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Immunol."],"abstract":"<jats:p>Epidemiological and experimental evidence has implicated a potent link between antibiotic exposure and susceptibility to various diseases. Clinically, antibiotic treatment during platinum chemotherapy is associated with poor prognosis in patients with malignancy. In the present study, mucosal antibiotic exposure was assessed for its impact on renal distress as a sequela of platinum-based chemotherapy. Clinical transcriptome dataset-based evaluations demonstrated that levels of dysbiosis-responsive genes were elevated during renal distress, indicating pathological communications between gut and kidney. Experimentally, mucosal exposure to streptomycin aggravated platinum-induced renal tubular lesions in a mouse model. Moreover, antibiotic-induced dysbiosis increased susceptibility to gut mucosal inflammation, epithelial disruption, and bacterial exposure in response to cisplatin treatment. Further investigation of the luminal microbes indicated that antibiotic-induced dysbiosis promoted the dominance of <jats:italic>Bacteroides<\/jats:italic> species. Moreover, the functional assessment of dysbiotic microbiota predicted tryptophan metabolic pathways. In particular, dysbiosis-responsive <jats:italic>Bacteroides acidifaciens<\/jats:italic> was associated with the production of the uremic toxin indoxyl sulfate and renal injuries. The results of this study including bacterial community-based evaluations provide new predictive insights into the interorgan communications and interventions against dysbiosis-associated disorders.<\/jats:p>","DOI":"10.3389\/fimmu.2022.737536","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:40:19Z","timestamp":1648546819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Antibiotic Exposure Aggravates Bacteroides-Linked Uremic Toxicity in the Gut-Kidney Axis"],"prefix":"10.3389","volume":"13","author":[{"given":"Navin","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoyoung","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasom","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuseok","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31827f520f","article-title":"Mother's and Offspring's Use of Antibiotics and Infant Allergy to Cow's Milk","volume":"24","author":"Metsala","year":"2013","journal-title":"Epidemiology"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.304","article-title":"Association Between the Use of Antibiotics and New Diagnoses of Crohn's Disease and Ulcerative Colitis","volume":"106","author":"Shaw","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.246","article-title":"Antibiotics Associated With Increased Risk of New-Onset Crohn's Disease But Not Ulcerative Colitis: A Meta-Analysis","volume":"109","author":"Ungaro","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01346-15","article-title":"Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus Faecium From the Intestinal Epithelium","volume":"6","author":"Hendrickx","year":"2015","journal-title":"mBio"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-309059","article-title":"Antibiotics Promote Inflammation Through the Translocation of Native Commensal Colonic Bacteria","volume":"65","author":"Knoop","year":"2016","journal-title":"Gut"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00430-13","article-title":"Streptomycin-Induced Inflammation Enhances Escherichia Coli Gut Colonization Through Nitrate Respiration","volume":"4","author":"Spees","year":"2013","journal-title":"mBio"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-3-237","article-title":"Clostridium Difficile Infection and Antibiotic-Associated Diarrhoea","volume":"18","author":"Mullish","year":"2018","journal-title":"Clin Med (Lond)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080905","article-title":"The Gut Microbiome, Kidney Disease, and Targeted Interventions","volume":"25","author":"Ramezani","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000020678","article-title":"Endotoxin-Induced Renal Failure. 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