{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:18:44Z","timestamp":1793089124794,"version":"4.5.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Myocardial infarction (MI) is a cardiovascular disease (CVD) with high morbidity and mortality worldwide, often leading to adverse cardiac remodeling and heart failure, which is a serious threat to human life and health. The immune system makes an important contribution to the maintenance of normal cardiac function. In the disease process of MI, necrotic cardiomyocytes release signals that activate nonspecific immunity and trigger the action of specific immunity. Complex immune cells play an important role in all stages of MI progression by removing necrotic cardiomyocytes and tissue and promoting the healing of damaged tissue cells. With the development of biomaterials, cardiac patches have become an emerging method of repairing MI, and the development of engineered cardiac patches through the construction of multiple animal models of MI can help treat MI. This review introduces immune cells involved in the development of MI, summarizes the commonly used animal models of MI and the newly developed cardiac patch, so as to provide scientific reference for the accurate diagnosis and effective treatment of MI.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1084460","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:36:15Z","timestamp":1674113775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["The role of major immune cells in myocardial infarction"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiang","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengzong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongliang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.114.300639","article-title":"Exosomes and cardiac repair after myocardial infarction","volume":"114","author":"Sahoo","year":"2014","journal-title":"Circ Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00804-4","article-title":"Myocardial infarction redefined\u2013a consensus document of the joint European society of Cardiology\/American college of cardiology committee for the redefinition of myocardial infarction","volume":"36","author":"Alpert","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.011","article-title":"Universal definition of myocardial infarction","volume":"50","author":"Thygesen","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0065-8","article-title":"Cardioimmunology: The immune system in cardiac homeostasis and disease","volume":"18","author":"Swirski","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1056\/nejm200007063430107","article-title":"The immune system. first of two parts","volume":"343","author":"Delves","year":"2000","journal-title":"N Engl J Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.017","article-title":"Adaptive immunity","volume":"125","author":"Bonilla","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/circresaha.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: From inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.02.016","article-title":"The in-situ pig heart with regional Ischemia\/Reperfusion - ready for translation","volume":"50","author":"Heusch","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.04.018","article-title":"Conductive biomaterials for cardiac repair: A review","volume":"139","author":"Li","year":"2022","journal-title":"Acta Biomater"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00454","article-title":"Role of biomaterials in cardiac repair and regeneration: Therapeutic intervention for myocardial infarction","volume":"8","author":"Tariq","year":"2022","journal-title":"ACS Biomater Sci Eng"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1907","article-title":"The mechanistic basis of infarct healing","volume":"8","author":"Frangogiannis","year":"2006","journal-title":"Antioxid Redox Signal"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/fjc.0000000000000876","article-title":"The role of immune cells in cardiac remodeling after myocardial infarction","volume":"76","author":"Zhang","year":"2020","journal-title":"J Cardiovasc Pharmacol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol Ther"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz050","article-title":"Immune cells as targets for cardioprotection: New players and novel therapeutic opportunities","volume":"115","author":"Andreadou","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12929-017-0322-3","article-title":"Macrophage activation and polarization in post-infarction cardiac remodeling","volume":"24","author":"Gombozhapova","year":"2017","journal-title":"J BioMed Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","article-title":"Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction","volume":"62","author":"Yan","year":"2013","journal-title":"J Mol Cell Cardiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.243162","article-title":"Regulation of the inflammatory response in cardiac repair","volume":"110","author":"Frangogiannis","year":"2012","journal-title":"Circ Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-214049","article-title":"Monocytes\/Macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction","volume":"27","author":"Frantz","year":"2013","journal-title":"FASEB J"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.916346","article-title":"Monocytes: Protagonists of infarct inflammation and repair after myocardial infarction","volume":"121","author":"Nahrendorf","year":"2010","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.115.303567","article-title":"Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction","volume":"115","author":"Heidt","year":"2014","journal-title":"Circ Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.114.303204","article-title":"Ly-6chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium","volume":"114","author":"Hilgendorf","year":"2014","journal-title":"Circ Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00595.2019","article-title":"Monocytes prime autoreactive T cells after myocardial infarction","volume":"318","author":"DeBerge","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.yjmcc.2021.06.006","article-title":"Inhibition of interleukin-21 prolongs the survival through the promotion of wound healing after myocardial