{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:02:57Z","timestamp":1793145777089,"version":"4.5.0"},"reference-count":156,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>C-C motif ligand 2 (CCL2), also known as monocytic chemotactic protein 1 (MCP-1), is an integral chemotactic factor which recruits macrophages for the immune response. Together with its receptors (e.g., CCR2, ACKR1, and ACKR2), they exert noticeable influences on various diseases of different systems. At the maternal-fetal interface, CCL2 is detected to be expressed in trophoblasts, decidual tissue, the myometrium, and others. Meanwhile, existing reports have determined a series of physiological regulators of CCL2, which functions in maintaining normal recruitment of immunocytes, tissue remodeling, and angiogenesis. However, abnormal levels of CCL2 have also been reported to be associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and preterm labor. In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the multidimensional aspects of CCL2 in pregnancy.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1053457","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T14:13:35Z","timestamp":1673014415000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":107,"title":["CCL2: An important cytokine in normal and pathological pregnancies: A review"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Lu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Meng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13046-020-01666-z","article-title":"Cancer-associated adipocytes: Emerging supporters in breast cancer","volume":"39","author":"Zhao","year":"2020","journal-title":"J Exp Clin Cancer Res CR"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.12.010","article-title":"A brief look at the role of monocyte chemoattractant protein-1 (Ccl2) in the pathophysiology of psoriasis","volume":"110","author":"Behfar","year":"2018","journal-title":"Cytokine"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6101(99)00005-2","article-title":"The Mcp\/Eotaxin subfamily of cc chemokines","volume":"10","author":"Van Coillie","year":"1999","journal-title":"Cytokine Growth Factor Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nri722","article-title":"Chemokine receptors: Multifaceted therapeutic targets","volume":"2","author":"Proudfoot","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00064-9","article-title":"Production and function of monocyte chemoattractant protein-1 and other beta-chemokines in murine glial cells","volume":"60","author":"Hayashi","year":"1995","journal-title":"J Neuroimmunol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.2.478","article-title":"Differential Production of and Migratory Response to Beta Chemokines by Human Microglia and Astrocytes","volume":"175","author":"Peterson","year":"1997","journal-title":"J Infect Dis"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.437","article-title":"Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells","volume":"48","author":"Prodjosudjadi","year":"1995","journal-title":"Kidney Int"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz308","article-title":"Chronic inflammation within the vascular wall in pulmonary arterial hypertension more than a spectator","volume":"116","author":"Huertas","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp238","article-title":"The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice","volume":"84","author":"Grassia","year":"2009","journal-title":"Cardiovasc Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.230078","article-title":"Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries","volume":"31","author":"Ialenti","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20598","article-title":"Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (Mcp-1\/Ccl2) in rat brain: Evidence for its colocalization with neurotransmitters and neuropeptides","volume":"489","author":"Banisadr","year":"2005","journal-title":"J Comp Neurol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052723","article-title":"The Many Roles of Chemokines and Chemokine Receptors in Inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N Engl J Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00224","article-title":"Atypical chemokine receptors and their roles in the resolution of the inflammatory response","volume":"7","author":"Bonecchi","year":"2016","journal-title":"Front Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02759","article-title":"More than just attractive: How Ccl2 influences myeloid cell behavior beyond chemotaxis","volume":"10","author":"Gschwandtner","year":"2019","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.10.016","article-title":"Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in Ra pathogenesis","volume":"65","author":"Rana","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.722916","article-title":"Ccl2: An important mediator between tumor cells and host cells in tumor microenvironment","volume":"11","author":"Jin","year":"2021","journal-title":"Front Oncol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nature15376","article-title":"Microenvironment-induced pten loss by exosomal microrna primes brain metastasis outgrowth","volume":"527","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.135","article-title":"The chemokine mcp-1 (Ccl2) in the host interaction with cancer: A