{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:16:07Z","timestamp":1767856567101,"version":"3.49.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000888","name":"W. M. Keck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>During chronic antigen exposure, a subset of exhausted CD8<jats:sup>+<\/jats:sup> T cells differentiate into stem cell-like or progenitor-like T cells expressing both transcription factor Tcf-1 (T cell factor-1) and co-inhibitory receptor PD-1. These Tcf-1<jats:sup>+<\/jats:sup> stem-like or progenitor exhausted T cells represent the key target for immunotherapies. Deeper understanding of the biology of Tcf-1<jats:sup>+<\/jats:sup>PD-1<jats:sup>+<\/jats:sup> CD8<jats:sup>+<\/jats:sup> T cells will lead to rational design of future immunotherapies. Here, we summarize recent findings about the migratory and resident behavior of Tcf-1<jats:sup>+<\/jats:sup> T cells. Specifically, we will focus on TGF-\u03b2-dependent lymphoid tissue residency program of Tcf-1<jats:sup>+<\/jats:sup> T cells, which may represent a key to understanding the differentiation and maintenance of Tcf-1<jats:sup>+<\/jats:sup> stem-like CD8<jats:sup>+<\/jats:sup> T cells during persistent antigen stimulation.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1074698","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T04:28:29Z","timestamp":1670387309000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells"],"prefix":"10.3389","volume":"13","author":[{"given":"Chaoyu","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-012017-043208","article-title":"CD8 T cell exhaustion in chronic infection and cancer: Opportunities for interventions","volume":"69","author":"Hashimoto","year":"2018","journal-title":"Annu Rev Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801497105","article-title":"Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade","volume":"105","author":"Blackburn","year":"2008","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/ni.1679","article-title":"Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection","volume":"10","author":"Blackburn","year":"2009","journal-title":"Nat Immunol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229620","article-title":"Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection","volume":"338","author":"Paley","year":"2012","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature19317","article-title":"Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection","volume":"537","author":"He","year":"2016","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3543","article-title":"CXCR5(+) follicular cytotoxic T cells control viral infection in b cell follicles","volume":"17","author":"Leong","year":"2016","journal-title":"Nat Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.021","article-title":"T Cell factor 1-expressing memory-like CD8(+) T cells sustain the immune response to chronic viral infections","volume":"45","author":"Utzschneider","year":"2016","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aai8593","article-title":"The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness","volume":"1","author":"Wu","year":"2016","journal-title":"Sci Immunol 1"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.immuni.2019.10.009","article-title":"CD4(+) T cell help is required for the formation of a cytolytic CD8(+) T cell subset that protects against chronic infection and cancer","volume":"51","author":"Zander","year":"2019","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.immuni.2019.11.002","article-title":"Proliferating transitory T cells with an effector-like transcriptional signature emerge from PD-1(+) stem-like CD8(+) T cells during chronic infection","volume":"51","author":"Hudson","year":"2019","journal-title":"Immunity"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nature22367","article-title":"Chromatin states define tumour-specific T cell dysfunction and reprogramming","volume":"545","author":"Philip","year":"2017","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0312-6","article-title":"Subsets of exhausted CD8(+) T cells differentially mediate tumor control and respond to checkpoint blockade","volume":"20","author":"Miller","year":"2019","journal-title":"Nat Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.immuni.2018.12.021","article-title":"Intratumoral Tcf1(+)PD-1(+)CD8(+) T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy","volume":"50","author":"Siddiqui","year":"2019","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05105-1","article-title":"MYB orchestrates T cell exhaustion and response to checkpoint inhibition","volume":"609","author":"Tsui","year":"2022","journal-title":"Nature"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0311-z","article-title":"The transcription factor c-myb regulates CD8(+) T cell stemness and antitumor immunity","volume":"20","author":"Gautam","year":"2019","journal-title":"Nat Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.immuni.2020.09.005","article-title":"Central memory CD8(+) T cells derive from stem-like Tcf7(hi) effector cells in the absence of cytotoxic differentiation","volume":"53","author":"Pais Ferreira","year":"2020","journal-title":"Immunity"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01131-3","article-title":"Tcf1 preprograms the mobilization of glycolysis in central memory CD8(+) T cells during recall responses","volume":"23","author":"Shan","year":"2022","journal-title":"Nat Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01263-6","article-title":"Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8(+) T cell homeostasis","volume":"23","author":"Shan","year":"2022","journal-title":"Nat Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.immuni.2018.01.012","article-title":"Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells","volume":"48","author":"Johnson","year":"2018","journal-title":"Immunity"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.02.010","article-title":"Understanding subset diversity in T cell