infarction","volume":"159","author":"Kubota","year":"2021","journal-title":"J Mol Cell Cardiol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa598","article-title":"Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor Cxcr4","volume":"41","author":"Hess","year":"2020","journal-title":"Eur Heart J"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.314357","article-title":"The functional heterogeneity of resident cardiac macrophages in myocardial Injury(Ccr2(+) cells promote inflammation, whereas Ccr2(-) cells protect)","volume":"124","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.118.314028","article-title":"Tissue resident Ccr2- and Ccr2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0221-9","article-title":"Mesenchymal stromal cells mediate a switch to alternatively activated Monocytes\/Macrophages after acute myocardial infarction","volume":"106","author":"Dayan","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"B32","article-title":"Inhibiting the mobilization of Ly6c(High) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling","volume":"7","author":"Lu","year":"2015","journal-title":"Am J Transl Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.052126","article-title":"Regulatory role of dendritic cells in postinfarction healing and left ventricular remodeling","volume":"125","author":"Anzai","year":"2012","journal-title":"Circulation"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e000839","DOI":"10.1161\/jaha.114.000839","article-title":"Decreased myocardial dendritic cells is associated with impaired reparative fibrosis and development of cardiac rupture after myocardial infarction in humans","volume":"3","author":"Nagai","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.023106","article-title":"Infarcted myocardium-primed dendritic cells improve remodeling and cardiac function after myocardial infarction by modulating the regulatory T cell and macrophage polarization","volume":"135","author":"Choo","year":"2017","journal-title":"Circulation"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004406","article-title":"Interleukin-37 and dendritic cells treated with interleukin-37 plus troponin I ameliorate cardiac remodeling after myocardial infarction","volume":"5","author":"Zhu","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B37","article-title":"Isolation of granulocytes: Which transcriptome do we analyse - neutrophils or eosinophils","volume":"56","author":"Stejskal","year":"2010","journal-title":"Folia Biol (Praha)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","article-title":"Temporal neutrophil polarization following myocardial infarction","volume":"110","author":"Ma","year":"2016","journal-title":"Cardiovasc Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw002","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur Heart J"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz461","article-title":"Inhibition of pro-inflammatory myeloid cell responses by short-term S100a9 blockade improves cardiac function after myocardial infarction","volume":"40","author":"Marinkovi\u0107","year":"2019","journal-title":"Eur Heart J"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66808","article-title":"Expansion of Cd10(Neg) neutrophils and Cd14(+)Hla-Dr(Neg\/Low) monocytes driving proinflammatory responses in patients with acute myocardial infarction","volume":"10","author":"Fraccarollo","year":"2021","journal-title":"Elife"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/jci151268","article-title":"Gasdermin d inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction","volume":"132","author":"Jiang","year":"2022","journal-title":"J Clin Invest"},{"key":"B43","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1038\/s41467-020-19297-5","article-title":"Eosinophils improve cardiac function after myocardial infarction","volume":"11","author":"Liu","year":"2020","journal-title":"Nat Commun"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.05.005","article-title":"Eosinophil deficiency promotes aberrant repair and adverse remodeling following acute myocardial infarction","volume":"5","author":"Toor","year":"2020","journal-title":"JACC Basic Transl Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab237","article-title":"Interleukin-5-Induced eosinophil population improves cardiac function after myocardial infarction","volume":"118","author":"Xu","year":"2022","journal-title":"Cardiovasc Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"131(13)","DOI":"10.1172\/jci136778","article-title":"Basophils balance healing after myocardial infarction Via il-4\/Il-13","author":"Sicklinger","year":"2021","journal-title":"J Clin Invest"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1172\/jci150555","article-title":"Healing and repair after myocardial infarction: The forgotten but resurgent basophil","volume":"131","author":"Prabhu","year":"2021","journal-title":"J Clin Invest"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100219-020937","article-title":"Regulatory T cell development","volume":"38","author":"Savage","year":"2020","journal-title":"Annu Rev Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: Implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.304072","article-title":"Role of lymphocytes in myocardial injury, healing, and remodeling after myocardial infarction","volume":"116","author":"Hofmann","year":"2015","journal-title":"Circ Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/635672","article-title":"Circulating Th22 and Th9 levels in patients with acute coronary syndrome","volume":"2013","author":"Lin","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9515346","article-title":"Il-37 plays a beneficial role in patients with acute coronary syndrome","volume":"2019","author":"Mao","year":"2019","journal-title":"Mediators Inflammation"},{"key":"B53","doi-asserted-by":"publisher","first-page":"193","DOI":"10.4067\/s0716-97602012000200012","article-title":"Il-17a levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction","volume":"45","author":"\u00c1valos","year":"2012","journal-title":"Biol Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7150\/thno.68437","article-title":"Cd4(+)Foxp3(+)Cd73(+) regulatory T cell promotes cardiac healing post-myocardial infarction","volume":"12","author":"Zhuang","year":"2022","journal-title":"Theranostics"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.046789","article-title":"A