foe or ally","volume":"15","author":"Yoshimura","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41392-020-0205-z","article-title":"Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies","volume":"5","author":"Cervantes-Villagrana","year":"2020","journal-title":"Signal transduction targeted Ther"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2018.12.001","article-title":"Macrophage biology in the peripheral nervous system after injury","volume":"173","author":"Zigmond","year":"2019","journal-title":"Prog Neurobiol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.51","article-title":"Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy","volume":"7","author":"Navarro-Gonz\u00e1lez","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0497-8","article-title":"Monocyte chemoattractant protein-1-Induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese Db\/Db mice","volume":"50","author":"Chow","year":"2007","journal-title":"Diabetologia"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.05.002","article-title":"Chrono-pharmacological targeting of the Ccl2-Ccr2 axis ameliorates atherosclerosis","volume":"28","author":"Winter","year":"2018","journal-title":"Cell Metab"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107799","article-title":"Role of inflammatory chemokines in hypertension","volume":"223","author":"Mikolajczyk","year":"2021","journal-title":"Pharmacol Ther"},{"key":"B25","doi-asserted-by":"publisher","first-page":"8598","DOI":"10.1038\/s41598-018-26870-y","article-title":"Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension","volume":"8","author":"Kashyap","year":"2018","journal-title":"Sci Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem208","article-title":"Regulation of c-c motif chemokine ligand 2 and its receptor in human decidual stromal cells by pregnancy-associated hormones in early gestation","volume":"22","author":"He","year":"2007","journal-title":"Hum Reprod (Oxford England)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401536","article-title":"The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages","volume":"194","author":"Svensson-Arvelund","year":"2015","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02597","article-title":"Regulation of placental extravillous trophoblasts by the maternal uterine environment","volume":"9","author":"Pollheimer","year":"2018","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.04.004","article-title":"Secretion of cytokines by villous cytotrophoblast and extravillous trophoblast in the first trimester of human pregnancy","volume":"86","author":"Naruse","year":"2010","journal-title":"J Reprod Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.861931","article-title":"The role of atypical chemokine receptor D6 (Ackr2) in physiological and pathological conditions; friend, foe, or both","volume":"13","author":"Gowhari Shabgah","year":"2022","journal-title":"Front Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401096","article-title":"Atypical chemokine receptor Ackr2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice","volume":"193","author":"Teoh","year":"2014","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2013.67","article-title":"Decidual stromal cells recruit Th17 cells into decidua to promote proliferation and invasion of human trophoblast cells by secreting il-17","volume":"11","author":"Wu","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000287","article-title":"Placental chemokine compartmentalisation: A novel mammalian molecular control mechanism","volume":"17","author":"Lee","year":"2019","journal-title":"PLos Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13480","article-title":"Immune status of decidual macrophages is dependent on the Ccl2\/Ccr2\/Jak2 pathway during early pregnancy","volume":"86","author":"Wei","year":"2021","journal-title":"Am J Reprod Immunol (New York NY 1989)"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108070","article-title":"Tlrs induce Th1\/Th2 responses by affecting the secretion of Ccl2 at the maternal-foetal interface","volume":"100","author":"Yu","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.68","article-title":"The integrative roles of chemokines at the maternal-fetal interface in early pregnancy","volume":"11","author":"Du","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0008-0","article-title":"Three macrophage subsets are identified in the uterus during early human pregnancy","volume":"15","author":"Jiang","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI122182","article-title":"Regulatory T cells in embryo implantation and the immune response to pregnancy","volume":"128","author":"Robertson","year":"2018","journal-title":"J Clin Invest"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.07.017","article-title":"The decidual stromal cells-secreted Ccl2 induces and maintains decidual leukocytes into Th2 bias in human early pregnancy","volume":"145","author":"He","year":"2012","journal-title":"Clin Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2019.05.009","article-title":"Decidual immune cells: Guardians of human pregnancies","volume":"60","author":"Solano","year":"2019","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat6114","article-title":"Immune responses at the maternal-fetal interface","volume":"4","author":"Ander","year":"2019","journal-title":"Sci Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev067","article-title":"Estrogen-dependent