memory","volume":"48","author":"Jameson","year":"2018","journal-title":"Immunity"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010201107","article-title":"Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence","volume":"107","author":"Wakim","year":"2010","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"B25","doi-asserted-by":"publisher","first-page":"110852","DOI":"10.1016\/j.celrep.2022.110852","article-title":"Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface","volume":"39","author":"Loi","year":"2022","journal-title":"Cell Rep"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0711-8","article-title":"Peripherally induced brain tissue-resident memory CD8(+) T cells mediate protection against CNS infection","volume":"21","author":"Urban","year":"2020","journal-title":"Nat Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aag2031","article-title":"Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity","volume":"2","author":"Slutter","year":"2017","journal-title":"Sci Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0282-0","article-title":"The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8(+) T cells","volume":"559","author":"Borges da Silva","year":"2018","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.immuni.2020.06.010","article-title":"Sensing of ATP via the purinergic receptor P2RX7 promotes CD8(+) trm cell generation by enhancing their sensitivity to the cytokine TGF-beta","volume":"53","author":"Borges da Silva","year":"2020","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.immuni.2021.11.017","article-title":"Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8(+) tissue-resident memory T cells","volume":"55","author":"Peng","year":"2022","journal-title":"Immunity"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat Immunol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.007","article-title":"Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function","volume":"40","author":"Sheridan","year":"2014","journal-title":"Immunity"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.019","article-title":"Transforming growth factor-beta signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention","volume":"39","author":"Zhang","year":"2013","journal-title":"Immunity"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402369","article-title":"Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells","volume":"194","author":"Hu","year":"2015","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"101975","DOI":"10.1016\/j.isci.2020.101975","article-title":"The downregulation of IL-18R defines bona fide kidney-resident CD8(+) T cells","volume":"24","author":"Liao","year":"2021","journal-title":"iScience"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01229-8","article-title":"Tissue-resident memory CD8(+) T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments","volume":"23","author":"Crowl","year":"2022","journal-title":"Nat Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.immuni.2020.10.022","article-title":"Competition for active TGFbeta cytokine allows for selective retention of antigen-specific tissue- resident memory T cells in the epidermal niche","volume":"54","author":"Hirai","year":"2021","journal-title":"Immunity"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav5728","article-title":"Migratory DCs activate TGF-beta to precondition naive CD8(+) T cells for tissue-resident memory fate","volume":"366","author":"Mani","year":"2019","journal-title":"Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01004-1","article-title":"Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity","volume":"22","author":"Christo","year":"2021","journal-title":"Nat Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6970","article-title":"Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection","volume":"2","author":"Pizzolla","year":"2017","journal-title":"Sci Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2017.62","article-title":"And","volume":"95","author":"Shwetank","year":"2017","journal-title":"Immunol Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02493-10","article-title":"Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes","volume":"85","author":"Lee","year":"2011","journal-title":"J Virol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202288109","article-title":"Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation","volume":"109","author":"Mackay","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200402","article-title":"Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues","volume":"188","author":"Casey","year":"2012","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nature11522","article-title":"A vaccine strategy that protects against genital herpes by establishing local memory T cells","volume":"491","author":"Shin","year":"2012","journal-title":"Nature"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151855","article-title":"Local antigen in nonlymphoid tissue promotes resident memory CD8+ T cell formation during viral infection","volume":"213","author":"Khan","year":"2016","journal-title":"J Exp Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160888","article-title":"Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells","volume":"213","author":"Muschaweckh","year":"2016","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002781","article-title":"Cutting edge: Intrinsic programming of thymic gammadeltaT cells for specific peripheral tissue localization","volume":"185","author":"Jin","year":"2010","journal-title":"J Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03351-3","article-title":"Expansible residence decentralizes immune homeostasis","volume":"592","author":"Wijeyesinghe","year":"2021","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.immuni.2020.09.003","article-title":"T Cell receptor is required for differentiation, but not maintenance, of intestinal CD4(+) intraepithelial lymphocytes","volume":"53","author":"Bilate","year":"2020","journal-title":"Immunity"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181077","article-title":"Viral MHCI inhibition evades tissue-resident memory T cell formation and responses","volume":"216","author":"Lauron","year":"2019","journal-title":"J