{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:04:02Z","timestamp":1766732642506,"version":"3.41.2"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>In this conceptual analysis, we present our concepts on two issues regarding autoimmune bullous diseases (AIBD), namely (i) current nomenclature of AIBD requires updating by incorporating molecular data and (ii) pemphigus vulgaris (PV) \u201clikes\u201d areas adjacent to natural body orifices. The problem of inadequacy of the currently used nomenclature was noticed recently by Zillikens, who proposed to form a group with the task of updating it. The early efforts by Dmochowski to update this nomenclature happened to be a daunting task. Nevertheless, the ideal nomenclature should retain the bulk of clinical data, which generations of dermatologists are accustomed to, including triggers if known, and incorporate molecular data revealing targets of autoimmune response and immunoglobulin isotypes involved. The natural body orifices affected by PV were previously described in numerous publications. However, these openings are described separately in these publications. Here, Dmochowski comes up with an intellectual concept that this propensity of PV unifies seemingly diverse clinical features of this disease.<\/jats:p>","DOI":"10.3389\/fimmu.2022.1103375","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T08:44:58Z","timestamp":1671439498000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Issues occupying our minds: Nomenclature of autoimmune blistering diseases requires updating, pemphigus vulgaris propensity to affect areas adjacent to natural body orifices unifies seemingly diverse clinical features of this disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Marian","family":"Dmochowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Ja\u0142owska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bowszyc-Dmochowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"B1","first-page":"164","article-title":"Autorska klasyfikacja chor\u00f3b p\u0119cherzowych sk\u00f3ry z autoimmunizacji\/The classification of blistering autoimmune dermatoses according to m. dmochowski","volume":"20","author":"Dmochowski","year":"2003","journal-title":"Adv Dermatol Allergol."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.017","article-title":"Immunoglobulin m pemphigoid","volume":"85","author":"Boch","year":"2021","journal-title":"J Am Acad Dermatol"},{"volume-title":"Autoimmune bullous diseases associated with malignancy. 31st EADV congress: Designing the future of dermatology and venereology","year":"2022","author":"Dmochowski","key":"B3"},{"volume-title":"Are patients with anti-BP230 IgG antibodies but without anti-BP180NC16a IgG antibodies suffering from less stereotypical varieties of bullous pemphigoid? international pre IID 2013 meeting on autoimmune bullous diseases","year":"2013","author":"Dmochowski","key":"B4"},{"key":"B5","first-page":"86","volume-title":"Misnomers & misconception in oral medicine: A retrospection. skin disease","author":"Nethan","year":"2016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2012.30461","article-title":"IgA autoantibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase are associated, but unrelated to neutrophil elastase expression in lesional skin in human dermatitis herpetiformis","volume":"29","author":"Gornowicz-Porowska","year":"2012","journal-title":"Postepy Dermatol Alergol."},{"key":"B7","first-page":"159","volume-title":"Malignancy in relation to autoimmune blistering dermatoses: Molecular and clinical aspects. highlights in skin cancer","author":"Pietkiewicz","year":"2013"},{"key":"B8","article-title":"Naturalne otwory cia\u0142a i b\u0142ony \u015bluzowe w p\u0119cherzycy zwyk\u0142ej\/Body orifices and mucous membranes in pemphigus vulgaris","volume":"9","author":"Dmochowski","year":"2007","journal-title":"Dermatologia Kliniczna"},{"key":"B9","first-page":"37","article-title":"Przypadek \u015bluz\u00f3wkowo-sk\u00f3rnej odmiany p\u0119cherzycy zwyk\u0142ej w przebiegu raka p\u0142askonab\u0142onkowego w obr\u0119bie jamy ustnej leczonego radioterapi\u0105\/Mucocutaneous pemphigus vulgaris in a patient with oral squamous cell carcinoma treated with radiotherapy","volume":"11","author":"Chru\u015bli\u0144ski","year":"2009","journal-title":"Dermatologia Kliniczna"},{"volume-title":"Leki przeciwnadci\u015bnieniowe a wyzwalanie p\u0119cherzycy - heterogenno\u015b\u0107 schorze\u0144 p\u0119cherzycowych\/ Antihypertensive drugs and pemphigus triggering: Heterogeneity of pemphigus diseases. X Jubileuszowe Sympozjum Naukowo-Szkoleniowe Polskiej Akademii Dermatologii i Wenerologii \u201eSk\u00f3ra zwierciad\u0142em wn\u0119trza cz\u0142owieka i jego zdrowia''","year":"2015","author":"Dmochowski","key":"B10"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00227","article-title":"Involvement of nail apparatus in pemphigus vulgaris in ethnic poles is infrequent","volume":"14","author":"Pietkiewicz","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2021.102857","article-title":"Clinical significance of umbilical region involvement in pemphigus vulgaris in a series of 81 ethnic poles: a comparative analysis of the distribution of lesions in two infrequent locations","volume":"39","author":"Ja\u0142owska","year":"2022","journal-title":"Adv Dermatol Allergol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11102855","article-title":"Sacral dimple, conjunctiva, and nipple as less obvious pemphigus vulgaris locations around natural body orifices: A report of three cases","volume":"11","author":"Ja\u0142owska","year":"2022","journal-title":"J Clin Med"},{"volume-title":"P\u0119cherzyca zwyk\u0142a \u201elubi\u201d okolice naturalnych otwor\u00f3w cia\u0142a\/Pemphigus vulgaris \"likes\" areas around natural body orifices. 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