{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:58:08Z","timestamp":1777485488662,"version":"3.51.4"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the correlation between postpartum hepatitis and changes of plasmacytoid dendritic cells\u2019 (pDC) function and frequency in hepatitis B e antigen (HBeAg)-positive pregnant women with chronic hepatitis B virus (HBV) infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women with chronic HBV infection receiving antiviral treatment (treated group) or not receiving antiviral treatment (untreated group) were enrolled and demographic information was collected before delivery. Clinical biochemical, virological serology, pDC frequency and functional molecular expression were tested before delivery and at 6, 12, 24 weeks after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>90 eligible pregnant women were enrolled, 36 in the untreated group and 54 in the treated group. 36 patients developed postpartum hepatitis, including 17 (17\/36, 47.2%) in the untreated group and 19 (19\/54, 35.2%) in the treated group (\u03c72 = 1.304 p=0.253), and 22 cases of hepatitis occurred at 6 weeks postpartum, 12 at 12 weeks postpartum, and 2 at 24 weeks postpartum. The alanine transaminase (ALT) levels at any time postpartum were significantly higher than that of the antepartum, especially at 6 weeks and 12 weeks postpartum. However, the frequencies of pDCs, CD83<jats:sup>+<\/jats:sup> pDCs and CD86<jats:sup>+<\/jats:sup> pDCs antepartum had no significant difference from any time postpartum. The frequencies of CD83<jats:sup>+<\/jats:sup> pDCs, CD86<jats:sup>+<\/jats:sup> pDCs in the treated group antepartum were significantly higher than those in the untreated group [12.70 (9.46, 15.08) vs. 10.20 (7.96, 11.85), p=0.007; 22.05 (19.28, 33.03) vs. 18.05 (14.33, 22.95), p=0.011], and the same at 12 weeks postpartum [12.80 (10.50, 15.50) vs. 9.38 (7.73, 12.60), p=0.017; 22.50 (16.80, 31.20) vs. 16.50 (12.65, 20.80), p=0.001]. The frequency of CD86<jats:sup>+<\/jats:sup> pDCs in the treated group was significantly higher than that in the untreated group at 24 weeks postpartum [22.10 (16.70, 30.00) vs. 17.10 (13.70, 20.05), p=0.006].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postpartum hepatitis in HBV infected women mainly occurs at 6-12 weeks postpartum. Antiviral treatment during pregnancy can significantly increase the frequencies of CD83<jats:sup>+<\/jats:sup> pDCs and CD86<jats:sup>+<\/jats:sup> pDCs in pregnant women with chronic HBV infection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.1062123","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:29:37Z","timestamp":1667971777000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The relation of the frequency and functional molecules expression on plasmacytoid dendritic cells to postpartum hepatitis in women with HBeAg-positive chronic hepatitis B virus infection"],"prefix":"10.3389","volume":"13","author":[{"given":"Fuchuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiying","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanjiao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiao","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxue","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.05.103","article-title":"Screening of pregnant women for hepatitis bvirus surface antigen (HBsAg) and subsequent management, qiandongnan prefecture, guizhou, China, 2010","volume":"31","author":"Huang","year":"2013","journal-title":"Vaccine"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/ped4.12205","article-title":"Prevention strategies of mother-to-child transmission of hepatitis b virus (HBV) infection","volume":"4","author":"Hu","year":"2020","journal-title":"Pediatr Investig"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2019.04.007","article-title":"Hepatitis b in pregnant women and their infants","volume":"23","author":"Cryer","year":"2019","journal-title":"Clinics liver Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4753267","article-title":"Antiviral therapy for a postpartum flare in women with chronic HBV infection shortens the ALT recovery time and reduces hepatitis re-flare rates within 4 years","volume":"2022","author":"Quan","year":"2022","journal-title":"Can J Gastroenterol Hepatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abf8442","article-title":"Depleting plasmacytoid dendritic cells reduces local type I interferon responses and disease activity in patients with cutaneous lupus","volume":"13","author":"Karnell","year":"2021","journal-title":"Sci Trans Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00011-012-0493-z","article-title":"Down regulation of TLR7\/9 leads to deficient production of IFN-\u03b1 from plasmacytoid dendritic cells in chronic hepatitis b","volume":"61","author":"Xu","year":"2012","journal-title":"Inflamm Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1089\/jir.2018.0014","article-title":"Quantitation of plasmacytoid dendritic