{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:36:00Z","timestamp":1790386560464,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The cutaneous microbiome is increasingly recognized as a contributor to skin diseases like atopic dermatitis (AD) and psoriasis. Although traditionally AD and psoriasis have been viewed as having opposing immunologic findings, recent evidence suggests an overlap in ceramide-family lipid production in the protection against symptoms. We recently identified that specific environmental pollutants may drive dysbiosis through direct suppression of ceramide-family lipids produced by health-associated skin bacteria in atopic dermatitis (AD). We further demonstrated that one such bacteria, <jats:italic>Roseomonas mucosa<\/jats:italic>, generated significant clinical improvement in AD lasting beyond active treatment <jats:italic>via<\/jats:italic> lipid-mediated modulation of tumor necrosis factor (TNF) signaling. To assess the potential preclinical benefit of <jats:italic>R. mucosa<\/jats:italic> in psoriasis we assessed for direct effects on surface TNF signaling in cell cultures and identified direct effects on the TNF axis. We also identified preclinical efficacy of <jats:italic>R. mucosa<\/jats:italic> treatment in the imiquimod mouse model of psoriasis. Finally, we expanded our previous environmental assessment for psoriasis to include more traditional markers of air quality and found a strong association between disease rates and ambient carbon monoxide (CO), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), and particulate matter (PM). At the current stage this work is speculative but does support consideration of further preclinical models and\/or clinical assessments to evaluate any potential for therapeutic benefit through microbial manipulation and\/or environmental mitigation.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1094376","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:06:03Z","timestamp":1671519963000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis"],"prefix":"10.3389","volume":"13","author":[{"given":"Portia","family":"Gough","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Zeldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian 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