regulation of human uterine natural killer cells promotes vascular remodelling Via secretion of Ccl2","volume":"30","author":"Gibson","year":"2015","journal-title":"Hum Reprod (Oxford England)"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63071-4","article-title":"Chemokine ligand and receptor expression in the pregnant uterus: Reciprocal patterns in complementary cell subsets suggest functional roles","volume":"159","author":"Red-Horse","year":"2001","journal-title":"Am J Pathol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2140","article-title":"Endometrial intracrinology\u2013generation of an estrogen-dominated microenvironment in the secretory phase of women","volume":"98","author":"Gibson","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4465","article-title":"The effects of estradiol on inflammatory and endothelial dysfunction in rats with preeclampsia","volume":"45","author":"Lin","year":"2020","journal-title":"Int J Mol Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2016.12.20","article-title":"Characteristic changes in decidual gene expression signature in spontaneous term parturition","volume":"51","author":"El-Azzamy","year":"2017","journal-title":"J Pathol Transl Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gav018","article-title":"Pgf2\u0391 modulates the output of chemokines and pro-inflammatory cytokines in myometrial cells from term pregnant women through divergent signaling pathways","volume":"21","author":"Xu","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13579","article-title":"Decidual factors and vasoactive intestinal peptide guide monocytes to higher migration, efferocytosis and wound healing in term human pregnancy","volume":"232","author":"Paparini","year":"2021","journal-title":"Acta Physiol (Oxf)"},{"key":"B50","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.mce.2017.07.006","article-title":"Vip induces the decidualization program and conditions the immunoregulation of the implantation process","volume":"460","author":"Grasso","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gat094","article-title":"Il-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of Ccl2\/Ccr2 Via nf-\u039ab and Erk1\/2 signaling","volume":"20","author":"Hu","year":"2014","journal-title":"Mol Hum Reprod"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.04.020","article-title":"Rankl promotes the growth of decidual stromal cells in an autocrine manner Via Ccl2\/Ccr2 interaction in human early pregnancy","volume":"34","author":"Meng","year":"2013","journal-title":"Placenta"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.01.001","article-title":"Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells Via differential activation of mapk pathways","volume":"30","author":"Renaud","year":"2009","journal-title":"Placenta"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050082","article-title":"Regulation of monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha and interleukin-1beta in first trimester human decidual cells: Implications for preeclampsia","volume":"168","author":"Lockwood","year":"2006","journal-title":"Am J Pathol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2021.100516","article-title":"Thrombin impairs the angiogenic activity of extravillous trophoblast cells Via monocyte chemotactic protein-1 (Mcp-1): A possible link with preeclampsia","volume":"21","author":"Br\u00fcnnert","year":"2021","journal-title":"Reprod Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.09.008","article-title":"Thrombin regulates monocyte chemoattractant protein-1 expression in human first trimester and term decidual cells","volume":"196","author":"Matta","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq347","article-title":"Thrombin-induced chemokine production in endometrial stromal cells","volume":"26","author":"Kawano","year":"2011","journal-title":"Hum Reprod"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.023","article-title":"Heparin modulates chemokines in human endometrial stromal cells by interaction with tumor necrosis factor \u0391 and thrombin","volume":"103","author":"Spratte","year":"2015","journal-title":"Fertil Steril"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1A0116-020RR","article-title":"Infiltration of myeloid cells in the pregnant uterus is affected by heme oxygenase-1","volume":"101","author":"Zhao","year":"2017","journal-title":"J Leukoc Biol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2039000","article-title":"A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence","volume":"18","author":"Yang","year":"2022","journal-title":"Autophagy"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0779","article-title":"Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-\u0391, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: Possible roles in angiogenesis and immune regulation","volume":"151","author":"Yang","year":"2010","journal-title":"Endocrinology"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.072","article-title":"Lactate produced during labor modulates uterine inflammation Via Gpr81 (Hca1)","volume":"216","author":"Madaan","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2020.4465","article-title":"Pregnancy Characteristics and Maternal Risk of Breast