cells in chronic hepatitis b patients with HBeAg positivity during PEG-IFN and entecavir therapy","volume":"38","author":"Cao","year":"2018","journal-title":"J Interferon Cytokine Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-308211","article-title":"Clinical and virological predictors of hepatic flares in pregnant women with chronic hepatitis b","volume":"64","author":"Giles","year":"2015","journal-title":"Gut"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.3390\/jcm10132926","article-title":"Hepatitis b virus infection in pregnancy: Immunological response, natural course and pregnancy outcomes","volume":"10","author":"Sirilert","year":"2021","journal-title":"J Clin Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12072-015-9675-4","article-title":"Asian-Pacific clinical practice guidelines on the management of hepatitis b: a 2015 update","volume":"10","author":"Sarin","year":"2016","journal-title":"Hepatol Int"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00249","article-title":"Plasmacytoid dendritic cells as cell-based therapeutics: A novel immunotherapy to treat human immunodeficiency virus infection","volume":"10","author":"van der Sluis","year":"2020","journal-title":"Front Cell infection Microbiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1039\/c9ra00818g","article-title":"Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration","volume":"9","author":"Kim","year":"2019","journal-title":"RSC Adv"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1547603","article-title":"Phenotypic and functional profile of IFN-\u03b1-differentiated dendritic cells (IFN-DCs) from HIV-infected individuals","volume":"15","author":"Santillo","year":"2019","journal-title":"Hum Vaccin Immunother"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01005","article-title":"Semaphorin-3E produced by immature dendritic cells regulates activated natural killer cells migration","volume":"9","author":"Alamri","year":"2018","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"599","DOI":"10.4252\/wjsc.v14.i8.599","article-title":"Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance","volume":"14","author":"Huang","year":"2022","journal-title":"World J Stem Cells"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2022.152246","article-title":"COMBAT consortium. properdin produced by dendritic cells contributes to the activation of T cells","volume":"227","author":"van Essen","year":"2022","journal-title":"Immunobiology"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1159\/000522339","article-title":"Streptococcus pneumoniae impairs maturation of human dendritic cells and consequent activation of CD4+ T cells via pneumolysin","volume":"14","author":"Paulikat","year":"2022","journal-title":"J Innate Immun"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.936995","article-title":"The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis","volume":"13","author":"Royzman","year":"2022","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020732","article-title":"Tilting the balance: Therapeutic prospects of CD83 as a checkpoint molecule controlling resolution of inflammation","volume":"23","author":"Peckert-Maier","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B20","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.3390\/cancers14174132","article-title":"Genetics and epigenetics in neoplasms with plasmacytoid dendritic cells","volume":"14","author":"Renosi","year":"2022","journal-title":"Cancers"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3760\/cam.j.cn112866-20191205-00196","article-title":"Study on the pathogenesis of HBeAg positive chronic hepatitis b and plasmacytoid dendritic cells function","volume":"34","author":"Lu","year":"2020","journal-title":"Chin J Exp Clin Virol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891424","article-title":"Expression of functional molecule on plasmacytoid dendritic cells is associated with HBsAg loss in HBeAg-positive patients during PEG-IFN \u03b1-2a treatment","volume":"13","author":"Cao","year":"2022","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0010-2","article-title":"The characteristics and predictors of postpartum hepatitis flares in women with chronic hepatitis b","volume":"113","author":"Yi","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2019.1610428","article-title":"Aberrant phenotype and function of dendritic cells in adult b lineage acute lymphoblastic leukemia","volume":"48","author":"Zhou","year":"2019","journal-title":"Immunol Invest"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1062123\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T05:29:39Z","timestamp":1667971779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1062123\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":24,"alternative-id":["10.3389\/fimmu.2022.1062123"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1062123","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]},"article-number":"1062123"}}