{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:00:07Z","timestamp":1792872007420,"version":"4.5.0"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015925","name":"California Table Grape Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant health\/economic burdens. Existing therapies are not fully effective, necessitating development of new approaches for AD management. Here, we report that dietary grape powder (GP) mitigates AD-like symptoms in 2,4-dinitrofluorobenzene (DNFB)-induced AD in NC\/NgaTndCrlj mice. Using prevention and intervention protocols, we tested the efficacy of 3% and 5% GP-fortified diet in a 13-weeks study. We found that GP feeding markedly inhibited development and progression of AD-like skin lesions, and caused reduction in i) epidermal thickness, mast cell infiltration, ulceration, excoriation and acanthosis in dorsal skin, ii) spleen weight, extramedullary hematopoiesis and lymph nodes sizes, and iii) ear weight and IgE levels. We also found significant modulations in 15 AD-associated serum cytokines\/chemokines. Next, using quantitative global proteomics, we identified 714 proteins. Of these, 68 (normal control) and 21 (5% GP-prevention) were significantly modulated (\u22652-fold) vs AD control (DNFB-treated) group, with many GP-modulated proteins reverting to normal levels. Ingenuity pathway analysis of GP-modulated proteins followed by validation using ProteinSimple identified changes in acute phase response signaling (FGA, FGB, FGG, HP, HPX, LRG1). Overall, GP supplementation inhibited DNFB-induced AD in NC\/NgaTndCrlj mice in both prevention and intervention trials, and should be explored further.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1051472","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T13:54:08Z","timestamp":1674136448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC\/NgaTndCrlj mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Chandra K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Mintie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Ndiaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan","family":"Chhabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Jack","family":"Longley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan M.","family":"Schieke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","first-page":"35","article-title":"Atopic dermatitis: An overview","volume":"86","author":"Berke","year":"2012","journal-title":"Am Fam Phys"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.08.028","article-title":"Atopic dermatitis in America study: A cross-sectional study examining the prevalence and disease burden of atopic dermatitis in the US adult population","volume":"139","author":"Chiesa Fuxench","year":"2019","journal-title":"J Invest Dermatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jid.2016.07.012","article-title":"The burden of atopic dermatitis: Summary of a report for the national eczema association","volume":"137","author":"Drucker","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"354250","DOI":"10.1155\/2014\/354250","article-title":"Atopic dermatitis: natural history, diagnosis, and treatment","volume":"2014","author":"Thomsen","year":"2014","journal-title":"ISRN Allergy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2012.09.002","article-title":"Management of difficult-to-treat atopic dermatitis","volume":"1","author":"Arkwright","year":"2013","journal-title":"J Allergy Clin Immunol Pract"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.09.023","article-title":"The role of air pollutants in atopic dermatitis","volume":"134","author":"Ahn","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081","article-title":"Atopic dermatitis","volume":"358","author":"Bieber","year":"2008","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2019.1619569","article-title":"Comparison of treatment standards in atopic dermatitis management across selected geographies prior to emerging targeted therapies onset","volume":"8","author":"Kowalska-Oledzka","year":"2019","journal-title":"J Drug Assess"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3390\/cells10061392","article-title":"Current insights into immunology and novel therapeutics of atopic dermatitis","volume":"10","author":"Kader","year":"2021","journal-title":"Cells"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1203475417690306","article-title":"Botanicals with dermatologic properties derived from first nations healing: Part 1-Trees","volume":"21","author":"Colantonio","year":"2017","journal-title":"J Cutan Med Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2019.10.014","article-title":"Whole fruit phytochemicals combating skin damage and carcinogenesis","volume":"13","author":"Mintie","year":"2020","journal-title":"Transl Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12798","article-title":"Resveratrol, in its natural combination in whole grape, for health promotion and disease management","volume":"1348","author":"Singh","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.10.014","article-title":"Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice","volume":"23","author":"Karuppagounder","year":"2014","journal-title":"Int Immunopharmacol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1889","article-title":"Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium","volume":"4","author":"Caglayan Sozmen","year":"2016","journal-title":"PeerJ"},{"key":"B15","article-title":"Resveratrol exerts therapeutic effects on mice with atopic