{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:45:20Z","timestamp":1789073120079,"version":"build-2803163510"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>In this paper we aimed to study the characteristics, laboratory data and outcomes of monkeypox virus (MPV) and COVID-19 co-infection. On 2<jats:sup>nd<\/jats:sup>October 2022, we used the search term \u201c(\u201cmonkeypox virus\u201d OR \u201cMPV\u201d OR \u201cmonkey pox\u201d OR \u201cmonkeypox\u201d) AND (\u201cCOVID-19\u201d OR \u201cCOVID 19\u201d OR \u201cnovel coronavirus\u201d OR \u201cSARS\u2212CoV\u22122\u201d)\u201d in five databases to collect the relevant articles. We found three male patients, who had sex with men prior to the infection, had multiple comorbid conditions, were diagnosed with PCR, and were admitted to the hospital. The length of hospital stay was 4, 6, and 9 days. On admission, two cases had multiple vesicular lesions on various sites of the body associated with tonsillar inflammation, while the third case had genital ulcers and inguinal lymph node enlargement. All cases were managed in the hospital and recovered well. It might still be too early to establish solid evidence about the exact cause-effect association between SARS-CoV-2 and MPV co-infection and patient\u2019s outcomes because of the current low sample size. Accordingly, future relevant investigations, estimating the risk ratio of this association are needed to formulate definite evidence.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1094346","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T05:14:20Z","timestamp":1670994860000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["COVID-19 and monkeypox co-infection: A rapid systematic review"],"prefix":"10.3389","volume":"13","author":[{"given":"Amr Ehab","family":"El-Qushayri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Reda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffer","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2339","article-title":"Does dengue and COVID-19 co-infection have worse outcomes? A systematic review of current evidence","volume":"32","author":"El-Qushayri","year":"2022","journal-title":"Rev Med Virol"},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-056549","article-title":"Risk factors for SARS-CoV-2 infection and hospitalisation in children and adolescents in Norway: A nationwide population-based study","volume":"12","author":"St\u00f8rdal","year":"2022","journal-title":"BMJ Open"},{"key":"B3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/00365513.2020.1855470","article-title":"How do routine laboratory tests change in coronavirus disease 2019","volume":"81","author":"Mertoglu","year":"2021","journal-title":"Scand J Clin Lab Invest"},{"key":"B4","doi-asserted-by":"crossref","first-page":"20499361221124027","DOI":"10.1177\/20499361221124027","article-title":"First monkeypox deaths outside Africa: no room for complacency","volume":"9","author":"Sah","year":"2022","journal-title":"Ther Adv Infect Disease"},{"key":"B5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jiph.2021.06.011","article-title":"Clinical manifestations and socio-demographic status of COVID-19 patients during the second-wave of pandemic: A Bangladeshi experience","volume":"14","author":"Ali","year":"2021","journal-title":"J infect Public Health"},{"key":"B6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.54026\/CREM\/1041","article-title":"Co-Infection of COVID-19 and monkeypox: A case report from Florida, USA, 2022","volume":"2","author":"Knopp","year":"2022","journal-title":"Curr Res Emerg Med"},{"key":"B7","article-title":"First case of monkeypox virus, SARS-CoV-2 and HIV co-infection","author":"Nolasco","year":"","journal-title":"J Infect"},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.21203\/rs.3.rs-1960471\/v1","article-title":"Coinfection of monkeypox, COVID-19 and syphilis in a PrEP using MSM: A case report from Barcelona","author":"Vives","year":"2022"},{"key":"B9","doi-asserted-by":"crossref","first-page":"102456","DOI":"10.1016\/j.tmaid.2022.102456","article-title":"The clinical manifestations and severity of the 2022 monkeypox outbreak among 4080 patients","volume":"50","author":"Reda","year":"2022","journal-title":"Travel Med Infect disease"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1094346\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T09:35:02Z","timestamp":1728552902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2022.1094346\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":9,"alternative-id":["10.3389\/fimmu.2022.1094346"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2022.1094346","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]},"article-number":"1094346"}}