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Immunol."],"abstract":"<jats:p>Sj\u00f6gren\u2019s syndrome is a chronic inflammatory autoimmune disease characterized by diminished secretory function of the exocrine glands. Although extensive investigation has been done to understand Sj\u00f6gren\u2019s syndrome, the causes of the disease are as yet unknown and treatments remain largely ineffective, with established therapeutic interventions being limited to use of saliva substitutes with modest effectiveness. A primary feature of Sj\u00f6gren\u2019s syndrome is uncontrolled inflammation of exocrine tissues and previous studies have demonstrated that lipid-based specialized pro-resolving mediators reduce inflammation and restores tissue integrity in salivary glands. However, these studies are limited to a single specialized pro-resolving lipid mediator\u2019s family member resolvin D1 or RvD1 and its aspirin-triggered epimer, AT-RvD1. Consequently, additional studies are needed to explore the potential benefits of other members of the specialized pro-resolving lipid mediator\u2019s family and related molecules (<jats:italic>e.g.<\/jats:italic>, additional resolvin subtypes as well as lipoxins, maresins and protectins). In support of this goal, the current review aims to briefly describe the range of current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sj\u00f6gren\u2019s syndrome, including both strengths and weaknesses of each approach where this information is known. With this article, the possibilities presented by specialized pro-resolving lipid mediators will be introduced to a wider audience in immunology and practical advice is given to researchers who may wish to take up this work.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1094278","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T07:38:42Z","timestamp":1673509122000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Current experimental methods to investigate the impact of specialized pro-resolving lipid mediators on Sj\u00f6gren\u2019s syndrome"],"prefix":"10.3389","volume":"13","author":[{"given":"Harim T.","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kihoon","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata","family":"Yellepeddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga J.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"B1","article-title":"One year in review 2015: Sjogren\u2019s syndrome","volume":"33","author":"Luciano","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh647","article-title":"Sjogren\u2019s syndrome and the danger model","volume":"44","author":"Bredberg","year":"2005","journal-title":"Rheumatol (Oxford)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2008.08.004","article-title":"New concepts in the pathogenesis of sjogren\u2019s syndrome","volume":"34","author":"Delaleu","year":"2008","journal-title":"Rheumatic Dis Clinics North America"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00183.x","article-title":". 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