dermatitis","volume":"31","author":"Shen","year":"2019","journal-title":"Wounds"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.02.011","article-title":"Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis","volume":"21","author":"Karuppagounder","year":"2016","journal-title":"Drug Discovery Today"},{"key":"B17","doi-asserted-by":"publisher","first-page":"105676","DOI":"10.1016\/j.intimp.2019.105676","article-title":"Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis","volume":"74","author":"Hou","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12685","article-title":"Modulation of HMGB1 translocation and RAGE\/NFkappaB cascade by quercetin treatment mitigates atopic dermatitis in NC\/Nga transgenic mice","volume":"24","author":"Karuppagounder","year":"2015","journal-title":"Exp Dermatol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"790436","DOI":"10.1155\/2011\/790436","article-title":"Evaluation of itch by using NC\/NgaTnd mice: a model of human atopic dermatitis","volume":"2011","author":"Tanaka","year":"2011","journal-title":"J BioMed Biotechnol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC\/Nga mice","volume":"9","author":"Matsuda","year":"1997","journal-title":"Int Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2005.00361.x","article-title":"Scratching behavior in spontaneous- or allergic contact-induced dermatitis in NC\/Nga mice","volume":"14","author":"Takahashi","year":"2005","journal-title":"Exp Dermatol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.09.028","article-title":"Chemoprotective effects of dietary grape powder on UVB radiation-mediated skin carcinogenesis in SKH-1 hairless mice","volume":"139","author":"Singh","year":"2019","journal-title":"J Invest Dermatol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.49","article-title":"Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC\/Nga mice","volume":"131","author":"Kim","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3390\/cancers12071751","article-title":"Protective effects of dietary grape on UVB-mediated cutaneous damages and skin tumorigenesis in SKH-1 mice","volume":"12","author":"Mintie","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.jid.2021.08.434","article-title":"Antimelanoma effects of concomitant inhibition of SIRT1 and SIRT3 in Braf(V600E)\/Pten(NULL) mice","volume":"142","author":"Chhabra","year":"2022","journal-title":"J Invest Dermatol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3231","article-title":"Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach","volume":"6","author":"Singh","year":"2015","journal-title":"Oncotarget"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1013","article-title":"PrimerBank: A PCR primer database for quantitative gene expression analysis, 2012 update","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J Invest Dermatol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311431467","article-title":"Differentiation of rodent immune and hematopoietic system reactive lesions from neoplasias","volume":"40","author":"Ward","year":"2012","journal-title":"Toxicol Pathol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"155664","DOI":"10.1016\/j.cyto.2021.155664","article-title":"Novel pathogenesis of atopic dermatitis from the view of cytokines in mice and humans","volume":"148","author":"Nakajima","year":"2021","journal-title":"Cytokine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3030268","DOI":"10.1155\/2019\/3030268","article-title":"IFN-gamma reduces epidermal barrier function by affecting fatty acid composition of ceramide in a mouse atopic dermatitis model","volume":"2019","author":"Kanoh","year":"2019","journal-title":"J Immunol Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: An expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat Rev Drug Discovery"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.83","article-title":"TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents","volume":"134","author":"Danso","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.028","article-title":"Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab","volume":"143","author":"Brunner","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.594735","article-title":"The IL-23\/IL-17 pathway in inflammatory skin diseases: From bench to bedside","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.07.006","article-title":"Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes","volume":"49","author":"Chang","year":"2016","journal-title":"J Microbiol Immunol Infect"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.7417\/CT.2015.1852","article-title":"Atopic dermatitis and alpha-chemokines","volume":"166","author":"Di Bari","year":"2015","journal-title":"Clin Ter"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14003","article-title":"Effects of beta-carotene on oxazolone-induced atopic dermatitis in hairless mice","volume":"28","author":"Kake","year":"2019","journal-title":"Exp Dermatol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00982.x","article-title":"Increased levels in vivo of mRNAs for IL-8 and macrophage inflammatory protein-1 alpha (MIP-1 alpha), but not of RANTES mRNA in peripheral blood mononuclear cells of patients with atopic dermatitis (AD)","volume":"117","author":"Hatano","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"8707","DOI":"10.1038\/s41598-017-09207-z","article-title":"The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins","volume":"7","author":"Brunner","year":"2017","journal-title":"Sci Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-016-0303-9","article-title":"An overlook to the characteristics and roles played by eotaxin network in the pathophysiology of food allergies: Allergic