Cancer","volume":"294","author":"Cnattingius","year":"2015","journal-title":"JAMA"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.102856","article-title":"Human chorionic gonadotropin promotes recruitment of regulatory T cells in endometrium by inducing chemokine Ccl2","volume":"137","author":"Huang","year":"2020","journal-title":"J Reprod Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1124\/pr.111.005074","article-title":"Cc chemokine receptors and chronic inflammation\u2013therapeutic opportunities and pharmacological challenges","volume":"65","author":"White","year":"2013","journal-title":"Pharmacol Rev"},{"key":"B66","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.immuni.2018.07.017","article-title":"Interferons and proinflammatory cytokines in pregnancy and fetal development","volume":"49","author":"Yockey","year":"2018","journal-title":"Immunity"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00558","article-title":"Tnf-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during lps-induced intrauterine inflammation","volume":"11","author":"Presicce","year":"2020","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146089","article-title":"Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury","volume":"6","author":"Gomez-Lopez","year":"2021","journal-title":"JCI Insight"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ Res"},{"key":"B70","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/s0140-6736(98)85022-8","article-title":"Increased thrombin generation in women with recurrent miscarriage","volume":"352","author":"Vincent","year":"1998","journal-title":"Lancet"},{"key":"B71","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","article-title":"Chemokines and chemokine receptors: Positioning cells for host defense and immunity","volume":"32","author":"Griffith","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.6.1300","article-title":"Chemokine and cyclooxygenase-2 expression in human endometrium coincides with leukocyte accumulation","volume":"12","author":"Jones","year":"1997","journal-title":"Hum Reprod (Oxford England)"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-016-0337-1","article-title":"Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface","volume":"59","author":"Fu","year":"2016","journal-title":"Sci China Life Sci"},{"key":"B74","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4103\/2096-2924.281858","article-title":"Innate lymphoid cells in normal pregnancy and pregnancy-related diseases","volume":"4","author":"Wang","year":"2020","journal-title":"Reprod Dev Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0055","article-title":"Nfkappab and Jnk\/Mapk activation mediates the production of major macrophage- or dendritic cell-recruiting chemokine in human first trimester decidual cells in response to proinflammatory stimuli","volume":"96","author":"Li","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103264","article-title":"Functional regulation of decidual macrophages during pregnancy","volume":"143","author":"Sun","year":"2021","journal-title":"J Reprod Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00316","article-title":"Human decidual macrophages and nk cells differentially express toll-like receptors and display distinct cytokine profiles upon tlr stimulation","volume":"5","author":"Duriez","year":"2014","journal-title":"Front Microbiol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601458","article-title":"Ccr2 regulates the immune response by modulating the interconversion and function of effector and regulatory T cells","volume":"198","author":"Bakos","year":"2017","journal-title":"J Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"Pelletier","year":"2010","journal-title":"Blood"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/35006097","article-title":"Control of Th2 polarization by the chemokine monocyte chemoattractant protein-1","volume":"404","author":"Gu ST","year":"2000","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.41","article-title":"Human trophoblast cells induced mdscs from peripheral blood Cd14(+) myelomonocytic cells Via elevated levels of Ccl2","volume":"13","author":"Zhang","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.36","article-title":"Liaison between natural killer cells and dendritic cells in human gestation","volume":"11","author":"Leno-Duran","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"20409","DOI":"10.1038\/srep20409","article-title":"Human monocytes undergo functional re-programming during differentiation to dendritic cell mediated by human extravillous trophoblasts","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci Rep"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803494","article-title":"Ccr2 plays a critical role in dendritic cell maturation: Possible role of Ccl2 and nf-kappa b","volume":"184","author":"Jimenez","year":"2010","journal-title":"J Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00739-z","article-title":"Biology and pathology of the uterine microenvironment and its natural killer cells","volume":"18","author":"Wang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jri.2019.05.001","article-title":"Metabolic syndrome mediates inflammatory and oxidative stress responses in patients with recurrent pregnancy loss","volume":"133","author":"Azizi","year":"2019","journal-title":"J Reprod Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e41869","DOI":"10.1371\/journal.pone.0041869","article-title":"Monocyte