unique population of regulatory T cells in heart potentiates cardiac protection from myocardial infarction","volume":"142","author":"Xia","year":"2020","journal-title":"Circulation"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.078","article-title":"Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target","volume":"203","author":"Wang","year":"2016","journal-title":"Int J Cardiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv639","article-title":"Role of T-cells in myocardial infarction","volume":"37","author":"Hofmann","year":"2016","journal-title":"Eur Heart J"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.044164","article-title":"Activation of Cd4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice","volume":"125","author":"Hofmann","year":"2012","journal-title":"Circulation"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42943","article-title":"Specific ablation of Cd4(+) T-cells promotes heart regeneration in juvenile mice","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1038\/s41467-021-21737-9","article-title":"Cytotoxic Cd8(+) T cells promote granzyme b-dependent adverse post-ischemic cardiac remodeling","volume":"12","author":"Santos-Zas","year":"2021","journal-title":"Nat Commun"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0232-6","article-title":"Regulatory T cells ameliorate cardiac remodeling after myocardial infarction","volume":"107","author":"Tang","year":"2012","journal-title":"Basic Res Cardiol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1172\/jci152418","article-title":"Cd69 expression on regulatory T cells protects from immune damage after myocardial infarction","volume":"132","author":"Blanco-Dom\u00ednguez","year":"2022","journal-title":"J Clin Invest"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.036053","article-title":"C-X-C motif chemokine receptor 4 blockade promotes tissue repair after myocardial infarction by enhancing regulatory T cell mobilization and immune-regulatory function","volume":"139","author":"Wang","year":"2019","journal-title":"Circulation"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.7150\/thno.32734","article-title":"Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner","volume":"9","author":"Li","year":"2019","journal-title":"Theranostics"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat Med"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0612-x","article-title":"Rituximab in b-cell hematologic malignancies: A review of 20 years of clinical experience","volume":"34","author":"Salles","year":"2017","journal-title":"Adv Ther"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab113","article-title":"Rituximab in patients with acute St-elevation myocardial infarction: An experimental medicine safety study","volume":"118","author":"Zhao","year":"2022","journal-title":"Cardiovasc Res"},{"key":"B68","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00395-021-00886-4","article-title":"Regulatory b cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration","volume":"116","author":"Jiao","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00395-022-00956-1","article-title":"Bone marrow-derived na\u00efve b lymphocytes improve heart function after myocardial infarction: A novel cardioprotective mechanism for empagliflozin","volume":"117","author":"Xu","year":"2022","journal-title":"Basic Res Cardiol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.024590","article-title":"Exosomal microrna transfer into macrophages mediates cellular postconditioning","volume":"136","author":"de Couto","year":"2017","journal-title":"Circulation"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s003950200046","article-title":"A model of closed chest regional myocardial infarction in the rabbit: A clinically relevant in vivo assay system of post-infarction remodelling","volume":"97","author":"Edwards","year":"2002","journal-title":"Basic Res Cardiol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.04.030","article-title":"Cardiac repair achieved by bone marrow mesenchymal stem Cells\/Silk Fibroin\/Hyaluronic acid patches in a rat of myocardial infarction model","volume":"33","author":"Chi","year":"2012","journal-title":"Biomaterials"},{"key":"B73","doi-asserted-by":"publisher","first-page":"138ra80","DOI":"10.1126\/scitranslmed.3003551","article-title":"Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes","volume":"4","author":"Gottumukkala","year":"2012","journal-title":"Sci Transl Med"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.079","article-title":"Myocardial infarction primes autoreactive T cells through activation of dendritic cells","volume":"18","author":"Van der Borght","year":"2017","journal-title":"Cell Rep"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63642","article-title":"Hypoxia-primed Monocytes\/Macrophages enhance postinfarction myocardial repair","volume":"12","author":"Zhu","year":"2022","journal-title":"Theranostics"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy200","article-title":"Peroxisome proliferator-activated receptor-gamma targeting nanomedicine promotes cardiac healing after acute myocardial infarction by skewing Monocyte\/Macrophage polarization in preclinical animal models","volume":"115","author":"Tokutome","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat9683","article-title":"An off-the-Shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs","volume":"12","author":"Huang","year":"2020","journal-title":"Sci Transl Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41419-021-03610-1","article-title":"Adropin-based dual treatment enhances the therapeutic potential of mesenchymal stem cells in rat myocardial infarction","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36464","article-title":"Application of tissue-engineered pericardial patch in rat models of myocardial infarction","volume":"106","author":"Kameli","year":"2018","journal-title":"J BioMed Mater Res A"},{"key":"B80","doi-asserted-by":"publisher","first-page":"24","DOI":"10.7150\/thno.7188","article-title":"Towards stratifying ischemic components by cardiac mri and multifunctional stainings in a rabbit model of myocardial infarction","volume":"4","author":"Feng","year":"2013","journal-title":"Theranostics"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00033.2003","article-title":"Developmental