{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:58:01Z","timestamp":1793678281596,"version":"4.5.1"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Pyroptosis is an inflammatory form of programmed cell death implicated in inflammation and disease. Moreover, inducing pyroptosis has been appreciated as anti-cancer therapy for its ability to unleash anti-cancer immune responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing the data available in The Cancer Genome Atlas (TCGA), pyroptosis-related genes\u2019 (PRGs) expression, genomic aberrations, and clinical significance were systematically analyzed in pan-cancer. A GSVA score was obtained to rate pyroptosis level and divide the cancers into pyroptosis-low and pyroptosis-high groups. Immunohistochemistry (IHC) was used to evaluate the differential expression of major PRGs (GSDMC, GSDMD, GSDME, NLRP3, NLRC4, IL1B) in selected tumor types (COAD, HNSC, KIRC, LIHC, LUAD, LUSC). Selection of tumors for immunohistochemistry (IHC) was based on their expression pattern in TCGA cancers, clinical relevance, tumor epidemiology, and sample availability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differential expression of PRGs was evident in various cancers and associated with prognosis which was driven by genomic variations and epigenetic abnormalities, such as single nucleotide variations (SNVs), copy number variation (CNV) and DNA methylation level. For example, methylation of PRGs in lower grade glioma (LGG), uveal melanoma (UVM) and kidney renal clear cell carcinoma (KIRC) were predictive of improved survival as upregulation of PRGs was risky in these cancers. Pyroptosis level significantly differentiated tumor from normal samples in 15 types of cancers, exhibited a progressive trend with cancer stage, observed variation among cancer subtypes, and showed a significant association with cancer prognosis. Higher pyroptosis level was associated with worst prognosis in majority of the cancers in terms of OS (KIRC, LGG, and UVM), PFS (GBM, KIRC, LGG, PRAD, THCA, and THYM) and DSS (KIRC and LGG) as estimated by Kaplan-Meier survival curves. Moreover, Pyroptosis level was strongly indicative of a hot tumor immune microenvironment with high presence of CD8+ T cell and other T cell subtypes. Several oncogenic pathways, such as P53 pathway, DNA repair, KRAS signaling, epithelial-mesenchymal transition (EMT), IL6 JAK STAT3 signaling, IL2 STAT5 signaling, PI3K AKT MTOR signaling and angiogenesis, were enriched in pyroptosis-hi subgroups across cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Genetic alterations in PRGs greatly influence the pyroptosis level and cancer prognosis. A relatively hot tumor immune microenvironment was associated with pyroptosis irrespective of the cancer prognosis. Overall, our study reveals the critical role of pyroptosis in cancer and highlights pyroptosis-based therapeutic vulnerabilities.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fimmu.2022.1062225","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T08:28:36Z","timestamp":1671524916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective"],"prefix":"10.3389","volume":"13","author":[{"given":"Muhammad","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpeng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anbang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: Host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: Mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00602-2","article-title":"Gasdermins: making pores for pyroptosis","volume":"21","author":"Shao","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: Mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: Gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aax7969","article-title":"Gasdermin e-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome","volume":"5","author":"Liu","year":"2020","journal-title":"Sci Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme a from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin d causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00063","article-title":"NLRP3 inflammasome in neurological diseases, from functions to therapies","volume":"11","author":"Song","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.autrev.2018.01.020","article-title":"NLRP3: A promising therapeutic target for autoimmune diseases","volume":"17","author":"Shen","year":"2018","journal-title":"Autoimmun Rev"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.028","article-title":"Role of pyroptosis in cardiovascular diseases","volume":"67","author":"Jia","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.03.007","article-title":"Pyroptosis in combinatorial treatment to improve cancer patients' outcome, is that what we want","volume":"41","author":"Pezuk","year":"2019","journal-title":"EBioMedicine"},{"key":"B18","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41419-019-1883-8","article-title":"The role of pyroptosis in cancer: pro-cancer or pro-\u201dhost\u201d","volume":"10","author":"Xia","year":"2019","journal-title":"Cell Death Dis"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.26","article-title":"NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma","volume":"36","author":"Zhai","year":"2017","journal-title":"Oncogene"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0509","article-title":"NLRP3 suppresses NK cell-mediated responses to carcinogen-induced tumors and metastases","volume":"72","author":"Chow","year":"2012","journal-title":"Cancer Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402098","article-title":"The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis","volume":"194","author":"Williams","year":"2015","journal-title":"J Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100050","article-title":"The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer","volume":"207","author":"Allen","year":"2010","journal-title":"J Exp Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016814108","article-title":"Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4","volume":"107","author":"Hu","year":"2010","journal-title":"Proc Natl Acad Sci United States America"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3908","article-title":"Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and akt","volume":"21","author":"Wilson","year":"2015","journal-title":"Nat Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1053\/j.gastro.2017.11.276","article-title":"Pyrin inflammasome regulates tight junction integrity to restrict colitis and tumorigenesis","volume":"154","author":"Sharma","year":"2018","journal-title":"Gastroenterology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/00313020701716250","article-title":"Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues","volume":"40","author":"Carl-McGrath","year":"2008","journal-title":"Pathology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1593\/tlo.08112","article-title":"Expression of GSDML associates with tumor progression in uterine cervix cancer","volume":"1","author":"Sun","year":"2008","journal-title":"Transl Oncol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20636","article-title":"Distinctive expression and function of four GSDM family genes (GSDMA-d) in normal and malignant upper gastrointestinal epithelium","volume":"48","author":"Saeki","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2001.tb01076.x","article-title":"Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells","volume":"92","author":"Watabe","year":"2001","journal-title":"Jpn J Cancer Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166422","article-title":"Gasdermin c is upregulated by inactivation of transforming growth factor \u03b2 receptor type II in the presence of mutated apc, promoting colorectal cancer proliferation","volume":"11","author":"Miguchi","year":"2016","journal-title":"PloS