chemoattractant protein-1 secreted by decidual stromal cells inhibits nk cells cytotoxicity by up-regulating expression of Socs3","volume":"7","author":"Xu","year":"2012","journal-title":"PLos One"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/rda.13647","article-title":"Embryo gene expression in pig pregnancy","volume":"55","author":"Llobat","year":"2020","journal-title":"Reprod Domest Anim"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.02.009","article-title":"What exactly is endometrial receptivity","volume":"111","author":"Lessey","year":"2019","journal-title":"Fertil Steril"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: Strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1159\/000511439","article-title":"Expression of the peptidase \"Fibroblast activation protein\" on decidual stromal cells facilitating tissue remodeling","volume":"85","author":"Segerer","year":"2020","journal-title":"Gynecol Obstet Invest"},{"key":"B92","doi-asserted-by":"publisher","first-page":"12968","DOI":"10.1038\/s41598-019-49502-5","article-title":"Chemokines as the modulators of endometrial epithelial cells remodelling","volume":"9","author":"Zlotkowska","year":"2019","journal-title":"Sci Rep"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.12.049","article-title":"Chemokine Ccl2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating akt and Mapk\/Erk1\/2 signal pathway","volume":"97","author":"Li","year":"2012","journal-title":"Fertil Steril"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2020.106475","article-title":"Modulatory effect of chemokines on porcine endometrial stromal and endothelial cells","volume":"72","author":"Zlotkowska","year":"2020","journal-title":"Domest Anim Endocrinol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: Human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa054","article-title":"Embryo implantation in the laboratory: An update on current techniques","volume":"27","author":"Ojosnegros","year":"2021","journal-title":"Hum Reprod Update"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00729","article-title":"Trophoblasts acquire a chemokine receptor, Ccr1, as they differentiate towards invasive phenotype","volume":"130","author":"Sato","year":"2003","journal-title":"Development"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16191","article-title":"M2 macrophage-derived G-csf promotes trophoblasts emt, invasion and migration Via activating Pi3k\/Akt\/Erk1\/2 pathway to mediate normal pregnancy","volume":"25","author":"Ding","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B99","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3390\/ijms18040742","article-title":"Possible roles of cc- and cxc-chemokines in regulating bovine endometrial function during early pregnancy","volume":"18","author":"Sakumoto","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.3390\/ijms21061973","article-title":"Physiologic events of embryo implantation and decidualization in human and non-human primates","volume":"21","author":"Ochoa-Bernal","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1126\/science.1220030","article-title":"Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface","volume":"336","author":"Nancy","year":"2012","journal-title":"Science"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.7554\/10","article-title":"Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids","volume":"10","author":"Lucas","year":"2021","journal-title":"Elife"},{"key":"B103","doi-asserted-by":"publisher","first-page":"S6.e1\u2013S6-8","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta","volume":"213","author":"Burton","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9452-3","article-title":"Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia","volume":"18","author":"Pratt","year":"2015","journal-title":"Angiogenesis"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab070","article-title":"Placental angiogenesis in mammals: A review of the regulatory effects of signaling pathways and functional nutrients","volume":"12","author":"Huang","year":"2021","journal-title":"Adv In Nutr (Bethesda Md)"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa368","article-title":"Uterine remodelling bleeds into the second trimester: Digitalised historic samples illuminate vascular adaptation to pregnancy","volume":"36","author":"Ruane","year":"2021","journal-title":"Hum Reprod"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms015","article-title":"Extravillous trophoblast and decidual natural killer cells: A remodelling partnership","volume":"18","author":"Wallace","year":"2012","journal-title":"Hum Reprod Update"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303117","article-title":"Identification of a novel neutrophil population: Proangiogenic granulocytes in second-trimester human decidua","volume":"193","author":"Amsalem","year":"2014","journal-title":"J Immunol (Baltimore Md 1950)"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00606","article-title":"M1\/M2 macrophage polarity in normal and complicated pregnancy","volume":"5","author":"Brown","year":"2014","journal-title":"Front Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.4.2651","article-title":"Ccl2 regulates angiogenesis Via activation of ets-1 transcription factor","volume":"177","author":"Stamatovic","year":"2006","journal-title":"J