anatomy of the heart: A tale of mice and man","volume":"15","author":"Wessels","year":"2003","journal-title":"Physiol Genomics"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.075","article-title":"Myocardial infarction and intramyocardial injection models in swine","volume":"7","author":"McCall","year":"2012","journal-title":"Nat Protoc"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050545","article-title":"Relevant radiological anatomy of the pig as a training model in interventional radiology","volume":"8","author":"Dondelinger","year":"1998","journal-title":"Eur Radiol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.7150\/thno.72289","article-title":"Acellular cardiac scaffolds enriched with msc-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model","volume":"12","author":"Mongui\u00f3-Tortajada","year":"2022","journal-title":"Theranostics"},{"key":"B85","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1093\/eurheartj\/ehaa791","article-title":"Cdr132l improves systolic and diastolic function in a Large animal model of chronic heart failure","volume":"42","author":"Batkai","year":"2021","journal-title":"Eur Heart J"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1126\/science.1139247","article-title":"Evolutionary and biomedical insights from the rhesus macaque genome","volume":"316","author":"Gibbs","year":"2007","journal-title":"Science"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510280051032","article-title":"Remodeling of coronary arteries in human and nonhuman primates","volume":"271","author":"Clarkson","year":"1994","journal-title":"Jama"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-011-9129-8","article-title":"Electrocardiographic characterization of rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation","volume":"11","author":"Yang","year":"2011","journal-title":"Cardiovasc Toxicol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s12012-022-09754-6","article-title":"An improved monkey model of myocardial ischemic infarction for cardiovascular drug development","volume":"22","author":"Wang","year":"2022","journal-title":"Cardiovasc Toxicol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11138","article-title":"Chimeric 2c10r4 anti-Cd40 antibody therapy is critical for long-term survival of Gtko.Hcd46.Htbm pig-to-Primate cardiac xenograft","volume":"7","author":"Mohiuddin","year":"2016","journal-title":"Nat Commun"},{"key":"B91","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/bmb\/ldn026","article-title":"Myocardial tissue engineering","volume":"87","author":"Jawad","year":"2008","journal-title":"Br Med Bull"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0110","article-title":"Current state of the art in myocardial tissue engineering","volume":"13","author":"Giraud","year":"2007","journal-title":"Tissue Eng"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/s0142-9612(03)00339-9","article-title":"Biomimetic materials for tissue engineering","volume":"24","author":"Shin","year":"2003","journal-title":"Biomaterials"},{"key":"B94","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.biomaterials.2018.01.002","article-title":"Engineered cardiac tissue patch maintains structural and electrical properties after epicardial implantation","volume":"159","author":"Jackman","year":"2018","journal-title":"Biomaterials"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e2001175","DOI":"10.1002\/adhm.202001175","article-title":"Cardiomyocyte induction and regeneration for myocardial infarction treatment: Cell sources and administration strategies","volume":"9","author":"He","year":"2020","journal-title":"Adv Healthc Mater"},{"key":"B96","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.actbio.2021.03.073","article-title":"Anisotropic conductive reduced graphene Oxide\/Silk matrices promote post-infarction myocardial function by restoring electrical integrity","volume":"139","author":"Zhao","year":"2022","journal-title":"Acta Biomater"},{"key":"B97","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.biomaterials.2019.03.015","article-title":"Engineering a naturally-derived adhesive and conductive cardiopatch","volume":"207","author":"Walker","year":"2019","journal-title":"Biomaterials"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201856","article-title":"A conductive bioengineered cardiac patch for myocardial infarction treatment by improving tissue electrical integrity","author":"Yin","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"B99","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.biomaterials.2018.05.044","article-title":"Reactive oxygen species scavenging with a biodegradable, thermally responsive hydrogel compatible with soft tissue injection","volume":"177","author":"Zhu","year":"2018","journal-title":"Biomaterials"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101855","article-title":"Alleviating oxidative injury of myocardial infarction by a fibrous polyurethane patch with condensed ros-scavenging backbone units","volume":"11","author":"Xie","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.09.015","article-title":"A honeybee stinger-inspired self-interlocking microneedle patch and its application in myocardial infarction treatment","volume":"153","author":"Lu","year":"2022","journal-title":"Acta Biomater"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e0165255","DOI":"10.1371\/journal.pone.0165255","article-title":"Cardiosphere-derived cells facilitate heart repair by modulating M1\/M2 macrophage polarization and neutrophil recruitment","volume":"11","author":"Hasan","year":"2016","journal-title":"PloS One"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-00613-9","article-title":"Extensive germline genome engineering in pigs","volume":"5","author":"Yue","year":"2021","journal-title":"Nat BioMed Eng"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1084460\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:36:21Z","timestamp":1674113781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1084460\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":103,"alternative-id":["10.3389\/fimmu.2022.1084460"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1084460","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"article-number":"1084460"}}