asthma and atopic dermatitis","volume":"39","author":"Ahmadi","year":"2016","journal-title":"Inflammation"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.5483\/bmbrep.2008.41.4.316","article-title":"Regulation of macrophage inflammatory protein-2 gene expression in response to 2,4-dinitrofluorobenzene in RAW 264.7 cells","volume":"41","author":"Kim","year":"2008","journal-title":"BMB Rep"},{"key":"B43","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/08977190500055836","article-title":"G-CSF: A key regulator of neutrophil production, but that's not all","volume":"23","author":"Roberts","year":"2005","journal-title":"Growth Factors"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119496","article-title":"Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. implications for sustained dendritic cell activation in the skin","volume":"99","author":"Pastore","year":"1997","journal-title":"J Clin Invest"},{"key":"B45","article-title":"IL-4 and IL-13 inhibition in atopic dermatitis","volume":"15","author":"Matsunaga","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/ni805","article-title":"Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP","volume":"3","author":"Soumelis","year":"2002","journal-title":"Nat Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37338","article-title":"NBAS mutations cause a multisystem disorder involving bone, connective tissue, liver, immune system, and retina","author":"Segarra","year":"2015","journal-title":"Am J Med Genet A"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.21.3641","article-title":"Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: A model for recessive dystrophic epidermolysis bullosa","volume":"112","author":"Heinonen","year":"1999","journal-title":"J Cell Sci"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14508","article-title":"TOX expression in cutaneous T-cell lymphomas: an adjunctive diagnostic marker that is not tumour specific and not restricted to the CD4(+) CD8(-) phenotype","volume":"175","author":"Schrader","year":"2016","journal-title":"Br J Dermatol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-02-768234","article-title":"Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E)","volume":"130","author":"Park","year":"2017","journal-title":"Blood"},{"key":"B51","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/1523-1747.ep12274479","article-title":"Monoclonal antibodies selected to discriminate between malignant melanomas and nevocellular nevi","volume":"85","author":"Ruiter","year":"1985","journal-title":"J Invest Dermatol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/bs.mie.2019.04.024","article-title":"Monitoring gasdermin pore formation in vitro","volume":"625","author":"Xia","year":"2019","journal-title":"Methods Enzymol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.04.025","article-title":"MicroRNA-211 regulates oxidative phosphorylation and energy metabolism in human vitiligo","volume":"137","author":"Sahoo","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2017.06.009","article-title":"Control of lipid droplet fusion and growth by CIDE family proteins","volume":"1862","author":"Gao","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.02.038","article-title":"UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6","volume":"445","author":"Miyata","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.271","article-title":"BMP9 promotes cutaneous wound healing by activating Smad1\/5 signaling pathways and cytoskeleton remodeling","volume":"11","author":"Chai","year":"2021","journal-title":"Clin Transl Med"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0358","article-title":"Leucine-rich alpha-2 glycoprotein (LRG): A novel acute phase protein expressed in stage 3 grade c periodontitis before and after periodontal therapy","volume":"92","author":"Keles Yucel","year":"2021","journal-title":"J Periodontol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jid.2019.06.143","article-title":"LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1alpha stability","volume":"140","author":"Gao","year":"2020","journal-title":"J Invest Dermatol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.3390\/cancers13133279","article-title":"LRG1 promotes metastatic dissemination of melanoma through regulating EGFR\/STAT3 signalling","volume":"13","author":"Kwan","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188580","article-title":"Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation","volume":"12","author":"Ottas","year":"2017","journal-title":"PloS One"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800044","article-title":"Bioengineering a humanized acne microenvironment model: proteomics analysis of host responses to propionibacterium acnes infection in vivo","volume":"8","author":"Nakatsuji","year":"2008","journal-title":"Proteomics"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5672","article-title":"Haptoglobin protein and mRNA expression in psoriasis and its clinical significance","volume":"14","author":"Tian","year":"2016","journal-title":"Mol Med Rep"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/BF00557962","article-title":"Serum hemopexin in patients with dermatitis herpetiformis on dapsone (di(4-aminophenyl)sulphone)","volume":"254","author":"Kastrup","year":"1975","journal-title":"Arch Dermatol Res (1975)"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00050-20","article-title":"Putative beta-barrel outer membrane proteins of the bovine digital dermatitis-associated treponemes: Identification, functional characterization, and immunogenicity","volume":"88","author":"Staton","year":"2020","journal-title":"Infect