Exp Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400003","article-title":"Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs","volume":"192","author":"Schenkel","year":"2014","journal-title":"J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.immuni.2018.01.015","article-title":"T Cells in nonlymphoid tissues give rise to lymph-Node-Resident memory T cells","volume":"48","author":"Beura","year":"2018","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68662","article-title":"Protective function and durability of mouse lymph node-resident memory CD8(+) T cells","volume":"10","author":"Anthony","year":"2021","journal-title":"Elife"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192197","article-title":"Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection","volume":"217","author":"Stolley","year":"2020","journal-title":"J Exp Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01370","article-title":"Immunity to respiratory infection is reinforced through early proliferation of lymphoid TRM cells and prompt arrival of effector CD8 T cells in the lungs","volume":"10","author":"Suarez-Ramirez","year":"2019","journal-title":"Front Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.026","article-title":"Spatial map of human T cell compartmentalization and maintenance over decades of life","volume":"159","author":"Thome","year":"2014","journal-title":"Cell"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005799","article-title":"Compartmentalization of total and virus-specific tissue-resident memory CD8+ T cells in human lymphoid organs","volume":"12","author":"Woon","year":"2016","journal-title":"PloS Pathog"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1917298117","article-title":"PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection","volume":"117","author":"Im","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"B60","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.immuni.2020.04.014","article-title":"Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms","volume":"52","author":"Beltra","year":"2020","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00878-5","article-title":"Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands","volume":"22","author":"Duckworth","year":"2021","journal-title":"Nat Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.immuni.2021.11.002","article-title":"CXCL10 chemokine regulates heterogeneity of the CD8(+) T cell response and viral set point during chronic infection","volume":"55","author":"Ozga","year":"2022","journal-title":"Immunity"},{"key":"B63","doi-asserted-by":"publisher","first-page":"110266","DOI":"10.1016\/j.celrep.2021.110266","article-title":"CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels","volume":"38","author":"Bangs","year":"2022","journal-title":"Cell Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2021.06.007","article-title":"Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection","volume":"54","author":"Gabriel","year":"2021","journal-title":"Immunity"},{"key":"B65","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/s41590-021-00965-7","article-title":"BATF regulates progenitor to cytolytic effector CD8(+) T cell transition during chronic viral infection","volume":"22","author":"Chen","year":"2021","journal-title":"Nat Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211574","article-title":"TGF-beta regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection","volume":"219","author":"Hu","year":"2022","journal-title":"J Exp Med"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20211538","article-title":"TGF-beta promotes stem-like T cells via enforcing their lymphoid tissue retention","volume":"219","author":"Ma","year":"2022","journal-title":"J Exp Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1836-5","article-title":"An intra-tumoral niche maintains and differentiates stem-like CD8 T cells","volume":"576","author":"Jansen","year":"2019","journal-title":"Nature"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03862-z","article-title":"Functional HPV-specific PD-1(+) stem-like CD8 T cells in head and neck cancer","volume":"597","author":"Eberhardt","year":"2021","journal-title":"Nature"},{"key":"B70","doi-asserted-by":"publisher","first-page":"eabg7836","DOI":"10.1126\/sciimmunol.abg7836","article-title":"A reservoir of stem-like CD8(+) T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response","volume":"6","author":"Connolly","year":"2021","journal-title":"Sci Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.08.026","article-title":"Conventional type I dendric cells maintain a reservoir of proliferative tumor-antigen specific TCF-1(+) CD8(+) T cells in tumor-draining lymph nodes","volume":"54","author":"Schenkel","year":"2021","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.1038\/s41467-022-33768-x","article-title":"TGF-beta-dependent lymphoid tissue residency of stem-like T cells limits response to tumor vaccine","volume":"13","author":"Li","year":"2022","journal-title":"Nat Commun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210749","article-title":"In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue","volume":"219","author":"Li","year":"2022","journal-title":"J Exp Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04248-x","article-title":"An autoimmune stem-like CD8 T cell population drives type 1 diabetes","volume":"602","author":"Gearty","year":"2022","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2745","article-title":"Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells","volume":"14","author":"Skon","year":"2013","journal-title":"Nat Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1016\/j.immuni.2021.08.019","article-title":"Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma","volume":"54","author":"Molodtsov","year":"2021","journal-title":"Immunity"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1074698\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T04:28:31Z","timestamp":1670387311000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1074698\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2022.1074698"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1074698","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"article-number":"1074698"}}