-title":"Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses","volume":"319","author":"Jiang","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.05.050","article-title":"Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency","volume":"357","author":"Schriever","year":"2017","journal-title":"Neuroscience"},{"key":"B130","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/JOE-21-0159","article-title":"Adipose tissue immune cells in obesity, type 2 diabetes mellitus and cardiovascular diseases","volume":"252","author":"Cinkajzlova","year":"2021","journal-title":"J Endocrinol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01587","article-title":"Tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900477RR","article-title":"Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation","volume":"33","author":"Watanabe","year":"2019","journal-title":"FASEB J"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-017-1082-3","article-title":"Lymphocytes and macrophages in adipose tissue in obesity: markers or makers of subclinical inflammation","volume":"254","author":"Cinkajzlova","year":"2017","journal-title":"Protoplasma"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12853","article-title":"Adipose tissue macrophages: Unique polarization and bioenergetics in obesity","volume":"295","author":"Caslin","year":"2020","journal-title":"Immunol Rev"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"B136","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s12944-020-01342-3","article-title":"A review on the biology and properties of adipose tissue macrophages involved in adipose tissue physiological and pathophysiological processes","volume":"19","author":"Li","year":"2020","journal-title":"Lipids Health Dis"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O'Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.molmet.2017.11.002","article-title":"Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-syk-ceramide dependent mechanism","volume":"7","author":"Serbulea","year":"2018","journal-title":"Mol Metab"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1964158","article-title":"Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis","volume":"12","author":"Han","year":"2021","journal-title":"Bioengineered"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000236","article-title":"Hepcidin regulation in the anemia of inflammation","volume":"23","author":"Wang","year":"2016","journal-title":"Curr Opin Hematol"},{"key":"B141","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1194\/jlr.RA119000256","article-title":"TNF-alpha induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells","volume":"61","author":"Jung","year":"2020","journal-title":"J Lipid Res"},{"key":"B142","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2021.07.019","article-title":"Glycyrrhetinic acid induces oxidative\/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells","volume":"173","author":"Wen","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2019.01.007","article-title":"Hepcidin and IL-1beta","volume":"110","author":"Kanamori","year":"2019","journal-title":"Vitam Horm"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190672","article-title":"Mitochondrial ROS-induced lysosomal dysfunction impairs autophagic flux and contributes to M1 macrophage polarization in a diabetic condition","volume":"133","author":"Yuan","year":"2019","journal-title":"Clin Sci (Lond)"},{"key":"B146","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/jre.12912","article-title":"Hyperglycemia modulates M1\/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis","volume":"56","author":"Zhang","year":"2021","journal-title":"J Periodontal Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202049114","article-title":"Differential sensitivity of inflammatory macrophages and alternatively activated macrophages to ferroptosis","volume":"51","author":"Piattini","year":"2021","journal-title":"Eur J Immunol"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01961","article-title":"Regulation, communication, and functional roles of adipose tissue-resident CD4 T cells in the control of metabolic homeostasis","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Immunol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02509","article-title":"T Cells in adipose tissue: Critical players in immunometabolism","volume":"9","author":"Wang","year":"2018","journal-title":"Front Immunol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13705","article-title":"Perivascular adipose tissue inflammation in vascular disease","volume":"174","author":"Nosalski","year":"2017","journal-title":"Br J Pharmacol"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2021.1965314","article-title":"The roles of T cells in obese adipose tissue inflammation","volume":"10","author":"Wang","year":"2021","journal-title":"Adipocyte"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters","volume":"15","author":"Feuerer","year":"2009","journal-title":"Nat Med"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13506","article-title":"Cardiorespiratory fitness modulates the proportions of monocytes and T helper subsets in lean and obese men","volume":"29","author":"Dorneles","year":"2019","journal-title":"Scand J Med Sci Sports"},{"key":"B155","doi-asserted-by":"publisher","first-page":"109235","DOI":"10.1016\/j.celrep.2021.109235","article-title":"The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain treg cell activation and suppression of antitumor immunity","volume":"35","author":"Xu","year":"2021","journal-title":"Cell Rep"},{"key":"B156","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cellimm.2014.02.003","article-title":"Increased oxidative stress and the apoptosis of regulatory T cells in obese mice but not resistant mice in response to a high-fat diet","volume":"288","author":"Wang","year":"2014","journal-title":"Cell Immunol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00478-8","article-title":"Redox regulation of immunometabolism","volume":"21","author":"Muri","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3868","article-title":"Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor","volume":"18","author":"Maj","year":"2017","journal-title":"Nat Immunol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0701-2","article-title":"The metabolite BH4 controls T cell proliferation in autoimmunity and cancer","volume":"563","author":"Cronin","year":"2018","journal-title":"Nature"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2353","article-title":"B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies","volume":"17","author":"Winer","year":"2011","journal-title":"Nat Med"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215840110","article-title":"B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile","volume":"110","author":"DeFuria","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B162","doi-asserted-by":"publisher","first-page":"20176","DOI":"10.1038\/srep20176","article-title":"miR-150 regulates obesity-associated insulin resistance by controlling b cell functions","volume":"6","author":"Ying","year":"2016","journal-title":"Sci Rep"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90350","article-title":"Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4\/LTB4R1 signaling","volume":"127","author":"Ying","year":"2017","journal-title":"J Clin Invest"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307166","article-title":"Protective role for b-1b b cells and IgM in obesity-associated inflammation, glucose intolerance, and insulin resistance","volume":"36","author":"Harmon","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601031","article-title":"B cell activity is impaired in human and mouse obesity and is responsive to an essential fatty acid upon murine influenza infection","volume":"198","author":"Kosaraju","year":"2017","journal-title":"J Immunol"},{"key":"B166","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1016\/j.celrep.2019.10.070","article-title":"B1 and marginal zone b cells but not follicular B2 cells require Gpx4 to prevent lipid peroxidation and ferroptosis","volume":"29","author":"Muri","year":"2019","journal-title":"Cell Rep"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat Med"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.01.001","article-title":"Regulating neutrophil apoptosis: New players enter the game","volume":"32","author":"Witko-Sarsat","year":"2011","journal-title":"Trends Immunol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1177\/1753425920951985","article-title":"Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion","volume":"27","author":"Yuyun","year":"2021","journal-title":"Innate Immun"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat Immunol"},{"key":"B171","doi-asserted-by":"publisher","first-page":"1052699","DOI":"10.1155\/2022\/1052699","article-title":"Research progress of ferroptosis in adiposity-based chronic disease (ABCD)","volume":"2022","author":"Du","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1049936\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T06:18:52Z","timestamp":1669011532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1049936\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":172,"alternative-id":["10.3389\/fimmu.2022.1049936"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1049936","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]},"article-number":"1049936"}}