Immun"},{"key":"B66","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/1523-1747.ep12469875","article-title":"Increased interleukin 6 production by T cells derived from patients with atopic dermatitis","volume":"100","author":"Toshitani","year":"1993","journal-title":"J Invest Dermatol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500945","article-title":"Combination chemoprevention with grape antioxidants","volume":"60","author":"Singh","year":"2016","journal-title":"Mol Nutr Food Res"},{"key":"B68","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/978-3-030-39855-2_12","article-title":"Grape chemopreventive agents against angiogenesis and metastasis","volume-title":"Natural products for cancer chemoprevention: Single compounds and combinations","author":"Singh","year":"2020"},{"key":"B69","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2340\/000155551146771","article-title":"Epidermal changes in atopic dermatitis","volume":"114","author":"van Neste","year":"1985","journal-title":"Acta Derm Venereol Suppl (Stockh)"},{"key":"B70","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-375154-6.00015-X","article-title":"Lymphadenopathy and splenomegaly","volume-title":"Manual of pediatric hematology and oncology","author":"Lanzkowsky","year":"2011"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041503","article-title":"Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin","volume":"202","author":"Yoo","year":"2005","journal-title":"J Exp Med"},{"key":"B72","first-page":"8","article-title":"A retrospective study of idiopathic ulcerative dermatitis in mice with a C57BL\/6 background","volume":"45","author":"Kastenmayer","year":"2006","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1186\/s12906-016-1325-4","article-title":"Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB\/c mice","volume":"16","author":"Zhang","year":"2016","journal-title":"BMC Complement Altern Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11882-014-0433-9","article-title":"Skin barrier defects in atopic dermatitis","volume":"14","author":"Agrawal","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.106484","article-title":"Atopic dermatitis: New insights and opportunities for therapeutic intervention","volume":"105","author":"Leung","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5669","article-title":"Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis","volume":"103","author":"Spergel","year":"1999","journal-title":"J Clin Invest"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00210-9","article-title":"The two faces of IL-6 on Th1\/Th2 differentiation","volume":"39","author":"Diehl","year":"2002","journal-title":"Mol Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.6.631","article-title":"Selective inhibition of beta-Catenin\/Co-Activator cyclic AMP response element-binding protein-dependent signaling prevents the emergence of hapten-induced atopic dermatitis-like dermatitis","volume":"31","author":"Matsuda-Hirose","year":"2019","journal-title":"Ann Dermatol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10405","article-title":"Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2\/HO-1 axis","volume":"20","author":"Wu","year":"2019","journal-title":"Mol Med Rep"},{"key":"B80","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000331883","article-title":"Angiogenesis, lymphangiogenesis and atopic dermatitis","volume":"96","author":"Genovese","year":"2012","journal-title":"Chem Immunol Allergy"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1242-4","article-title":"Characterization of EGFR and ErbB2 expression in atopic dermatitis patients","volume":"304","author":"Saaf","year":"2012","journal-title":"Arch Dermatol Res"},{"key":"B82","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1089\/ped.2019.1137","article-title":"Quercetin improves inflammation, oxidative stress, and impaired wound healing in atopic dermatitis model of human keratinocytes","volume":"33","author":"Beken","year":"2020","journal-title":"Pediatr Allergy Immunol Pulmonol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.02088.x","article-title":"Localization of haptoglobin in normal human skin and some skin diseases","volume":"44","author":"Li","year":"2005","journal-title":"Int J Dermatol"},{"key":"B84","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.3390\/ijms23062972","article-title":"A new role of acute phase proteins: Local production is an ancient, general stress-response system of mammalian cells","volume":"23","author":"Hamar","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B85","doi-asserted-by":"crossref","DOI":"10.1016\/B978-012455900-4\/50272-5","article-title":"Chapter 10 - Acute-phase proteins and inflammation: Immunological and clinical implications","volume-title":"Measuring immunity","author":"Liu","year":"2005"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00442","article-title":"Identification of molecular targets of dietary grape-mediated chemoprevention of ultraviolet b skin carcinogenesis: A comparative quantitative proteomics analysis","volume":"18","author":"Mintie","year":"2019","journal-title":"J Proteome Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1051472\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T13:54:18Z","timestamp":1674136458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1051472\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":86,"alternative-id":["10.3389\/fimmu.2022.1051472"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1051472","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"article-number":"1051472"}}