Immunol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2021.06.010","article-title":"Macrophage regulation of angiogenesis in health and disease","volume":"119","author":"Martin","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20200891","article-title":"Phenotypic and functional characterization of first-trimester human placental macrophages, hofbauer cells","volume":"218","author":"Thomas","year":"2021","journal-title":"J Exp Med"},{"key":"B114","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13287-021-02192-1","article-title":"Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or Sub-cultured placental tissue promoted huvec angiogenesis in vitro","volume":"12","author":"Ma","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1113\/JP274489","article-title":"Angiogenesis during pregnancy: All routes lead to mapks","volume":"595","author":"Hu","year":"2017","journal-title":"J Physiol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107598","article-title":"Mcp-1: Function, regulation, and involvement in disease","volume":"101","author":"Singh","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B117","author":"Jurkovic","year":""},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)00682-6","article-title":"Miscarriage matters: The epidemiological, physical, psychological, and economic costs of early pregnancy loss","volume":"397","author":"Quenby","year":"2021","journal-title":"Lancet"},{"key":"B119","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12958-018-0411-5","article-title":"Cytokines in relation to hcg are significantly altered in asymptomatic women with miscarriage - a pilot study","volume":"16","author":"Freis","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"B120","article-title":"Correlations between chemokines Cxcl12, Ccl2, rantes and early abortion","volume":"92","author":"Zhang","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093320","article-title":"A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage","volume":"9","author":"Hannan","year":"2014","journal-title":"PLos One"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-0992-5","article-title":"Chemokine (C-c motif) ligand-2 (Ccl2) and oxidative stress markers in recurrent pregnancy loss and repeated implantation failure","volume":"34","author":"Namli Kalem","year":"2017","journal-title":"J Assist Reprod Genet"},{"key":"B123","doi-asserted-by":"publisher","first-page":"gmr6882","DOI":"10.4238\/gmr.15016882","article-title":"Relationship between Tlr4 and Ccl2 expression and recurrent spontaneous abortion","volume":"15","author":"Li","year":"2016","journal-title":"Genet Mol Res"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.02.006","article-title":"Chinese Herbal medicine for miscarriage affects decidual micro-environment and fetal growth","volume":"36","author":"Piao","year":"2015","journal-title":"Placenta"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.772729","article-title":"Pro-inflammatory signature in decidua of recurrent pregnancy loss regardless of embryonic chromosomal abnormalities","volume":"12","author":"Wu","year":"2021","journal-title":"Front Immunol"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.689019","article-title":"The immune atlas of human deciduas with unexplained recurrent pregnancy loss","volume":"12","author":"Chen","year":"2021","journal-title":"Front Immunol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jri.2006.03.002","article-title":"Regulation of chemokine production in response to pro-inflammatory cytokines in first trimester decidual cells","volume":"72","author":"Huang","year":"2006","journal-title":"J Reprod Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia-pathophysiology and clinical presentations: Jacc state-of-the-Art review","volume":"76","author":"Ives","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: Pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015080","article-title":"Immune imbalance is associated with the development of preeclampsia","volume":"98","author":"Ma","year":"2019","journal-title":"Med (Baltimore)"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.12.025","article-title":"Combined use of serum mcp-1\/Il-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia","volume":"473","author":"Cui","year":"2017","journal-title":"Clin Chim Acta"},{"key":"B132","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jri.2017.10.048","article-title":"Early pregnancy immune biomarkers in peripheral blood may predict preeclampsia","volume":"125","author":"Salazar Garcia","year":"2018","journal-title":"J Reprod Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.12.015","article-title":"Expression of Ackr2 in placentas from different types of preeclampsia","volume":"90","author":"Yan","year":"2020","journal-title":"Placenta"},{"key":"B134","article-title":"Effects of Nrf-2 expression in trophoblast cells and vascular endothelial cells in preeclampsia","volume":"13","author":"Zhang","year":"2021","journal-title":"Am J Transl Res"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29766","article-title":"Elevated cell-free fetal DNA contributes to placental inflammation and antiangiogenesis Via Aim2 and Ifi16 during pre-eclampsia","volume":"235","author":"Li","year":"2020","journal-title":"J Cell Physiol"},{"key":"B136","doi-asserted-by":"publisher","first-page":"3695","DOI":"10.3390\/ijms20153695","article-title":"Role