One"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10837","article-title":"Overexpression of GSDMC is a prognostic factor for predicting a poor outcome in lung adenocarcinoma","volume":"21","author":"Wei","year":"2020","journal-title":"Mol Med Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/1751-2980.12576","article-title":"Downregulation of gasdermin d promotes gastric cancer proliferation by regulating cell cycle-related proteins","volume":"19","author":"Wang","year":"2018","journal-title":"J Dig Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3892\/or.2018.6634","article-title":"Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR\/Akt signaling and predicts a good prognosis in non\u2212small cell lung cancer","volume":"40","author":"Gao","year":"2018","journal-title":"Oncol Rep"},{"key":"B34","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/j.1349-7006.2006.00351.x","article-title":"Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer","volume":"98","author":"Akino","year":"2007","journal-title":"Cancer Sci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1211021","article-title":"Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma","volume":"27","author":"Kim","year":"2008","journal-title":"Oncogene"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16654","article-title":"DFNA5 promoter methylation a marker for breast tumorigenesis","volume":"8","author":"Croes","year":"2017","journal-title":"Oncotarget"},{"key":"B37","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13046-021-01959-x","article-title":"Pyroptosis: a new paradigm of cell death for fighting against cancer","volume":"40","author":"Tan","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2079-1","article-title":"A bioorthogonal system reveals antitumour immune function of pyroptosis","volume":"579","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"key":"B43","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cell.2013.03.008","article-title":"Interplay between the cancer genome and epigenome","volume":"153","author":"Shen","year":"2013","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3729","article-title":"Mechanisms underlying mutational signatures in human cancers","volume":"15","author":"Helleday","year":"2014","journal-title":"Nat Rev Genet"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gendis.2018.01.002","article-title":"DNA Methylation in human diseases","volume":"5","author":"Jin","year":"2018","journal-title":"Genes Dis"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2021.05.002","article-title":"Navigating the DNA methylation landscape of cancer","volume":"37","author":"Nishiyama","year":"2021","journal-title":"Trends Genet"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12744","article-title":"Distinct chromatin signatures of DNA hypomethylation in aging and cancer","volume":"17","author":"P\u00e9rez","year":"2018","journal-title":"Aging Cell"},{"key":"B48","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41392-022-01003-0","article-title":"Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine","volume":"7","author":"Xue","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3834","article-title":"The impact of structural variation on human gene expression","volume":"49","author":"Chiang","year":"2017","journal-title":"Nat Genet"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/bfgp\/elv017","article-title":"The impact of human copy number variation on gene expression","volume":"14","author":"Gamazon","year":"2015","journal-title":"Brief Funct Genomics"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MIR0120-625R","article-title":"Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk","volume":"108","author":"Hachim","year":"2020","journal-title":"J Leukoc Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0805","article-title":"Fueling the fire: Inflammatory forms of cell death and implications for cancer immunotherapy","volume":"11","author":"Rosenbaum","year":"2021","journal-title":"Cancer Discov"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1158\/2326-6066.CIR-20-0525","article-title":"Lighting a fire: Can we harness pyroptosis to ignite antitumor immunity","volume":"9","author":"Zhang","year":"2021","journal-title":"Cancer Immunol Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.781365","article-title":"Epithelial-mesenchymal transition induces GSDME transcriptional activation for inflammatory pyroptosis","volume":"9","author":"Jia","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3390\/ijms19020611","article-title":"The role of the estrogen pathway in the tumor microenvironment","volume":"19","author":"Rothenberger","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30627","article-title":"Pyroptosis: A possible link between obesity-related inflammation and inflammatory diseases","volume":"237","author":"Miao","year":"2021","journal-title":"J Cell Physiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02918","article-title":"NLRP3 inflammasome: A possible link between obesity-associated low-grade chronic inflammation and colorectal cancer development","volume":"9","author":"Ahechu","year":"2018","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3727\/096504018X15462920753012","article-title":"E2-induced activation of the NLRP3 inflammasome triggers pyroptosis and inhibits autophagy in HCC cells","volume":"27","author":"Wei","year":"2019","journal-title":"Oncol Res"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.08.010","article-title":"Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor \u03b1-mediated autophagy","volume":"28","author":"Meng","year":"2021","journal-title":"J Adv Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239659","article-title":"Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway","volume":"15","author":"Xu","year":"2020","journal-title":"PloS One"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin e suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s41467-019-09397-2","article-title":"Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation","volume":"10","author":"Rogers","year":"2019","journal-title":"Nat Commun"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.156","article-title":"GSDME mediates caspase-3-dependent pyroptosis in gastric cancer","volume":"495","author":"Wang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-019-01515-1","article-title":"Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3\/GSDME activation","volume":"24","author":"Zhang","year":"2019","journal-title":"Apoptosis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/s41420-020-00349-0","article-title":"The caspase-3\/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer","volume":"6","author":"Jiang","year":"2020","journal-title":"Cell Death Discov"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.02.012","article-title":"A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma","volume":"41","author":"Wu","year":"2019","journal-title":"EBioMedicine"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1441","article-title":"Two worlds collide: Unraveling the role of the immune system in BRAF-MEK inhibitor responses","volume":"10","author":"Smalley","year":"2020","journal-title":"Cancer Discov"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0672","article-title":"Mutant BRAF and MEK inhibitors regulate the tumor immune microenvironment via pyroptosis","volume":"10","author":"Erkes","year":"2020","journal-title":"Cancer Discov"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1062225\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T08:28:38Z","timestamp":1671524918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1062225\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,20]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2022.1062225"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1062225","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,20]]},"article-number":"1062225"}}