{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:16:25Z","timestamp":1793812585446,"version":"4.6.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Since sepsis was defined three decades ago, it has been a target of intensive study. However, there is no specific sepsis treatment available, with its high mortality and morbidity. \u03b1D\u03b22 (CD11d\/CD18) is one of the four \u03b22 integrin members. Its role in sepsis has been limitedly studied. Using an experimental polymicrobial sepsis model, we found that the deficiency of \u03b1D\u03b22 was associated with less lung injury and better outcome, which was in sharp contrast to other \u03b22 integrin member \u03b1L\u03b22 (CD11a\/CD18), and \u03b1M\u03b22 (CD11b\/CD18). This phenotype was supported by a reduction of bacterial loads in \u03b1D\u03b22 knockout mice. Further analysis showed that the deficiency of \u03b1D\u03b22 led to a reduction of neutrophil cell death as well as an increase in neutrophil phagocytosis in both murine and human systems. Our data showed a unique role of \u03b1D\u03b22 among the \u03b22 integrin members, which would serve as a potential target to improve the outcome of sepsis.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1059996","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T01:54:05Z","timestamp":1668736445000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["\u03b1D\u03b22 as a novel target of experimental polymicrobial 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