of the monocyte-macrophage system in normal pregnancy and preeclampsia","volume":"20","author":"Vishnyakova","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B137","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00005-019-00552-7","article-title":"Role of macrophages in pregnancy and related complications","volume":"67","author":"Jena","year":"2019","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B138","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.placenta.2016.03.002","article-title":"Curcumin improves lps-induced preeclampsia-like phenotype in rat by inhibiting the Tlr4 signaling pathway","volume":"41","author":"Gong","year":"2016","journal-title":"Placenta"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)02169-5","article-title":"Increased endothelial monocyte chemoattractant protein-1 and interleukin-8 in preeclampsia","volume":"100","author":"Scott Kauma","year":"2002","journal-title":"Obstetricians Gynecologists"},{"key":"B140","doi-asserted-by":"publisher","first-page":"5462","DOI":"10.3390\/ijms20215462","article-title":"Involvement of receptor for advanced glycation endproducts in hypertensive disorders of pregnancy","volume":"20","author":"Akasaka","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816","article-title":"Preterm labor one syndrome, many causes","volume":"345","author":"Romero","year":"2014","journal-title":"Science"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.46","article-title":"Immune cells in term and preterm labor","volume":"11","author":"Gomez-Lopez","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1506","article-title":"Stretch and inflammatory cytokines drive myometrial chemokine expression Via nf-\u039ab activation","volume":"153","author":"Hua","year":"2012","journal-title":"Endocrinology"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1530\/REP-22-0046","article-title":"The immunobiology of preterm labor and birth: Intra-amniotic inflammation or breakdown of maternal-fetal homeostasis","volume":"164","author":"Gomez-Lopez","year":"2022","journal-title":"Reprod (Cambridge England)"},{"key":"B145","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.3390\/cells10071724","article-title":"Ace2 is expressed in immune cells that infiltrate the placenta in infection-associated preterm birth","volume":"10","author":"Lye","year":"2021","journal-title":"Cells"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioz188","article-title":"Ccr2 mediates the adverse effects of lps in the pregnant mouse","volume":"102","author":"Hua","year":"2020","journal-title":"Biol Reprod"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.22","article-title":"An imbalance between innate and adaptive immune cells at the maternal-fetal interface occurs prior to endotoxin-induced preterm birth","volume":"13","author":"Arenas-Hernandez","year":"2016","journal-title":"Cell Mol Immunol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0140","article-title":"Irf5 is increased in labouring myometrium and regulates pro-labour mediators","volume":"156","author":"Lim","year":"2018","journal-title":"Reprod (Cambridge England)"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6454282","article-title":"Inhibition of Gpr91 reduces inflammatory mediators involved in active labor in myometrium","volume":"2020","author":"Lim","year":"2020","journal-title":"Mediators Inflammation"},{"key":"B150","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.3390\/molecules25194579","article-title":"Verbascoside-rich abeliophyllum distichum nakai leaf extracts prevent lps-induced preterm birth through inhibiting the expression of proinflammatory cytokines from macrophages and the cell death of trophoblasts induced by tnf-alpha","volume":"25","author":"Kim","year":"2020","journal-title":"Molecules"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gax041","article-title":"A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes","volume":"23","author":"Lappas","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010128","article-title":"A broad-spectrum chemokine inhibitor blocks inflammation-induced myometrial myocyte-macrophage crosstalk and myometrial contraction","volume":"11","author":"Boros-Rausch","year":"2021","journal-title":"Cells"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.028","article-title":"Uterine overdistention induces preterm labor mediated by inflammation: Observations in pregnant women and nonhuman primates","volume":"213","author":"Adams Waldorf","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"20190079","DOI":"10.1098\/rsfs.2019.0079","article-title":"Generation of a three-dimensional collagen scaffold-based model of the human endometrium","volume":"10","author":"Abbas","year":"2020","journal-title":"Interface Focus"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum Reprod Update"},{"key":"B156","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat Rev Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1053457\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T14:13:40Z","timestamp":1673014420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1053457\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,6]]},"references-count":156,"alternative-id":["10.3389\/fimmu.2022.1053457"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1053457","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,6]]},"article-number":"1053457"}}