{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:25:04Z","timestamp":1791509104757,"version":"4.3.4"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The characterization of frequency and phenotypes of natural killer (NK) cells and T cells in BAL and peripheral blood of patients with sarcoidosis was evaluated, to discriminate the differential status of these cells in these two compartments. The analysis revealed that CD56<jats:sup>bright<\/jats:sup>CD16<jats:sup>neg<\/jats:sup> resulted higher in BAL than PB of sarcoidosis and healthy subjects, while CD56<jats:sup>dim<\/jats:sup>CD16<jats:sup>+<\/jats:sup> showed a different proportion between BAL and PB of both Sarcoidosis patients and HC. Moreover, in comparison with autologous PB, BAL was characterized by a higher expression of activated NK cell markers NKp44, CD69 and CD25. Significantly increased levels of PD-1<jats:sup>+<\/jats:sup> NK cells in the BAL of patients were detected. Regarding the maturation of CD4 and CD8, an increase of Effector Memory T cells (T<jats:sub>EM<\/jats:sub>) was reported in BAL compared to PB. A better characterization of NK and T cells may lead to an improvement of the pathogenetic mechanisms in sarcoidosis.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1080556","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T16:17:39Z","timestamp":1672849059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of natural killer and T cells in bronchoalveolar lavage and peripheral blood of sarcoidosis patients"],"prefix":"10.3389","volume":"13","author":[{"given":"Laura","family":"Bergantini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriana","family":"d\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genny","family":"Del 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