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Natural phytochemicals, with known anticancer properties, been reported to mediate their effects by modulating both traditional cancer pathways and immunity. The mechanism of phytochemical mediated-immunomodulatory activity may be attributed to the remodeling of the tumor immunosuppressive microenvironment and the sensitization of the immune system. This allows for improved recognition and targeting of cancer cells by the immune system and synergy with chemotherapeutics. In this review, we will discuss several well-known plant-derived biomolecules and examine their potential as immunomodulators, and therefore, as novel immunotherapies for cancer treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1070367","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T12:10:43Z","timestamp":1673266243000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Natural biomolecules and derivatives as anticancer immunomodulatory 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